We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

Really happy to join NeuroPSI at Paris Saclay to lead a research group funded by an ERC Consolidator grant #ERCCoG . We'll study the origins of the vertebrate brain using shark embryos. 🦈 🧠 Reach out if you are interested in joining the team 🤍

Join us at SMBE26! We are in a golden period for understanding the evolution of gene regulation.

Aged mice and human samples show patterned loss of Purkinje cells in the cerebellum, revealing a spatial signature of ageing that may help explain why motor coordination and behaviour decline over time.

In 2018, Tomasz Nowakowski received our Fellows-to-Faculty Award to jumpstart his new lab. We spoke with him about his research and the Fellows-to-Faculty program, which is open for apps: https://www.simonsfoundation.org/fellows-to-faculty-alum-tomasz-nowakowski-studies-human-cortical-development/

#ERCCogG granted!!! Immensely grateful for this opportunity. Thanks @erc.europa.eu . Many news coming soon. New lab opening and will be posting positions. 🦈🧠🤍 Go sharkies!

We tend to think of neurons as either excitatory or inhibitory, but some neurons chemically inhibit their downstream targets while electrically exciting their neighbors. What is gained by having an inhibitory neuron excite its neighbor? www.biorxiv.org/content/10.6...

JASPAR 2026 is out 🎉 The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models. Database: jaspar.elixir.no Paper (NAR): doi.org/10.1093/nar/... 🧵1/2

Claudia Feng's Ph.D work is now out, co-led with @brittavelten.bsky.social and @steglelab.bsky.social . Large-scale CRISPRi perturbations in genetically heterogenous iPSC lines, with single cell readout - enjoy :)

Deadline approaching for participating in the international Stanford Course on Neural Assembloids in spring 2026! This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.

Nice cerebellum development paper 👀 www.pnas.org/doi/10.1073/...

We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...

NEW pub in @science.org 🥳 Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life? For over 15 years, #phylogenomic studies have been divided. We provide new evidence suggesting that... 🔗: www.science.org/doi/10.1126/...

Interested in applying for our Fellows-to-Faculty Award? Watch the recording of our informational webinar for more details on the program: https://www.simonsfoundation.org/grant/fellows-to-faculty-award/#:~:text=Brain%20(SCPAB).-,Informational%20Webinar,-An%20informational%20webinar #science

Our intelligence and cognitive abilities are perhaps due to an expansion of our cerebral cortex. But surprisingly, compared to highly intelligent birds, primates have many more neurons in their cerebellum as compared to the cerebral cortex. doi.org/10.1073/pnas...

Share this funding opportunity! We offer the Fellows-to-Faculty program to nurture new talent in the basic sciences and to broaden the community of scientists contributing to Simons Foundation Autism Research Initiative (SFARI) and Simons Collaboration on Plasticity and the Aging Brain (SCPAB).

Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies” shorturl.at/H3Qww This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon. Bluetorial below.

🚀 𝗣𝗼𝘀𝘁𝗱𝗼𝗰 𝗢𝗽𝗲𝗻𝗶𝗻𝗴 We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens. 👉 Apply by Nov 30 | www.bonevlab.com/join

Happy to have contributed to this work on how transposable elements shape the regulatory landscape of cerebellar cells - together with @tyamadat.bsky.social , @ioansarr.bsky.social and @kaessmannlab.bsky.social. Tetsuya's scientific journey is just taking off - definitely one to watch!

Excited to share the preprint from my main postdoc project! It’s been a long journey—huge thanks to everyone who made it possible, especially @leticiarm1618.bsky.social for being the best collaborator one could ask for, and the amazing @kaessmannlab.bsky.social lab for the invaluable support!

We are thrilled to share our new preprint entitled “The origin and molecular evolution of the mammalian liver cell architecture” www.biorxiv.org/content/10.1...

Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social

Announcing our 9 new Fellows-to-Faculty Fellows! These awards help senior postdoctoral researchers with fresh perspectives on autism & neuroscience transition to tenure-track faculty positions: https://www.simonsfoundation.org/simons-foundation-announces-recipients-of-2025-fellows-to-faculty-awards/

👇 !!!

Huge congrats @klehto.bsky.social on this achievement!! Her work has already enriched the @estbiobank.bsky.social and will continue to do so! 💙🖤🤍

🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu! 🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you! 🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...

🔬 New preprint out! Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches. 📄 www.biorxiv.org/content/10.1... #scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

Human de novo mutation rates from a four-generation pedigree reference www.nature.com/articles/s41... - amazingly comprehensive study from Evan Eichler and colleagues

Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators! www.nature.com/articles/s41... 1/n

🤩 Happy to see my PhD mentor Tõnis Timmusk elected as a Member of the European Molecular Biology Organization ‪@embo.org‬. So well-deserved! An inspiring scientist, supportive mentor, and generous friend! ‪ @taltech.bsky.social‬

Did the miss the Cerebellum Development and Disease conference last year? Never fear, as we wrote up a conference report! link.springer.com/article/10.1...

Excited to share the first 2(!) preprints from the Kebschull Lab. The amazing @hyopilkim.bsky.social developed MAPseq2 & POINTseq and used them to map the dopaminergic cells of VTA and SNc. tl;dr MAPseq2=10x cheaper, 4x better; POINTseq=easy cell type specific barcoding; DA neurons=very cool.

We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...

What about the social cerebellum during development we wondered? Here you find some cool insights on this awesome part of the brain! BIG thanks for the great work Katerina Manoli, and support from Charlotte Grosse Wiesmann and Frank van Overwalle 🧠🦋 rdcu.be/epKmZ

Get the word out far and wide. New opportunity from the Simons Foundation in the Eco-Evo space. 2026 Simons Graduate Fellowship in Ecology and Evolution Awards, due July 31, 2025, only for incoming PhD students who plan to start their PhDs in Fall 2026. www.simonsfoundation.org/grant/simons...

New preprint alert 📣 #Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬 Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵

Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis 🧬🩸 screen of fully synthetic enhancers in blood progenitors 🤖 AI that creates new cell state specific enhancers 🔍 negative synergies between TFs lead to specificity! www.cell.com/cell/fulltex... 🧵

Big congrats to our longtime collaborators in the Stefan Pfister and @lenakutscher.bsky.social labs — large-scale chromosomal changes as early tumour-initiating events in Group 3/4 medulloblastoma!

Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social. www.nature.com/articles/s41... This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu

🎉 This paper has been a long time and a labour of love (and hardship) for multiple group members, but, finally: we MPRA'ed 25k introgressed variants (Denisovan and Neanderthal) segregating at allele frequencies > 0.15 in humans today to evaluate their potential to regulate gene expression.

Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development! www.biorxiv.org/content/10.1... Read on for more: 🧵 1/16 #GeneReg 🧬🖥️

Delighted to share our new preprint, the outcome of many years of collaborative work with Giuseppe Testa’s group, both at the bench & in front of the computer, probing human brain evolution using organoids. We tried something cool, and learned a lot 🧪🧫🧠🧬 [follow 🧵] www.biorxiv.org/content/10.1...

What an elegant study - uncovering the regulatory basis of an evolutionary adaptation

We are super excited to share our latest pre-print in collaboration with @sonjavernes.bsky.social lab! www.biorxiv.org/content/10.1... : Evolution of the cellular landscape in mammalian striatum 🧠🧬🧵

It’s been a hectic few days, here’s a quick thread on our latest endeavour exploring GABAergic neurogenesis in the human cerebellum published in @pnas.org. Key takeaways: Purkinje cells are born very early in human development — much earlier than previously appreciated. www.pnas.org/doi/10.1073/...