We've been busy in the lab, and I'm super proud of the team right now. These three papers are great examples of "Night Science", creative, curiosity driven work at its best! All are works in progress. www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

This was huge effort that involved many great friends and colleagues, including Sourav Banerjee, Howard Chang, C.K. Chen, Xiang Li, Wei Wei, @irinavoineagu.bsky.social, @anggonolab.bsky.social, and the entire lab @QueenslandBrainInstute.

How do neurons deal with fitting large regulatory proteins into small spaces to control plasticity and memory? By generating micropeptides via local translation of circRNAs, of course! Here’s to shedding new light on the ‘dark’ proteome in the brain. www.biorxiv.org/cgi/content/...

First of two major paper drops this week. Ever hear of extrachromosomal DNA? Mostly studied in the context of cancer and oncogene amplification, we’ve found an important role for these peculiar DNA elements in the brain! #neuroepigenetics #memory www.biorxiv.org/cgi/content/...

Long non-coding RNA Cerox1 targets components of the mitochondrial electron transport chain to regulate the memory impairment caused by sleep deprivation https://www.biorxiv.org/content/10.1101/2025.09.15.676326v1

Happy days with images like this….

RNA can conduct electricity. Isn’t that interesting?

It would be interesting to learn whether the Crispr babies have enhanced memory.

Nice review on lncRNAs in the brain by John Mattick and colleagues. doi.org/10.1038/s415...

Higher resolution approaches are required to fully understand how plasticity and memory work. www.biorxiv.org/content/10.1...

#A-RNA2025 off to a great start. @martinalexsmith.bsky.social sharing his views on why lncRNAs should no longer be consider wallflowers.

This! Nice work by @martinalexsmith.bsky.social and his team.

Mesmerising image.

Congrats to @michaelbclark.bsky.social and team! Moving the needle on RNA modifications in the brain.

Hello Sydney!

I love this. @neurohalfling.bsky.social have a look!

If this one holds up, it's a huge discovery. www.nature.com/articles/s41...

x.com/nobelprize/s... Prof Craig Mello knows what’s up.

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].

A monkey wrench for single cell studies……. www.biorxiv.org/content/10.1...

Agreed. We will go there too. This is a fantastic initiative.

#bloomscrolling. Guess where these are from.

Wow! @raflynn5.bsky.social see this?

The IncaRNAto lab is seeking a motivated #PhD candidate, interested in studying #RNA structural ensemble dynamics in living cells. Here's the link to the vacancy: www.rug.nl/about-ug/wor.... Please share!

RNA methods!

What are people’s thoughts on ScholarGPS? Do you include these metrics in your grant applications?

5 years in the making! Myristoylation is necessary for LTP and memory acquisition. Great PhD work from Ben Matthews: The EMBO Journal www.embopress.org/doi/full/10....

There’s no doubt that these things are present and functional in the brain.

More and more amazing RNA structures emerging.

DNA structure states are dope.

To accelerate #mRNA vaccine and therapy research, we're excited to share our end-to-end protocol for mRNA design, synthesis and encapsulation in @natprot.nature.com. Protocol development led by @laura-leighton.bsky.social, Natasha Chaudhary and Tim [email protected] rdcu.be/eqiF1

Just to put into perspective, vaults are (now, hopefully, were) a complete mystery in the field for the last 40 years: highly conserved and highly symmetric cytoplasmic structures in eukaryotes with a lot of implications but no proven function. That's why this preprint is super exciting!

In good company at IBANGS2025. Thanks for sharing and giving such a great talk @thebalelab.bsky.social

New review article. With Alex Walsh, we talk about recent findings on noncoding RNA and memory, and look to the future. pdf.sciencedirectassets.com/272014/1-s2....

Every hear of Vaults? If not, read this preprint! New from the lab, exploring novel mechanisms of RNA trafficking in neurons and what they might mean for memory. Led by stellar PhD student Mason Musgrove. #RNAsky www.biorxiv.org/cgi/content/...

This is the future of medicine. On demand, personalised RNA therapeutics. We’ll get these into the brain with cell and compartment specificity. innovativegenomics.org/news/first-p...

Today, a huge milestone for personalised #mRNA therapeutics for inherited disease! A baby with an ultra-rare mitochondrial metabolic disease was treated at UPenn with an mRNA-encoded gene-corrector. The mRNA was made to treat a single individual in just 7 months! www.nejm.org/doi/full/10....

More awesome memory work this week.

Solid.

www.wehi.edu.au/careers/make... WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social

…. in the US…. but not everywhere else.

I cannot get over how awesome this image is. www.nature.com/articles/s41...

Call for abstracts: 🔬🧬🧠Abstract submissions and registration for the #ANS2025 Annual Scientific Meeting in Hobart, Tasmania are open now! 🔬🧬🧠 Register and Submit Your Abstract Here: tas.currinda2.com/register/eve... We look forward to seeing you in Hobart!

Michael Levin at it again!

As the US withdraws from vaccine research, there's an opportunity for our biotech industry to push forward with mRNA technology. theconversation.com/from-covid-t...

My lab at NYU is hiring a postdoc interested in RNA biology and local translation in neurons following axonal injury/neurodegenerative diseases!! Apply here: apply.interfolio.com/165681

Relevant. www.pbs.org/video/see-me...

The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs! www.biorxiv.org/content/10.1...

🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...