Out now in @pnas.org We present a new metabolism-weighted brain connectome that incorporates each region’s energy expenditure into the mapping of brain connectivity. www.pnas.org/doi/10.1073/...

it‘s hot again in Bordeaux 😎 and Wednesday is neuroenergetics day: find Mahnaz‘s oral presentation and Samira‘s poster dates below and drop by for discussions! #ohbm2026 @samomat.bsky.social, @mahnazAshrafi

See our science at Deep Piction, how we use it to develop new precision medicine.

Samira's work made the cover of @natneuro.nature.com this month 🎉 🔗 nature.com/neuro/volumes/29/issues/5 I also want to highlight two recent comments that engage with our quantitative approach to interpreting the BOLD signal; both are worth reading (see below).

Multiplexed magnetic resonance imaging (MRx). www.nature.com/articles/s41... 22 measures incl. T1, T2, main metabolites in 14 min. A technical tour de force, but I'm not sure where/how it will find clinical applications.

I didn’t expect a short video about an octopus to stay with me this long. At first, it looks like a simple, almost playful interaction. But the more you watch, the more something deeper emerges: a learning process unfolding between two completely different forms of intelligence. 🧵 1/

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature: rdcu.be/fdC2A @uclbrainscience.bsky.social

This looks like a significant discovery from Doris Tao's lab: Rapid concerted switching of the neural code in the inferotemporal cortex @nature.com "..our findings indicate that there is a previously unknown mechanism for neural representation:.." www.nature.com/articles/s41...

fMRI signals “up,” but neural metabolism might be going “down.” In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes. rdcu.be/eUPO8 funds @erc.europa.eu #neuroskyence 🧵:

What started as a spinoff project for Madeleine's PhD became one of the most striking indications that glucose levels play an important role in regulating everyday stress responses. This shows the potential of biosensors to evaluate whether metabolism alters stress reactivity #neuroskyence 🩺

What if complex life began when evolution hit a search bottleneck? Across 6,500+ species, 🧬 length follow a scale-invariant law. At eukaryote origins, proteins plateau while 🧬 keep growing as noncoding regulatory DNA. Phase transition? www.pnas.org/doi/10.1073/... 👉 manlius.substack.com

One of the more provocative and important articles I've read in a while: A call for a "map" of neuroscience understanding and relationships between domains. apertureneuro.org/article/1388...

Our new review is out today! 𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀 We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility. onlinelibrary.wiley.com/doi/10.1111/...

🧵 What does it take to build a small, scrappy, and successful communication neuroscience lab? Our lab, @gongxuanjun.bsky.social, @rachaelkee.bsky.social, Allyson Snyder, Ziyu Zhao, and I put out heads together to answer this question. Here's what we came up with: link.springer.com/chapter/10.1...

Ever wonder how you read so fast? Your brain gets a head start—processing the next word before your eyes move. Our MEG + eye tracking study out in Nature Communications study from @thechbh.bsky.social reveals orthographic & semantic previews predicting reading speed www.nature.com/articles/s41...

Hello! It has been a while, but for the Hector Fellow Academy I created a small project at the interface of neuroscience and music. In short, it is like a neuro-jukebox of projects of friends and colleagues integrating music and art. I thought it would be nice to share here cng-lab.github.io/kiosk

Nature research paper: Mitochondrial origins of the pressure to sleep go.nature.com/40oC7Y4

Your brain doesn’t just passively track time ⏳ - it structures it. In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2) 👉 www.science.org/doi/10.1126/...

At today's layer-fMRI seminar, @ofgulban.bsky.social presented stunning high resolution vein mapping tools. It left me quite excited. youtu.be/0V8fSjo2T2w?...

Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....

truely multiscale brain data on neuroenergetics

The brain’s energy landscape as a potential window into brain health www.nature.com/articles/d41... (study led by Martin Picard and Michel Thiebaut de Schotten)

Have questions about the ISMRM MiniHub in Lille, France? Get all your questions answered in an informal drop-in Zoom session with the Organizing Committee. Whether you're already registered or considering attending, stop by and ask us anything! Register now: ow.ly/8Rgx50V6Xgr #ISMRM #ISMRMMiniHub

Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78) I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine 1/n

Synaptome architecture shapes regional dynamics in the mouse brain | www.biorxiv.org/content/10.1... Led by Justine Hansen Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️

Neurons primarily rely on glucose—rather than lactate from astrocytes—to generate energy, according to recent findings in mice. By @giorgiag-sciwriter.bsky.social www.thetransmitter.org/metabolism/f...

