🛑 Attention researchers who train freely-moving rodents! Jess Breda and I developed a protocol for training center-port nose fixation 61% faster than a previous curriculum while keeping violation rates low. Preprint here: www.biorxiv.org/content/10.1...

It's been amazing to watch this beautiful work come together over the last couple of years. Congrats @thomas-zhihao-luo.bsky.social and @timkimd.bsky.social !

How does the brain decide? 🧠 Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc. After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up. rdcu.be/eGUrv

This article is truly impressive, both for the significance of its findings and the enormous amount of work it represents! Briefly, it demonstrates that the gut-brain vagal axis exerts a considerable influence on dopamine-dependent reward-related processes... 1/n www.biorxiv.org/content/10.1...

I can't think of a single activity that brings out more neuroticism (in myself) than figure formatting

Excited to see this now out in the world! We identify a computational basis for how persistent underconfidence is maintained in the face of intact performance, finding that it is grounded in impaired updating of global self-beliefs from local metacognition www.nature.com/articles/s41... 1/N

Two flagship papers from the International Brain Laboratory, now out in ‪@Nature.com‬: 🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0 🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +

Can anyone explain how we went to bed with two cats each in cones and woke up to one cat in two cones??

Check out our new multisensory decision study! We tackle a decades-old Q: does faster detection of bimodal targets come from a race or co-activation between modalities? And also a vital, orthogonal Q: is it one decision process or two? A1: co-activation A2: two! Read here: rdcu.be/eASYd

The updated version of the database of PhD fellowships produced and maintained by my team can be downloaded by anyone here: research.jhu.edu/rdt/funding-... For each of the 187 fellowships, you will find a short description, deadline, $ amount, link, etc. Good luck!

I still get chills Meet Mike *30+ years severe depression *first hospitalized @ 13y *20 meds *3 rounds of ECT *2 near-fatal suicide attempts Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE see videos, read paper, follow thread doi.org/10.31234/osf...

Happy to have some good science news - our new study with @aqperkins.bsky.social is out in @plosbiology.org! dx.plos.org/10.1371/jour...

We are expected just to sit back and watch two million people be starved to death—half of them children—while real estate investors eagerly plan to build oceanside condos. What’s happening is the most evil thing I’ve witnessed in my lifetime. PLEASE call your elected representatives and speak out:

Super excited to share our new article: “Dissociable cortical regions represent things and stuff in the human brain” with @nancykanwisher.bsky.social, @rtpramod.bsky.social and @joshtenenbaum.bsky.social Video abstract: www.youtube.com/watch?v=B0XR... Paper: authors.elsevier.com/a/1lWxv3QW8S...

NEW The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year Chokes off billions in research funding Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social

👨‍💻 Open PI position in our institute 👨‍💻 !! If you are an expert in Computational Neuroscience and want to start your lab in Bordeaux, contact us ! www.fens.org/careers/job-... @neuromagendie.bsky.social @neurobordeaux.bsky.social

(1/23) In addition to the new Lady Gaga album "Mayhem," my paper with Manuel Beiran, "Structure of activity in multiregion recurrent neural networks," has been published today. PNAS link: www.pnas.org/doi/10.1073/... (see dclark.io for PDF) An explainer thread...

Out today in @nature.com: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables. www.nature.com/articles/s41...

Working in a wet lab in this summer heat is making me wish I had a pair of these

I just finished reading (listening to) @nicolecrust.bsky.social's new book. It's phenomenal. I highly recommend it to anyone who studies the brain, even if they think they're not interested in brain disorders.

How long has Princeton been negotiating with our postdoc union?

How can you know if gene delivery in a primate worked Typically through expensive scans or histology. With @vincentcostaphd.bsky.social and co-authors we made synthetic markers that monitor gene delivery and Cre-dependent expression with a blood test: www.biorxiv.org/content/10.1...

we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team. publicusaresearchbenefits.com please re-post so we get more great stories in there!

