What if part of Huntington's disease wasn't just damage, but a circuit stuck in the wrong pattern? Our new paper, out today in Nature, tests that idea.

HHMI’s Janelia Research Campus will close two of its programs dedicated to rodent work, @thetransmitter.bsky.social has learned. #neuroskyence By @callimcflurry.bsky.social www.thetransmitter.org/community/ex...

for "AI" to be profitable, costs need to be aligned with token use rather than subscription, and then everyone needs to use orders of magnitude more tokens. "Agentic" workflows are for making massive token spend palatable by making the point of comparison "20 engineers" despite being the same thing.

Neuropixels + Optogenetics = Neuropixels Opto Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors. Today in @natmethods.nature.com doi.org/10.1038/s415... Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team.

1/ 🚨🚨Preprint alert! "Perfect" isn't always smart 🧠. Anyone can tell apart two stimuli (including our mice). But how do we extract rules that apply to new stimuli? 🧵 biorxiv.org/content/10.6... @marius10p.bsky.social @computingnature.bsky.social #neuroAI #neuroscience #AI

🚨🧠 Our paper is out! We introduce a simple computational model that generates macroscopic, long-timescale dynamics as seen in large-scale neural recordings. #neuroscience #dynamics @marius10p.bsky.social @zhong-lin.bsky.social @hhmijanelia.bsky.social Link: go.nature.com/4tRNjIu

New preprint with @lingqiz.bsky.social: Neurodata Without Boredom: Benchmarking Agentic AI for Data Reuse arxiv.org/abs/2605.12808 1/10

🚨 Ever wanted a simple way to control the activity of thousands of neurons? We introduce an all-optical raster photostimulation method to do just that! w/ @computingnature.bsky.social @marius10p.bsky.social #FluorescenceFriday #neuroskyence www.biorxiv.org/content/10.6... 1/n

We apologize for the delay but our next profile is here! Dr. Ann Kennedy (@antihebbiann.bsky.social) combines theory & biological data to study how internal states shape social behavior by reconfiguring neural circuit dynamics. Follow the link to learn more! www.storiesofwin.org/profiles/202...

Two-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday

👋 Neuromatch is looking for more TAs to help facilitate comp neuro + neuroAI learning this summer! You'll get to work with students from around the world and share your expertise with the global community 🧠 🌎 🤖 🌍💻 🌏 #cosyne2026 #neuroscience

📢📢 Announcing this year's conference on the Mathematics of Neuroscience & AI (Rome, 9-12th June). We’ve got a stellar line-up and venue, and invite everyone to join: www.neuromonster.org

Applications for July #CompNeuro, #DeepLearning, #NeuroAI & #ClimateScience are open. Learn in small collaborative pods with a dedicated TA, build real research skills, and join 13,000+ alumni worldwide. ➡️ Apply by 15 March: neuromatch.io/courses/

🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

🚨 new work from the lab on how eye movements 👀 versus orofacial movements influence 🐭 visual cortex activity 🧠 #neuroscience #behavior #neuroAI

Planyourscience.com now applauds the good changes you make - and pushes back on the less good one.

@sebastianseung.bsky.social Did you follow through on your plan to visit Epstein island?

Hey @eboyden3.bsky.social care to explain?

Excited to share “Orofacial behaviors, not eye movements, govern neural activity in mouse visual cortex” www.biorxiv.org/content/10.6... Summary below...

A System for Live Sorting of Neuronal Spiking Activity from Large-scale Recordings https://www.biorxiv.org/content/10.64898/2025.12.29.696938v1

High performance sorting of motor unit action potentials with EMUsort https://www.biorxiv.org/content/10.64898/2026.01.06.697952v1

I have so many issues with this podcast with @earlkmiller.bsky.social . I think that this podcast nicely shows why I have trouble with such approaches. Lets go through some of the claims.

Still beta-testing the app that helps people plan science, make it super clear, design their todos, and write a first version of the paper. Feeling overwhelmed by the countless aspects of doing science? Try this (for free): planyourscience.com

Even colleagues who should know better are claiming that we are halting animal research. No, we're not. Now this NYT opinion piece appears (gift link) www.nytimes.com/2025/10/08/o... You can't just move everything to cell culture, organoids, and computers. Even this NYT piece admits that. 1/3

Is visual cortex more like chatGPT or a masked autoencoder? Come to my BCCN seminar tomorrow at 10am ET on zoom (or read the paper) to find out! #neuroscience Zoom: urldefense.com/v3/__https:/... Paper: www.biorxiv.org/content/10.1...

