On March 24, clinically focused Damon Runyon scientists and industry partners gathered at Amgen in Cambridge, MA for the 2026 Accelerating Cancer Cures Symposium. The symposium aims to foster conversation and spark collaboration between academia and industry. Read more: https://bit.ly/47XXWkQ

A little late to Bluesky but my postdoc work w/ @jbuenrostro.bsky.social now out in @nature.com "Epigenetic memory of colitis promotes tumour growth" www.nature.com/articles/s41... We wanted to understand how transient inflammation can create an increase in cancer risk, even after full recovery 🧵

850 Tomahawk missiles could be $3,060,000,000... That is 3 billion sixty million US dollars. That is 1224 5 year biomedical research grants. Literally, over 6 millennia of biomedical research.

We found a new brain shuttle! Mucins on brain endothelium mediate transcytosis of cargo linked to mucin-binding “C domain”. Congratulations Sophia Shi, now a Roland Fellow @harvard.edu, and longtime collaborator Tony Wyss-Coray @stanfordmedicine.bsky.social www.biorxiv.org/content/10.6...

Excited to see our MagMix platform on the cover of Device! MagMix is a modular, compact, material-agnostic in situ mixing platform for 3D bioprinters that actively + safely homogenizes cell-laden bioinks with no printer hardware/software mods: www.cell.com/device/fullt... @cellpress.bsky.social

New preprint to share! Incredible collab w/ Fei Chen’s lab: developed in vivo CRISPR screening platform for 🫁 epithelium, allowing single cell perturbation in post-flu repair. Take a peek to see what we found! Huge congrats to the leaders of this work @daisyah.bsky.social & @sundakao.bsky.social 🎉

The US-Israel war on Iran has emitted 5 million tonnes of CO₂ₑ in its first 14 days. The world currently has 0.6 million tonnes of novel and permanent CO₂ removal (CDR) capacity annually.

A nature-inspired ion trap for parallel manipulation of ions on a massive scale | Science Advances www.science.org/doi/10.1126/.... Very nice work by Brian Chait and Andrew Krutchinsky from @rockefeller.edu inspired by parallel sequencing in genomics and other technologies. Congratulations

Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...

The big reveal… so proud of Sonika Kohli and Angel Bu for winning a Koch Institute Image Award for their piece titled “Repairing Lost Connections” featuring our lab’s work on treating nerve injuries. Check it out for yourself by visiting the public galleries at the MIT Koch Institute!

Today we report single-cell APEX-seq (scAPEX-seq)—a method for unbiased mapping of subcellular transcriptomes at single-cell resolution. It reveals cell states invisible to standard scRNA-seq and identifies regulators of CAR T function that improve solid tumor killing. tinyurl.com/32pf6b8p

This is why we love #CalciumSignaling Look how mechanical damage triggers long range Ca2+ waves in this plant !! By @annalisabellandi.bsky.social, who is now around here ;) Full www.science.org/doi/10.1126/... @science.org #microscopy #cell #mechanobiology 🧪🔬

The vast majority of labs in the U.S. rely on federal funding to do their research - labs like my own. We're already running on fumes and while top-line budgets have been maintained, for now, research isn't getting funded. Once those fumes are out 👉 🪦. elizabethginexi.substack.com/p/i-wrote-re...

We made the front cover of Advanced Science with our paper on using tendons to make muscle-powered robots stronger! Happy to be part of an exciting special issue on "Sustainable Materials in Soft Robotics and Electronics". Check out our paper here: doi.org/10.1002/advs... #biofabrication #robotics

HIV joining the circular RNAs Club ? Welcome !

Kathrin @katleppek.bsky.social and Ina @inahuppertz.bsky.social cordially invite all RNA enthusiasts based in the Rhineland to attend our series of inspiring in-person talks on RNA-related topics, delivered by local and invited speakers.

A new mechanism for “RNA memory”! This time in Planaria! (Here's a video of a Planarian with mulitple heads, one of the heritable phenotypes we studied). This work summarizes >10 years of research and is an amazing collaboration with the labs of Jochen Rink and Omri Wurtzel labs. Read thrad below👇

Angelika showed us all how to pursue science with limitless enthusiasm, rigor, and generosity. Excited to announce the call for this year's Angelika Amon Young Scientist Award! Please encourage PhD students outside the United States who embody her infectious passion for biology to apply.

1st McKinley Lab grad student’s 1st preprint! @claireang.bsky.social studied how the uterus safely excises massive amounts of tissue during menstruation and pregnancy. Come for her GORGEOUS images, stay for her incredible discoveries. www.biorxiv.org/content/10.6... w/ @akelleher1017.bsky.social

The 2026 National Science Foundation budget is $8.75 Billion.

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations. www.nature.com/articles/s41...

Hey I did a fun thing with @warren.senate.gov about breaking up giant healthcare conglomerates

Successful day today at the @asbmb.bsky.social Capitol Hill Day. Great conversations with several offices. We have received great engagement. Appreciate their time and willingness to speak with us. Thank you to ASBMB for arranging over 120 meetings today with congressional representatives staff.

