Subhojit Roy MD, PhD
@roylab-ucsd.bsky.social
📤 301
📥 232
📝 238
Science & Music. Sometimes funny. www.roylab.org
https://www.youtube.com/@pandemicmelodica
“One discovers the light in darkness, that is what darkness is for; but everything in our lives depends on how we bear the light,” James Baldwin
@themarginalian.org.web.brid.gy
www.themarginalian.org/2023/09/28/i...
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I Touched the Sun: A Tender Illustrated Fable About How to Find and Bear Your Inner Light
“One discovers the light in darkness, that is what darkness is for; but everything in our lives depends on how we bear the light,” James Baldwin wrote in one of his finest, least known …
https://www.themarginalian.org/2023/09/28/i-touched-the-sun-leah-hayes/
4 days ago
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How does the axonal sub-membrane periodic cytoskeleton develop? Nick & Rohan from our lab found that building blocks are delivered in packets and co-assemble locally with actin for final structure. Fun collaboration with imaging Guru
@christlet.bsky.social
and his team.
www.cell.com/iscience/ful...
add a skeleton here at some point
6 days ago
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I was in Bondi beach about this time last year...
11 days ago
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"The gene therapy was previously licensed by Orchard Therapeutics which stopped work in 2022 to save cash amid layoffs. It’s one of the many gene therapies abandoned by industry even with promising clinical data because they may not be profitable" New paradigm?
endpoints.news/in-a-first-f...
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In a first, FDA approves a gene therapy from a nonprofit
The FDA on Tuesday approved Waskyra for a rare immune disease called Wiskott-Aldrich syndrome, for which patients have little options besides a bone marrow transplant.
https://endpoints.news/in-a-first-fda-approves-a-gene-therapy-from-a-nonprofit/
16 days ago
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Keynote in a hat...has this been done before?
16 days ago
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"None of my siblings went to college. So I was the first person in my family to go to college"
today.ucsd.edu/story/the-sh...
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The Shock of a Lifetime: A Conversation with UC San Diego’s Newest Nobel Laureate Alumnus
Ahead of the Nobel Prize Award ceremony on Dec. 10, biochemistry and cell biology graduate Fred Ramsdell discusses his time at UC San Diego, his Nobel Prize-winning research in immunology and the cons...
https://today.ucsd.edu/story/the-shock-of-a-lifetime-a-conversation-with-uc-san-diegos-newest-nobel-laureate-alumnus
16 days ago
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reposted by
Subhojit Roy MD, PhD
The Company of Biologists
18 days ago
Our next extraordinary biologist is Manu Prakash, plenary speaker at the Biologists @ 100 conference, who was recently interviewed for
@jcellsci.bsky.social
.
#100biologists
@prakashlab.bsky.social
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WHAT
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17 days ago
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reposted by
Subhojit Roy MD, PhD
Journal of Cell Science
21 days ago
In our latest interviews, we hear from Giampietro Schiavo and Subhojit Roy
@roylab-ucsd.bsky.social
, past and present JCS Editors specialising in neuronal cell biology.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
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Like many labs, we lost an R01 grant on Parkinson's dementia that scored single digits but was cut after NIH council-approval due to multi-year funding. If this persists next year - which seems likely - research in US will be decimated. Though...to be fair, we are probably already there.
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21 days ago
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Scientists are already broken and have literally no voice now, and what are you peddling? Your f-ing book? I wonder what these people gain by piling misinformation on decades of painstaking scientific work and double-blinded clinical trials across multiple continents.
21 days ago
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There was a time when these were all my possessions. Figures of my first paper on floor. Goal is to go back to this state.
21 days ago
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reposted by
Subhojit Roy MD, PhD
Journal of Cell Science
22 days ago
Also in Issue 22: - Research Highlights on spindle assembly & cell migration - Interviews with past & present JCS Editors Giampietro Schiavo & Subhojit Roy
@roylab-ucsd.bsky.social
- Clathrin-mediated endocytosis at a glance - Adherens junction Review
journals.biologists.com/jcs/issue/13...
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reposted by
Subhojit Roy MD, PhD
Journal of Cell Science
23 days ago
Our Editors will be attending
#CellBio2025
@ascbiology.bsky.social
@embo.org
. Reach out to
@seemagrewal.bsky.social
and Amelia Glazier to discuss JCS,
@focalplane.bsky.social
and our other
@biologists.bsky.social
initiatives.
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First flush tea in
#kolkata
with
@m1singh.bsky.social
Apparently made with the first 3 (and only 3) leaves of the season.
23 days ago
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Why did the English rule India for so many years?
24 days ago
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“Election Twitter is a space dominated by teenagers who care deeply about politics but lack a way to express it on a level seen like this. I think that this is a motivation that says one of our own did this really cool thing, I think I can do a cool thing too.”
www.theguardian.com/us-news/2025...
