A new #publication from CRN Team Alessi maps lysosomal protein composition across major brain cell types, revealing cell-type diversity and identifying SLC45A1 as a neuron-specific lysosomal protein tied to lysosomal dysfunction. 🔗 bit.ly/3QsxZEM

New #preprint from CRN Team Vila explores GABAergic cell clusters in the human midbrain. By identifying inhibitory neurons in the RMTg and RRF, the team lays the groundwork for studying their role in #neurodegenerative diseases. 🔗 Read the full preprint: bit.ly/4vbmGPx

In a new #preprint, CRN Team Harper reveals how LLOMe damages lysosomes. Using cryo-electron tomography, the team found that LLOMe forms amyloid structures that rupture lysosomal membranes, providing new insights into neurodegeneration and lysosomal storage disorders. 🔗: bit.ly/4oKzzy9

🧪 How do environmental exposures, like pesticides and chemicals, shape #Parkinsons risk, and point us toward new therapeutic strategies? Four CRN teams are studying how toxins interact with biology and genetics to drive disease, opening new paths for prevention and treatment. bit.ly/44wpUlv

What determines whether neurons resist or succumb to #ParkinsonsDisease? Discovery Fellows Jonathan Brenton, Kate Brynildsen, Raquel Garza Gomez, and Weiqiang Liu are uncovering how gene regulation, RNA processing, and epigenomic programs shape neuronal resilience ⬇️ 🔗 bit.ly/3PzdS7h

🧬 In a new blog, GP2 shares a three-year strategic roadmap, outlining the next phase that expands research beyond genetic discovery to better understand Parkinson’s disease through the study of genetic risk, biological mechanisms, disease subtypes, and environmental factors. 🔗 bit.ly/4eDthMd

Check out this new #preprint from CRN Team Strick exploring how cardiac-sympathetic activity helps regulate action restraint during reward- and loss-driven decision-making tasks. 🔗 Read the full preprint: bit.ly/4eKazUo

#TeamTuesday 🧫 CRN Team Ulusoy, one of our new Tool Generation teams, is developing labeled antibodies to better detect and measure mitochondrial and oxidative stress pathways in #Parkinsons disease, improving how researchers visualize disease biology. Follow the series👇 🔗 bit.ly/4nGXjD1

🔬 June’s #OpenScience Champion is Elena Coccia (CRN Team Vangheluwe)! Elena’s commitment to open science helped her recent preprint achieve compliance with ASAP’s Open Science Policy. She responded to each compliance report in under three weeks, helping the process move forward quickly.

We’re excited to welcome Jean-Marc Taymans, PhD, from the University of Lille as the June LRRK2 Central #webinar speaker. 👇 Reserve your spot using the link below. 📅 June 25, 2026 ⏰ 1:00 PM ET RSVP: bit.ly/4vJj0oQ

Each fall, ASAP CRN researchers gather for a focused discussion on the cell biology of #ParkinsonsDisease. This year’s conference explored endolysosomal pathways, key disease drivers, and how in-person collaboration helps trainees exchange ideas and advance their work. 🧪 bit.ly/4aQIOak

#TeamTuesday 🔍 CRN Team McDonough, one of our new Tool Generation teams, is creating high-quality iPSC models with precise gene edits to study #Parkinson’sDisease. Built for reproducibility — and to be shared widely across the field. Follow along 👇 🔗 bit.ly/4tOFTpx

In a new #preprint, CRN Team Cragg discovers that dopamine and acetylcholine interactions in the striatum are spatially organized, with a hotspot in the anterior dorsolateral striatum linked to learning and movement-related behaviors. 🔗 Read the full preprint: bit.ly/4usoP8W

Why are some dopamine neurons more vulnerable in #Parkinsons? Discovery Fellows Sayan Dutta, Janko Kajtez, Christiana Kontaxi, Mukesh Kumar, Matthew McGregor, and Kathryn Todd are studying how circuit function, metabolism, and synaptic signaling drive selective vulnerability ⬇️ 🔗 bit.ly/4eW6BbU

The CRN Cloud is expanding how Parkinson’s researchers access and analyze multi-omics data. Explore how CRN Cloud now supports interoperability with AMP® PDRD and GP2, plus CURTAIN, an open-source tool for navigating proteomics data 🧪 Read the blog: bit.ly/4fDFF14

This month’s Discover ASAP features Talitha Forcier of CRN Team Jakobsson. Talitha uses TEsingle, a machine learning tool that maps transposable element expression at single-cell resolution, to uncover how these genomic elements may contribute to #Parkinsons & neuroinflammation. 📺 : bit.ly/4vCxjeV

#TeamTuesday 🧠 CRN Team Koob, one of our new Tool Generation teams, is developing full human gene replacement mouse models for #ParkinsonsDisease. New models designed to better reflect human biology and support translational research. More spotlights ahead 👇 🔗https://bit.ly/4ug5TuV