Check out our new review on binder discovery! In a fast-moving world, here are some thoughts we have in the moment. Congrats @jzy2799.bsky.social and Eddy!! www.sciencedirect.com/science/arti...

I wonder... 🤔🤔🧪 #chemsky a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT b) how such high school science level of disgrace pass peer review in @nature.com? Note this was Fig.4.a NOT in SI www.nature.com/articles/s41...

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...

Silvia's simulations showed that while all epitopes expose Sia for binding, Siglec-6 recognises and binds only GM1 because of a key interaction with the membrane through W127 and K126, which orientates the V-set domain to bind the Sia through Arg122 and the terminal Gal to the C-C' loop 😎

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

I was sad to learn that my postdoctoral mentor, David Botstein, died yesterday. I started with David as a postdoc in 1998, and he had a profound effect on both my life and scientific career. He was a giant in the field of genetics, making seminal contributions in both yeast and human genetics. 1/

Here's a chart showing who funds basic research in the US. It's easy to tell that private funding cannot make up for significant cuts to government funding.

MS/MS scan range can be an afterthought that doesn't receive attention in method design, but improper settings can affect experimental outcomes. This is especially true in glycoproteomics. A #glycotime thread about a new #JASMS paper on this idea from @riley-research.bsky.social 1/10

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true. Here is a graph showing how many fewer new funding opportunities that NIH has posted over time. -91%, a trend that started on Jan 2025.

The Glycomics Core at Beth Israel Deaconess Medical Center is looking for a Postdoctoral Research Fellow with LC-MS/MS proteomics/glycoproteomics experience. For more information check: research.bidmc.org/ncfg/careers... #proteomics #glycomics #glycoproteomics #lcms

Get to know biomedical researchers @stanfordbiosci.bsky.social @stanfordchemistry.bsky.social @stanford-chemh.bsky.social through our new “walk with me” series stanmed.stanford.edu/we-are-stanf...

It’s finally out! Together with @embopress.org and @reviewcommons.org, we conducted a structured side-by-side comparison of human peer review and our AI scientific review (see thread 👇👇👇🔥).

Read the paper here: link.springer.com/article/10.1... A pleasure doing this with the great Thomas Lemberger @tlemberger.bsky.social and Niv Samuel Mastboim @nivsm.bsky.social

(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.1...

Our latest work on fluorescent probes for imaging infections in vivo is out. Check it out! www.biorxiv.org/content/10.6...

Twitter/X "promotes conservative content and demotes posts by traditional media...algorithm substantially shifts attitudes towards more conservative opinions" www.nature.com/articles/s41...

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes www.science.org/doi/full/10.... From Erin Schuman's lab @erin-schuman.bsky.social #RNAbiology

NIH funding rate per applicant dropped 38% in FY2025 vs 2022, from 27.1% to 16.7% Here's a breakdown by career stage. Why FY2022 vs FY2025? • FY2022 was first FY with budget passed and administered by Biden • FY2025 budget was in CR until 3/15/2025, so budget and most grants were under the Trump WH

Upcoming Gordon Research Conference on ENDOTHELIAL CELLS Spain (July 5-10, 2026).The latest breaking topics in vascular biology focused on endothelial cells will be featured. Open slots reserved for oral presentations. Register early to reserve your spot. www.grc.org/endothelial-...

Now THAT's a headline. "The U.S. spent $30 billion to ditch textbooks for laptops and tablets: The result is the first generation less cognitively capable than their parents" fortune.com/2026/02/21/l...

“cathepsin K…uniquely degrades cell-surface mucins, proteoglycans, and polysialylated glycoproteins, and…reduces total glycocalyx thickness…a promising starting point for the development of a glycocalyx-debulking enzyme for cancer therapeutics.” #glycotime @carolynbertozzi.bskyverified.social 👏

We are looking for two exceptional Research Assistants! 1) Experimental, to drive forward quantitative studies of transcription factor function in development 2) computational, to develop and apply cutting-edge deep learning models of gene regulation. Links below

Started this project years ago, but now everything is deposited on @addgene.bsky.social and a short @protocolsio.bsky.social is online. Try it out to make your own (cheap) homemade nuclease/Benzonase! dx.doi.org/10.17504/protocols.io.261ged7xov47/v2 Thank you @jcoker10.bsky.social and Michael Lim!

Happy to contribute to this Science Robotics perspective led by Raman Lab postdoc Dr. Ronald Heisser. We highlight how fostering relationships between the disability and soft #robotics communities could spark innovations that benefit society: www.science.org/doi/10.1126/...

“The best that I can do in terms of making the next breakthrough or discovery is not to do it by myself, but to enable other scientists to do it” — Jennifer Doudna www.forbes.com/sites/amyfel...

Big congrats to Dr. Len Zon for being awarded the 2026 @marchofdimes.org Richard B Johnston Jr, MD Prize for his work in #devbio. His pioneering research has illuminated how blood develops in embryos, leading to a deeper understanding of genetic blood diseases. www.marchofdimes.org/about/news/r... 🧪