Peptide drugs can target complex proteins but often lack stability in the body. ⏯️ Vahe Bandarian discusses how Sethera Therapeutics is engineering complex peptides and translating academic discoveries into real-world applications: youtu.be/Iwtz4Ew08u8?.... #PeptideTherapeutics #EnzymeChemistry

We're thrilled to announce the Center for Therapeutic Genetics (CTG) — a new collaboration between JAX, @broadinstitute.org, and @bostonchildrens.bsky.social to develop genetic medicines for rare and ultra-rare diseases. 🔬🧪🧬 go.jax.org/Center-Therapeutic-Genetics

New from the Putnam Lab @bmolchem.bsky.social--critical information for controlling phase separation experiments!

Congratulations to Isiah (and his mentor Ray) for completing the STEM Catalyst Program @uwmadscience.bsky.social!

Interesting idea, but I really wish @cellpress.bsky.social would make sure that people with strong biochemical and structural backgrounds in splicing would review such papers... www.sciencedirect.com/science/arti...

Kaitlyn continues to break barriers with her innovations for using LEA proteins to solve another major cryo-EM sample prep issue! This work should be of great interest to friends who are struggling with particle orientation bias. Another funtastic Lim X Grant collaboration! @uwbiochem.bsky.social

" (...) we find strong selective effects associated with higher institutional prestige, larger team size, and certain topics and countries. Corresponding authors who are men exhibit a small but significant advantage at Science, while authors based in China have a significant disadvantage"

The air quality in Wisconsin is crazy bad right now. It smells like you are sitting AT a campfire--not just like there is one nearby! It has also noticeably dropped the air temperature though...

This would seem to throw some cold water on the @cellpress.bsky.social paper claiming to have made "the first eukaryote functionally independent of the spliceosome"

Interesting. Full deletion of all introns in yeast was actually my project in the Staley lab, *20 years ago*. I actually found a bunch of phenotypes. We did this in collaboration with the Guthrie lab. www.cell.com/cell/abstrac...

Benchmarking dynamic analysis methods in diffusion-based single-molecule FRET

Important new observations from Adrian's lab!

After 15 years, I was finally able to convince my lab to have our summer outing at The House on the Rock...

WEBINAR: Everything you wanted to know about pre-mRNA splicing but were afraid to ask 📆 July 15 | 12:15 p.m. ET @uwmadisonrna.bsky.social will give an overview of pre-mRNA splicing and the cellular machine responsible—the spliceosome! 💻 Free registration required: www.asbmb.org/meetings-eve...

In print today @science.org Laser phase plate improves structure determination of small proteins by cryo-EM | Science www.science.org/doi/10.1126/...

I'm a bit torn. I posted an ad for an undergraduate job that I need filled related to website/computer-y things. The cover letters are 100% written by AI (for the applicants so far). I'm not sure if that is a good thing or bad thing for someone I need to do some computer-y things...

Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41...

Important caveat, it it still required energy from phosphodiester bond hydrolysis--just preferential use of dTTP over ATP. Still interesting though. I think the rate-limiting step in DNA synthesis is dNT(D)P formation, so this may help couple replication to dNTP availability is my guess...

This is super interesting. I'll note that how Aar2 gets released from Prp8 is an outstanding mystery. Neurochondrin promotes U5 snRNP maturation by regulating AAR2 release from PRPF8 academic.oup.com/nar/article/...

This is neat pubmed.ncbi.nlm.nih.gov/42391048/

Out now in #CurrentOpinioninStructuralBiology! Our perspective on progress toward linking single-molecule behavior and emergent condensate properties! Led by Pablo Garcia and @ananyac2000.bsky.social 🙂 www.sciencedirect.com/science/arti...

Congratulations to Professor Monica Neugebauer, who has been selected as a 2026 Beckman Young Investigator! Learn more about how the award will further Neugebauer's work, which aims to expand the chemical capabilities of living systems: biochem.wisc.edu/2026/06/29/n...

