🚨New preprint! We built a cell-free genomics platform (GATO-seq) to probe transcriptional regulation and discovered a “super pause” sequence that triggers a new Pol II active-site conformation. Huge shout-out to @robertovn.bsky.social for pulling off this monster of a project. tinyurl.com/superpause

Preprint alert 🚨Happy to share my first Posdoc manuscript from the Vos lab @voslab.org. We introduce GATO-seq, a high-throughput, fully in vitro technique that maps RNA polymerases at base pair resolution over time. Using it, we found a new pause state of Pol II: sidetracking tinyurl.com/superpause

How do SMC complexes load onto DNA to get ready for loop extrusion? @roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️. Check out the new paper: www.cell.com/molecular-ce...

🧬 Ever wonder how metres of #DNA 🧬 fit into a single cell? @gruberlab.bsky.social, working at @unil.bsky.social uncovered how protein machines fold DNA into loops – key for cell division & genome stability. Learn more 👉 buff.ly/PrfdXnr #BioTech #Chromosomes #Crystallography #GeneEditing 🧪

We wrapped up our most successful year to date at Symbiotic STEM! Check out what we accomplished at symbioticstem.org 🌱🌱