Some thoughts on personalized medicine. open.substack.com/pub/andrewms...

Some poorly conceived thoughts on modern science. open.substack.com/pub/andrewms...

My lab is hiring a postdoc to work on new TDP-43 biomarkers! Please get in touch and re-post!

BREAKING: Field makes inchwise progress over decades on intractable problem of dementia with interesting leads and blind alleys but smart people are doing their best and please don’t overinterpret their results because it takes a long time for a real breakthrough www.bostonglobe.com/2025/08/06/m...

First highlight... Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH. The details are not available, but the bill will be released ofter the hearing. This is not a done-deal, but it does show where the Senate is on a bipartisan basis.

My lab is hiring a postdoc to work on new TDP-43 biomarkers! Please get in touch and re-post!

New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...

Well said!

We studied the binding of clinical antibodies to human brain extracts and found no evidence that lecanemab binds a more soluble population of Abeta than aducanumab or donanemab, nor that binding preferences to CAA vs plaque explained different ARIA rates. www.biorxiv.org/content/10.1...

Thrilled to share my first first-author paper is out @cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes. Read here www.sciencedirect.com/science/arti...

Oh! It was finally approved today! 🍾🍾 ec.europa.eu/newsroom/san...

Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!

If you're headed to #ADPD next week, be sure to stop by the TYP lab presentations by @gizemterzioglu.bsky.social and Zach Augur to learn about some of the amazing work the lab is doing!

Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"

@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"

A very thoughtful and sobering piece by Dr. Jason Karlawish. "The problem is that the facts don't support Piller's message. It's sensational, and in my experience, it's causing harm." How a Book Is Undermining Progress Against Alzheimer's www.medpagetoday.com/opinion/seco...

It was distressing to see the skepticism about Alzheimer's disease research expressed at the Bhattahcharya hearing today. This has been fueled by Charles Piller's sensationalized (NOT sensational) reporting and book. 1/n

Many Alzheimer’s researchers are also unhappy with Piller’s recent book and its negative characterization of the field, in which he inflates the significance of isolated fraud cases to argue that the entire field is corrupt. Here’s a rebuttal from my colleague Dennis Selkoe, published in STAT News:

@baldwin.senate.gov released a press release calling out the administration for damaging the Alzheimer's Disease Research Center network through it's screwing up NIH processes. www.baldwin.senate.gov/news/press-r... 1/2

If you want to learn about Charlie Piller's journalistic integrity, read this (long) thread. bsky.app/profile/jere... It is pretty telling...sensationalism without regard to getting the facts right.

Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!

(To the tune of My Sharona) CNS’s macrophage Myeloid fate Can disease-associate Microglia!

RNA xkcd.com/3056

Some thoughts on “protofibrils.” www.alzforum.org/news/researc...

It appears RFK Jr has read this dangerously misinformed book and may try to come for the “amyloid cabal.” @bostonglobe.com @statnews.com @alzassociation.bsky.social @nytopinion.nytimes.com

As Dr. Selkoe powerfully articulates, you don't have to agree with the amyloid hypothesis to know that Piller is getting a lot wrong and doing considerable harm -- including by providing dangerous talking points to political appointees who traffic in misinformation to undermine science.

Hear, hear! www.statnews.com/2025/02/14/a...

The argument I would make about the IDC cuts is less about the effect on science (though this is important), and more that an IDC cut is directed specifically at plumbers, electricians, equipment technicians, construction workers, janitors, security guards, and other working/middle class employees.

Please see a collective response from an esteemed group of leaders in the dementia field to the NYT article and book “doctored” by Charles Piller. www.nytimes.com/2025/01/24/o...

I am disappointed by the "Doctored" book. While a handful of scientists have put ego over integrity, this does not diminish from the tireless work of thousands of dementia researchers. Suggesting the field is fraught with fraud does a disservice to the millions of Alzheimer’s patients and caregivers

Thank you for this great thread. Fraud and scientific misconduct are terrible and must be exposed and corrected. But implying that the entire Alzheimer disease reseach field is based on incorrect assumptions because of rare fraudulent papers is also misleading. Context is essential to truth.

Bang-on analysis. Also, @charlespiller.bsky.social’s own former editor in chief @jeremymberg.bsky.social has noted his misleading, exaggerated, even negligent reporting on separate scientific stories in the past.

My first science post here on BlueSky is a long one. Setting the contrarian tone from the very beginning, I take strong issue with the recent op-ed by Charles Piller published in the January 24th NY Times on #Alzheimer's disease (nam12.safelinks.protection.outlook.com?url=https%3A...)

Even Marder on glam pubs, erosion of truth and need for keeping things in brains vs phones: rupress.org/jgp/article/...

Incident dementia risk decreases at age 85-95 compared to 75-84. Dementia is not due to “brain biological aging,” it is caused by specific pathologies that peak in incidence in the eighth decade. www.nature.com/articles/s41...

If you follow some lab methods’ “as previously described” citation trails far enough back, you get to some interesting Sumerian cuneiform tablets.

My suspicion is sabirnetug will fail because its binding target has never been definitively isolated from human brain, but I’m hoping to be proven overly skeptical. www.sciencedirect.com/science/arti...

Naive q for immunologists/rheumatologists: how do autoantibodies to intranuclear antigens like Sm, U1RNP, Ro/La, cause (or not cause) disease? The antibody presumably can’t access these antigens unless they’re mislocalized/secreted?

Pharmaceutical company Roche announce that their Phase IIb PADOVA study of the alpha synuclein targeting antibody Prasinezumab just missed its primary endpoint (p=0.0657), but their data suggests possible clinical benefit in early-stage #Parkinsons www.roche.com/media/releas...

How beautiful is this?! Serial block face EM of human cortex

Been anecdotally seeing some ARIA-E in ApoE e2 carriers. Anyone else?

In the late 1980s, before anyone knew how Abeta was made, Wisniewski hypothesized that microglia made plaques because TEM showed amyloid in communication with microglial ER. Something to this I suppose? Maybe endosomes, not ER? I’m not a cell biologist. www.nature.com/articles/s41...

Shame on @alzassociation.bsky.social for scheduling AAIC in Toronto while the Blue Jays are on the road!

Wow, thought-provoking presentation today by @millermb.bsky.social on somatic mutations in #aging and neurodegenerative diseases Check out this paradigm shifting work 👇 www.nature.com/articles/s41... Cause or consequence still up for debate, but fascinating nonetheless

I'm traveling to Mayo-Jacksonville today to share our research and meet with colleagues @DrNeuroChic, @dennis_w_d, and more! Looking forward to great discussions on tau, neurodegeneration, and more!

This is because ageing is not a useful biological construct. It is a loose tying-together of actual pathologies.

In case anyone on BlueSky hasn't seen it, this may be the funniest scientific study ever published. Bringing it up now as the amazing @scotsfriction.bsky.social has just issued a "teaspoon amnesty" for our common room www.bmj.com/content/331/...

I see a little silhouetto of a plaque! Is it cored? Or diffuse? Can you also see tangles?!

Hi @brfalcon.bsky.social and lab, great work on the tau-EV paper! Did you ever try it without the 0.2-um filter? The EVs seem around 1 um in size, and I wonder if the filter could shear membranes. www.nature.com/articles/s41...

I’m starting a new journal: “Cell Science and Nature.” Now accepting submissions. If accepted, you can then say you’re published in Cell Science and Nature.