Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease | Science Advances www.science.org/doi/10.1126/...

Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social

Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity @cellpress.bsky.social www.cell.com/cell/fulltex...

IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness: @cellpress.bsky.social www.cell.com/cell/fulltex...

Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy www.nature.com/articles/s41...

Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia www.nature.com/articles/s41...

A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease www.nature.com/articles/s41...

Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social

Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function www.nature.com/articles/s41...

Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment @cellpress.bsky.social www.cell.com/cell/fulltex...

Therapeutic VEGFC treatment protects against traumatic brain injury-driven tauopathy pathogenesis @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...

Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...

@lukensjohnr.bsky.social Interesting summary by @erictopol.bsky.social! Also, @erictopol.bsky.social should definitely have you on Ground Truths sometime for your work!

Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/...

Alzheimer’s disease transcriptional landscape in ex vivo human microglia www.nature.com/articles/s41...

Human brain vascular multi-omics elucidates disease-risk associations @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Neural anticipation of virtual infection triggers an immune response www.nature.com/articles/s41...

Spatial proteomics of Alzheimer’s disease-specific human microglial states www.nature.com/articles/s41...

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Mast cells regulate the brain-dura interface and CSF dynamics @cellpress.bsky.social www.cell.com/cell/fulltex...

Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense @science.org www.science.org/doi/10.1126/...

APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases www.nature.com/articles/s41...

Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease www.nature.com/articles/s41...

Taking the STING out of neurodegenerative disease url: rupress.org/jem/article/...

Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...

Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal @science.org www.science.org/doi/10.1126/...

Synthetic efferocytic receptor microglia enhances anti-inflammatory clearance of amyloid-β for AD treatment in mice | Science Advances www.science.org/doi/10.1126/...

Turbocharged ‘killer’ cells show promise for autoimmune disease @nature.com www.nature.com/articles/d41...

Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/science/arti...

Excitatory-neuron-derived interleukin-34 supports cortical developmental microglia function: @cp-immunity.bsky.social www.cell.com/immunity/ful...

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

How fast is your brain ageing? Ordinary scans reveal the pace nature.com/articles/d41... @nature.com

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity www.nature.com/articles/s41...

By #genetically removing STING in mice, researchers saw significant improvements such as better control of harmful #amyloid #plaques, healthier #microglial activity, and protection against #cognitive decline. GENEWIZ is honored to be cited in this study, providing #RNAseq: hubs.ly/Q03sPs0B0

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia www.nature.com/articles/s41...

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...

Neuroinflammation across neurological diseases @science.org www.science.org/doi/10.1126/...

Nerve-associated portal macrophages function to maintain liver immune homeostasis www.nature.com/articles/s41...

Defective peripheral B cell tolerance leads to dysregulated B cell responses in Fibromyalgia Syndrome www.researchsquare.com/article/rs-6...

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation @nature.com www.nature.com/articles/s41...

Peripheral infection wires T cells in the brain www.nature.com/articles/s41...

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: @cellpress.bsky.social www.cell.com/cell/fulltex...

Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo. @cp-immunity.bsky.social www.cell.com/immunity/ful...

Decoding extracellular matrix–lysosome cross-talk and its implications for neurodegenerative diseases | Science Signaling www.science.org/doi/10.1126/...

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain www.nature.com/articles/s41...

Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes www.nature.com/articles/s41...