New work from the lab, mismatch responses consistent with spatial but not temporal predictive coding theory.

Does predictive coding work in SPACE or in TIME? Most neuroscientists assume TIME, i.e. neurons predict their future sensory inputs. We show that in visual cortex predictive coding actually works across SPACE, just like the original Rao+Ballard theory #neuroscience www.biorxiv.org/cgi/content/...

💻A new class of simplified ‘minimodels’ developed by Fengtong Du, Miguel Angel Núñez-Ochoa, @marius10p.bsky.social & @computingnature.bsky.social can predict the visual responses of individual neurons in the primary visual cortex, helping shed light on how we see.👀 ➡️ www.janelia.org/news/new-com...

Doing this might make you smarter ... (www.vice.com/en/article/d...) News coverage of our study on unsupervised learning in mice by @zhong-lin.bsky.social + @marius10p.bsky.social #neuroscience #AI www.nature.com/articles/s41...

🧠Zoning out could be beneficial—and may actually help us learn faster. 🥼New research led by @zhong-lin.bsky.social @marius10p.bsky.social @computingnature.bsky.social 🔗 www.janelia.org/news/zoning-...

Your brain learns for you even when you're not actively learning. Maybe. (in mice).

Our paper on NHP neuropixels is finally out in Nat Neuro! These probes have already been transformative and will usher in a new era of primate neuroscience. I am extremely proud to have played a very small role in this project. I can't wait to see what our community discovers. tinyurl.com/54u3hrj8

AI doesn't have to be shit

🚶Aimlessly wandering around a city or exploring the new mall may seem unproductive, but new research led by @zh0ng0.bsky.social @marius10p.bsky.social @computingnature.bsky.social suggests it could play an important role in how our brains learn.‬‬ 🧠 🔗 www.janelia.org/news/zoning-...

Everyone in the lab is raving about Cellpose-SAM. Segmenting the previously unsegmentable across a range of different cell types and markers.

Wouldn't it be great if we could not only image large connectomic volumes but also completely reconstruct them? And if a whole mouse brain project didn't cost billions? With the PATHFINDER preprint (www.biorxiv.org/content/10.1...), we preview a future where it doesn't have to.

A neuroscientist’s bold proposal for tackling one of the greatest challenges of our time—brain and mental illnesses. Nicole C. Rust's Elusive Cures publishes June 10. Learn more and preorder yours: press.princeton.edu/books/hardco... (5 August UK pub) @nicolecrust.bsky.social

If you're planning a course with mathematical methods content, or use such methods in your own work, please take a look at "Mathematics in Biology", by Meister, Lee, and Portugues, published at MIT Press. 1/2 @portugueslab.bsky.social mitpress.mit.edu/978026204940...

we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team. publicusaresearchbenefits.com please share and re-share so we get more great stories in there!

🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸‍♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n

🌟 Teaching Assistants are who make Neuromatch Academy run! 🌟 Thinking of becoming a Teaching Assistant (TA) for Neuromatch or Climatematch Academy? Here’s why you should GO FOR IT! 🚀 Learn more and apply here: neuromatch.io/courses/ #Education #TA #TeachingOpportunity #mentorship

🚨 Neuromatch Academy Course Applications are OPEN for 2025!! 🚨 Get your application in early to be a student or teaching assistant for this year’s courses! Applications are due Sunday, March 23. Apply & learn more: neuromatch.io/courses/ #mlsky #compneurosky #ai #climatesolutions #ScienceEdu 🧪

Bring your samples into focus! A new version of the #Cellpose cell boundary mapping tool, developed at @hhmijanelia.bsky.social by @computingnature.bsky.social and @marius10p.bsky.social, now works on less-than-perfect microscopy images that are noisy, blurry, or undersampled.

(1/11) Today I preprinted a lot of work from my postdoc with @dudman.bsky.social, which started with a question of how the nervous system balances flexibility with efficiency of learning. The thread below gives some background.... www.biorxiv.org/content/10.1...

#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...

🖥️ A new version of #Cellpose – the popular tool developed by @computingnature.bsky.social & @marius10p.bsky.social that maps the boundaries of diverse cells in microscopy images – now works on less-than-perfect pictures that are noisy, blurry, or undersampled. 🔗 www.janelia.org/news/newest-...

The trilogy is complete.

Tutorial talk here: youtu.be/TZZZlGk6AKo?... ; Code is here: github.com/MouseLand/ce...

Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro Apply by: February 16th!

What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...