Sarah Keane
@keanelab.bsky.social
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Associate Professor of Biophysics and Chemistry @Umich. Structural Biology. NMR. Biochemistry.
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Sarah Keane
Bruce Springsteen
19 days ago
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free
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Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
https://youtu.be/wWKSoxG1K7w?si=7ciYwNLv34RrdD1p
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Sarah Keane
Admirable Women
21 days ago
Biochemist/molecular biologist Joan Steitz was born
#OTD
in 1941. She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need.
#WomenInSTEM
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Sarah Keane
Timothy Bredy
26 days ago
www.colorado.edu/today/2026/0...
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Tom Cech to Davos: RNA research is 'still a big deal'
The Nobel laureate and CU Boulder professor, recently ranked #1 globally for RNA research, will speak at the World Economic Forum annual meeting in Davos,
https://www.colorado.edu/today/2026/01/20/tom-cech-davos-rna-research-still-big-deal
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Sarah Keane
Communications Chemistry
2 months ago
Just out: NMR data processing, visualization, analysis and structure calculation with NMRFx
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NMR data processing, visualization, analysis and structure calculation with NMRFx
Communications Chemistry, Published online: 05 December 2025; doi:10.1038/s42004-025-01812-8NMR spectroscopy’s effectiveness across scientific disciplines hinges on robust computational tools for data analysis. Here, the authors introduce NMRFx, a software that enhances data processing and visualization, demonstrating its utility through diverse case studies, including protein, RNA, natural product, and metabolomics analyses.
https://bit.ly/4oCZh66
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I'm also late in posting this work, but really proud of Megan
@mnwestwood.bsky.social
, Sydney, and Jocelyn for their contributions to making RNA NMR spectroscopy more accessible for novice learners! Check out their preprint here:
chemrxiv.org/engage/chemr...
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A practical guide to RNA NMR spectral analysis for undergraduate students
Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool that can be used to determine the structures of both small organic molecules and large biomacromolecules. Many undergraduate...
https://chemrxiv.org/engage/chemrxiv/article-details/68f91e9d5dd091524fd6f1ad
3 months ago
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Congratulations are in order!! Cade
@chembiocade.bsky.social
received the Sokol, Margaret and Herman, Fellowship in the Chemical Sciences and Antigone was selected as a departmental nominee for the Rackham-wide outstanding GSI award!
3 months ago
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Congratulations to postbac Sydney Steele for receiving a poster award at the Rustbelt RNA meeting last weekend!
4 months ago
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Sarah Keane
RSC Medicinal Chemistry
4 months ago
🔓Explore recent
#OpenAccess
work by
@keanelab.bsky.social
and colleagues where they describe a virtual screening approach to explore the druggability of the precursor structure of microRNA-31đź‘€
pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
📍
@umich.edu
đź§Ş
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Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31…
https://pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
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Congratulations to the lab for placing 1st for the College of Literature, Science, and the Arts unit in the 2025 Freezer Challenge! A big thanks to Antigone and
@chembiocade.bsky.social
for leading the lab in sustainable practices.
6 months ago
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Two papers from Grace's thesis have been published! Our journey into the world of small molecule RNA targeting.
6 months ago
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And another poster award! This one to Antigone, who presented at the Karle Symposium today!!
7 months ago
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Congratulations are in order! Two members of the lab, Moriah (a @NSF funded D-RISE high school student) and Diane (a UM undergrad) were awarded poster prizes at the URAN|UM symposium today!
7 months ago
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Sarah Keane
Jon Paczkowski🌹
7 months ago
I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center.
#nmr
#academicsky
#postdoc
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Glad to see this work out in its final form! Congrats to the team!
www.sciencedirect.com/science/arti...
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Structural Features Within Precursor microRNA-20a Regulate Dicer-TRBP Processing
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miR…
https://www.sciencedirect.com/science/article/pii/S0022283625003833?via%3Dihub
7 months ago
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Sarah Keane
Jill Townley
7 months ago
Learn more about how Eterna puzzles are being used for RNA education and outreach at the middle school, high school, and college level in the latest RCSB PDB newsletter. 🧬 🧪
cdn.rcsb.org/rcsb-pdb/gen...
