I feel like introns are then just the nucleus striking back....

Congratulations Danny!

New from Matt DeJong & the @pollyfordyce.bsky.social and Dunn groups at Stanford! Engineering the mechanosensitivity of single DNA molecules via high-throughput microfluidic force spectroscopy Matthew P. DeJong et al. www.biorxiv.org/content/10.6...

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! 🧪🧫

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

Congratulations to Emeritus Professor Judith Kimble, who received the Thomas Hunt Morgan Medal awarded by @genetics-gsa.bsky.social.

This is really neat stuff! Leveled here means similar (high) GC content in the intron and flanking exons.

Metabolic stress reveals widespread accumulation of cap-unmethylated RNAs Zheng Xing, Anna V Freitas, Benjamin M Sutter, Ngoc Khoi Dang, Nicholas T Ingolia, Benjamin P Tu www.biorxiv.org/content/10.6...

Already time for the next Maxigroup! Can't wait to host @oawlab.bsky.social to talk about mechanisms and therapies related to splicing & cancer! Next Tues, March 3 at 5:30pm! Thanks to @bmolchem.bsky.social @uwbiochem.bsky.social the CMB program and @rnasociety.bsky.social for sponsorship!

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For those interested, here's a (pre-recorded) video of my acceptance presentation which gives a bit of an overview of some of our single-molecule biophysics research: www.biophysics.org/video-librar...

Latest work! 🧬 We uncover how evolution of translation initiation factor 2 (IF2) extensions links translation to bacterial stress response. We map 7 structural architectures & show how terminal extensions are enriched in intrinsic disorder & phase-separation features. Link: doi.org/10.64898/202...

If you’re around @biophysicalsoc.bsky.social 2026 and looking for some cool RNA-protein work related to microRNA biogenesis, stop by my poster today at 1:45 and I’ll tell you about some of my near-complete work with @keanelab.bsky.social! #BPS2026

Brielle and Paige representing the Hoskins Lab undergrads at the @biophysicalsoc.bsky.social poster session at #BPS2026!

Remix’s Co-Founder and CEO was recently featured in Pharmaceutical Technology, highlighting how modulating RNA processing can dramatically expand the universe of druggable targets. Read the article by Jam Bensilum here: bit.ly/4aKtGdL #REM422 #RNAdegradation #RNAdegraders #RNAtherapeutics

So may lab alumni at @biophysicalsoc.bsky.social BPS2026! Josh at @ei-science.bsky.social and @chembiocade.bsky.social !

To me the most interesting part of this story involves an explanation for the 2D ribosome sheets in chicken eggs...

Evolution of error correction through a need for speed | Science www.science.org/doi/10.1126/...

Wow! I've been curious about this for years. From Nam et al from the Sandy Wolin and Susan Lea groups. Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens: Cell www.cell.com/cell/fulltex...

Potential new use for PladB and other SF3B1 inhibitors in treatment of platinum-resistant lung cancers www.biorxiv.org/content/10.6...

Big congrats to Dr. Len Zon for being awarded the 2026 @marchofdimes.org Richard B Johnston Jr, MD Prize for his work in #devbio. His pioneering research has illuminated how blood develops in embryos, leading to a deeper understanding of genetic blood diseases. www.marchofdimes.org/about/news/r... 🧪

One of my pet peeves is people calling proteins "metazoan-specific splicing factors" just because they aren't found in S. cerevisiae. Please take a look at this paper from @hitenmadhani.bsky.social and Scott Roy! pubmed.ncbi.nlm.nih.gov/34555349/

Wither in vitro studies of RNA/protein interactions? (I hope not but this particular review doesn't seem to recognize contributions of in vitro work to in vivo understanding...) www.nature.com/articles/s41...

Conserved sequence elements in the final exon of MDM2-eight-exon skipping event reveal a cassette regulon model of alternative splicing controlled by a distal regulatory element. From Safiya Khurshid, Dawn S Chandler and coworkers www.biorxiv.org/content/10.6...

