What happens when you suddenly remove half of an essential enzyme from cells? 🤔 We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance. Our lab's new preprint 👇 bit.ly/4pyPgax

HHMI CEO: "diamond funding should be deployed to sustain repositories [i.e. preprint servers] and connective infrastructure that focus on researcher-shared outputs" zenodo.org/records/1960...

Trying to wrap my head around going from making eco-friendly shoes to making AI computing infrastructure (not eco-friendly). I literally own 4 pairs of Allbirds and am wearing some now... www.reuters.com/business/all...

Full article: The Goldilocks state of transcriptional readthrough for chimeric splicing www.tandfonline.com/doi/10.1080/...

Amazing photos of the storms yesterday in Madison (and the aftermath). This one was by Crystal Pearson and found via the link below. No AI involved! The weather was really bonkers yesterday afternoon/evening. www.channel3000.com/news/news-3-...

www.biorxiv.org/content/10.6... UFMylation anchors splicing factors at the ER to reprogram nuclear splicing Zhan et al.

In @science.org for chemsky this week, @tehshik.bsky.social teams up with @chemguyeli.bsky.social to showcase the versatile advantages of pairing a pybox ligand with a carbazole chromophore in one molecular catalyst www.science.org/doi/10.1126/...

Jeff Coller‘s Opinion in today’s NYT on RNA and gene editing medicines and rare disease www.nytimes.com/2026/04/09/o...

A much needed review from @achilleskap.bsky.social

2nd call for postdoc positions in the lab. Get in touch for more information or simply apply here: mbg.au.dk/en/news-and-...

New from Heather Hundley's lab rnajournal.cshlp.org/content/earl...

Forgot to post this! 2 current Hoskins Lab undergrads (Ellie and Antonio) connect with a former undergrad (Charlie) and @uwbiochem.bsky.social major who is now a scientist at Merck!

Wisconsinites vote today! Forward!

Lots of papers out today! From Doug Black and Hong Zhou's labs: structural mechanism of RBM5 regulated splicing via U2 interactions The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing Shiheng Liu et al.. www.biorxiv.org/content/10.6...

And edited by Mo! pubmed.ncbi.nlm.nih.gov/41915743/

New from the krainer lab--splice switching ASOs targeting H3.3K27M Exon-Skipping Antisense Oligonucleotides for H3.3K27M-Altered Diffuse Midline Glioma Therapy Lucia Yang et al. www.biorxiv.org/content/10.6...

New from Hope Merens in @stirlingchurchman.bsky.social lab! SRSF1 regulates polyadenylation site selection independently of and through coordination with U1 snRNP Hope E. Merens et al. www.biorxiv.org/content/10.6...

Wrapping up the semester with our last RNA Maxigroup talk featuring Blake Wiedenheft! Thanks to @bmolchem.bsky.social @uwbiochem.bsky.social and @rnasociety.bsky.social for sponsoring!

“Through a genetic screen targeting ribonucleases, we identified RNASEK as a specific circRNA-cleaving ribonuclease” I’m extremely curious how you get specificity for circular RNAs…

Check out our new preprint on IRES studies (www.biorxiv.org/content/10.6...). We show a recently proposed IRES “toolbox” results in mRNA annotation errors and false-positive IRES activities. We provide an alternative set of robust approaches. (1/4)

🎉 Congrats to 2026 Thomas Hunt Morgan Medal recipient Judith Kimble of @uwbiochem.bsky.social! Her work has built an entire field and inspired generations of scientists through her mentorship and leadership. 🔗Read more: buff.ly/0yzHXvk

IT WORKED

This was such an amazing experience. I’m definitely going to volunteer again!

Interesting paper on U2 snRNA mutations in a human disease. Unfortunate that they show an egregiously incorrect structure of the U2-U6 spliceosomal complex (Extended Data Figure 4), which is used to interpret the molecular impact of the mutations. www.nature.com/articles/s41...

Wow!

MicroRNAs are required within a critical time window to define neural patterning during early human brain development www.biorxiv.org/content/10.6...

New from Melissa J's lab pubmed.ncbi.nlm.nih.gov/41885209/

Neat result from @bjgreber.bsky.social. Any structural insights into how it forms a complex with SF3B1 though? It would be neat to see an alpha fold model of SF3b, RBM17, and the complex...

Congrats @mabinjw.bsky.social and coworkers!

🔬 You helped move the field forward at ASBMB 2026. 💬 Ready to keep the conversation going? Submit your idea for a mini-symposium, interest group session or workshop for ASBMB 2027. ➡️ www.asbmb.org/annual-meeti... #ASBMB27 #ResearchCommunity #ScientificConference

My lab released a new preprint today. The work is the culmination of a long term project led by Peren Coskun, Ph.D., who investigated the biological role of the C. elegans glp-1 3'UTR in its endogenous context. Please join me in congratulating Peren! www.biorxiv.org/content/10.6...

A high-affinity split-HaloTag for live-cell protein labeling. And much more. www.nature.com/articles/s41...

This is also neat. Turning back on expression of a miRNA cluster of two genes results in perennial like growth similar to wild rice. A cool agricultural impact of miRNAs... Resetting of a tandem microRNA156 enables vegetative perennial growth in rice | Science www.science.org/doi/10.1126/...

While I'm certain this is going to be valuable, I really wish they would have done more analysis of the snRNA variant expression...for splicing people there's not a lot to go on here in the paper itself (compared to, for example, Mabin et al....)

Elizabeth Banks

This is neat www.nature.com/articles/s41...

The Candida Genome Database’s new website is now live! Everything has been entirely rewritten from scratch! A quarter of a century old Perl code (some of which I wrote!) producing HTML 2.0 (😬) is all gone, with modern python in its place, producing modern webpages with JavaScript and CSS to make

New from @alicepyne.bsky.social and David Rueda! www.nature.com/articles/s41...

This article is definitely a fun read.... www.nature.com/articles/d41...

New preprint from our lab! An H3.3 knockout does two things at once: it removes H3.3 from chromatin and destabilizes DAXX. We disentangle those functions and find that DAXX-mediated H3.3 deposition can be uncoupled from ERV silencing. www.biorxiv.org/content/10.6...

A Bed of Red Azaleas, by Alma Thomas, 1968 (rotated, detail), 📸 by David Stluka

1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).

Happy to share our latest work on the previously uncharacterized splicing factor Cwc15! Importantly, all of the people who did this work are/were undergrads! S. cerevisiae Cwc15p Tunes the Spliceosome Active Site for 5' Splice Site Cleavage www.biorxiv.org/content/10.6...

:(

Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicing doi.org/10.7554/eLif...

Congratulations Badgers Women Hockey!!! www.nytimes.com/athletic/713...

@mukherja.bsky.social work on RNAPII clusters is in print today: www.nature.com/articles/s41... Congrats! TLDR: RNAPII clusters represent transcriptonally engaged molecules at single genes, not super-stochiometric assemblies. Please check it out and see the the thread below for a summary.

New from Jeff Coller et al.. @rnajournal.bsky.social rnajournal.cshlp.org/content/earl...