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Congrats Qi!!
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8 months ago
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Grace's manuscript describing a combined virtual/experimental screening approach for identifying small molecule ligands that bind pre-miR-31 is online!
www.biorxiv.org/content/10.1...
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Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the Dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31 (miR-31)...
https://www.biorxiv.org/content/10.1101/2025.06.20.660744v1
8 months ago
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2nd defense of the summer! Congratulations to Dr. Aldrex Munsayac! It has been a pleasure to work with and learn from you!
8 months ago
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Sarah Keane
Magnetic Resonance News
8 months ago
ACS Bio & Med Chem Au (open) Consolidated 3-Fold Isotopic Lens for Probing RNAs, Solomon K. Attionu, Lukasz T. Olenginski, Frances P. Stump, Theodore K. Dayie*
pubs.acs.org/doi/10.1021/...
#NMRchat
🧲
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Consolidated 3-Fold Isotopic Lens for Probing RNAs
Undesired scalar and dipolar couplings are two major interactions that complicate structural and dynamic studies in solution nuclear magnetic resonance (NMR) spectroscopy. Recent developments in site-...
https://pubs.acs.org/doi/10.1021/acsbiomedchemau.5c00075#NMRchat
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Sarah Keane
Carolyn Bertozzi
8 months ago
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
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Congratulations to Dr. Arhin for an outstanding thesis defense earlier this week!
8 months ago
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Thrilled that
@mnwestwood.bsky.social
and I have been recognized with a PACE Fellowship for Graduate Student-Faculty Mentor Pairs! More great things to come!
9 months ago
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Sarah Keane
Neil Lewis, Jr.
9 months ago
After resigning from Michigan and bending over backwards to try and appease them, "The Florida Board of Governors voted Tuesday to reject Santa Ono as the next president of the University of Florida"
www.insidehighered.com/news/governa...
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Florida Board Rejects Ono for UF Job
The Florida Board of Governors decided against confirming Santa Ono as president of the University of Florida in a contentious vote focused on diversity, equity and inclusion.
https://www.insidehighered.com/news/governance/executive-leadership/2025/06/03/florida-board-rejects-ono-uf-job
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CONGRATULATIONS DENISE!!
cen.acs.org/biological-c...
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2025 Talented 12: Denise Okafor
Studying protein-drug interactions to avoid side effects
https://cen.acs.org/biological-chemistry/biochemistry/2025-Talented-12-Denise-Okafor/103/web/2025/05
9 months ago
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Sarah Keane
Yamuna Krishnan
9 months ago
This is why he is The Boss
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Sarah Keane
Goss Scientific
9 months ago
It's National Limerick day! A slight deviation from our regular posts. English artist, illustrator, author and poet Edward Lear was born on this day in 1812. To celebrate, Goss Scientific have put their own spin* on the classic limerick form.
#NationalLimerickDay
#nmr
*pun intended
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Another preprint posted! Yaping and Cade
@chembiocade.bsky.social
uncovered important structural elements in pre-miR-20a that impact Dicer processing. Huge thanks to both Megan
@mnwestwood.bsky.social
and Aldrex whose experiments rounded out this work!
www.biorxiv.org/content/10.1...
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Structural features within precursor microRNA-20a regulate Dicer-TRBP processing
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miRNA expression levels, the enzymatic processing of ...
https://www.biorxiv.org/content/10.1101/2025.05.07.652689v1
9 months ago
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New preprint from the lab - Grace has been instrumental in leading the lab into the RNA-targeting space.
www.biorxiv.org/content/10.1...
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In silico discovery of compounds targeting NPSL2: a regulatory element in the human oncomiR-1 primary microRNA.
