"Jared Cooney Horvath said Gen Z is less cognitively capable than previous generations, despite its unprecedented access to technology...Gen Z is the first generation in modern history to score lower on standardized tests than the previous one" fortune.com/article/how-...

Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...

Interesting to see how few of the "1% papers" say something definitive with a high degree of certainty. Give me something I know is real has become gimme something fuzzy but scintillating that can go in glossy journal. I don't know how to do science anymore.

Souvenir from the Cell Biology of the Neuron GRC in beautiful Tuscany. A great community, looking forward to meet everyone again in two years with @barrlab.bsky.social and @roylab-ucsd.bsky.social at the helm!

Good!

"But doing the minimum required just to keep your advisor or supervisor satisfied probably isn’t the goal. Hopefully, you’re motivated by more than the prospect of avoiding discipline or dismissal" helpimascientist.com/2022/11/20/h...

If you use this, ask yourself: do you really like your job? 🧪

"It's been 84 years but I can still smell the fresh DNA paint...." @christlet.bsky.social reminiscing with @francescabartolini.bsky.social and me at GRC Cell biology of the Neuron, Italy

A fantastic week at the Cell Biology of the Neuron GRC in Tuscany. @roylab-ucsd.bsky.social & I are organizing 2028, June 4-9: same location A great perk of being a scientist is getting to hang with other scientists. My cup is full. Thank you! @channyskye.bsky.social @rodallab.bsky.social

GRC Cell Biology of the Neuron Italy. Same venue in 2028 I'm co-chairing with @barrlab.bsky.social

"We lived below the poverty line and my stepfather [abused] my mother and me...Not long after, I escaped from our dingy apartment with a suitcase of essentials and never looked back" From homeless to Ph.D.: How I found my way into research | Science | AAAS share.google/uOXeuM5rJ7GL...

expect less hair tho...

A perfectly reasonable statement...except Barbara was not purifying tubulin. Crazy story with ups and downs shows how scientific discoveries are really made: onlinelibrary.wiley.com/doi/10.1111/...

yesterday we discussed that for a PI, every experiment takes 6 months or less because stupendous success at every corner is the norm and 18 hour workdays (including weekends) is expected.

Would you write a figure legend like this today (John Heuser 1980)? Hey, good thing we are so much more certain of our data than John was in 1980...

"No matter how much we tell ourselves AI is like spell-check, it isn’t. When we use AI to flesh out ideas, we lose the most important part of the writing process: thinking...the effort and the hang-ups are a feature of the human thought process, not a bug" www.theatlantic.com/technology/2...

Giving a talk? Don't waste time with "practice talks". Stay in slide sorter view & practice 3 things for each slide: 1. What point/s do I want to convey with this slide (</=3). 2. What's the 1-line summary of this slide? 3. What is the transition to the next slide? Something doesn't fit? FIX IT

"Over the last 7 yrs, we published >700 ‘First Person’ interviews...But JCS has been around much longer – in fact, JCS was first established in 1853 as the Quarterly Journal of Microscopical Science (QJMS), re-branded as JCS in 1966" @jcellsci.bsky.social journals.biologists.com/jcs/article/...

"Intellia Therapeutics announced that its systemic CRISPR–Cas9 gene editing medicine had met primary and secondary endpoints, leading the biotech to start a rolling submission for US Food and Drug Administration approval" www.nature.com/articles/s41...

"They are, after all, what our society is. A society in which it is commonplace to discriminate and other people based on religion, region, caste, class, colour of skin, gender and sexuality" www.espncricinfo.com/story/ipl-20...

I was interviewed by @snehakhedkar.bsky.social for The Scientist about our work using super-resolution microscopy to map the neuronal architecture, and make nice pictures along the way! Check the article here: www.the-scientist.com/super-resolu...

