To be clear, there are no data that provide a link between short-term use of Tylenol during pregnancy and autism. In fact, one of the best prospective studies w/ sibling controls, if anything, pointed to a protective effect for use less than 7 days acamh.onlinelibrary.wiley.com/doi/10.1002/...

Confocal bat signal! Or Ant-man maybe? Guess that makes Clair our lab’s super hero!!!

Regulation of REM and NREM sleep by preoptic glutamatergic neurons academic.oup.com/sleep/articl...

Super cool. Prefrontal cortex controls sleep.

new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface

⭐CALL FOR PAPERS⭐ Infectious Agents- Causal or Risk? ▶️ Linking infection-related biomarkers to ADRD pathophysiology ▶️Relationships between infectious exposures and clinical trials & more! ⏰Deadline: June 1, 2026 #TRCI alz-journals.onlinelibrary.wiley.com/hub/journal/...

MIF-induced CD74+ microglia/macrophages are clinically relevant disease-associated subpopulations in brain metastasis and other CNS disorders https://www.biorxiv.org/content/10.1101/2025.09.06.673623v1

Oooh! Yesssss!

Absolutely fantastic talk and visit with @mzilberter.bsky.social ! Thanks so much for coming to visit us in Kentucky and sharing your elegant work, Misha!

Cleveland Clinic seeks Chair of Neurosciences to lead 20 labs and 190 researchers, driving global innovation in brain health, neurological disease, and discovery. Apply by: 8th October www.dementiaresearcher.nihr.ac.uk/job/chair-de...

New online! Neuronal ceroid lipofuscinosis: underlying mechanisms and emerging therapeutic targets

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD Thanks to Nina and all of the team!

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.1101/2025.08.25.672093v1

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging www.nature.com/articles/s41...

The unexpected value of communicating science to the public — a World View article by Nicole C. Rust @nicolecrust.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

Sad that the summer conference season is almost over? Interested in #lipids and #lipoproteins? Save the date for the @Kern Lipid Conference 2026, and join us in beautiful Breckenridge, CO, on August 10th-12th, 2026. kernconference.org

Fresh results now in bioRxiv! 🎉 We know about the function of NREM sleep for overnight memory consolidation. But what about REM sleep? We found that in aging, slow delta waves can intrude phasic REM periods, and this, is associated with worse overnight consolidation 🧠 (1/5) doi.org/10.1101/2025...

A paper published in Nature Medicine presents multimodal data from 347 individuals, linking gut microbiome diversity and resting heart rate to glucose levels. This approach enhances understanding of Type 2 diabetes beyond traditional HbA1c measurements. go.nature.com/4mmNCbi 🧪

New content online: The role of bone in whole-body energy metabolism

I’m absolutely elated to hear our UK Prep R25 received its NOA for this year! So glad our lab’s very own, Sierra Turner, can continue on in this program!!!

Loss of brain insulin production impairs learning and memory in female mice

An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing www.nature.com/articles/s41...

Brain on standby — how torpor made ‘tauopathy’ reversible — a Journal Club article by Nina M. Rzechorzek @dynamicbrain.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

'Early intervention anti-Aβ #immunotherapy attenuates #microglial activation without inducing exhaustion at residual plaques' Lis de Weerd @lisdeweerd.bsky.social Selina Hummel, Stephan A. Müller...Christian Haass @haasslab.bsky.social #AlzheimersDisease #amyloid bit.ly/3V8PDMa

#Throwback 🧪 METABOLIC MESSENGERS | Itaconate ‪@lukeanthonyoneill.bsky.social‬ et al

Interested in brain access for Tirzepatide-based drugs? Have a look at the fluorescent Tirzepatide analogue developed by Johannes Broichhagen and David Hodson @daveyboyhod.bsky.social‬ out now in Nature Metabolism www.nature.com/articles/s42.... Proud to contribute to this great multi-lab effort.

Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease

Are you an ATP!?! We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs). Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY. Apply here! rb.gy/3zk4cm

New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...

We’re hosting our 2nd annual CNS Metabolism Symposium on December 3rd! Come apply to join us!!! Details below. 👇 Please R/T! Thanks!

What a day for the lab! Clair Ashley CRUSHED her quals and is officially a PhD candidate! Amunet Jacobs, MD/PhD student, got her white coat and is officially part of the lab! Nick Constantino got not one but two awards!! 1) Poster award at CASH-KY Symposium & 2) SFN Trainee Development Award!

ROSMAP-Compass: A data-harmonised, AI-ready atlas of 22 million single nuclei from the ROSMAP cohort #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.1101/2025.08.11.668964v1

Succinate preserves CD8+ T cell fitness to augment antitumor immunity: Immunity www.cell.com/immunity/ful...

🚀 Join our Lab at @bostonu.bsky.social! We’re welcoming motivated undergraduate, master’s, and PhD students to collaborate on innovative research projects 🌟 Speaking multiple languages is a big plus! 🌎 Join our vibrant, multidisciplinary team! 🧠 #Alzheimer Learn more at bostonmapp.org/training 🎓

This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...

Macauley Lab 2025! What a fantastic group to work with! 🧠 🔬

Online Now: Brain myelin as a deficient energy source in aging and disease #trends #endocrinology #metabolism

Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort doi.org/10.1016/j.te...

Really cool stuff on #pericytes @natureportfolio.nature.com !

A reminder that the mRNA vaccine technology saved millions of lives during the Covid pandemic and received the 2023 Nobel Prize for Medicine

Tau deletion results in sex-dependent modulation of synaptic weakening in rat hippocampus https://www.biorxiv.org/content/10.1101/2025.08.07.665155v1

***🚨 New Paper 🚨*** Both #sleep and eyes-closed waking rest improve memory. But sleep also increases FALSE recall in some paradigms. Q: Does eyes-closed rest similarly increase false recall? A: No. Free access link: authors.elsevier.com/a/1lYgb3qNaA... #sleeppeeps #psychscisky 🧠🟦

Delighted to share our latest review in Nature Reviews Neuroscience! We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies. www.nature.com/articles/s41...

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...

#OCaMP is now on bioRxiv and reagents are available on #Addgene! 🧪 A sensitive orange fluorescent calcium ion indicator for imaging neural activity www.biorxiv.org/content/10.1...

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance

Tau controls NMDA receptor trafficking during homeostatic synaptic plasticity

Tau controls NMDA receptor trafficking during homeostatic synaptic plasticity https://www.biorxiv.org/content/10.1101/2025.07.28.667139v1

First highlight... Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH. The details are not available, but the bill will be released ofter the hearing. This is not a done-deal, but it does show where the Senate is on a bipartisan basis.