Often when I find no answers to a question, it turns out to be the wrong question.

Cotton wool Abeta plaque

"My student’s feedback prompted me to think why I pursued career in academia in first place. I recalled the excitement I felt as a postdoc, when curiosity was king for me...I lost sight of this when I was consumed by problems and fears under the tenure clock" www.science.org/content/arti...

"What I wish for now is no longer happiness but simply awareness… I hold onto the world with every gesture, to men with all my gratitude and pity" share.google/Jf3cKGPKY9mr...

"I might not have felt the need to step away from academia had we aimed for a lower impact journal...success isn’t solely a matter of high-impact papers...its tracing a path that isn’t defined by what others expect of me" www.science.org/content/arti...

"His groundbreaking work was not the result of mythical serendipity alone, but rather the culmination of perseverance, intellect and a willingness to think differently from the heart of a colonial world" aeon.co/essays/why-s...

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine www.nytimes.com/interactive/...

the original language in the Senate appropriations bill kept the MYF policy to 2024 levels ask your congressional representatives for the current language in the funding bill to be replaced with this language: keep MYF at 2024 levels, NOT 2025 levels 🧪

The NIH's MYF policy in 2025 resulted in 4000 fewer grants and fellowships that touched every area of biology and medicine; continuing it in 2026 would be disastrous for science, technology and health in the United States 🧪 www.nytimes.com/interactive/...

"The first is the pleasure in having the initial idea or insight. The insight could be asking a new question or finding a new answer; there is surprisingly not much difference...in either case, the essential event is a shift of perspective..." journals.biologists.com/jcs/article/...

Clock in and Clock out to make new discoveries and improve human health. Simple.

Annie Dillard in An American Childhood. All great writers are ultimately Yogis.

Full pdf @cp-iscience.bsky.social collab w/ @christlet.bsky.social www.cell.com/action/showP... I may go down ya'll but this was the best thing I wrote: DECLARATION OF GENERATIVE AI AND AI-ASSISTED TECHNOLOGIES IN THE WRITING PROCESS "No AI/AI-assisted tools were used in the writing process"

"More recently, I've also noticed that trainees don't spend time thinking on their own and only do so when prodded" Didn't want to sound like dad in interview...BUT I think this is due to passive consumption of media. Specifically excessive cell phone usage. journals.biologists.com/jcs/article/...

American author Joan Didion once said: “I write entirely to find out what I am thinking.” What happens when we stop writing? Do we stop finding out? www.theguardian.com/commentisfre...

Looking forward to #2026

“One discovers the light in darkness, that is what darkness is for; but everything in our lives depends on how we bear the light,” James Baldwin @themarginalian.org.web.brid.gy www.themarginalian.org/2023/09/28/i...

How does the axonal sub-membrane periodic cytoskeleton develop? Nick & Rohan from our lab found that building blocks are delivered in packets and co-assemble locally with actin for final structure. Fun collaboration with imaging Guru @christlet.bsky.social and his team. www.cell.com/iscience/ful...

I was in Bondi beach about this time last year...

"The gene therapy was previously licensed by Orchard Therapeutics which stopped work in 2022 to save cash amid layoffs. It’s one of the many gene therapies abandoned by industry even with promising clinical data because they may not be profitable" New paradigm? endpoints.news/in-a-first-f...

Keynote in a hat...has this been done before?

"None of my siblings went to college. So I was the first person in my family to go to college" today.ucsd.edu/story/the-sh...

Our next extraordinary biologist is Manu Prakash, plenary speaker at the Biologists @ 100 conference, who was recently interviewed for @jcellsci.bsky.social. #100biologists @prakashlab.bsky.social

WHAT

In our latest interviews, we hear from Giampietro Schiavo and Subhojit Roy @roylab-ucsd.bsky.social, past and present JCS Editors specialising in neuronal cell biology. journals.biologists.com/jcs/article/... journals.biologists.com/jcs/article/...

Like many labs, we lost an R01 grant on Parkinson's dementia that scored single digits but was cut after NIH council-approval due to multi-year funding. If this persists next year - which seems likely - research in US will be decimated. Though...to be fair, we are probably already there.

Scientists are already broken and have literally no voice now, and what are you peddling? Your f-ing book? I wonder what these people gain by piling misinformation on decades of painstaking scientific work and double-blinded clinical trials across multiple continents.

There was a time when these were all my possessions. Figures of my first paper on floor. Goal is to go back to this state.

Also in Issue 22: - Research Highlights on spindle assembly & cell migration - Interviews with past & present JCS Editors Giampietro Schiavo & Subhojit Roy @roylab-ucsd.bsky.social - Clathrin-mediated endocytosis at a glance - Adherens junction Review journals.biologists.com/jcs/issue/13...

Our Editors will be attending #CellBio2025 @ascbiology.bsky.social @embo.org. Reach out to @seemagrewal.bsky.social and Amelia Glazier to discuss JCS, @focalplane.bsky.social and our other @biologists.bsky.social initiatives.

First flush tea in #kolkata with @m1singh.bsky.social Apparently made with the first 3 (and only 3) leaves of the season.

Why did the English rule India for so many years?

“Election Twitter is a space dominated by teenagers who care deeply about politics but lack a way to express it on a level seen like this. I think that this is a motivation that says one of our own did this really cool thing, I think I can do a cool thing too.” www.theguardian.com/us-news/2025...

"An apartment in one of the city's poshest complexes can cost about 150 million rupees (around $1.7m)," he says. "With just 22 million rupees, we've restored 92 buildings, eight or nine clocks, and some 1,300 tombstone plaques" www.bbc.com/news/article...

JCS @jcellsci.bsky.social - strong reputation, true non-profit, run by working scientists, free to publish, and they even plant a tree for every paper you publish.

Did you know that @jcellsci.bsky.social has a new editor for neuronal cell biology? It's that guy @roylab-ucsd.bsky.social, I've heard good things about him

Advocating for understanding Physiology to decipher Pathology, something we should've done first IMO...next Thursday @dukenus Singapore:

Didn't realize Gipi (Giampietro Schiavo) was Neuro Editor @jcellsci.bsky.social longer than I have had a lab...: journals.biologists.com/jcs/article/...

Mole's Comedia III. Purgatorio. Canto I–XXIV. journals.biologists.com/jcs/article/...

🧬 CRN Team Gradinaru developed CRISPR-Cas9 tools to lower alpha-synuclein levels and tag the protein in living neurons. These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social. 🔗 Check out the full #publication: bit.ly/43YpVyL

"Until recently, the reality check would come when very poor scores on the SAT and ACT. They would not have made it into a university like UCSD, which is one of the top-ranked and most selective public universities in the country" www.theargumentmag.com/p/when-grade...

Keying the note in Singapore on Friday Nov 28 sfn.sg/sfn-sg-annua...

Atmospheric river in San Diego means #sfn2025 must be in town.

Last ditch experiments before starting new journey!

Transformative medical discoveries from utterly basic science is not an exception. Its the rule. nature.com/articles/d41...

"True; it might be a sin and shame, in such a world as ours, to spend a lifetime in this manner; but, for a few summer-weeks, it is good to live as if the world were Heaven"

Scientists are obsessed with intelligence. But you don't need an astronomical IQ to design a simple experiment that will slash through the darkness. In fact high IQ people often lack the simple-minded clarity needed for designing good experiments.

Yup. That outta do it.

Incredible by @odedrechavi.bsky.social...an AI-thingy that reviews your manuscript with a very high bar and takes no prisoners. But you can do this in your pajamas and no one gets to see it. Takes a while but once you get the results you'll know why: www.qedscience.com