Neuron (@cp-neuron.bsky.social)

Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits Oelschlegel et al. report that the schizophrenia-risk gene calneuron-1 is elevated in schizophrenia, elicits schizophrenia-like behavior, and impairs network communication in mice. Calneuron-1 is an accessory subunit of muscarinic M1R that inhibits G-protein coupling and shuts off M1R signaling in schizophrenia. The M1R agonist xanomeline interrupts calneuron-1/M1R interaction and rescues schizophrenia-related deficits. http://dlvr.it/TPsrZv