CRN Team Alessi found that PPM1H has an allosteric binding site for non-phosphorylated Rab8A and Rab10, and that non-phosphorylated Rab GTPases keep PPM1H on membranes so it can reach its phosphoRab targets. ✏️ @suzannepfeffer.bsky.social, PhD 🔗 Read the full #publication: bit.ly/4pKzx9q

We’re proud to support the @parkinsondotorg.bsky.social PD GENEration study of 30,000+ participants, including nearly 10,000 this year 🧪 This growth is building a diverse PD genetics registry & expanding access to testing & counseling at no cost. See more in our 2025 #AnnualReport: bit.ly/48OZtcw

We’re working with the Michael J. Fox Foundation to shift the #Parkinson’s timeline 🔬 This year, PPMI lowered its screening age to 40 to assess early disease stages. Learn more through our 2025 #AnnualReport: bit.ly/48OZtcw

Grounded in discovery, powered by open science 🧪 This year, we pushed #Parkinsons research forward with new mechanistic insights, expanded global genetics studies, and progress in biomarker discovery across our programs. Explore the highlights in our 2025 #AnnualReport: bit.ly/48OZtcw

GP2's 5th Annual Investigators Meeting in Honolulu brought together 230 investigators from 52 countries. It was an energizing event of new discoveries, expanded tools and training, and a big milestone as GP2 reached 100,000 genotyped samples. 📺 Watch the full video: bit.ly/4s7beUT

In a new publication, Team Harper found that α-synuclein fibrils cause ESCRT-III loss through “collateral degradation,” weakening endolysosomes and promoting further aggregation🔬 🔗 Read the full #publication: bit.ly/4iPUayj

This month’s Discover ASAP features Madeline Klinger, PhD, with Leonardo Parra-Rivas, PhD, of CRN Team Gradinaru 🧬 They discuss a CRISPR-based protocol to precisely edit and visualize α-synuclein in neurons, advancing tools to study its role in #Parkinsons and beyond. 📺 : bit.ly/4iMyG5i

This fall, global leaders joined GP2 in Hawai’i for our Annual Investigators Meeting. We shared progress and set future directions in #ParkinsonsDisease research. We’re grateful for the collaboration and momentum! 🌍 🔗 bit.ly/4rUL3Ay

The ASAP website has a fresh, new look, making it easier for researchers to find what they need. Check out the new site to see the updates, including our new homepage, improved highlights overview, and a dedicated tools & resources section! 🔗 bit.ly/3Mey2RX

Our 2025 #AnnualReport drops next week 🔬 We will highlight advances across #Parkinsons mechanisms, genetics, biomarkers, and open science, plus the global collaborations that made them possible. Stay tuned for our 2025 Year in Review.

GP2’s 11th Data Release just passed 100k genotyped samples! 🧪 See how GP2 is shaping the future of #ParkinsonsResearch at bit.ly/4paucYC

👏 A huge milestone for the Parkinson’s Foundation: 30,000 participants enrolled in PD GENEration! This groundbreaking study is expanding access to free genetic testing and building a diverse PD genetics registry. 🔗 Learn more: bit.ly/3JDbwRL @parkinsondotorg.bsky.social

🔬New preprint from Team Rio! They released a study on 12 familial PD mutations, using midbrain dopaminergic neurons to map mutation-specific splicing changes. These patterns point to potential biomarkers and future therapeutic targets. 🔗 Read the full #preprint: bit.ly/48QeuMr

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Michael Rape, PhD, from the University of California. 👇 Reserve your spot using the link below. 📅 December 11 ⏰ 11:00 AM EST RSVP: bit.ly/44jzLeP

CRN Team Chen analyzed multi-year data from 564 participants to study how α-syn SAA status affects progression. They saw a trend toward faster motor decline in α-syn SAA-positive LRRK2 PD, but no significant differences in sporadic PD. 🔗 Read the full #publication: bit.ly/4if1y65

🧬 CRN Team De Camilli found that BLTP3A/UHRF1BP1 binds VAMP7 vesicles to lysosomes and activates the CASM pathway after lysosome damage. This drives mATG8 recruitment and helps restore lysosome integrity. 🔗 Check out the full #publication to read more about their findings: bit.ly/4o27nF0

“For the first time, we have the power to answer questions that we could not address.” Thanks to 100k+ genotyped samples, the Global Parkinson's Genetics Program is accelerating discovery toward targeted #Parkinsons therapies. 🧪 bit.ly/4pCpSkI

GP2 just hit a major milestone 🎉 The 11th data release includes more than 100k samples from people around the world, including a strong share from underrepresented populations. This scale is helping researchers reveal more than 50 new genetic risk factors. Read the blog: bit.ly/4rjqhdu

This Thanksgiving, we’re thankful for the scientists, researchers, and advocates driving progress in Parkinson’s research. 🍂🦃 Each idea tested, discovery shared, and partnership formed moves us closer to a future transformed by science. Thank you for advancing understanding and hope.

