Enjoying a flying visit to Boston. Strange to think that last time I was here was back in 2017, on the way to my first GRC (Catecholamines). I remember my PhD advisor’s sage advice when choosing between conferences: SfN is fun, but go to a GRC to really make connections with people in the field.

Caught most of the @python.org documentary as part of a showing today @hhmijanelia.bsky.social. Fun and interesting viewing for fellow pythonistas: m.youtube.com/watch?v=GfH4... (Also appreciated the commentary on getting women into coding!)

Preprint - Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo. www.biorxiv.org/content/10.1...

Brain as a computer arguments in shambles. Brain as toilet arguments reign.

pyPhotometry v2 is now in our store! 🚀 ⚡Output current of the 2 onboard LED drivers increased to 300 mA 🔦🔦 2 alternative LED digital output channels to trigger external optical hardware that have integrated LED drivers 🔌Additional connections to the pyBoard for expansion #OpenEphys #pyPhotometry

Thanks so much for having me Mark!

Deadline for abstract submission has been extended to 29th August!

I enjoyed reading this and agree with a lot of the takes here. I also think the lack of any resounding “yes”es would surprise the average non-neuroscientist...

✨ We’re #hiring Theory Fellows!✨ Janelia is recruiting early-career scientists to join our collaborative research environment and use #computation & #theory to tackle bold questions in #biology. 🔗 Apply by Nov. 3 👉 janelia.link/theoryfellow... @hhmi.org

Abstract submission open for The Mechanistic Basis of Foraging 2025 (University of Birmingham, 3–5 November) A multidisciplinary event exploring the neural, behavioural and computational foundations of foraging across species: uobevents.eventsair.com/the-mechanis... Deadline: August 17, 2025

A landmark volume, The Handbook of Dopamine, is now online: www.sciencedirect.com/handbook/han... Big kudos to the editors, Stephanie Cragg and Mark Walton, for putting this together.

New preprint from Yipei Guo and Ann Hermundstad (@hhmijanelia.bsky.social) - a wonderfully in-depth investigation into environmental variability and optimal behavioural strategies.

Abstract submission open for The Mechanistic Basis of Foraging 2025 (U. Birmingham, 3-5 November) uobevents.eventsair.com/the-mechanis... Deadline: August 17 A meeting for all fascinated by the brain's role in foraging Pls share!

Just listened to @brainapps.bsky.social deliver a wonderful inaugural lecture. It’s been quite something seeing him go strength to strength in his research and with his lab. Congratulations Prof. Apps!

This really was a cool opportunity. Highly recommend for any postdoc neuroscientists who want to share their work with an engaging, thoughtful community.

Super excited to announce a follow-up to the Janelia 'mechanistic basis of foraging' conference - this time held in Birmingham, UK! Join us from the 3rd - 5th November to discuss all things foraging: uobevents.eventsair.com/the-mechanis...

Some light-hearted satire from another age. From a fun anthology titled "A random walk in science".

Very happy to see our work finally in print! www.pnas.org/doi/10.1073/... TLDR: Tilt illusion is not a bug, but a feature of a well-designed visual system that maximizes information capacity adaptively based on spatial context. (1/6)

Important topics being discussed on the #cosyne2025 Whova app

This is my first time at the #cosyne2025 workshops and I’m entirely convinced that the layout of rooms, placement of room signs etc. is part of some elaborate experiment being done on us to see how quickly we can learn a cognitive map of the space

🥼 Janelia researchers led by @boazmohar.bsky.social @nspruston.bsky.social @rhodamine110.bsky.social & @svoboda314.bsky.social @alleninstitute.bsky.social have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠 🔗 www.janelia.org/news/new-ima...

Favourite quote from #cosyne2025 so far, from @tpvogels.bsky.social’s talk earlier today: “science is like trying to find a black cat in a dark room, and it’s not a cat”

I know there's a 𝒍𝒐𝒕 going on right now, but I couldn’t be prouder to share this long-incubated labor of love: the complete connectome of the male 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 optic lobe 🧠🪰 🔗 www.nature.com/articles/s41...

Excited to be presenting this work at #cosyne2025 this week - as a poster (session 3, no. 3-017) and as part of the “Reimagining RL in the Brain” workshop organised by Alison Comrie and @nathanieldaw.bsky.social. My first in-person cosyne, so looking forward to it!