Open science is part of how research contributions are recognized, shared, and assessed, making research more reproducible, reusable, & actionable. A new DORA guide for research funders highlights ASAP’s #OpenScience resources & Output Catalog as examples of these principles in use🧪 bit.ly/3RAfEFL

How do immune and genetic drivers shape vulnerability in #ParkinsonsDisease? 🧠 Discovery Fellows M. Elizabeth Deerhake, James Evans, Amandine Even, Alexandra Kazanova, and Indrani Poddar are linking inflammation, genomics, and systemic factors to disease progression ⬇️ 🔗 bit.ly/3P9uqCM

The Collaborative Research Network is built on team science. A new Alzforum article highlights how CRN investigators are working across institutions and disciplines to advance #Parkinson’s disease research through shared tools, data, and expertise. Read more: bit.ly/4dj8ePI

🧪 Meet the 2025 MoMa Awardees! ASAP has selected 9 CRN researchers to lead multi-omics meta-analysis projects using CRN Cloud data, advancing genetic insight, new analytical tools, and therapeutic discovery in #ParkinsonsDisease. 🔗 Learn more: bit.ly/4u9idMw

#TeamTuesday 🧬 CRN Team Gijsbers, one of our new Tool Generation teams, is building a viral vector toolbox to enable precise gene knockdown, knockout, and overexpression across models, expanding how researchers study disease mechanisms in #Parkinsons. Follow the series 👇 🔗 bit.ly/4vwL9PZ

👏 Thank you to Andrew Singleton, PhD, for representing GP2 at The Michael J. Fox Foundation’s webinar on what causes #ParkinsonsDisease. A powerful discussion on genetics, environment, and aging, and how collaboration is driving progress 🧪 🔗 bit.ly/4tSc3kS

What happens when cells lose their internal quality control systems? 🧬 Discovery Fellows @odettaantico.bsky.social, @bishalb.bsky.social, Amanda Bentley-DeSousa, and @prosenjit.bsky.social are studying how organelle dysfunction contributes to #ParkinsonsDisease ⬇️ 🔗 bit.ly/4uXq0Oy

📢 A new paper from @aligningscience.com explores the importance of genetic diversity in Parkinson’s disease research and how GP2 is helping drive new discoveries and precision medicine through global representation and participation. 🔗 Check it out here: bit.ly/4347QyC

🚨 Funding opportunity: The GBA1-PD Research Catalyst Program is accepting proposals to advance understanding of the biology underlying GBA1-associated #ParkinsonsDisease. Full proposals due July 22, 2026, 5 p.m. ET. Learn more and apply: bit.ly/4tcJRYL

#TeamTuesday Team Fraser is developing small-molecule tools for Parkinson’s targets using structure-based and computational approaches. These probes will help researchers better understand target biology and accelerate discovery. More teams each week 👇 🔗 bit.ly/4wL2GoX

🔬 May’s #OpenScience Champion is Kaelyn Long (CRN Team MAC)! Kaelyn is advancing open science in #ParkinsonsDisease by organizing metagenomic data submissions to the CRN Cloud, setting new standards for reproducibility as this data type comes online.

#ParkinsonsDisease is not uniform - it varies widely in symptoms, progression, and underlying biology. A new blog explores how PD Heterogeneity teams are mapping these differences to better understand what drives the disease, and move toward more precise treatments. 🔗 http://bit.ly/4dY59ok

GP2 is hiring a Project Manager! Join a global effort advancing #Parkinsons genetics research through international collaboration and coordination across diverse cohorts worldwide. PhD + project management experience preferred. Learn more: bit.ly/4uuIjec Apply by June 5 👉 bit.ly/49ZW0cy

As part of our #TeamTuesday series, we’re spotlighting CRN Team Ashton’s work to strengthen #Parkinsons-related biomarker detection. Their ultrasensitive multiplex immunoassays will help measure protein targets across blood and CSF samples, supporting broader biomarker discovery. bit.ly/4u7lvRp

This month’s Discover ASAP features CRN Team Voet's @olgasigalova.bsky.social, Alexandra Pančíková, @juliedeman.bsky.social, & Koen Theunis 🧪 They share a dataset linking non-coding variants to cell type–specific gene regulation in the brain, revealing how genetic risk shapes #PD bit.ly/4trTmmN

How do early molecular events shape the spread of #ParkinsonsDisease? Discovery Fellows Caroline Haikal, Eric Herrmann, Patrick Kearney, and Naman Vatsa are probing how alpha-synuclein pathology begins and propagates ⬇️ 🔗 bit.ly/42XLNtg