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A teenager redrew the Alabama voting map – and it’s now state law
Daniel DiDonato, 18, drafted new state senate districts at home on free software – and a judge picked his map ahead of professionals’ efforts to remedy voting rights violations
https://www.theguardian.com/us-news/2025/nov/30/alabama-teenager-election-map-voting-rights
25 days ago
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"An apartment in one of the city's poshest complexes can cost about 150 million rupees (around $1.7m)," he says. "With just 22 million rupees, we've restored 92 buildings, eight or nine clocks, and some 1,300 tombstone plaques"
www.bbc.com/news/article...
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Kolkata: The Indian city that sparkles like Paris at night
In 21 months, citizens have lit up 92 Kolkata landmarks with a simple model: your property, their lights.
https://www.bbc.com/news/articles/c14704vj4r2o
26 days ago
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JCS
@jcellsci.bsky.social
- strong reputation, true non-profit, run by working scientists, free to publish, and they even plant a tree for every paper you publish.
add a skeleton here at some point
about 1 month ago
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reposted by
Subhojit Roy MD, PhD
Christophe 🔬 L
about 1 month ago
Did you know that
@jcellsci.bsky.social
has a new editor for neuronal cell biology? It's that guy
@roylab-ucsd.bsky.social
, I've heard good things about him
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Interview with Journal of Cell Science Editor Subhojit Roy
ABSTRACT. Subhojit Roy is Professor of Pathology at the University of California San Diego (UCSD) in the USA. Subhojit completed his MD in Kolkata, India and then moved to Temple University in Philade...
https://journals.biologists.com/jcs/article/138/22/jcs264518/369878/Interview-with-Journal-of-Cell-Science-Editor
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Advocating for understanding Physiology to decipher Pathology, something we should've done first IMO...next Thursday @dukenus Singapore:
about 1 month ago
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Didn't realize Gipi (Giampietro Schiavo) was Neuro Editor
@jcellsci.bsky.social
longer than I have had a lab...:
journals.biologists.com/jcs/article/...
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Interview with Professor Giampietro Schiavo
ABSTRACT. Giampietro Schiavo is a Professor of Cellular Neuroscience, Deputy Director for strategy at Queen Square Institute of Neurology, academic lead of the Alzheimer Research UK Drug Discovery Ins...
https://journals.biologists.com/jcs/article/138/22/jcs264403/369877/Interview-with-Professor-Giampietro-Schiavo
about 1 month ago
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reposted by
Subhojit Roy MD, PhD
Journal of Cell Science
about 1 month ago
Mole's Comedia III. Purgatorio. Canto I–XXIV.
journals.biologists.com/jcs/article/...
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reposted by
Subhojit Roy MD, PhD
Aligning Science Across Parkinson's
about 1 month ago
🧬 CRN Team Gradinaru developed CRISPR-Cas9 tools to lower alpha-synuclein levels and tag the protein in living neurons. These methods may help researchers better understand its role in
#Parkinsons
with contributions from
@roylab-ucsd.bsky.social
. đź”— Check out the full
#publication
:
bit.ly/43YpVyL
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"Until recently, the reality check would come when very poor scores on the SAT and ACT. They would not have made it into a university like UCSD, which is one of the top-ranked and most selective public universities in the country"
www.theargumentmag.com/p/when-grade...
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When grades stop meaning anything
The UC San Diego math scandal is a warning
https://www.theargumentmag.com/p/when-grades-stop-meaning-anything
about 1 month ago
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Keying the note in Singapore on Friday Nov 28
sfn.sg/sfn-sg-annua...
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SfN.SG Annual Symposium 2025 - Society for Neuroscience Singapore Chapter
The Society for Neuroscience, Singapore Chapter (SfN.SG) is happy to announce that registration and abstract submission for the Annual Symposium are now open! The symposium will
https://sfn.sg/sfn-sg-annual-symposium-2025/
about 1 month ago
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Atmospheric river in San Diego means
#sfn2025
must be in town.
about 1 month ago
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Last ditch experiments before starting new journey!
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about 2 months ago
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Transformative medical discoveries from utterly basic science is not an exception. Its the rule.
nature.com/articles/d41...
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7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
https://nature.com/articles/d41586-025-03474-x
about 2 months ago
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"True; it might be a sin and shame, in such a world as ours, to spend a lifetime in this manner; but, for a few summer-weeks, it is good to live as if the world were Heaven"
add a skeleton here at some point
about 2 months ago
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Scientists are obsessed with intelligence. But you don't need an astronomical IQ to design a simple experiment that will slash through the darkness. In fact high IQ people often lack the simple-minded clarity needed for designing good experiments.
about 2 months ago
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Yup. That outta do it.
about 2 months ago
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Incredible by @odedrechavi.bsky.social...an AI-thingy that reviews your manuscript with a very high bar and takes no prisoners. But you can do this in your pajamas and no one gets to see it. Takes a while but once you get the results you'll know why:
www.qedscience.com
add a skeleton here at some point
2 months ago
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New lab pic with people who happened to be in the area...messy, so let's assume work is getting done.
