Human Cerebral Cortex Organization Characterized by Functional PET-FDG "Metabolic Connectivity" https://www.biorxiv.org/content/10.64898/2026.02.15.706044v1

Finally, on a more holistic level, Guang Sheng Ling and colleagues suggest a two-pronged approach to targeting #immunometabolism therapeutically through pharmaceutical and lifestyle interventions, with a focus on #cancer plos.io/4jNASKk

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New work from our lab! Link: rdcu.be/e0sfU 𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 A quick thread on our findings!

New work from our lab! Link: rdcu.be/e0sfU 𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 A quick thread on our findings!

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Chronic low-grade metabolic #inflammation drives insulin resistance and metabolic dysfunction in #obesity. Yun Sok Lee highlights the lesser known beneficial effects of this inflammation and how they can transition into detrimental outcomes. 🧪

Cerebral amyloid angiopathy and Alzheimer's and related pathologies across APOE genotypes academic.oup.com/brain/advanc...

The Shingles vaccine has outperformed all expectations. Why? erictopol.substack.com/p/spotlight-...

Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2: @cellpress.bsky.social www.cell.com/cell/fulltex...

Go Sanders Brown and the Macauley Lab! So bummed to miss it!

Great study on @molneurodegen.bsky.social showcasing the differences of Aβ generated from glutamatergic and GABAergic neurons with distinct implications for plaque compaction, reactive gliosis, and axonal dystrophy! link.springer.com/article/10.1...

This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. buff.ly/hFHjKy9

Rethinking diabetes diagnosis: a meta-analysis shows that 1 h plasma glucose is superior to FPG, 2 h plasma glucose, #HbA1c or FPG plus HbA1c for detecting #Type2Diabetes earlier, potentially improving prevention and care #DiabetesResearch link.springer.com/article/10.1... 🔓

Lactate dehydrogenase A (#LDHA)-driven metabolic and epigenetic reprogramming in beta cell dedifferentiation during diabetes development, identifying LDHA inhibition as a promising therapeutic target. #DiabetesResearch #Pancreatic-β-cell #Dedifferentiaton link.springer.com/article/10.1...

#ArtAdventCalendar, Day 14! Another hometown fav. Watercolor, Lobster Landing, Clinton, CT

This is so important in the context of Alzheimer’s. Many studies suggest MetS or diabetes is not associated with AD risk, however they fail to consider T2D is treated. This reinforces the idea that managing metabolic dysfunction has widespread improvement for many age related diseases.

Paper accepted!!!!!!! Yahooooo!!!

#ArtAdventCalendar, Day 11! Watercolor, Seashells, Hammonasset State Park, Madison, CT.

#ArtAdventCalendar, Day 11 Watercolor, seagull on channel marker, Clinton Harbor, Clinton CT

#ArtAdventCalendar, Day 10 Watercolor, alcohol inks, acrylics. Inspired by Ramon y Cajal and Greg Dunn’s work.

#ArtAdventCalendar Day 8! Carolina chickadee, watercolor.

I forgot about this! #ArtAdventCalendar Day 7 Watercolor, mouse, EVs. Painted it for my student after we discovered a method to isolate EVs from the interstitial fluid of the mouse’s brain (Pait et al, 2023).

There's a software engineer in Hong Kong who makes incredibly detailed scientific diagrams for wikipedia, like this clickable metro-style map of metabolic pathways!!!

So very pretty! Iba1, Cmec7a, Amylo-glo. Courtesy of @clairashley.bsky.social

Kudos to Sanders-Brown researchers 𝐖𝐞𝐢𝐤𝐚𝐧𝐠 𝐂𝐚𝐢, 𝐏𝐡𝐃, 𝐉𝐨𝐬𝐡 𝐌𝐨𝐫𝐠𝐚𝐧𝐭𝐢, 𝐏𝐡𝐃, 𝐚𝐧𝐝 𝐃𝐚𝐧𝐢𝐞𝐥 𝐋𝐞𝐞, 𝐏𝐡𝐃., who shared about their COBRE Pilot grant projects during the second annual 𝐂𝐍𝐒-𝐌𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐬𝐦 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦! @ukresearch.bsky.social @neurosciencerpa.bsky.social @macauleylab.bsky.social

We're very excited for our upcoming CNS Metabolism Symposium at University of Kentucky! We have a great line up of speakers, including our ATP Showcase and a keynote from Dr. Tim Ryan! Register now! uky.az1.qualtrics.com/jfe/form/SV_...

At SFN? Check out Dr. Karina Meyer-Acosta’s talk on APOE, neurodevelopment, and network formation using organoids. We were lucky to have Kaisha join the lab earlier this fall from Dr. Jenny Hsieh’s lab for her postdoc!

At #SFN2025? Stop by @ncons95.bsky.social and Sierra’s posters to learn about research from the lab!

We are happy to announce our new preprint: “Slow Intrinsic Oscillations in the Ventrolateral Preoptic Nucleus” We identify <1 Hz rhythmic bursting in #VLPO neurons that persists under TTX, revealing intrinsic oscillatory mechanisms that may shape NREM #sleep dynamics. www.biorxiv.org/content/10.1...

#Throwback 🧪 METABOLIC MESSENGERS | Itaconate ‪@lukeanthonyoneill.bsky.social‬ et al

Our new review is out today! 𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀 We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility. onlinelibrary.wiley.com/doi/10.1111/...

Sanders-Brown was well represented at the 𝟐𝟎𝟐𝟓 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥-𝐓𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦! @ukresearch.bsky.social @selenicalab.bsky.social @macauleylab.bsky.social #research #TDP43 #sleepdisruption #astrocytes

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics www.nature.com/articles/s41...

While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from @bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...

Macauley Lab- dressed to impress- at the Markesbery Symposium! @uksbcoa.bsky.social

Loss of MFE-2 impairs microglial lipid homeostasis and drives neuroinflammation in Alzheimer’s pathogenesis @nataging.nature.com www.nature.com/articles/s43...

Our paper on CSF, BOLD, pupil, and physiological measures in sleep deprivation and recovery sleep is finally out! 🎉 Congrats Zinong! www.nature.com/articles/s41...

Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Very cool. Obesity v age impact on metabolic flux: Re: lactate (obvi): Aging: serum lactate concentration increases (even though whole-body lactate flux stays ~ same). Obesity (ob/ob): serum lactate concentration increases, and lactate flux also rises strongly (~50–85% vs. lean).

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Pretty Fluorescent Friday by Sierra Turner!

Sweetening the diet with artificial sweeteners reveals in a clinical trial that prolonged consumption of S&SEs in a healthy diet is a safe strategy for #obesity management #weightloss #microbiota www.nature.com/articles/s42...

Macauley Lab representing at the Walk to End Alzheimer’s!

www.medrxiv.org/content/10.1... Working with our great collaborators at Pfizer we have uncovered a common genetic contributor to metabolic ill health/

To be clear, there are no data that provide a link between short-term use of Tylenol during pregnancy and autism. In fact, one of the best prospective studies w/ sibling controls, if anything, pointed to a protective effect for use less than 7 days acamh.onlinelibrary.wiley.com/doi/10.1002/...

Confocal bat signal! Or Ant-man maybe? Guess that makes Clair our lab’s super hero!!!

Regulation of REM and NREM sleep by preoptic glutamatergic neurons academic.oup.com/sleep/articl...