In their recent preprint, CRN Team Scherzer introduces EVscope, a new open-source computational pipeline designed to analyze extracellular vesicle (EV) RNA-seq data, which are often low in abundance and fragmented. 🔗 Check out the full #preprint to read more about EVscope: bit.ly/48Nzh3Q

Exciting news! 🎉 This year marks significant progress for the BLAAC PD study–1,000 participants enrolled. As one of the most extensive studies of Black and African American people with Parkinson’s, BLAAC PD is advancing genetic diversity in global #ParkinsonsResearch. Learn more: bit.ly/4of0OzX

🎉 We’re proud to celebrate the incredible progress featured in the new CRN website’s Impact section! Across 5 years & 35 teams, the CRN has advanced #ParkinsonsResearch through sharing 1,500+ research outputs, uniting 600+ PD donor brains, & integrating 100+ microbiome studies 🧪 🔗 www.asapcrn.org

We’re #hiring! 🧪 GP2 is looking for a Project Manager to lead global #Parkinson’s genetics research and advance discovery worldwide. Strong science background, PhD preferred, and PM experience. Share with others who may be interested! Apply by November 7 👉 bit.ly/49dC32s

CRN Team Schlossmacher investigated how nasally-acquired influenza A H1N1 infections interact with #ParkinsonsDisease genes to affect long-term neurological outcomes 🧪 🔗 Check out the full #preprint to read more about their findings: bit.ly/4h7OQFw

👏 This month’s Network Spotlight goes to Teams Kordower, Liddle, & Rio! Their open-access protocols ranked among the top 100 most viewed on @protocolsio.bsky.social in August 🎉 ➡️ Mouse Perfusions (bit.ly/4qH6rIY) ➡️ Y-Maze (bit.ly/47aITTC) ➡️ Culture/transfection of HEK293T cells (bit.ly/4o4ytfR)

The Collaborative Research Network has a new home! Explore the new CRN website, a designated space to discover research teams, working groups, and impact highlights driving discovery in #ParkinsonsDisease 🧪 👉 www.asapcrn.org

13 countries. 16 trainees. 1 powerful hackathon 🌍 GP2 Hackathon united global minds in Lübeck, Germany to tackle #Parkinsons research with data, mentorship & collaboration. 🔗 Dive into the recap: bit.ly/4nfmeeX

October’s Open Science Champions are Teams Hardy, Hurley, and Strick 👏 They’ve maintained a near-perfect record of preprinting with a CC BY or CC0 license, advancing accessibility and collaboration across the research community. #OpenScience

CRN Team Hurley outputs with @jimhurley.bsky.social @mito911.bsky.social 🧪 ⬅️ Identified a Mitophagic Stress Response (MitoSR) that supports mitochondrial quality. 🔗 bit.ly/4o3O4fD ➡️ Found that cells use autophagy to recycle damaged or unneeded material. 🔗 bit.ly/4hrGeKa

GP2 is hiring a Project Manager! Help lead global #Parkinsons genetics research, manage 15+ projects, and support diverse cohorts worldwide. PhD + PM experience preferred. Mission-driven. Science-forward. Apply now 👉 bit.ly/49dC32s

New CRN Team Alessi outputs with @prosenjit.bsky.social ⬅️ New protein identified that may be a future drug target for PD. #preprint 🔗 bit.ly/3W7KXH5 ➡️ GBA1 mutations block a neuroprotective pathway by changing the lipid composition of primary cilia. #publication 🔗 bit.ly/3W7LjgT

Open Access Week highlights the power of free, immediate access to research by ensuring science benefits all. Proud to join @parkinsondotorg.bsky.social, @parkinsons.org.uk, @cureparkinsons.org.uk, @alleninstitute.org, @dataseerai.bsky.social, @strategiesos.bsky.social, @orfg.bsky.social & others 🔓

👏 Congrats to Monther Abu-Remaileh, PhD, of CRN Team Alessi, recipient of the 2026 Walter A. Shaw Young Investigator Award in Lipid Research, honoring his groundbreaking contributions to lipid biology! 🔗 bit.ly/3KzsOzz @abu-remaileh.bsky.social

We are excited to welcome Huw Morris, MD, PhD, and Ed Jabbari, MBBS, PhD, from University College London as the October LRRK2 Central #webinar speakers. 👇 Reserve your spot using the link below. 📅 October 30, 2025 ⏰ 1:00 PM ET RSVP: bit.ly/47c5Ve9

🎉The LARGE-PD Annual Meeting brought together 76 researchers from 14 countries across Latin America and the Caribbean in Querétaro, Mexico, to exchange ideas, strengthen collaboration, and advance Parkinson’s research. 🔗 Check out the recap blog: bit.ly/3IzTmjy