🥼 Using a novel system developed at Janelia, researchers in the Dudman Lab are shedding new light on the role of the striatum in motor control – information that could improve our understanding of movement disorders, like Parkinson’s & Huntington’s. hhmi.news/3FgFJU2

This is a very cool preprint articulating a lot of important considerations re: the way we think about “naturalistic” behavior in (sys) neuro.

This is a very important paper about problems that go to the core of cognitive science. A must read! 🌟 (humbled by recognition for developing a formal subtype of Ryle’s regress) 🔁 😌

🧠New research from @dudman.bsky.social, Junchol Park & collaborators challenges textbook ideas of how the brain specifies movement, showing that the striatum & motor cortex work together to specify movement parameters needed to carry out an action. 🔗 www.janelia.org/news/janelia...

3.5 year PhD studentship in cognitive computational neuroscience open in my MSN lab, @thechbh.bsky.social, co-supervised with @selmalugtmeijer.bsky.social & @simonlittle.bsky.social. Deadline 23rd March. Only open to UK candidates. More details here: www.findaphd.com/phds/project... Pls repost

My mum’s been enjoying reading this, so it must be good. Congrats Masud!

Was so much fun sharing my work and hearing about all of the cool science happening at @sainsburywellcome.bsky.social during my recent visit. So many lovely (and incredibly smart) people there. And this Q&A was a lot of fun too!

Students + postdocs in theoretical biophysics , Join us @hhmijanelia.bsky.social in October to present your research, engage in lively discussions, and network with peers. Hotel, meals, & travel covered Learn more + apply by June 10 @ janelia.news/THB25 @allysonsgro.bsky.social @hhmi.bsky.social

#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...

Jason is a super thoughtful and smart neuroscientist, and this preprint certainly reflects that - bespoke behaviour (head-fixed 'jumping'?!), extensive Neuropixel recordings + opto manipulations, resulting in some unique insights into cortical/subcortical interactions during learning.

In an effort to bring #neuroskyence to @bsky.app I wanted to share our recent paper in Neuron tinyurl.com/LesionsOfM1 @markolas.bsky.social and I asked what forelimb M1 contributes to striatal and behavioral dynamics using joystick tasks and CFA lesions @cmuscience.bsky.social @the-cnbc.bsky.social

1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social Video: www.youtube.com/watch?v=yw_4... Paper: www.nature.com/articles/s41...

Just returned to Janelia after 7(!) weeks away. Within hours have offers of being taken grocery shopping, co-ordinating with the wonderful people who’ve taken care of my cat and plants whilst I’ve been away. The sense of community here is quite special.

One of the weirdest things about being home when you live abroad (especially when home is a relatively small country) are the cultural zeitgeists that pass you by. Everyone seems obsessed with The Traitors and I have no idea what’s going on…

Our paper from Junchol Park and collaborators that has been brewing for a while. Trying to capture our thinking about what action specification in striatum means and what would constitute evidence for such a model. Longer thread soon, but it’s online now. www.cell.com/neuron/fullt...

Looking forward to this!

How can we use machine learning to find subtle patterns in our data and have them visualized? Read the thread below to find out how! Or head to @adjavon.bsky.social's blog post and let Simon the duck walk you through it (like a duck of course): tinyurl.com/yy7csdcd www.biorxiv.org/content/10.1...

David Krakauer’s analogy of different types of scientists as foveal vs. peripheral in their approach (both being crucial for advancement) is very on point

What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...

This book sounds fascinating - and also sounds like something a lot of systems neuroscientists should be reading.

Honored that a piece I wrote made it to NYTimes. It’s about how my mom’s stroke changed my connection to time, science, and nature. What a privilege to honor my mom in Modern Love. Below is a gift link. Let me know your thoughts 🙏🏼 www.nytimes.com/2024/12/20/s...

📚 For me, this is the best philosophy book of 2024! 🌟 Highly recommend it to anyone interested in the philosophy of (neuro)science. Plus, it's open access! Check it out here: direct.mit.edu/books/oa-mon... #Philosophy #Neuroscience #OpenAccess

Entropy is one of those formulas that many of us learn, swallow whole, and even use regularly without really understanding. (E.g., where does that “log” come from? Are there other possible formulas?) Yet there's an intuitive & almost inevitable way to arrive at this expression.

This is now full!

Two stages of writing: 1) This shouldn't take too long 2) Oh no

Some very cool stuff coming from E11 Bio.