Validation of the mRNA epitranscriptome: SCARPET reveals that mapped m1A sites are inosine link.springer.com/article/10.1...

The LMB warmly welcomes Reinhard Lührmann to deliver the Max Perutz Lecture at 11am (BST) on Monday 13 July titled ‘Structural insights into the cascade of snRNP remodelling steps leading to the formation of a catalytically activated spliceosome’ Read more here: mrclmb.ac.uk/news-events/... #LMBNews

Found this paper from 2014 that claims to have used 5% Bailey's in TBS-T for blocking western blots: www.tandfonline.com/doi/full/10....

Beautiful work (and beautiful figures!) from Sashital lab alum @yuktidhingra.bsky.social! Congrats, and looking forward to seeing more exciting RNAP work in the future!

A detailed molecular picture of protein folding during active translation www.biorxiv.org/content/10.6...

Happy to say that I just submitted an awesome paper that didn't include ANY new acronyms...

I find it absolutely astounding that someone who has spent considerable time at a reputable medical school has so little understanding of how this all works. Does he think Marconi would have developed the wireless without previous discoveries of radio waves? 7/7

Had a blast putting this video abstract together with colleagues for @zjmaggiexu.bsky.social story in @currentbiology.bsky.social on how the "vampire cell" P. collini builds the perfect feeding trap 👀. Be sure to check out the full paper: www.cell.com/current-biol... www.youtube.com/watch?v=Ikzm...

We're no longer asking whether mRNA works. We're refining it. New in Nature: ac4C, an mRNA modification that boosts protein yield AND accuracy, reducing translational errors. This is what a maturing platform looks like—precision, molecule by molecule. 🔗 www.nature.com/articles/s41...

Single-molecule FRET and tracking of transfected biomolecules in living cells: Biophysical Journal www.cell.com/biophysj/ful...

New paper led by postdoc @yannikipouros.bsky.social is out today in Nature! We show how metal coordination mining of AlphaFold reveals dozens of new radical halogenase families, including the promiscuous biocatalyst BtnX. #enzymes #bioinformatics #biocatalysis #secmet www.nature.com/articles/s41...

⏰July 13 deadline: Proposed OMB research funding rule comments OMB has proposed major changes to the rules governing federal research grants: www.asbmb.org/asbmb-today/.... 📝Review practical tips for participating in the process: www.asbmb.org/advocacy/omb... #ScienceServesUsAll #ASBMBAdvocates

A High-Affinity Nanobody Recognizing mNeonGreen Enables Versatile Biochemical, Cellular, and in vivo Applications. by Steffen Frey and team: www.biorxiv.org/content/10.6...

ICYMI: New online: Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity

GOOD NEWS! A personalized mRNA vaccine, known as mRNA-4157, has shown promise in keeping melanoma, a deadly skin cancer, from returning. FIVE years later, NEARLY 70% of people in the vaccine group are CANCER-FREE. The vaccine also cut a person’s risk of the cancer metastasizing by NEARLY 60%.

The Kaplan Lab at the University of Pittsburgh has received funds to recruit a postdoctoral fellow to establish a multiplexed assay of variant effect for a disease gene. This relates to our studies on RNA Polymerase II. This project requires experience with human cell lines and genomics 1/

More evidence that splicing is the cause and solution to all of life's problems... Lariat RNA debranching prevents harmful siRNA burst in plants | Science www.science.org/doi/10.1126/...

Welcome to the resistance (checks notes) Moody's Ratings fixedincome.fidelity.com/ftgw/fi/FINe...

@zjmaggiexu.bsky.social's story on suctorian trap structure adaptation is now online in @currentbiology.bsky.social , with new evolutionary analyses and modeling! This fall, Maggie will keep exploring predatory protists as a PD in @nbellono.bsky.social group; keep an eye out for her she's amazing!

Thanks to @jmcoller.bsky.social for writing this important piece. Describes exactly what we stand to lose from the Lysenkoization of US science. 💪🏼