“One discovers the light in darkness, that is what darkness is for; but everything in our lives depends on how we bear the light,” James Baldwin @themarginalian.org.web.brid.gy www.themarginalian.org/2023/09/28/i...

How does the axonal sub-membrane periodic cytoskeleton develop? Nick & Rohan from our lab found that building blocks are delivered in packets and co-assemble locally with actin for final structure. Fun collaboration with imaging Guru @christlet.bsky.social and his team. www.cell.com/iscience/ful...

I was in Bondi beach about this time last year...

"The gene therapy was previously licensed by Orchard Therapeutics which stopped work in 2022 to save cash amid layoffs. It’s one of the many gene therapies abandoned by industry even with promising clinical data because they may not be profitable" New paradigm? endpoints.news/in-a-first-f...

Keynote in a hat...has this been done before?

"None of my siblings went to college. So I was the first person in my family to go to college" today.ucsd.edu/story/the-sh...

Our next extraordinary biologist is Manu Prakash, plenary speaker at the Biologists @ 100 conference, who was recently interviewed for @jcellsci.bsky.social. #100biologists @prakashlab.bsky.social

WHAT

In our latest interviews, we hear from Giampietro Schiavo and Subhojit Roy @roylab-ucsd.bsky.social, past and present JCS Editors specialising in neuronal cell biology. journals.biologists.com/jcs/article/... journals.biologists.com/jcs/article/...

Like many labs, we lost an R01 grant on Parkinson's dementia that scored single digits but was cut after NIH council-approval due to multi-year funding. If this persists next year - which seems likely - research in US will be decimated. Though...to be fair, we are probably already there.

Scientists are already broken and have literally no voice now, and what are you peddling? Your f-ing book? I wonder what these people gain by piling misinformation on decades of painstaking scientific work and double-blinded clinical trials across multiple continents.

There was a time when these were all my possessions. Figures of my first paper on floor. Goal is to go back to this state.

Also in Issue 22: - Research Highlights on spindle assembly & cell migration - Interviews with past & present JCS Editors Giampietro Schiavo & Subhojit Roy @roylab-ucsd.bsky.social - Clathrin-mediated endocytosis at a glance - Adherens junction Review journals.biologists.com/jcs/issue/13...

Our Editors will be attending #CellBio2025 @ascbiology.bsky.social @embo.org. Reach out to @seemagrewal.bsky.social and Amelia Glazier to discuss JCS, @focalplane.bsky.social and our other @biologists.bsky.social initiatives.

First flush tea in #kolkata with @m1singh.bsky.social Apparently made with the first 3 (and only 3) leaves of the season.

Why did the English rule India for so many years?

“Election Twitter is a space dominated by teenagers who care deeply about politics but lack a way to express it on a level seen like this. I think that this is a motivation that says one of our own did this really cool thing, I think I can do a cool thing too.” www.theguardian.com/us-news/2025...

"An apartment in one of the city's poshest complexes can cost about 150 million rupees (around $1.7m)," he says. "With just 22 million rupees, we've restored 92 buildings, eight or nine clocks, and some 1,300 tombstone plaques" www.bbc.com/news/article...

JCS @jcellsci.bsky.social - strong reputation, true non-profit, run by working scientists, free to publish, and they even plant a tree for every paper you publish.

Did you know that @jcellsci.bsky.social has a new editor for neuronal cell biology? It's that guy @roylab-ucsd.bsky.social, I've heard good things about him

Advocating for understanding Physiology to decipher Pathology, something we should've done first IMO...next Thursday @dukenus Singapore:

Didn't realize Gipi (Giampietro Schiavo) was Neuro Editor @jcellsci.bsky.social longer than I have had a lab...: journals.biologists.com/jcs/article/...

Mole's Comedia III. Purgatorio. Canto I–XXIV. journals.biologists.com/jcs/article/...

🧬 CRN Team Gradinaru developed CRISPR-Cas9 tools to lower alpha-synuclein levels and tag the protein in living neurons. These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social. 🔗 Check out the full #publication: bit.ly/43YpVyL

"Until recently, the reality check would come when very poor scores on the SAT and ACT. They would not have made it into a university like UCSD, which is one of the top-ranked and most selective public universities in the country" www.theargumentmag.com/p/when-grade...

Keying the note in Singapore on Friday Nov 28 sfn.sg/sfn-sg-annua...

Atmospheric river in San Diego means #sfn2025 must be in town.

Last ditch experiments before starting new journey!

Transformative medical discoveries from utterly basic science is not an exception. Its the rule. nature.com/articles/d41...

"True; it might be a sin and shame, in such a world as ours, to spend a lifetime in this manner; but, for a few summer-weeks, it is good to live as if the world were Heaven"

Scientists are obsessed with intelligence. But you don't need an astronomical IQ to design a simple experiment that will slash through the darkness. In fact high IQ people often lack the simple-minded clarity needed for designing good experiments.

Yup. That outta do it.

Incredible by @odedrechavi.bsky.social...an AI-thingy that reviews your manuscript with a very high bar and takes no prisoners. But you can do this in your pajamas and no one gets to see it. Takes a while but once you get the results you'll know why: www.qedscience.com

New lab pic with people who happened to be in the area...messy, so let's assume work is getting done.

"Even short, regular check-ins can make a difference. Time spent helping students to solve problems, or simply asking how a project is going, will pay dividends. It also saves time later by catching small problems before they become big ones" nature.com/articles/d41...

lol yes...i still remember most of them

4 Nobels for UC in 2025, 75 since 1934, 1/4 winning women have ties to a UC. www.universityofcalifornia.edu/news/uc-wins...

Case of the missing Lab Tupperware!

It won’t take you years to publish your work in JCS: most articles go from submission to acceptance in under 4 months. We also show a strong commitment at first decision, with over 95% of revisions being accepted. Find out more: journals.biologists.com/jcs/pages/re... #forscientists #notforprofit

I'm giving a talk at this SFN sponsored symposium in Singapore, students in the area consider submitting abstract - deadline coming up Oct 14: sfn.sg/sfn-sg-annua...

I went to #Chile for a conference 25 years ago - when Internet wasn't a thing - and this is all I needed to know. It went just fine.

“She took a character on the page and gave her such truth, precision and warmth that Hyacinth became part of the national conversation; instantly recognisable, endlessly quotable, and loved around the world"

"So far, just the headline findings have been released. Scientists say the full study needs to be published and assessed by independent experts to properly assess what has been achieved" Umm...yes. www.bbc.com/news/article...

Target engagement + "increased myelination (P = 0.0137) and improved MSEL developmental outcomes (P = 0.0171). Thus, interim results suggest that gene therapy with MYR-101 is well tolerated and shows early effects in Canavan's Disease" AAVs in oligos! www.nature.com/articles/s41...

We wrote a book chapter on #CRISPR and #Alzheimers if anyone is still reading books. link.springer.com/chapter/10.1...

So what are the #1 &2 journals in biochemistry ranked by impact factor? Brace yourself...1/2 www.science.org/content/blog...

If you think the troubles at NIH does not affect you, you just need to wait. Due to multi-year funding, NINDS will be able to fund 40% fewer grants next cycle...even if budget stays same. Yes, message from one of the highest levels. Talk to Congress, that's the only way now.

Silence of the labs www.washingtonpost.com/business/202...

Signs of new life amidst carnage. Postdoc Leo Parra (left, Brent on right) is heading East to U Maryland @UMmedschool as an Asst Professor with the Institute for Neuroscience Discovery (medschool.umaryland.edu/um-mind/)

"The MYF scheme only makes sense if the goal is to threaten the American research enterprise"