The NIH is exploring how to improve access to research and manage publishing costs. We shared a response grounded in #OpenScience. We recommend: 🔹 Requiring preprints 🔹 Funding preprint infrastructure 🔹 Supporting services that add real value to research 🧪 Read ASAP's full response: bit.ly/467PdME

CRN Team Vangheluwe studied ATP10B, a lipid flippase in late endosomes and lysosomes, and its role in #ParkinsonsDisease. They found that depleting ATP10B negatively affects the viability of dopaminergic neurons both in vivo and in vitro. 🔗 Read the full #publication: bit.ly/46wH9nI

As #OpenScienceWeek wraps up, we thank our partners and community for advancing a culture of collaboration and transparency. Open Science helps ensure that shared resources and data accelerate progress toward understanding and treating #Parkinsons. Resources ➡️ bit.ly/41NxZSa

🧑‍🔬🧪 For early-career scientists, Open Science means opportunity. As #OpenScienceWeek continues, Naman Vatsa, PhD (@namanvatsa.bsky.social) of CRN Team Biederer, shares how open datasets and training programs empower the next generation of #Parkinsons researchers ⬇️ #ScienceForAll

Global challenges require global solutions 🧪 For today’s #OpenScienceWeek feature, Bishal Basak, PhD of CRN Team Hurley, discusses how initiatives and programs like GP2, PPMI, and AMP PD are advancing #Parkinsons research through shared data and collaboration ⬇️ #ScienceForAll

How does rapid, transparent sharing accelerate #Parkinsons research? 🧪 Kicking off our #OpenScienceWeek highlights, Cole Sitron, PhD (@pelletfraction.bsky.social) of CRN Team Harper, explains how Open Science lays the foundation for faster, more equitable discovery ⬇️ #ScienceForAll

ASAP is celebrating #OpenScienceWeek! Open Science drives stronger collaboration, better accessibility, and faster discovery in #Parkinsons research. All week, we’ll highlight voices from the ASAP network on how they put open science into practice. 👉 Follow along for updates!

This month’s Discover ASAP episode features @danacobblewis.bsky.social talking with Miguel Gonzalez-Lozano, PhD, about EndoMap, a new open-access tool mapping the endosomal system in #Parkinsons 🗺️ 🧪 🔗 Learn how this resource accelerates discovery and supports drug development: bit.ly/4njfGfM

🧠📈 We are excited to welcome Alain Dagher, MD, PhD, from McGill University, as the September LRRK2 #webinar speaker. 👇 Reserve your spot using the link below. 📅 September 25 ⏰ 1:00 PM ET RSVP: bit.ly/3K1efUO

Last week, the ASAP team shared our commitment to #OpenScience at the 10th International Congress on Peer Review and Scientific Publication. The session highlighted how funders can expand the sharing of data, code, protocols, and materials. #PRC10 @peerreviewcongress.bsky.social 🔗 bit.ly/4ngFl8S

🧪 Calling PD cohort leads: Help map immune-focused PD cohorts. Your responses will shape funding, enable collaboration, and inform the immune biomarker strategy. Eligible cohorts include PD/at-risk participants who have immune data/samples. 🗓️ Survey closes September 17 👉 Take: bit.ly/3JR1fkN

CRN Team Edwards investigated changes in cholinergic modulation of striatal direct pathway medium spiny neurons (dMSNs) in mice with partial or complete dopamine (DA) depletion, modeling early and advanced stages of #ParkinsonsDisease (PD). 🔗 Check out the full #publication: bit.ly/4ngU5Vu

CRN Team Liddle used STC-1 enteroendocrine cells to evaluate how deltamethrin, a common pyrethroid, affects EEC function and found that deltamethrin alters serotonergic pathway expression and inhibits adrenergic-induced EEC hormone release. 🔗 Check out the full #publication: bit.ly/45Me7zP

A few weeks ago, GP2 researchers published a new paper in the @ajhgnews.bsky.social highlighting the importance of diversity in #ParkinsonsResearch and sharing key discoveries from the team. Check out the new blog for our perspective on these findings: bit.ly/ajhg-bsky-en

NIH is seeking comments on its proposal to limit publication costs and maximize research funds. This policy could have significant implications for how science is published and accessed. Submit your response by September 15: ➡️ bit.ly/3UK6CV2

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin. 👇 Reserve your spot using the link below. 📅 September 8 ⏰ 11:00 AM EST RSVP: bit.ly/4mUJeAc

👏 Thank you, @ajhgnews.bsky.social, for spotlighting GP2’s impact! We’re proud to see the consortium’s work advancing genetic discovery across diverse populations.

