An absolute must-read! The labs of @elphegenoralab.bsky.social and Leonid Mirny establish cohesin bridging as a central mode of enhancer-promoter communication. Great paper!

Looking forward!

We are looking for a PhD student to study chromatin changes related to heart regeneration, in collaboration with @bakkerslab.bsky.social . Please share and apply! www.hubrecht.eu/nl/vacature/...

Johannes Stein's new lab at the MPIMG will use microscopy to study the organization of the genome at a molecular level. We talked to him about how, despite being a trained physicist, he ended up in biology, the potential of his research and the power of interdisciplinary teams. @jmstein.bsky.social

Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? And why is DNMT3B specifically required for methylation on the inactive X? We set out to dissect the mechanism, now published in Genes & Development genesdev.cshlp.org/content/earl... [1/12]

Great collaboration with the lab of Edouard Bertrand, with important contributions from Benoît Lelandais, Marie-Cécile Robert, Michael Szalay, and Jean-Yves Tinevez. Thanks a lot to all. www.nature.com/articles/s41... (4/4)

TODAY! 👇

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

Happy to share our new review on 3D chromatin organisation by cohesin with you. It was a great pleasure to review recent advances and future prospects with @danielgerlich.bsky.social.

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

We are looking for a Postdoc to join us at the Center for Gene Expression @cgen2025.bsky.social at the University of Copenhagen! Full advertisement here: employment.ku.dk/faculty/?sho...

Exciting Expansion at CGEN! We’re thrilled to welcome Fena Ochs and Niels Erik Møllegaard. 🔬 Fena brings cutting-edge expertise in 3D chromatin organization and its role in gene regulation, DNA repair, and cell division. 🧬Niels Erik’s expertise is in genome structure and DNA helix conformation

Double celebration on our floor @oxfordbiochemistry.bsky.social with @guifengwei.bsky.social from the Brockdorff lab and Dounia and Sherry from Fisher lab having their papers published today! And I hear there is more to come... www.nature.com/articles/s41... www.nature.com/articles/s41...

Delighted to share our lab's first preprint identifying DDIAS as a mitotic DNA repair protein. Great collaboration with the @andrewblackford.bsky.social, @tcr-miller.bsky.social and @profstewartlab.bsky.social labs, and many more. Read the paper here: www.biorxiv.org/content/10.1...

New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n www.biorxiv.org/content/10.1...

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

What better way to launch our new account with the publication of @jmstein.bsky.social latest paper from the lab! 🧪 Check out the 🧵 below to learn more about tkPAINT and how we use it to image proteins, DNA, and RNA in the nucleus using DNA-PAINT.

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

I am happy to share that I have been nominated as Eppendorf Award 2025 finalist. It was a wonderful award ceremony, especially as this year's keynote speaker was Professor Sir Steve Jackson, who won the first Eppendorf Award in 1995. Read more about the event here: lnkd.in/dcRsH3gg

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

I am overjoyed to share that I have been selected as a Lundbeck Fellow 2025. Thank you to @lundbeckfonden.bsky.social for their trust in me - My lab and I cannot wait to get started on this important work.

All you nuclear biologists out there: Here is a cautionary tale not to be fooled by peripheral organelle staining. It might just be that your antibody got trapped because it is "too good".

Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today! Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes! With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs. See thread below:

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

🚨#CBC is happening today! Don’t forget—our next Chromosome Biology Club is today at 16:45 at the Biocenter! Three great speakers and exciting science await, followed by beer and pizza. See you there!

Wonderful, thought-provoking review by Sir Adrian Bird on cohesin loop extrusion as disrupter of chromatin organisation rather than generator. Great read! www.sciencedirect.com/science/arti...

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email [email protected] for info

This is such a cool paper!

A brilliant, kind, funny colleague gone too soon. We will miss you Bela. www.merton.ox.ac.uk/news/remembe...

Well done @fedeteloni.bsky.social and @danielgerlich.bsky.social @gerlichlab.bsky.social 🎉 Both pools of cohesin (loop extruding and cohesive) contribute to homology-directed repair. Back to back with nice work from Taekjip Ha and Jacob Corn labs!

Hi chromosome biologists, now that we're getting more and more connected online, how about starting an international mentorship network? Postdocs mentor PhDs, young PIs mentor Postdocs, senior PIs mentor young PIs? Comment or DM if interested, please RT. All input welcome.

Next step on the development of our @scienceofthetimes.bsky.social podcast complete. @sykhalid.bsky.social and I recorded the introductory episode. Soon to be released. @streamingspires.bsky.social

Postdoctoral Fellow position available in the DDR Biology and Functional Genomics teams at AstraZeneca in Cambridge UK. Closing date: 30-Jan-2025 astrazeneca.wd3.myworkdayjobs.com/Emerging-Tal...

Great to see this published. Congratulations @andibrunner.bsky.social @ellenberglab.bsky.social!

1/2 We’re hiring a Postdoc to join us at the University of Copenhagen. Are you fascinated by 3D chromatin function and super-resolution microscopy? Then this might be the job for you. Start date 1st of April 2025, starting salary 4700 Euro/month. Apply here: candidate.hr-manager.net/ApplicationI...

1/2 We’re hiring a Postdoc to join us at the University of Copenhagen. Are you fascinated by 3D chromatin function and super-resolution microscopy? Then this might be the job for you. Start date 1st of April 2025, starting salary 4700 Euro/month. Apply here: candidate.hr-manager.net/ApplicationI...

We are looking for a motivated Postdoc to join our lab at the University of Copenhagen. Please reach out if you have any questions regarding the position. Deadline for application is the 2nd of February 2026. candidate.hr-manager.net/ApplicationI...

Not surprised! Such a powerful technique 🚀

I'm very excited to share that I’ve started as group leader @karolinskainst.bsky.social . I am looking for curious, enthusiastic and collaborative postdocs and assistants (pre-PhD) to join us to decipher gene regulation of hypoxia cell states that govern systems oxygen homeostasis 1/3

How cool is @drewberry.bsky.social's newest animation 🤩 HDR with sound and to scale!

The Danish Bioimaging Network is hosting Professor Lothar Schermelleh for a talk on December the 10th at 9 am. Sign up here: eventsignup.ku.dk/talkbylothar...

We are establishing an open access infrastructure for optical pooled screening and looking for a computational scientist to join us for this great adventure. Come to Copenhagen and be part of a great scientific community: candidate.hr-manager.net/ApplicationI...

If you're seeing "Invalid Handle" on your profile, this should resolve on its own — thanks for your patience!! 🦋

First post here! New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...

Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...

Made a new starter pack for labs developing and applying advanced microscopy for biological discovery. Definitely still missing loads of labs, write me to be added. go.bsky.app/SHQCnEe