fMRI signals “up,” but neural metabolism might be going “down.” In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes. rdcu.be/eUPO8 funds @erc.europa.eu #neuroskyence 🧵:

The Power Pixels pipeline just keeps getting better! The latest update comes with: - OpenEphys support - AP_Histology support - automatic high-frequency noise reduction - NWB format export option - zarr compression of raw data And, most importantly: a cool new logo! github.com/NeuroNetMem/...

Halloween isn’t my thing. My idea of a scary night is reading the plots of horror movies on Wikipedia.

I never understood why everyone always complains about the clocks changing. Then I had a kid.

Want to make publication-ready figures come straight from Python without having to do any manual editing? Are you fed up with axes labels being unreadable during your presentations? Follow this short tutorial including code examples! 👇🧵

I was doing the second-to-last recording of my project and was happily thinking to myself that I haven't broken a single Neuropixel in the entire two year project. You can guess what happened next... Now I have to install a new probe just for one final recording 🙃

I love how they came up with all this random stuff but for this one area they were like "I really don't know, just put a question mark"

When I told my dad I published in Nature he was like "wow, you must have made a lot of money with that"

I don't know why people say X is going down the drain, my last post got lovely replies like this one:

Want to collaborate with the International Brain Laboratory on your own project? We have funding to work with groups anywhere in the world to do new large-scale projects and we are looking for new partners! Learn more and apply: www.internationalbrainlab.com/ibl-core-apply

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

If you're into podcasts, here's a good one on the @intlbrainlab.bsky.social brainwide map, by @newscientist.com www.newscientist.com/podcasts/fir...

Sad day for peope who still believe brain areas are the primary organizational units of function in the brain. www.nature.com/articles/s41...

The ‪@intlbrainlab.bsky.social published 2 papers today on their work to create a map of neural activity across the entire mouse brain. Learn more about the lab: https://www.simonsfoundation.org/2025/02/20/how-do-our-brains-make-decisions-the-international-brain-laboratory-is-closing-in-on-answers/

The first complete activity map of a mammalian brain has revealed unprecedented insights into how decisions are made – and may even hint at the roots of intuition.

Extremely proud to have contributed to this monumental effort of recording the entire mouse brain, at cellular resolution, during complex behavior 🧠🐭

PSA: don't buy duragel from Cambridge Neurotech, it's a scam! 🚨 They charge $200 (incl. shipping) for a 16 ml spout. But duragel is just DOWSIL 3-4680 (see paper below) of which you can buy a large container of 210 ml for only $110. That's 24 times cheaper! 💸 www.sciencedirect.com/science/arti...

Duct tape and hope are literally the only two things holding my rig together

Don't feel like reading? Check out my talk! www.youtube.com/watch?v=QIl6...

🚨Pre-print alert🚨 We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭 How is this possible? Strap in! (1/9) 👇🧵 doi.org/10.1101/2025...

Was watching Clarkson's Farm and kept wondering how AI was going to help them get calves only to realize it stands for artificial insemination

Just added Bombcell 💣 to the suite of automatic curation tools that's included in the Power Pixels pipeline! It runs Bombcell, UnitRefine and the IBL algorithm to classify which of your units are good single neurons. You can can then use one (or more!) of these to filter your units before analysis.

🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds. pip install and play around with our toy dataset: 🔗 github.com/Julie-Fabre/...

Do you do Neuropixel recordings and are you struggling with preprocessing? The Power Pixels pipeline is an easy-to-use pipeline from raw data to neural activity of single neurons in specified brain regions 🧠 Now on bioRxiv! www.biorxiv.org/content/10.1...

My daughter can now understand two words! When I say "clap" she claps her hands and when I say "shake" she shakes her head. Ten months of development and she's reached the level of intelligence of a dog.

Officially announcing my new game: GARBAGE COUNTRY. A lonely road trip through the ruins of a forgotten world. feat. vast wastelands, tower-defense battles, upgrades, mysteries, & lots of driving.

Oh wow. Starting grant 0-10 years post PhD from 2027, Consolidator 5-15

🚀 Datoviz v0.3 is out! High-performance GPU rendering for scientific data visualization, now with a Pythonic API, 2D axes, and improved docs & gallery. 🔗 datoviz.org 🐍 pip install datoviz #dataviz #vulkan #python #gpu #opensource #neuro #sciViz

I don't want to brag but my 9 month old baby already speaks two languages. She can say yes in Russian ("da") and grandfather in Hindi ("dada").