👏 We’re recognizing Ben Johnson (CRN Team De Camilli) as this month’s Open Science Champion! Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben! Check out the manual: bit.ly/46DuL6R

CRN Team Wichmann studied motor cortex activity in rhesus macaques using in vivo calcium imaging to track the activity of projection neurons in the motor cortices at rest and during an arm reaching task. 🔗 Check out their full #publication to learn more: bit.ly/4mhxE1I

📣 New #publications from CRN Team Alessi! ⬅️ They tested the LRRK2 inhibitor MLi-2 in a model of early stage, LRRK2 mutation–associated PD. 🔗 bit.ly/41nFBdA ➡️ They discovered that phosphatase PPM1M counteracts LRRK2 and identified a genetic variant in PPM1M present in PD. 🔗 bit.ly/4nkRVnR

CRN Team Cragg used array photometry in mice to reveal a topography of opposing changes in ACh release across distinct striatal regions. Reward prediction error encoding was localized to specific phases of ACh dynamics in anterior dorsal striatum. 🔗 Read the full #publication: bit.ly/3JjqQCE

GP2 will host the GP2 Hackathon in Lübeck, Germany on August 28-29! GP2 members from around the world will come together to tackle challenges in #ParkinsonsDisease research. 🔔 Stay tuned for highlights from the event.

🧠📈 We are excited to welcome Hilal Lashuel, PhD, Dennis Dickson, MD, & Poul Henning Jensen, MD, PhD, as the August LRRK2 #webinar speakers. Reserve your spot below for "LRRK2 and Alpha-syn." 📅 August 28 ⏰ 1:00 PM ET RSVP: bit.ly/4fcl3L5

#OpenScienceWeek is less than a month away, & we want to hear from you! While ASAP has a presence on LinkedIn, Bluesky, & YouTube, we know these aren’t the only spaces where dialogue is taking place. Let us know where you are engaging your communities & sharing your research! 🧪 bit.ly/3UW7dmu

Published today in @geneticssociety.bsky.social's American Journal of Human Genetics: GP2 leaders and researchers explore the need for genetic diversity in #ParkinsonsResearch, the discoveries the GP2 model made possible, and how GP2 is bolstering Parkinson's research worldwide. 🧪 bit.ly/3UACR97

CRN Team Vangheluwe developed GEM-SCOPe, a modular toolbox of fluorescent markers designed to inform the localization, distribution, turnover, and oxidative stress of specific organelles. 🔗 Read their full #publication to learn more about GEM-SCOPe: bit.ly/4oC2ILP

This month’s Discover ASAP features Sara Bandrés-Ciga, PhD, discussing the NeuroBooster Array, an inclusive genotyping tool advancing global genetic research in #Parkinsons, developed with GP2. With 2M+ variants & broad utility, it’s uncovering novel risk factors across ancestries 🧪 bit.ly/45VWKNl

CRN Team Reck-Peterson developed type II kinase inhibitors that target LRRK2, functionally distinct from targeting the active-like conformation using type I inhibitors. 🔗 Check out their full #publication to read more about their research: bit.ly/45ixwtd

CRN Team Liddle investigated colonic tissue using single-cell multiomic spatial molecular imaging and found localized inflammatory injury within epithelial cells that appears to be associated with iron mishandling in both IBD and #Parkinsons biosamples. 🔗 Read the full #preprint: bit.ly/455Qz8H

CRN Team De Camilli reveals a new molecular mechanism that regulates cystine efflux from lysosomes. This work is relevant to #Parkinsons research, as recent studies show JIP4 is downstream of LRRK2. 🔗 Read their #preprint: bit.ly/4l8zCkf ✏️ @shawnferguson.bsky.social @laylanassar.bsky.social

CRN Team Surmeier has now shown that individual neurons in the basal ganglia make highly precise decisions about when to allow and when to actively stop specific movements. 🔗 Read the full #publication: bit.ly/4785CBr ✏️ @antofala.bsky.social @harsh-kanodia.bsky.social

Honored to be featured in @aligningscience.com’s new Initiative Spotlight series! ASAP promotes team science and open research practices to accelerate progress in #ParkinsonsDisease research. 🧪 Learn more: bit.ly/3Ys7sIo

CRN Team Awatramani found that excitatory inputs from STN and PPN nuclei evoked frequency-dependent excitation in SN GABA neurons but complex multiphasic DA neuron responses, suggesting heterogeneous DA subtype responses. 🔗 Read their #preprint: bit.ly/4m6zcMf