Join us on Monday, February 23 for Biochemistry Colloquium with Traci Hall. Hall leads the Macromolecular Structure Group at the NIH National Institute of Environmental Health Sciences, and their lab focuses on mRNA stability and translation. More info: today.wisc.edu/events/view/...

Oh this is super interesting. How the cysteine becomes activated to attack the epoxide has puzzled me for a few years. Determinants of spliceostatin reactivity at a spliceosomal zinc finger Riccardo Rozza et al www.biorxiv.org/content/10.1...

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

Congratulations to one of my favorite RNA heroes @bbass.bsky.social !

When you organize a meeting and realize that two RNA-focused sessions are occurring at the same time...

Review on Brd9 and connections with splicing, chromatin, and cancer pubmed.ncbi.nlm.nih.gov/41672512/

🚨🍄Nancy Keller Fungal Research Published in PNAS! “What we hope people take away from this paper is that scientists are actively studying this serious issue. We’re working hard to understand why it’s happening.” -Nancy Keller mmi.wisc.edu/nancy-keller... 📸: Dr. Anna Pringle

Congrats to the best poster and talk winners at #SMB2026. :)

word of the day: eutectic ice www.science.org/doi/10.1126/... pubmed.ncbi.nlm.nih.gov/12448990/

Further insight into translation of a MALAT1 lncRNA ORF into a micro peptide in neurons via an IRES from the Pyle and Black labs www.biorxiv.org/content/10.6...

Roses are red, GlcNAc is blue, sugar is sweet, and we want YOU to read our latest in @natcomms.nature.com — where we identify small-molecules that disrupt OGlcNAc homeostasis via RNA splicing. Congrats Steven (@scheng23.bsky.social) and all the authors! 🟦🍭❤️ www.nature.com/articles/s41...

Front page of this month’s edition of The Onion.

Registration is OPEN for our 8th annual symposium @UMassChan.bsky.social #RNA Therapeutics: From Concept to Clinic, June 24-26, 2026. Early bird pricing ends April 3. Submit abstracts for short talks before March 6th! #RNATx2026 buff.ly/vi22rN6 Register early; we sold out by April last year!

Do you want to understand how RNA #splicing decisions are made? We‘ve got a PhD position open for you (see 👇👇)!! Please share #RNAsky and RT! tinyurl.com/4ztu9cb9

Can't wait for next week's RNA Maxigroup from @lapassmore.bsky.social! Thanks to @rnasociety.bsky.social, @uwbiochem.bsky.social , @bmolchem.bsky.social , and UW Madison CMB for funding! **Note that this is on THURSDAY but at the usual time and place.

5' SS modifying compound work www.biorxiv.org/content/10.1...

ASO's targeting 3' end processing www.biorxiv.org/content/10.6...

Highly transient U1 snRNP interactions are my favorite kind of U1 snRNP interactions :) Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www-science-org.ezproxy.library.wisc.edu/doi/10.1126/...

Thank you David Rueda and @nynkedekkerlab.bsky.social for an incredible #smb2026!

Now finishing off the 2026 Single-Molecule Biophysics meeting at the École de Physique des Houches this week - a week of fantastic science, mediocre food&lodging, meeting old and new scientific friends, and some great skiing in free times!

Technology developed by chemists Anastasia Khvorova, PhD, and Hassan Fakih, PhD, of UMass Chan has been licensed by nonprofit biotech company PLaN Therapeutics to develop a therapeutic for a rare, inherited heart disease, PLN-R14del cardiomyopathy: direc.to/oQwA #RNA @rti-umasschan.bsky.social

LINE-1 activation (!) in lung cancer www.nature.com/articles/s41...

New from the Zamore and Gainetdinov labs www.nature.com/articles/s41...

I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima www.biorxiv.org/content/10.6...

Yikes! PRMT5 inhibitors actively promote metastatic progression of lung adenocarcinoma Colin E Fowler, Jacqueline Lees, et al. www.biorxiv.org/content/10.6...