New tools. Shared globally. Built to move #Parkinsons research forward. A new blog explores CRN Tool Generation teams developing CRISPR-engineered cell lines, viral vectors, chemical probes, and more. Follow along for upcoming #TeamTuesday spotlights 👇 🔗 bit.ly/4tx24Aa

In a new #preprint, CRN Team Edwards shows that activating nAChRs directly modulates dopaminergic axon excitability, driving local burst firing followed by a period of refractory inhibition. 🔗 Read the full preprint: bit.ly/3OHPjVq

We’re excited to welcome Laurie Sanders, PhD, from Duke University as the May LRRK2 Central #webinar speaker. 👇 Reserve your spot using the link below. 📅 May 28, 2026 ⏰ 1:00 PM ET RSVP: bit.ly/4cz1qx3

In a new #preprint from CRN Team Lee, metabolic stress reveals a hidden layer of vulnerability in G2019S LRRK2 mice, driving widespread disruptions in nucleotide and energy metabolism and amplifying mitochondrial dysfunction. 🔗 Check out the full preprint: bit.ly/4d2P5jC

Computational and data-driven approaches are accelerating Parkinson’s research. The expanded Collaborative Research Network is using advanced models to uncover patterns across genetics, biology, and environment, helping move discovery forward. Learn more about our new teams: 🔗 bit.ly/4ujZUF5

👏 Miratul Muqit, PhD, Lead PI of Team Muqit and a Co-PI of CRN Team Alessi, is featured in The Lancet Neurology for his leadership in #ParkinsonsDisease research. His work on PINK1-Parkin biology and mitochondrial quality control continues to shape the field. 🔗 bit.ly/4dqzWuu

📢 New #publication from CRN Team Hardy! This study shows that GPNMB is secreted by macrophages in response to lysosomal stress via lysosomal exocytosis. 🔗 Read the full publication: bit.ly/4dalhTo

In a new #preprint, CRN Team Desjardins discovers that gastrointestinal infection in PINK1 KO mice triggers early neurodegeneration in the enteric nervous system, driven by mtDNA release and activation of cGAS/STING inflammatory pathways. 🔗 Read the full preprint: bit.ly/4vXlBfx

GP2 released a new #preprint examining ANO6 (TMEM16F) in #ParkinsonsDisease. Across large-scale genetic data (~63K cases; 1.7M controls), signals at the ANO6 locus were driven by linkage to LRRK2, not an independent Parkinson’s disease risk. 🔗 Read the full preprint: bit.ly/3Pc0llP

New #preprint from GP2 highlights SORL1 as a potential driver across neurodegenerative diseases. Analyzing large-scale biobank data, this study identifies SORL1 variants linked to Alzheimer’s disease and #ParkinsonsDisease risk across diverse populations. 🔗 Read the full preprint: bit.ly/4dHWVkC

🛠️ New tools power discovery. 6 CRN teams are building open, scalable resources to help validate targets and accelerate #ParkinsonsDisease research 🧪 🔗 Learn more: bit.ly/4mT16ws

🧠 #ParkinsonsDisease is not uniform — it varies widely. 26 CRN teams are studying PD heterogeneity across environmental exposures, co-pathologies, aging, brain circuits, alpha-synuclein biology, and protein clearance, defining subtypes and advancing targeted care. 🔗 bit.ly/4tEX6SP 🧪

📢 Unraveling Parkinson’s. Advancing Precision Medicine. New CRN grants in partnership with The Michael J. Fox Foundation for Parkinson’s Research bring together 32 global teams to map the biology of #ParkinsonsDisease and build tools to accelerate discovery. 🔗 Learn more: bit.ly/4ugkfes

👏 This month’s Network Spotlight goes to Cláudia Mendes, Laura Castilla-Vallmanya, & Johnson Agniswamy! Their leadership helped connect trainees across Teams Cragg, Jakobsson, & Wichmann to ASAP’s first Career Workshop—driving strong participation across the network 🎉"

CRN Team Chen released a new #preprint showing that MC1R loss-of-function variants are linked to faster motor progression in #ParkinsonsDisease. In 802 PPMI participants, affected individuals showed a 23% higher rate of motor decline vs. sporadic cases. 🔗 Read the full preprint: bit.ly/4cX0ZwC

🔬 April’s #OpenScience Champion is Joanne Stasiak (CRN Team Strick)! Joanne exemplified reproducible research by sharing fMRI data on OpenNeuro, publishing code + analysis scripts on GitHub & Zenodo, and documenting datasets with clear codebooks. 🔗 Check out her paper: bit.ly/3NNkPR8

🧪 April is #ParkinsonsAwarenessMonth, connecting people to the science driving progress. We’re proud to support @parkinsondotorg.bsky.social ’s PD GENEration study, expanding access to no-cost genetic testing. 📍 On-site testing at the World Parkinson’s Congress (May 24–27). 🔗 bit.ly/40BBxpF