#neuroskyence What are your favorite papers on the idea of redundancy in the brain? E.g. how a different neural circuit can step in when the "original" is damaged? Or just how the same function can be executed in different ways within the same brain?

Preprint alert 🚨! Excited to share our new work on metacognition in value-based decision-making. www.biorxiv.org/cgi/content/.... We ask whether it is possible to derive a computational measure of metacognitive ability for economic preference choices.

I really loved the finale of The Rehearsal, especially because my grandpa was a pilot who was probably on the spectrum

Fresh off the press - our latest publication on abstract choices with @siegellab.bsky.social @fsandhaeger.bsky.social @nimanoury.bsky.social @ezezelic.bsky.social at @commsbio.nature.com Link: www.nature.com/articles/s42... 🧵below (1/7)

writing this K99 like it wont end up in the dumpster behind the NIH

‘Timestamp on our minds’: Philadelphia marks 1985 Move bombing that killed 11 Police bombing targeting Black liberation group ignited fire that killed 11, including five children, and burned 61 houses www.theguardian.com/us-news/2025...

we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team. publicusaresearchbenefits.com please share and re-share so we get more great stories in there!

Calling all science advocates!! Carlos Brody+ are creating a searchable database of tangible science benefits, and they need you. publicusaresearchbenefits.com They are asking for suggestions - from brief to lengthy. The database is state-searchable, so all 50 states. Please spread the word!

Stick valuation is highly dynamic

US faculty and anyone who cares about academic freedom: I urge you to check out @wearehighered.bsky.social * read through compelling letters signed by thousands of faculty * learn about upcoming actions in which you can participate * spread the word to encourage others to get involved, too !

I so aspire to reach the level of hater of this house in my neighborhood

Reasoning Algorithms: Online workshop open to all, with a bunch of speakers from cognitive development, primate cognition, neuroscience, and computational modeling 🧪🧠 obssr.od.nih.gov/news-and-eve...

I'm excited to share that the last chapter of my PhD thesis is now published in Nature! 🍾 What drives serotonin neurons? We think it's the expectation of future reward and --- critically --- how fast this expectation is increasing. 📈 doi.org/10.1038/s415... 1/6

Out today in PNAS! We asked how Bayesian inference is implemented in macaque prefrontal cortex www.pnas.org/doi/10.1073/...

1/7 Our paper on individual variability in decision-making is finally out in @nature.com! Inspired by the classic work by Mante and Sussillo, we trained many rats to solve context-dependent decision-making, and we found that different brains use different neural mechanisms to solve the same task!

Rally for the release of Mahmoud Khalil on Monday in Philly

A second Columbia student has been detained by ICE. Leqaa Kordia is a Palestinian from the West Bank.

Rally for the release of Mahmoud Khalil on Monday in Philly

Democratic Senator Chris Murphy on Mahmoud Khalil.

UPDATE: Called all my NY reps - national and state, as well as my city councilperson, to ask them to speak out for and fight for the release of Mahmoud Khalil. Here's a quick script if you need one and want to make calls yourself. You can find your reps here: reps.fyi

UPDATE — Secretary of State Marco Rubio has now commented on the Trump admin’s detaining & attempted green card revocation of a Columbia Gaza encampment student negotiator: “We will be revoking the visas and/or green cards of Hamas supporters in America so they can be deported.”

If ICE agents are in your college dormitory, know your rights.

I just wrote a book about how the type of work @markhisted.org is doing is key to breaking through the bottlenecks holding back new treatments for brain and mental disorders (from Alzheimers to depression). Seeing his work in danger makes me ill, and angry. We must @standupforscience.bsky.social.

My speech for the Philly #StandUpForScience Protest. Everything I do is for my community 💜✨

They adopted a posture of total submission and it bought them precisely nothing. A lesson for the Trump era www.nytimes.com/live/2025/03...