On my way to New York for the @intlbrainlab.bsky.social annual meeting! Luckily, as a new father, the concept of jetlag doesn't apply to me anymore.

The lab's latest published project lead by our recently graduated Dr. Rhiannon Robke! --> Optogenetic stimulation of novel TPH2-Cre rats advances insight into serotonin’s role in locomotion, reinforcement, and compulsivity (www.jneurosci.org/content/earl...).

My lab @kinshiplab.bsky.social is recruiting a postdoc 🚨 with Sept start date Preference for in-vivo ephys / circuits experience / interest in applying quantitative methods to natural social behaviour. Funding & visa fees for 1-yr with possible extension. Send me your CV & visit kinshiplab.org

My theory is that our universe, and everything in it, is a computer simulation made by a highschool student of some advanced civilization. Not even a particularly bright one. He hard coded that nothing can go faster than the speed of light just because it would make the math more complicated. (1/2)

Only now I have a baby do I realize it's pretty crazy we have predators with sharp claws and teeth just chilling in our homes.

The PhD students started writing motivational quotes on the whiteboard

Kilosort4 detects a LOT of neurons, I recorded 15k neurons in one year 🤯 Traditionally, one would curate these detected units to see if they are well isolated single neurons. This is not feasible anymore, so today let's look at three options that are out there to automate this process! 🤖👇

Should you stick to your goal, try something else, or give up? Your median raphe nucleus in the brainstem knows and will decide for you 😉. First foray of my lab into foraging, behavioural strategies and exploration. Amazing work from the one and only Mehran Ahmadlou: www.nature.com/articles/s41...

I am incredibly proud to share my first, first-author paper as a postdoc with @benhayden.bsky.social . How does the human hippocampus, known for encoding concepts, represent the meanings of words while listening to narrative speech? www.biorxiv.org/content/10.1...

A cortical microcircuit model reveals the unique functional roles of PV and SOM cells in controlling network oscillations and stability. The model predicts hierarchical gradients in oscillation frequencies & seizure propensity based on SOM/PV densities and activation. www.biorxiv.org/content/10.1...

We are hiring a research assistant! Come join our ongoing project investigating the PFC-striatum pathway in cognitive flexibility. Head-fixed behavior, Neuropixels, optogenetics, and viral circuit tracing etc ki.varbi.com/en/what:job/.... Please spread.

I'm a neuroscientist by day and singer-songwriter by night! 🎸 I'm extremely happy to announce the release of my first EP "It's Brightening Up" on Spotify, iTunes and YouTube Music. open.spotify.com/album/7xkbd0...

For everyone new here, check out this starter pack by Guido Meijer!

Neuropixels and Optogenetics are delighted to announce the birth of Neuropixels Opto Combining high-resolution electrophysiology and optogenetics Today in bioRxiv 960 sites, 28 emitters, 2 colors By Lakunina, @karolinazsocha.bsky.social, Ladd, et al www.biorxiv.org/content/10.1... (1/2)

I just completely refactored the code base for Power Pixels, my python-based pipeline for processing of Neuropixel recordings. The pipeline is now much easier to use! So if you're doing Neuropixel recordings (with SpikeGLX), check it out: github.com/NeuroNetMem/...

In my spare time I'm a singer-songwriter and just recorded my first couple of songs!

You can pay $49 for an AI summary of your work futurism.com/springer-nat... or just get one for free on bioRxiv ;-) connect.biorxiv.org/news/2023/11...

New results for a new year! “Linking neural population formatting to function” describes our modern take on an old question: how can we understand the contribution of a brain area to behavior? www.biorxiv.org/content/10.1... 🧠👩🏻‍🔬🧪🧵 #neuroskyence 1/

Curious how place cells adapt to uncertainty in reward location? We found that predictable changes boost “reward place cells” & warp hippocampal maps. Check out our new preprint: with Feng Xuan, Jack Mellor, Peter Dayan and Dan Dombeck: www.biorxiv.org/content/10.1...