Wow!!!!

New Biochem Soc Trans review: eIF3 as a modular, central regulator of translation. Authored by @nickide.bsky.social and Colin Echeverría Aitken, this review integrates genetic, biochemical, and structural perspectives and highlights open mechanistic questions. doi.org/10.1042/BST2...

Can't wait for this meeting! Lots of exciting, macromolecular science lined up!

Slightly overdue article highlight! In PNAS, we use smFRET to reveal how polypeptide release factor 2 (RF2) undergoes a cascade of structural changes to catalyze polypeptide release during translation termination and ArfA-mediated ribosome rescue. 🧵⬇️ doi.org/10.1073/pnas...

Missed this from @daspliceisright.bsky.social www.nature.com/articles/s41...

Opportunity for scientists considering moving to Spain as tenured scientists! Happy to see openings in microbiology across the country (including at CNB which has incorporated fantastic micro eco/evo researchers lately) and functional & systems biology at IBFG www.ciencia.gob.es/en/Convocato...

Here’s a preview of some exciting events coming up at the 2026 ASBMB Annual Meeting! www.asbmb.org/annual... • Rapid Review: 5-minute manuscript feedback • Speaking Up, Making Change: science advocacy in action • Career & Education Fair: connect with academia, industry & more

There's still time to share your insights at #ASBMB26! Late-breaking abstract submission is open. Submit your abstract by Jan. 15 for the opportunity to present your research alongside other outstanding scientists who are driving research forward. www.asbmb.org/annual...

Following up on @lucksmith.bsky.social 's post from Casa Bonita. Guess what we saw over the holidays! IFYKYK...

The final Calvin and Hobbes, which appeared in papers 30 years ago today.

A good end to 2025: rhodamine-binders for bioimaging in JACS: pubs.acs.org/doi/10.1021/...

A New Year's Eve countdown, rendered in 3D! ➡️ Learn more about cutting-edge protein research at #ASBMB26: www.asbmb.org/annual-meeti.... 🎨 Structures from @rcsbpdb.bsky.social

Exollent! Congrats! #RNAExosome #RNA www.cell.com/cell-reports...

I had do this recently for a T32 RPPR for a grad student's paper in Cell Reports it is complete bullshit

Thanks @igorulitsky.bsky.social for doing a huge amount of reviewing!

"Results from experiments with N = 4 or less are shown to be highly misleading (...). For a cut-off of 2-fold expression differences, we find an N of 6-7 mice is required to consistently decrease the false positive rate to below 50%, and the detection sensitivity to above 50%"

New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1

Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...

This is a very interesting reaction catalyzed by a radical SAM enzyme on the ribosome (plus uses methyl cobalamin). Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria: Molecular Cell www.cell.com/molecular-ce...

Awesome to see Ye's work from my lab featured on the cover of @rnajournal.bsky.social 's January issue! It's an awesome story about 3' splice selection and how Prp8 and Prp22 may communicate with one another! The structure shown is @maxewilkinson.bsky.social 's P complex (9DTR)

As an Indiana native the choice of pie in @netflix.com Stranger Things Season 5 episode 3 had me over the moon (it is by far my favorite), but Erika's secret ingredient (one of them at least) made me ecstatic... Literally had that conversation over Thanksgiving.

This is my #1 favorite under-explored topic in cancer RNA research--how much do cancer cells rely on NMD? www.biorxiv.org/content/10.6...

This looks quite interesting. The vesicle angle is that U6 atac is unregulated in some cells, can be secreted, and then take up by other cells where it promotes minor intron splicing. www.biorxiv.org/content/10.6...

New paper on my favorite deadenylase, TOE1... www.biorxiv.org/content/10.6...

Be part of the conversation shaping the future at the 2026 ASBMB Annual Meeting! The late-breaking abstract deadline is Jan. 15. ✅Submit now to join an exciting program featuring the latest advances and trends in the molecular life sciences: www.asbmb.org/annual-meeti.... #ASBMB26 #MakeItPossible

Excited to share that this work is now published in its final form! link.springer.com/article/10.1...

Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS www.pnas.org/doi/10.1073/...

New work describes our efforts to achieve CRISPR editing of the mitochondrial genome. www.biorxiv.org/lookup/conte...

*A new pre-print on increasing gene expression!* 🧬📈 doi.org/10.64898/202...

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

High-fidelity human chromosome transfer and elimination | Science www.science.org/doi/10.1126/...

Nice Review #EJC www.nature.com/articles/s41...

Really interesting paper from David Stanek's group. R. humris doesn't have an apparent U1 snRNA, Snu66, OR SF3B1?!?!?! If they are present, the sequence divergence may be really interesting. rnajournal.cshlp.org/content/31/1...

Neat paper on wave patterns in bacterial colonies from the Shaevitz lab www.biorxiv.org/content/10.1...

New from Nav Toor's group. Take a look at Figure 8! www.biorxiv.org/content/10.1...

Awesome to see this!

This is a neat paper. Especially liked the use of fluoro nucleotides. The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin | Science www.science.org/doi/10.1126/...

📢 Our December issue is now online! Access the full issue 👉 www.cell.com/trends/bioch... 🎨 The cover brings warm, summertime vibes ☀️ and highlights a Feature Review on #AromaticAminoAcid biosynthesis in 🌱 from Jorge El-Azaz and @hiroshi-maeda.bsky.social. Cover art credit to Tae Park. (1/n)

Can't wait for this one! Eric @dnacurtain.bsky.social is one of my favorite scientists and I haven't seen him in ages :)

Super nice @uwbiochem.bsky.social @bmolchem.bsky.social seminar yesterday from Brandt Eichman highlighting work found in this preprint: pubmed.ncbi.nlm.nih.gov/41256537/

New from the Butcher Lab—defining the RNA binding mechanism of TDP-43. Happy to have played a small part in this amazing work! www.biorxiv.org/content/10.1...

From @kylecottrell.bsky.social lab rnajournal.cshlp.org/content/31/1...

New from Greg’s lab at New England Biolabs on phage genome assembly. www.pnas.org/doi/abs/10.1...

As an experiment to combat/come-to-terms-with AI use in homework assignments, I'm incorporating arts and crafts. Here a student used Lucky Charms for an exercise on the prochirality of citrate.

Fantastic opportunity for undergraduates pursuing summer research experience! @hhmi.org