Check it out all! Personalized Adaptive Cortical Electro-stimulation (PACE) for depression (osf.io/preprints/psya…) … ….is now coming to Bipolar Disorder thanks to @BD2Discoveries !!! So happy to keep the work of moving forward in this capacity! Onward!!!

super cool (& inspiring)! Finally read this and was wondering, for chronic stimulation (beyond initial 3-day electrode mappings), were all 4 electrode panels stimulated simultaneously? or were they isolated and that could vary with optimization? (didn't catch in paper, curious about PFC specificity)

Science of Learning symposium #flux2025 - sponsored by the Jacobs Foundation. First up: the LEVANTE research network which embraces open science principles to studying learning variability in children around the world. @fluxsociety.bsky.social

Welcome to Dublin! From winding cobblestone lanes to literary pubs and centuries of innovation, Dublin blends rich history with vibrant culture. We can’t wait for you to experience it all during Flux 2025 – excellent lineup of speakers, and our 2025 Pre-Conference Workshops, and more! #Flux2025

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Hello all, see below! Let’s support Russell support our kids and @umn-midb.bsky.social…take a read! 👇🏾👇🏾

@drjuliamoser.bsky.social keeps killing it with these papers! Check this one out! 👇🏾👇🏾👇🏾👇🏾

FYI all. Anyone having issues with downloading our preprints I believe can still get to them when logged in. We also have some alternative links. Please reach out if you are having any issues.

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A truly spectacular demonstration of the medical potential of precision mapping an individual patient's brain. I am so excited to be part of this work!

Qué bien

From 20+ failed treatments to lasting remission. After decades with treatment-resistant depression and two near-fatal suicide attempts, “Mike” found relief through Precision Functional Mapping and adaptive cortical stimulation developed at the University of Minnesota

Treatment resistant depression is incredibly cruel. This is beautiful

He actually is and very articulate. He is teaching us a lot

Cool work here

Yes, please!

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Oh do I understand. So full of happiness to see that Mike is doing better and has relief from the nightmare of treatment-resistant severe depression. Joy is bliss!

Congratulations! This is very important work.

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JOY 💕

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electrodes can stay forever though like anything they can slowly degrade over time! We have some patients with electrodes in their brain for more than 20 years!

Wow, that is amazing! I’d have a practical question: how long can the electrodes stay inside?

Unreal work--proud to be part of the team @umn-midb.bsky.social !

This is fascinating

Congratulations on the culmination of all this hard work! You missed @roberthermosillo.bsky.social , one of the folks responsible for calculating his precision brain map to estimate the placement of the electrodes, and lead author of this related paper: doi.org/10.1038/s415...

Thank you for this groundbreaking research to alleviate such terrible suffering. Question: Was the preoperative mapping done med - free?

This is just amazing!

Science. Brings. Joy. In so many ways

Very encouraging work; I'm inspired. What happened with the primary outcome (the LPP)? Regardless of whether the study was positive on its primary outcome, it's obvious there's something here worth exploring further. Congrats!

Fascinating, and indeed perfect example of what precision biological psychiatry can achieve! Congrats. Btw small question: you mention MB-ME fMRI with 4 echoes, but you report 5 TEs?

Wow

Ok so, this is absolutely fascinating.

That is completely amazing. Awesome work - I hope it ends up saving so many lives.

This is awesome research with the potential to save lives globally.

Very interesting case. Hope this is indeed a framework for future translation of cog-neuro into clinical improvements

More amazing progress in treating depression using neuromodulation rather than pharmaceutical approaches.

Wow! Amazing work!

Amazing

This is truly impressive and important work!

Wow…awesome and impactful work!!! Bravo! 👏👏👏

Wowowowow!!! My mind is blown!!!

this is a pretty incredible case study. congrats to the patient, Damien, @ndosenbach.bsky.social, and the dozens of others who contributed to this important clinical research.

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Wild if it scales and replicates

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