New #publication and #preprint from @jakobssonasap.bsky.social! ⬅️ L1 retrotransposons in stem cells & organoids link L1s to CNS development 🔗 bit.ly/3XyLvGz ➡️ Transposable elements activate in the #Parkinsons brain, tied to interferon responses & a new pathological process 🔗 bit.ly/3LKC5Fo

CRN Team Cragg gathered in Oxford this fall for a two-day sprint of ideas, data, & cross-lab creativity. They dug into emerging findings, tested new approaches, and mapped out next steps to push their work forward. Here’s to more collaboration, more curiosity, & more discoveries on the horizon 📚

📢 New #publication from CRN Team Wichmann! Simulations using NEURON/NetPyNE showed that decreased PT5B neuron excitability increased beta-band power (~15 Hz) in the M1 network, revealing how small neuronal changes can amplify Parkinson's-related oscillations. 🔗 Read more: bit.ly/4omkIZj

📣 Check out these new #publications from CRN Team Edwards! ⬅️ Developed a chemogenetic (DREADD) mouse model to increase dopamine neuron activity. 🔗 bit.ly/3XlA44T ➡️ Dopamine therapy, while easing motor symptoms in #Parkinsons, can trigger impulse control disorder (ICD). 🔗 bit.ly/3LyplBO

🔬 November’s #OpenScience Champion is Chuyu Chen, PhD (Team Awatramani)! She shared 4 image datasets from her recent preprint on the BioImage Archive, including confocal & 3D-SIM microscopy images, broadening access and collaboration across the CRN. 🔗 Read the full #preprint: bit.ly/3Lzu5Hd

🧠 CRN Team Sulzer used RNAseq, spatial transcriptomics, and T cell receptor (TCR) sequencing to analyze T cell and glial cell states in post-mortem #Parkinsons brain tissue. 🔗 Check out the full #publication to read more about their findings: bit.ly/498amYW

🧬 CRN Team Gradinaru developed CRISPR-Cas9 tools to lower alpha-synuclein levels and tag the protein in living neurons. These methods may help researchers better understand its role in #Parkinsons with contributions from @roylab-ucsd.bsky.social. 🔗 Check out the full #publication: bit.ly/43YpVyL

New CRN Team Desjardins #preprint and #publication! ⬅️ LRRK2(G2019S) disrupts iron balance in macrophages, blocking ferritinophagy under iron overload bit.ly/47VzxvC ➡️ LRRK2(G2019S) mutant mice show stronger gut inflammation post-infection, linking gut immune changes to early PD bit.ly/3LVKlCk

CRN Team Chen released a new #preprint on AutoMorphoTrack, an open-source Python package for live-cell imaging. It enables automated detection, tracking, and colocalization of mitochondria and lysosomes. 🔗 Read more about their findings: bit.ly/48XZtc9

This month’s Discover ASAP features Madeline Klinger, PhD, in conversation with Juan Li, PhD, of CRN Team Schlossmacher 🧠 They discuss NeuroScent, a quick, low-cost smell test that could help detect #Parkinsons earlier & enable broader screening in clinics & research studies. 📺 : bit.ly/3LH2bsM

AMP® PDRD is accepting applications from clinical investigators with study cohorts in #Parkinsons or related disorders. Selected projects will receive fully funded biomarker analyses, at no cost to investigators 🧪 🧠 Apply by November 21, 2025 🔗 See the RFA: bit.ly/49yx7oW

How do genetics shape Parkinson’s research? And what does global data mean for future discoveries? In this episode of the Parkinson’s Life Podcast, J Solle explains why GP2’s globally diverse dataset is transforming what we know about Parkinson’s genetics 🧪 🎧 Listen now: bit.ly/493nQFp

CRN Team Strick found temporal features of GPi neural responses were related to motor impairment severity in MPTP-induced parkinsonism, while variations in neural response magnitude & duration didn't reliably reflect symptom severity. 🔗 Read the #publication: bit.ly/42MJ0Dx

In their recent preprint, CRN Team Scherzer introduces EVscope, a new open-source computational pipeline designed to analyze extracellular vesicle (EV) RNA-seq data, which are often low in abundance and fragmented. 🔗 Check out the full #preprint to read more about EVscope: bit.ly/48Nzh3Q

Exciting news! 🎉 This year marks significant progress for the BLAAC PD study–1,000 participants enrolled. As one of the most extensive studies of Black and African American people with Parkinson’s, BLAAC PD is advancing genetic diversity in global #ParkinsonsResearch. Learn more: bit.ly/4of0OzX