GP2 just launched a new course: Return of Genetic Results! Learn how to navigate genetic data, interpret findings, and understand their impact in #ParkinsonsDisease research 🧪 🔗 Create an account on our learning platform: bit.ly/4nJfarZ 👉 Access the course: bit.ly/46IASX9

This month’s Discover ASAP features @rgast.bsky.social, PhD, of CRN Team Surmeier 🧪 He introduces PyRates, an open-source tool for generating code across languages to model complex biological systems. See how it advances computational neuroscience and #Parkinsons research. 📺 Watch: bit.ly/4h7Y5Wk

CRN Team Lee found that cellular vulnerability, independent from circuit connectivity, may be a significant factor in the spread of alpha-synuclein pathology. 🔗 Check out the full #publication to read more about their findings: bit.ly/4nV4ztR

Check out GP2 on last week’s episode of #TheGeneticsPodcast! Sonya Dumanis, PhD, and Andrew Singleton, PhD, share their transformative approach to #ParkinsonsDisease research and global collaboration 🧪 🎧 bit.ly/4mHbCFp

📣 New #publications from CRN Team Hurley! ➡️ Human transmembrane receptors initiate autophagosome biogenesis via ULK1 and WIPI–ATG13 complexes 🔗 bit.ly/47X259p ➡️ Neurons with pathogenic LRRK2 boost secretory autophagy and release exosomes for waste disposal and communication 🔗 bit.ly/45Mf1xx

GP2 is at the International Congress of Parkinson’s Disease and Movement Disorders® this week in Hawai’i! Visit booth 8 in Exhibit Hall I to meet the team, check out our poster presentations tomorrow (10/8), and learn more about our global research progress. 🔗 Schedule: bit.ly/48Sqr4J

📣 Don't miss out on the upcoming mito911 #webinar featuring Karin Reinisch, PhD, from the Yale School of Medicine. 👇 Reserve your spot using the link below. 📅 October 20 ⏰ 11:00 AM ET RSVP: bit.ly/4gPqCjo

GP2 is proud to be strongly represented at this year’s International Congress of Parkinson’s Disease and Movement Disorders®. Our global community will showcase 24 abstracts on innovation in #Parkinsons research and approaches. In Hawai’i this week? Stop by and say hello! @movedisorder.bsky.social

GP2 joined Patrick Short, PhD, on #TheGeneticsPodcast to discuss their publication in @ajhgnews.bsky.social, noting the scientific importance of diversifying genetic representation in #ParkinsonsResearch and how GP2 empowers scientists worldwide to lead research locally 🧪 🎧 bit.ly/4mHbCFp

New outputs from CRN Team De Camilli! ⬅️ Vps13a KO & Vps13c KO mice are viable, embryonic development of Vps13a/Vps13c DKO mice is arrested at midgestation. #publication 🔗 bit.ly/4nN1fkf ➡️ Local neuromodulation shapes a neuron's metabolic resilience. #preprint 🔗 bit.ly/3Kh9XJf

👏 We’re recognizing Anne-Caroline Martel, PhD, & Damien Pittard, MSc (Team Wichmann), as this month’s Open Science Champions! They shared an extensive dataset with DANDI in the NWB format & set up an Inscopix platform in their lab to streamline data sharing, advancing transparency in #OpenScience.

📣 New CRN Team Vangheluwe #publications! ⬅️ They expressed GEM-SCOPe in differentiated astrocytes & neurons from a stem cell PRKN-knockout model of PD. 🔗 bit.ly/4lbSNtg ➡️ They compared iPSC-derived DANs from two sibling pairs where siblings both had GD, but only one developed PD. 🔗 bit.ly/4mgKIVc

Using cryo-ET, CRN Team Reck-Peterson showed that full-length LRRK2 can oligomerize on microtubules in its autoinhibited state. Both WT-LRRK2 and PD-linked LRRK2 mutants formed filaments on microtubules. 🔗 Read the full #preprint to learn more about their recent research: bit.ly/3VrVNaB

LARGE-PD is building the first large genetic and environmental dataset for Hispanic communities with #ParkinsonsDisease, spanning 14 countries and 37 sites. We are now recruiting in the U.S. through the Cleveland Clinic 🌎 🧪 Learn more: bit.ly/3HSpLRR #HispanicHeritageMonth

In GP2’s latest blog, Dr. Cholpon Shambetova shows how supporting local scientists through training and fostering trust through collaboration and relationship-building has advanced #ParkinsonsDisease research in Kyrgyzstan. 🔗 Learn more: bit.ly/4mpezub

The NIH is exploring how to improve access to research and manage publishing costs. We shared a response grounded in #OpenScience. We recommend: 🔹 Requiring preprints 🔹 Funding preprint infrastructure 🔹 Supporting services that add real value to research 🧪 Read ASAP's full response: bit.ly/467PdME