2 months ago
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"Even short, regular check-ins can make a difference. Time spent helping students to solve problems, or simply asking how a project is going, will pay dividends. It also saves time later by catching small problems before they become big ones"
nature.com/articles/d41...
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What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
https://nature.com/articles/d41586-025-03416-7
2 months ago
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lol yes...i still remember most of them
add a skeleton here at some point
2 months ago
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4 Nobels for UC in 2025, 75 since 1934, 1/4 winning women have ties to a UC.
www.universityofcalifornia.edu/news/uc-wins...
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UC wins 5 Nobel Prizes in 3 days — and sets a new world record
These discoveries span decades and disciplines, but they all have one important thing in common: They’ve all relied on competitive funding from the federal government.
https://www.universityofcalifornia.edu/news/uc-wins-5-nobel-prizes-3-days-and-sets-new-world-record
3 months ago
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Case of the missing Lab Tupperware!
3 months ago
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reposted by
Subhojit Roy MD, PhD
Journal of Cell Science
3 months ago
It won’t take you years to publish your work in JCS: most articles go from submission to acceptance in under 4 months. We also show a strong commitment at first decision, with over 95% of revisions being accepted. Find out more:
journals.biologists.com/jcs/pages/re...
#forscientists
#notforprofit
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I'm giving a talk at this SFN sponsored symposium in Singapore, students in the area consider submitting abstract - deadline coming up Oct 14:
sfn.sg/sfn-sg-annua...
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SfN.SG Annual Symposium 2025 - Society for Neuroscience Singapore Chapter
The Society for Neuroscience, Singapore Chapter (SfN.SG) is happy to announce that registration and abstract submission for the Annual Symposium are now open! The symposium will
https://sfn.sg/sfn-sg-annual-symposium-2025/
3 months ago
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I went to
#Chile
for a conference 25 years ago - when Internet wasn't a thing - and this is all I needed to know. It went just fine.
3 months ago
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“She took a character on the page and gave her such truth, precision and warmth that Hyacinth became part of the national conversation; instantly recognisable, endlessly quotable, and loved around the world"
add a skeleton here at some point
3 months ago
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"So far, just the headline findings have been released. Scientists say the full study needs to be published and assessed by independent experts to properly assess what has been achieved" Umm...yes.
www.bbc.com/news/article...
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Huntington's disease breakthrough 'is like winning the lottery 10 times over'
Families are elated by news of the first treatment for Huntington's disease - but when and how will the NHS fund it?
https://www.bbc.com/news/articles/c3vzek4dkyyo
3 months ago
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Target engagement + "increased myelination (P = 0.0137) and improved MSEL developmental outcomes (P = 0.0171). Thus, interim results suggest that gene therapy with MYR-101 is well tolerated and shows early effects in Canavan's Disease" AAVs in oligos!
www.nature.com/articles/s41...
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Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial - Nature Medicine
Interim trial results of MYR-101, a novel recombinant vector with selective tropism for oligodendrocytes, support its tolerability and indicate improved myelination and reduced cerebrospinal fluid N-a...
https://www.nature.com/articles/s41591-025-03919-w
3 months ago
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We wrote a book chapter on
#CRISPR
and
#Alzheimers
if anyone is still reading books.
link.springer.com/chapter/10.1...
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CRISPR Therapies for Alzheimer’s Disease
Engineered CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats) have gone from proof-of-concept to an FDA-approved drug in little more than a decade (Fig. 1). This shrunken bench-to-bes...
https://link.springer.com/chapter/10.1007/978-3-031-89307-0_12
4 months ago
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So what are the #1 &2 journals in biochemistry ranked by impact factor? Brace yourself...1/2
www.science.org/content/blog...
4 months ago
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If you think the troubles at NIH does not affect you, you just need to wait. Due to multi-year funding, NINDS will be able to fund 40% fewer grants next cycle...even if budget stays same. Yes, message from one of the highest levels. Talk to Congress, that's the only way now.
4 months ago
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Silence of the labs
www.washingtonpost.com/business/202...
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Inside science labs trying to survive in the Trump era
Anastasia Khvorova’s lab at the University of Massachusetts Chan Medical School shows how quickly the administration is dismantling an 80-year partnership that made the U.S. a scientific superpower.
https://www.washingtonpost.com/business/2025/08/11/trump-science-nobel-innovation-cuts/
5 months ago
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Signs of new life amidst carnage. Postdoc Leo Parra (left, Brent on right) is heading East to U Maryland @UMmedschool as an Asst Professor with the Institute for Neuroscience Discovery (
medschool.umaryland.edu/um-mind/
)
5 months ago
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"The MYF scheme only makes sense if the goal is to threaten the American research enterprise"
add a skeleton here at some point
5 months ago
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