To understand the contributions of various brain cells to the spreading of α-synuclein (αS) pathology, CRN Team Lee examined the metabolism of αS aggregates in neuronal and glial cells. 🔗 Read their full #preprint: bit.ly/45F16ZZ

🎉 Big milestone: The ASAP Catalog now includes 2,500+ open science outputs! From publications and data to code/software, lab materials, and protocols, this growing collection is powered by a community that believes in sharing early and often. 🧪 Explore the catalog: parkinsonsroadmap.org/catalog/#

CRN Team Wichmann applied the MoSeq platform to study the spontaneous locomotor activities of neurotoxin and genetic mouse models of #Parkinsonism as the midbrain DA neurons progressively degenerate. 🔗 Read their full #preprint: bit.ly/45bw3U8

CRN Team Hafler investigated the interplay among key #ParkinsonsDisease (PD) biomarkers in patients with RBD & found the biomarkers to be highly associated. These findings may help predict short-term PD progression. 🔗 Read their full #preprint: bit.ly/3UfBWuC

CRN Team Hurley determined the cryo-electron microscopy structure of the human ULK1C core at amino-acid-level resolution. They examined the ULK1C core in complex with another autophagy core complex, the class III PI3KC3-C1. 🔗 Read the full #publication: www.nature.com/articles/s41594-025-01557-x

📢 Read this recent feature in Inside Precision Medicine about how we’re teaming up with @alleninstitute.org ‬to power new discoveries in #Parkinsons, #Alzheimers, & beyond. Learn more: bit.ly/3H8PYLu

👏 We’re recognizing Gerard Coughlin (CRN Team Gradinaru) as this month’s Open Science Champion! Gerard worked closely with the ASAP team to iteratively share data, custom code, protocols, and new lab materials. His efforts advanced transparency and collaboration across the network.

This month’s Discover ASAP features Ricardo Márquez Gómez of @craggasap.bsky.social, discussing a fluid-wall microfluidic platform to model human corticostriatal circuits 🧪 This platform enables axon studies, long-term culture, & scalable testing for #Parkinsons. 📺 youtu.be/dutY_mxext4

GP2's data releases are vital to our mission to understand the genetic architecture of #Parkinsons – they will help researchers illuminate the biology of the disease and develop new treatments. 📺 Watch to learn more about the latest data release and how to access the data: youtu.be/ybfTobQTc5k

Proud to support the new Preprint Policy Framework from @asapbio.bsky.social & @creativecommons.bsky.social that advances open, reusable, and rigorous research communication. A key step toward faster, fairer science. 🔗 asapbio.org/announcing-t...

👑 Big congratulations to Andrew Singleton, PhD, on being elected a Fellow of the Royal Society, a major honor recognizing his leadership in global Parkinson’s genetics research. A well-deserved spotlight for groundbreaking work! 🔗 royalsociety.org/news/2025/05/new-fellows/

This joint blog with collaborator @alleninstitute.org outlines the Parkinson’s data now included in the ABC Atlas and how it expands the future of neurodegenerative disease research. 🔗 Take a look: parkinsonsroadmap.org/news/collabo...

🧠📈 We are excited to welcome Amir Khan, PhD & Dario Alessi, PhD, from Trinity College Dublin & University of Dundee as the July @lrrk2central.bsky.social‬ speakers. RSVP below. 🗣️ Amir Khan & Dario Alessi, PhD 📅 July 24 ⏰ 1:00 PM ET RSVP: us06web.zoom.us/meeting/register/GjsZ7Y1xTwefDvHSzvr08g

Parkinson’s disease is the fastest growing neurodegenerative condition. Now researchers have a powerful new tool, thanks to a collaboration with @asapresearch.parkinsonsroadmap.org. Parkinson’s data is now available on the free and open ABC Atlas. 🧠 alleninstitute.org/news/a-new-v...

We’re proud to announce a new collaboration between ASAP’s CRN Cloud & @alleninstitute.org’s Brain Cell Atlas to help researchers use a common language when studying brain cells and unlock insights into #Parkinsons & other #neurodegenerative diseases. 🧪Explore: portal.brain-map.org/atlases-and-...

Exciting news! Thanks to GP2 funding, early-career researchers from regions like Ghana and Djibouti are receiving world-class training in fields related to #ParkinsonsDisease. 🔗 Learn more about these researchers: gp2.org/from-ghana-to-djibouti-gp2s-impact-on-african-trainee-development/

CRN Team Harper developed 229 3D models for endosomal protein pairs and additional higher-order assemblies supported by experimental crosslinks from their natural context. 🔗 Check out CRN Team Harper's full #publication to read more about their models: www.nature.com/articles/s41586-025-09059-y