NPSL2 is a stem loop element within the oncomiR-1 polycistronic primary microRNA (miRNA) cluster. NPSL2 is predicted to mediate conformational rearrangements within oncomiR-1 to regulate the biogenesi...
https://www.biorxiv.org/content/10.1101/2025.05.07.652683v1
9 months ago
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Sarah Keane
Christopher P Jones
9 months ago
Over the last 100 days at the NIH, the Trump administration has been dismantling science. In this Medium post linked below, I describe what the last 100 days have been like for an scientist at the bench, doing research on RNA viruses.
#science
#RNA
medium.com/@jones.cpric...
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The last 100 days at the NIH
Overview: My contract at the NIH was terminated on 25 April 2025. However, my science and NIH research more broadly have been stifled ever…
https://medium.com/@jones.cprice/the-last-100-days-at-the-nih-9b761f7d9bd4
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Congratulations to Megan! She received the Krimm Outstanding Graduate Student Award!
@mnwestwood.bsky.social
10 months ago
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Sarah Keane
U-M Life Sciences Institute
10 months ago
Congratulations to LSI Associate Director and Professor Janet Smith, Ph.D., who has been elected to the American Academy of Arts and Sciences in recognition of her outstanding achievements in science:
record.umich.edu/articles/fiv...
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Congratulations to the lab UGs who received departmental awards today! Jocelyn was awarded a summer research fellowship and Sydney was recognized with the outstanding student award!
10 months ago
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Experimenting with chromatography!
10 months ago
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Sarah Keane
Jeremy Berg
11 months ago
You look at science (or at least talk of it) as some sort of demoralizing invention of man, something apart from real life, and which must be cautiously guarded and kept separate from everyday existence. But science and everyday life cannot and should not be separated. Rosalind Franklin (to father)
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UMich Biophysics has an open search for a new faculty member. Application materials are due 5/15. Search is open rank (despite the title in the link). Would love to bring more structural biology colleagues to Biophysics.
#NMR
careers.umich.edu/job_detail/2...
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ASST PROFESSOR | U-M Careers
https://careers.umich.edu/job_detail/261588/asst-professor
11 months ago
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Sarah Keane
Irina Bezsonova
11 months ago
You can download my protein structure-inspired artwork from pdb webpage:
pdb101.rcsb.org/sci-art/bezs...
@rcsbpdb.bsky.social
@pdbeurope.bsky.social
#sciart
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PDB101: Irina Bezsonova Gallery
PDB-101: Training, Outreach, and Education portal of RCSB PDB
https://pdb101.rcsb.org/sci-art/bezsonova-gallery
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Sarah Keane
Amy Orsborn
11 months ago
I'm already hearing rumblings from academic leaders that tenure clock extensions may be part of how early career researchers weather this new storm. A reminder that clock extensions are not the easy solution some think them to be:
www.pnas.org/doi/10.1073/...
We must do better by junior faculty.
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Extended time, elevated expectations: The unappreciated downsides of pausing the tenure clock | PNAS
Extended time, elevated expectations: The unappreciated downsides of pausing the tenure clock
https://www.pnas.org/doi/10.1073/pnas.2403489121
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reposted by
Sarah Keane
Cade Harkner
12 months ago
#standupforscience
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Given my lab the day off on Friday, in case they have somewhere more important to be…
#standupforscience
12 months ago
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reposted by
Sarah Keane
Liana Lareau
12 months ago
xkcd with the truth today
xkcd.com/3056/
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RNA
https://xkcd.com/3056/
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Incredibly honored to be able to host Prof. Tom Cech for a Gomberg lecture yesterday. What an incredible scientist and person.
#RNA
12 months ago
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Love an early morning update from the beamline!!!
12 months ago
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There is (rightfully) a lot of frustration about the last minute cancellation of study sections. What I’m disappointed to see is academic colleagues turning on NIH staff, namely SROs, and somehow making them out to be the bad guys.
12 months ago
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Still finding my scientific community on this site, but very happy to share this work 'Selective deuteration of an RNA:RNA complex for structural analysis using small-angle scattering', now in press! Minor text changes relative to the preprint.
authors.elsevier.com/a/1karS3SNvc...
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https://authors.elsevier.com/a/1karS3SNvcEPRm
about 1 year ago
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