Mini-reunion of @costalaboratory.bsky.social from the 2020/21 era. Had a great time at the 94th Harden Conference in Crete, reconnecting with old colleagues and making new connections. Looking forward to the next one! @biochemsoc.bsky.social @tcr-miller.bsky.social @puehringertom.bsky.social

Well it's a wrap! Alessandro Costa @costalaboratory.bsky.social , Dana Branzei and I hosted the @biochemsoc.bsky.social Harden Conference Machines on Genes this week in beautiful Crete. www.eventsforce.net/biochemsoc/f...

Glad to have presented my postdoctoral work from the @voslab.org lab in the last machines on genes conference. Thank you to the organizers and to the @biochemsoc.bsky.social for the opportunity and for bringing us to beautiful Crete. #Biochemevents

Thanks to everyone who joined us at 94th Harden Conference: Machines on Genes! We hope you enjoyed it as much as we did and look forward to seeing you again soon! Huge thanks to our programme coordinators for making the event a success! @lapassmore.bsky.social, Alessandro Costa, and Dana Branzei

New preprint! How does Mcm10 promote the establishment of two divergent replication forks from one MCM double hexamer? Our @giacomopalm.bsky.social found the answer. 🧵 1/3

New preprint from our lab! We've been working out how the CMG replicative helicase gets built. 🧵 1/3

Today we celebrate our colleagues Colin Kleanthous and Rob Klose as they join the Fellowship of the Royal Society, one of the highest honours in the scientific world, in recognition of their impactful contributions to knowledge. Congratulations! 👏 👏 👏 Read more ⬇️

JCS congratulates our Editor-in-Chief Michael Way @drmichaelway.bsky.social on his election as a Fellow of the Royal Society, the UK’s national academy of sciences. royalsociety.org/news/2026/05...

Machines on Genes 2026 8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷 Two deadlines coming up on 8 April 2026 i. abstract submission ii. early bird submission (save €50) Four days of 🧑‍🔬🧬👩‍🔬☀️👨‍🔬🔬❄️🧪🧫 94th Harden Conference by @lapassmore.bsky.social, Dana Branzei, me with @biochemsoc.bsky.social.

Do you work on DNA or RNA protein complexes? 🧬 Come to Machines on Genes this June in Crete! ☀️ Super early discount is ending this Sunday so register now! 😃

Super Early Bird deadline Sunday 8 Mar! Save €100 Register for Machines on Genes 2026 ⚙️🧬 Biochemical Society Harden Conference 📍 Heraklion, Crete | 8–11 June 2026 🌊☀️ www.eventsforce.net/biochemsoc/f... Scientific organisers: Lori Passmore, Dana Branzei & Alessandro Costa

8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷 Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️ Organised by @lapassmore.bsky.social, Dana Branzei, me.

@nynkedekkerlab.bsky.social @dodonova-sveta.bsky.social @yuanhejhu.bsky.social @uwmadisonrna.bsky.social @kowaeva.bsky.social @fmattiroli.bsky.social @aliciakmichael.bsky.social @lisaracki.bsky.social @yeeles-lab.bsky.social

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA? Find the answer in our latest article rdcu.be/d6D8D Congratulations to Agata Butryn who led the entire project, with contributions from Julia Greiwe at the start. 🎉❄️🔬🧬

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

Congratulations Alessandro and team!

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m