🎉 We’re proud to celebrate the incredible progress featured in the new CRN website’s Impact section! Across 5 years & 35 teams, the CRN has advanced #ParkinsonsResearch through sharing 1,500+ research outputs, uniting 600+ PD donor brains, & integrating 100+ microbiome studies 🧪 🔗 www.asapcrn.org

We’re #hiring! 🧪 GP2 is looking for a Project Manager to lead global #Parkinson’s genetics research and advance discovery worldwide. Strong science background, PhD preferred, and PM experience. Share with others who may be interested! Apply by November 7 👉 bit.ly/49dC32s

CRN Team Schlossmacher investigated how nasally-acquired influenza A H1N1 infections interact with #ParkinsonsDisease genes to affect long-term neurological outcomes 🧪 🔗 Check out the full #preprint to read more about their findings: bit.ly/4h7OQFw

👏 This month’s Network Spotlight goes to Teams Kordower, Liddle, & Rio! Their open-access protocols ranked among the top 100 most viewed on @protocolsio.bsky.social in August 🎉 ➡️ Mouse Perfusions (bit.ly/4qH6rIY) ➡️ Y-Maze (bit.ly/47aITTC) ➡️ Culture/transfection of HEK293T cells (bit.ly/4o4ytfR)

The Collaborative Research Network has a new home! Explore the new CRN website, a designated space to discover research teams, working groups, and impact highlights driving discovery in #ParkinsonsDisease 🧪 👉 www.asapcrn.org

13 countries. 16 trainees. 1 powerful hackathon 🌍 GP2 Hackathon united global minds in Lübeck, Germany to tackle #Parkinsons research with data, mentorship & collaboration. 🔗 Dive into the recap: bit.ly/4nfmeeX

October’s Open Science Champions are Teams Hardy, Hurley, and Strick 👏 They’ve maintained a near-perfect record of preprinting with a CC BY or CC0 license, advancing accessibility and collaboration across the research community. #OpenScience

CRN Team Hurley outputs with @jimhurley.bsky.social @mito911.bsky.social 🧪 ⬅️ Identified a Mitophagic Stress Response (MitoSR) that supports mitochondrial quality. 🔗 bit.ly/4o3O4fD ➡️ Found that cells use autophagy to recycle damaged or unneeded material. 🔗 bit.ly/4hrGeKa

GP2 is hiring a Project Manager! Help lead global #Parkinsons genetics research, manage 15+ projects, and support diverse cohorts worldwide. PhD + PM experience preferred. Mission-driven. Science-forward. Apply now 👉 bit.ly/49dC32s

New CRN Team Alessi outputs with @prosenjit.bsky.social ⬅️ New protein identified that may be a future drug target for PD. #preprint 🔗 bit.ly/3W7KXH5 ➡️ GBA1 mutations block a neuroprotective pathway by changing the lipid composition of primary cilia. #publication 🔗 bit.ly/3W7LjgT

Open Access Week highlights the power of free, immediate access to research by ensuring science benefits all. Proud to join @parkinsondotorg.bsky.social, @parkinsons.org.uk, @cureparkinsons.org.uk, @alleninstitute.org, @dataseerai.bsky.social, @strategiesos.bsky.social, @orfg.bsky.social & others 🔓

👏 Congrats to Monther Abu-Remaileh, PhD, of CRN Team Alessi, recipient of the 2026 Walter A. Shaw Young Investigator Award in Lipid Research, honoring his groundbreaking contributions to lipid biology! 🔗 bit.ly/3KzsOzz @abu-remaileh.bsky.social

We are excited to welcome Huw Morris, MD, PhD, and Ed Jabbari, MBBS, PhD, from University College London as the October LRRK2 Central #webinar speakers. 👇 Reserve your spot using the link below. 📅 October 30, 2025 ⏰ 1:00 PM ET RSVP: bit.ly/47c5Ve9

🎉The LARGE-PD Annual Meeting brought together 76 researchers from 14 countries across Latin America and the Caribbean in Querétaro, Mexico, to exchange ideas, strengthen collaboration, and advance Parkinson’s research. 🔗 Check out the recap blog: bit.ly/3IzTmjy

GP2 just launched a new course: Return of Genetic Results! Learn how to navigate genetic data, interpret findings, and understand their impact in #ParkinsonsDisease research 🧪 🔗 Create an account on our learning platform: bit.ly/4nJfarZ 👉 Access the course: bit.ly/46IASX9

This month’s Discover ASAP features @rgast.bsky.social, PhD, of CRN Team Surmeier 🧪 He introduces PyRates, an open-source tool for generating code across languages to model complex biological systems. See how it advances computational neuroscience and #Parkinsons research. 📺 Watch: bit.ly/4h7Y5Wk