Target engagement + "increased myelination (P = 0.0137) and improved MSEL developmental outcomes (P = 0.0171). Thus, interim results suggest that gene therapy with MYR-101 is well tolerated and shows early effects in Canavan's Disease" AAVs in oligos! www.nature.com/articles/s41...

We wrote a book chapter on #CRISPR and #Alzheimers if anyone is still reading books. link.springer.com/chapter/10.1...

So what are the #1 &2 journals in biochemistry ranked by impact factor? Brace yourself...1/2 www.science.org/content/blog...

If you think the troubles at NIH does not affect you, you just need to wait. Due to multi-year funding, NINDS will be able to fund 40% fewer grants next cycle...even if budget stays same. Yes, message from one of the highest levels. Talk to Congress, that's the only way now.

Silence of the labs www.washingtonpost.com/business/202...

Signs of new life amidst carnage. Postdoc Leo Parra (left, Brent on right) is heading East to U Maryland @UMmedschool as an Asst Professor with the Institute for Neuroscience Discovery (medschool.umaryland.edu/um-mind/)

"The MYF scheme only makes sense if the goal is to threaten the American research enterprise"

If you're tired of AI and stuff...we published CRISPR-based protocols that you can actually use to delete alpha-synuclein (~100% efficiency) or knock it into endogenous locus (~53% eff) in cultured neurons: star-protocols.cell.com/protocols/4339

A timely reminder...

Looking forward to speaking at Gordon Conference about gene-editing and #Alzheimers (my talk is on the last day as usual :). Taking Amtrak from San Diego to Ventura this time, lets see how that goes... www.grc.org/alzheimer-s-...

Really pleased to have Subhojit (@roylab-ucsd.bsky.social) on board as a new Editor at @jcellsci.bsky.social! Send your neuronal cell biology papers his way! 👇

We are delighted to welcome Subhojit Roy @roylab-ucsd.bsky.social as an Editor at Journal of Cell Science. Subhojit will handle manuscripts on various aspects of neuronal cell biology.

Giving a talk at the @ucirvine.bsky.social MIND seminar series next Thursday (15th). Thanks Vivek Swarup for the invitation.

Happy to report that our very own undergrad scientist Arnav Godavarthi (NOT Rachin Ravindra NZ cricketer!) won the $5K Julia Brown Research Scholarship for Health and Medical Professions @ucsdhealthsci.bsky.social

Kinesins move faster in giraffes and pythons due to point mutations! www.biorxiv.org/node/4583755...

"The once active neurons that fired electrical and chemical signals from axons to dendrites inside the crevices and folds of the left frontal lobe, home to the language center, were now quiet. The memories produced in the hippocampus were now frozen" nautil.us/my-visit-wit...

Your entire opinion of yourself is what others think. Have you ever asked yourself who you really are? - Kabir (14th century)

Kabir in the 1400's. The world has been misguided for a long time.

Lesson in life from Serbian postdoc (translation): "You need to Smash your worries against the Wall of Joy"

100,000% tariff for saying something totally obvious followed by "...that being said..." and further monologue.

A huge majority of Americans (77%) oppose the cuts to medical research that the current administration has made. (Source: Wash. Post/ABC/Ipsos poll)

Finally a role for the most common synaptic marker in the world synaptophysin - maintaining synaptic vesicle diameter: www.science.org/doi/10.1126/...

Someone asked me what I've recently read leading to a flurry of 6 texts. 1. Yes she's crazy but a crazy good writer:

One of the most frustrating things for me is that I cannot summarize what my lab does. Huge problem when asked for elevator-pitch or speaker-summary. Super jealous of people who "build a unique xyz model system" and evaluate that system for the rest of their career.

Satellite EMBO Neurocytoskeleton #neurocyto2025 meeting at Torres del Paine? Went on an amazing hike with Karolina Kowalska and Jonas Vlasak from Daniel Rozbesky's lab. Then ran into @roylab-ucsd.bsky.social and @m1singh.bsky.social the next day. Great to see colleagues in beautiful places!

“It’s not nothing,” said Stephen Schmidt, a planetary scientist at Johns Hopkins University. I'm stealing this line. www.nytimes.com/2025/04/16/s...

"Single infusion of VERVE-102 led to dose-dependent decreases in blood PCSK9 and LDL-C, with mean reduction in LDL-C of 53% and a maximum reduction of 69% observed in the 0.6 mg/kg dose cohort" ir.vervetx.com/news-release...

“It’s going to go one way or another. I’m not taking it with me,” Gilbert said from a hospital bed as she received an infusion of a drug designed to prevent the disease from worsening. “I hope it gets used well. But, you know, you can’t guarantee anything.”

Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to [email protected]. Please share and repost!

What a great time with the one and only @christlet.bsky.social and @m1singh.bsky.social I miss him already 😢

Curdled milk in coffee today made me think of of phase separation.

I asked AI to make me a professional headshot and now I can't sleep...

So many rings....so little time. @christlet.bsky.social at #neurocyto2025

Best advice I ever got for number of slides for a talk. Delete as many as you can. Be ruthless and remove everything that does not linearly lead to the ONE point you want to make. Resist temptation to add more. Trust me no one will be impressed. I still make this mistake.

Bodies older, Vibe same - with @christlet.bsky.social at #neurocyto2025

Grand portrait space at #neurocyto2025 venue crying out for one of those @christlet.bsky.social selfies (pic: @m1singh.bsky.social)

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Being one with the clearing in the cytoskeleton forest @christlet.bsky.social practicing Vedanta at neurocyto2025

Not too shabby... neurocyto2025

Happy to keep @christlet.bsky.social busy with my paperwork on bus trip to conference venue neurocyto2025

I see you and raise you one.

most people are becoming their phone

Looks like a medieval torture device these days...

www.sciencehistory.org/education/sc... If you want to read something inspiring. I know I am in need of inspiration

Mike Sheetz (1946-2025) made immense contributions to our understanding of motor proteins, membrane biology, cytoskeleton and mechanobiology. Haguy Wolfenson, Gregory Giannone, and Martin Schwartz recall his life and work: rupress.org/jcb/article/...

Help I think I've created monsters

As long as PIs talk about #science as "big papers" and "small paper", glossy journals win.

twitter 😂😂

One day left to submit an abstract for short talk consideration at the upcoming Keystone Neurodegeneration meeting (Whistler, BC, June 8-11). We have an amazing set of speakers lined up already - please join us! For more info, see: vimeo.com/1068280559/9...