📢 New preprint from the lab: We are very excited to report the discovery of an oscillation in the Central Thalamus using rare direct recordings of human thalamic electrophysiology. The novel oscillation is tightly coupled to specific, natural states of consciousness.🧵

David Lynch was an artist in all aspects of his life. I am a particular fan of his hair. He would have played Karl Friston in an fMRI biopic. RIP

Honored that a piece I wrote made it to NYTimes. It’s about how my mom’s stroke changed my connection to time, science, and nature. What a privilege to honor my mom in Modern Love. Below is a gift link. Let me know your thoughts 🙏🏼 www.nytimes.com/2024/12/20/s...

Mapping neuropeptide signaling in the human brain | doi.org/10.1101/2024... Neuropeptides are among the functionally diverse signaling molecules in the brain and body. @cebric.bsky.social curates an atlas of neuropeptide receptors and relates it brain function 🧩 🧠 ⤵️

Having a difficult day, but I'm glad to have microscopy to inspire me and hopefully inspire others as well. 💔 The brain keeps being amazing. These are neurons in the neocortex #FluorescenceFriday 🔬

Quick reminder that Elsevier's share price has doubled in the past 5 years: www.relx.com/investors/sh...

beautiful and elegant 👏

Here are some important populations of columnar neurons in the #Drosophila right optic lobe, from the #connectome released in April 2024 again. Note the subtle variations in morphologies. I made this video with Michael Reiser ( @michaelreiser.bsky.social), using neuVid driving #Blender.

Intracranial lymphatic vessels in a larval zebrafish. Credit to @zebrafish007.bsky.social. #ZebrafishZunday 🧪

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇 @cellpress.bsky.social cell.com/cell-host-mi...

After a couple weeks, I've added a few hundred of you to Brain and Mind by request. The list is really an awesome source of posts in neuroscience, cognitive neuroscience, and compneuro. Has basically replaced my home feed! bsky.app/profile/did:...

The thing I am struggling with most as a PI is getting projects across the finish line. There are so many preprints, manuscripts, grants, tasks, and admin things to do that I feel like I am pushing the rock up the hill but never making true progress. Just picking a task each day becomes difficult.

A forest of neurons inside your head, happy #FluorescenceFriday! 🔬🧪🧠

#NewPI achievement unlocked: the first #obrownlab publication is officially accepted (🍾) about #zebrafish #glia (green) and the vasculature (magenta). Thanks to our reviewers and congrats to all of the lab members! What a great 1st paper experience. Happy #fluorescencefriday ya'll!

Mitochondria in axons! #FluorescenceFriday

Trying to start a "reviewer 2" starter pack but I'm still working through the extensive feedback on my first version.

This article with authors incl. @russpoldrack.bsky.social @summerfieldlab.bsky.social @katejj.bsky.social is still on my mind when I come to thinking about conferences 'Fly less' is an important perspective: www.cell.com/neuron/fullt...

rdcu.be/d07ia here we should how hemispheric asymmetry in the human cortex is rooted in microstructure. 🙏 Bin Wan, @amnsbr.bsky.social @sbe.bsky.social @borismontreal.bsky.social and all others not yet in Bluesky 💜

Nature Neuroscience The cell-type underpinnings of the human functional cortical connectome www.nature.com/articles/s41...

Neuroscientists are flocking to Bluesky, but X still has ten times more users. My story on the migration, featuring @nicolecrust.bsky.social @russpoldrack.bsky.social @charan-neuro.bsky.social @therealdrdukes.bsky.social @wiringthebrain.bsky.social + more! www.thetransmitter.org/community/hu...

paper alert 🔔 Network Neuroscience Does a brain region's energy demand reflect its control costs to transition between brain states? #neuroskyence #neuroimaging #MRI #neurometabolism direct.mit.edu/netn/article... 🧵…

8/ Takeaway In this era of massive brain age models, don’t underestimate the power of smaller, outcome-specific models. Precision can sometimes beat scale. 🌟

Next starter pack: go.bsky.app/69jMpXh