Our new review is out today! 𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀 We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility. onlinelibrary.wiley.com/doi/10.1111/...

Sanders-Brown was well represented at the 𝟐𝟎𝟐𝟓 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥-𝐓𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦! @ukresearch.bsky.social @selenicalab.bsky.social @macauleylab.bsky.social #research #TDP43 #sleepdisruption #astrocytes

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics www.nature.com/articles/s41...

While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from @bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...

Macauley Lab- dressed to impress- at the Markesbery Symposium! @uksbcoa.bsky.social

Loss of MFE-2 impairs microglial lipid homeostasis and drives neuroinflammation in Alzheimer’s pathogenesis @nataging.nature.com www.nature.com/articles/s43...

Our paper on CSF, BOLD, pupil, and physiological measures in sleep deprivation and recovery sleep is finally out! 🎉 Congrats Zinong! www.nature.com/articles/s41...

Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Very cool. Obesity v age impact on metabolic flux: Re: lactate (obvi): Aging: serum lactate concentration increases (even though whole-body lactate flux stays ~ same). Obesity (ob/ob): serum lactate concentration increases, and lactate flux also rises strongly (~50–85% vs. lean).

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Pretty Fluorescent Friday by Sierra Turner!

Sweetening the diet with artificial sweeteners reveals in a clinical trial that prolonged consumption of S&SEs in a healthy diet is a safe strategy for #obesity management #weightloss #microbiota www.nature.com/articles/s42...

Macauley Lab representing at the Walk to End Alzheimer’s!

www.medrxiv.org/content/10.1... Working with our great collaborators at Pfizer we have uncovered a common genetic contributor to metabolic ill health/

To be clear, there are no data that provide a link between short-term use of Tylenol during pregnancy and autism. In fact, one of the best prospective studies w/ sibling controls, if anything, pointed to a protective effect for use less than 7 days acamh.onlinelibrary.wiley.com/doi/10.1002/...

Confocal bat signal! Or Ant-man maybe? Guess that makes Clair our lab’s super hero!!!

Regulation of REM and NREM sleep by preoptic glutamatergic neurons academic.oup.com/sleep/articl...

Super cool. Prefrontal cortex controls sleep.

new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface

⭐CALL FOR PAPERS⭐ Infectious Agents- Causal or Risk? ▶️ Linking infection-related biomarkers to ADRD pathophysiology ▶️Relationships between infectious exposures and clinical trials & more! ⏰Deadline: June 1, 2026 #TRCI alz-journals.onlinelibrary.wiley.com/hub/journal/...

MIF-induced CD74+ microglia/macrophages are clinically relevant disease-associated subpopulations in brain metastasis and other CNS disorders https://www.biorxiv.org/content/10.1101/2025.09.06.673623v1

Oooh! Yesssss!

Absolutely fantastic talk and visit with @mzilberter.bsky.social ! Thanks so much for coming to visit us in Kentucky and sharing your elegant work, Misha!

Cleveland Clinic seeks Chair of Neurosciences to lead 20 labs and 190 researchers, driving global innovation in brain health, neurological disease, and discovery. Apply by: 8th October www.dementiaresearcher.nihr.ac.uk/job/chair-de...

New online! Neuronal ceroid lipofuscinosis: underlying mechanisms and emerging therapeutic targets

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD Thanks to Nina and all of the team!

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.1101/2025.08.25.672093v1

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging www.nature.com/articles/s41...

The unexpected value of communicating science to the public — a World View article by Nicole C. Rust @nicolecrust.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

Sad that the summer conference season is almost over? Interested in #lipids and #lipoproteins? Save the date for the @Kern Lipid Conference 2026, and join us in beautiful Breckenridge, CO, on August 10th-12th, 2026. kernconference.org

Fresh results now in bioRxiv! 🎉 We know about the function of NREM sleep for overnight memory consolidation. But what about REM sleep? We found that in aging, slow delta waves can intrude phasic REM periods, and this, is associated with worse overnight consolidation 🧠 (1/5) doi.org/10.1101/2025...

A paper published in Nature Medicine presents multimodal data from 347 individuals, linking gut microbiome diversity and resting heart rate to glucose levels. This approach enhances understanding of Type 2 diabetes beyond traditional HbA1c measurements. go.nature.com/4mmNCbi 🧪

New content online: The role of bone in whole-body energy metabolism

I’m absolutely elated to hear our UK Prep R25 received its NOA for this year! So glad our lab’s very own, Sierra Turner, can continue on in this program!!!

Loss of brain insulin production impairs learning and memory in female mice

An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing www.nature.com/articles/s41...

Brain on standby — how torpor made ‘tauopathy’ reversible — a Journal Club article by Nina M. Rzechorzek @dynamicbrain.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

'Early intervention anti-Aβ #immunotherapy attenuates #microglial activation without inducing exhaustion at residual plaques' Lis de Weerd @lisdeweerd.bsky.social Selina Hummel, Stephan A. Müller...Christian Haass @haasslab.bsky.social #AlzheimersDisease #amyloid bit.ly/3V8PDMa

#Throwback 🧪 METABOLIC MESSENGERS | Itaconate ‪@lukeanthonyoneill.bsky.social‬ et al

Interested in brain access for Tirzepatide-based drugs? Have a look at the fluorescent Tirzepatide analogue developed by Johannes Broichhagen and David Hodson @daveyboyhod.bsky.social‬ out now in Nature Metabolism www.nature.com/articles/s42.... Proud to contribute to this great multi-lab effort.

Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease

Are you an ATP!?! We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs). Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY. Apply here! rb.gy/3zk4cm

New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...

We’re hosting our 2nd annual CNS Metabolism Symposium on December 3rd! Come apply to join us!!! Details below. 👇 Please R/T! Thanks!

What a day for the lab! Clair Ashley CRUSHED her quals and is officially a PhD candidate! Amunet Jacobs, MD/PhD student, got her white coat and is officially part of the lab! Nick Constantino got not one but two awards!! 1) Poster award at CASH-KY Symposium & 2) SFN Trainee Development Award!

ROSMAP-Compass: A data-harmonised, AI-ready atlas of 22 million single nuclei from the ROSMAP cohort #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.1101/2025.08.11.668964v1

Succinate preserves CD8+ T cell fitness to augment antitumor immunity: Immunity www.cell.com/immunity/ful...

🚀 Join our Lab at @bostonu.bsky.social! We’re welcoming motivated undergraduate, master’s, and PhD students to collaborate on innovative research projects 🌟 Speaking multiple languages is a big plus! 🌎 Join our vibrant, multidisciplinary team! 🧠 #Alzheimer Learn more at bostonmapp.org/training 🎓

This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...