Our postdoctoral fellow Patrick Kearney, PhD @ucsandiego.bsky.social has been selected in the Inaugural Cohort of Discovery Fellows by Aligning Science Across Parkinson’s @asapresearch.parkinsonsroadmap.org (full fellowship + research funds): parkinsonsroadmap.org/newsroom/dis...

Someone decided THIS is what was missing @ucsandiego.bsky.social

The therapy, made by Intellia Therapeutics, uses CRISPR to inactivate that contributes to disfiguring and dangerous swelling attacks in people with hereditary angioedema. The one-time infusion reduced those attacks by 87% compared to placebo endpoints.news/intellias-in...

Interesting!

A high point of the roof at my parents house in #kolkata are the #trains that pass below...🔊

Issue 7 is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image is an UExM image of tubulin-based structures during the early stages of Toxoplasma gondii daughter cell formation. See article from Sladewski and Heaslip: journals.biologists.com/jcs/article/...

Post apocalyptic to Bordello inspired...all in one #Kolkata street

There is still time to apply. I'm now looking for someone who likes imaging, for a project like this: www.cell.com/neuron/fullt...

It's not hard to see why the average Englishman posted in East India Company #kolkata only lived a few months.

Golgi was right about this but wrong about the synapse and fought until the end with Cajal that it was all continuous and there was no synapse (gap). Ironically Cajal used Golgi's staining method to define synapses in multiple brain circuits.

There is still time to apply. I'm now looking for someone who likes imaging, for a project like this: www.cell.com/neuron/fullt...

The methods betray a motivation to dilute positive studies with negative ones. We've seen this in the past as a pathetic attempt to dismiss the efficacy of these drugs. www.nytimes.com/2026/04/15/h...

Why choose JCS? - FREE to publish (with OA options available) - Fast-track option for papers with reports - Submissions handled by Academic Editors - Published by a not-for-profit publisher - A tree planted for every peer-reviewed article🌳 Find out more at: journals.biologists.com/jcs/pages/re...

We know why some trials worked and others didn't (time of intervention for ex). You can't combine all of them LOL. It's like averaging results of every exam you ever took and conclude you aren't the topper. www.cochranelibrary.com/cdsr/doi/10....

#Kolkata in the rain is really something @m1singh.bsky.social

The Ideal Postdoc (from Indian comic Amar Chitra Katha)

Reminder that countries following self interest is not new...half of the world was tortured for centuries because Europeans couldn't get cheap spices.

China...

Why is publishing so expensive? In this Editorial, we (@katherine-brown.bsky.social @drmichaelway.bsky.social & @seemagrewal.bsky.social) provide details and context on JCS's finances, and hope to dispel some of the myths around the economics of publishing. journals.biologists.com/jcs/article/...

BIGGEST problem in #science peer review (wasting massive time/$$): Say you created device that prevents dogs from wagging tail (novel, lets say works, ?utility). Rev #1: "This is all good but does it work in Pekingese poodles?". Why, because he has one. Guess what Editor agrees...she has one too!

I'm not getting this go around the moon and come back home thing. If we are doing the 70s again lets bring back disco.

"[A] way to reduce the effects of news overwhelm is to unplug from the news" www.nature.com/articles/d41...

#JNeurosci: In this work, Tumminia, Mezache, @christlet.bsky.social et al. have developed a new method to induce the formation of synapses along axons directly on the glass coverslip rather than in contact with another neuron. https://doi.org/10.1523/JNEUROSCI.1741-24.2026

Great video to help set up your Biosketch in SciENcv www.youtube.com/watch?v=lThi...

Excited to share a pre-print from a collaboration between my lab at NIH, Len Petrucelli's lab at University of Miami, and Shyamal Mosalaganti's lab at University of Michigan.

I was at a barbershop this morning where the guy said his mother and sister think all scientists are hiding information ("there IS a cure for cancer!!"). I gave him a 20 min lecture on the joys of peer review. Jokes aside surprising how little people know about the scientific process.

@juanbonifacino.bsky.social ...about time!