CRN Team Vangheluwe studied ATP10B, a lipid flippase in late endosomes and lysosomes, and its role in #ParkinsonsDisease. They found that depleting ATP10B negatively affects the viability of dopaminergic neurons both in vivo and in vitro. 🔗 Read the full #publication: bit.ly/46wH9nI

As #OpenScienceWeek wraps up, we thank our partners and community for advancing a culture of collaboration and transparency. Open Science helps ensure that shared resources and data accelerate progress toward understanding and treating #Parkinsons. Resources ➡️ bit.ly/41NxZSa

🧑‍🔬🧪 For early-career scientists, Open Science means opportunity. As #OpenScienceWeek continues, Naman Vatsa, PhD (@namanvatsa.bsky.social) of CRN Team Biederer, shares how open datasets and training programs empower the next generation of #Parkinsons researchers ⬇️ #ScienceForAll

Global challenges require global solutions 🧪 For today’s #OpenScienceWeek feature, Bishal Basak, PhD of CRN Team Hurley, discusses how initiatives and programs like GP2, PPMI, and AMP PD are advancing #Parkinsons research through shared data and collaboration ⬇️ #ScienceForAll

How does rapid, transparent sharing accelerate #Parkinsons research? 🧪 Kicking off our #OpenScienceWeek highlights, Cole Sitron, PhD (@pelletfraction.bsky.social) of CRN Team Harper, explains how Open Science lays the foundation for faster, more equitable discovery ⬇️ #ScienceForAll

ASAP is celebrating #OpenScienceWeek! Open Science drives stronger collaboration, better accessibility, and faster discovery in #Parkinsons research. All week, we’ll highlight voices from the ASAP network on how they put open science into practice. 👉 Follow along for updates!

This month’s Discover ASAP episode features @danacobblewis.bsky.social talking with Miguel Gonzalez-Lozano, PhD, about EndoMap, a new open-access tool mapping the endosomal system in #Parkinsons 🗺️ 🧪 🔗 Learn how this resource accelerates discovery and supports drug development: bit.ly/4njfGfM

🧠📈 We are excited to welcome Alain Dagher, MD, PhD, from McGill University, as the September LRRK2 #webinar speaker. 👇 Reserve your spot using the link below. 📅 September 25 ⏰ 1:00 PM ET RSVP: bit.ly/3K1efUO

Last week, the ASAP team shared our commitment to #OpenScience at the 10th International Congress on Peer Review and Scientific Publication. The session highlighted how funders can expand the sharing of data, code, protocols, and materials. #PRC10 @peerreviewcongress.bsky.social 🔗 bit.ly/4ngFl8S

🧪 Calling PD cohort leads: Help map immune-focused PD cohorts. Your responses will shape funding, enable collaboration, and inform the immune biomarker strategy. Eligible cohorts include PD/at-risk participants who have immune data/samples. 🗓️ Survey closes September 17 👉 Take: bit.ly/3JR1fkN

CRN Team Edwards investigated changes in cholinergic modulation of striatal direct pathway medium spiny neurons (dMSNs) in mice with partial or complete dopamine (DA) depletion, modeling early and advanced stages of #ParkinsonsDisease (PD). 🔗 Check out the full #publication: bit.ly/4ngU5Vu

CRN Team Liddle used STC-1 enteroendocrine cells to evaluate how deltamethrin, a common pyrethroid, affects EEC function and found that deltamethrin alters serotonergic pathway expression and inhibits adrenergic-induced EEC hormone release. 🔗 Check out the full #publication: bit.ly/45Me7zP

A few weeks ago, GP2 researchers published a new paper in the @ajhgnews.bsky.social highlighting the importance of diversity in #ParkinsonsResearch and sharing key discoveries from the team. Check out the new blog for our perspective on these findings: bit.ly/ajhg-bsky-en

NIH is seeking comments on its proposal to limit publication costs and maximize research funds. This policy could have significant implications for how science is published and accessed. Submit your response by September 15: ➡️ bit.ly/3UK6CV2

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin. 👇 Reserve your spot using the link below. 📅 September 8 ⏰ 11:00 AM EST RSVP: bit.ly/4mUJeAc

👏 Thank you, @ajhgnews.bsky.social, for spotlighting GP2’s impact! We’re proud to see the consortium’s work advancing genetic discovery across diverse populations.

👏 We’re recognizing Ben Johnson (CRN Team De Camilli) as this month’s Open Science Champion! Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben! Check out the manual: bit.ly/46DuL6R

CRN Team Wichmann studied motor cortex activity in rhesus macaques using in vivo calcium imaging to track the activity of projection neurons in the motor cortices at rest and during an arm reaching task. 🔗 Check out their full #publication to learn more: bit.ly/4mhxE1I