An atlas of NK cell receptor expression on healthy donor T and NK lymphocytes @biorxivpreprint.bsky.social @jeanetteeb.bsky.social www.biorxiv.org/content/10.1...

A TGF-βR/IL-2R immunomodulatory fusion protein transforms immunosuppression into T cell activation to enhance adoptive T cell therapy @fredhutch.org www.pnas.org/doi/10.1073/...

Apical surface inhalation of monoclonal antibodies against human metapneumovirus halted spread of established infection in hamsters more efficiently than far higher concentrations of antibody dosed basally www.pnas.org/doi/10.1073/...

Th17 cells with regulatory phenotype are the main IL-17F and IL-26 producers in palmoplantar pustulosis @jci-insight.bsky.social @umich.edu insight.jci.org/articles/vie...

HMGB1 couples LEF1 to regulate B cell immunity @jci-insight.bsky.social insight.jci.org/articles/vie...

@cincyresearch.bsky.social @jclinical-invest.bsky.social Allergen-Specific mRNA-Lipid Nanoparticle Therapy for Prevention and Treatment of Experimental Allergy in Mice www.jci.org/articles/vie...

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine. 1) MMG (my dept): fundamental research in med micro 2) Peds ID / I4Kids institute 3) Center for Vaccine Research 🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

Whether they're blaming vaccines and Tylenol, or selling dubious "remedies," what they're really doing is promoting the perception that families (and especially mothers) can prevent and treat Autism. And thus also the perception that people with Autism and their families don't need social support.

Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity www.science.org/doi/10.1126/...

The receptor TIM3 inhibits the cytolytic activity of murine and human CD8+ T cells only in three-dimensional contexts @carissacwwong.bsky.social @bristoluni.bsky.social www.science.org/doi/10.1126/...

Designing immunity with cytokines: A logic-based framework for programmable CAR therapies www.sciencedirect.com/science/arti... @weillcornell.bsky.social

Type I IFN drives neutrophil swarming, impeding lung T cell–macrophage interactions and TB control @jem.org rupress.org/jem/article/...

Preprint: Phase-Separated Peptide Coacervates as Delivery Vehicles for mRNA Vaccines www.researchsquare.com/article/rs-7...

Preprint: The Mannose Receptor on Sinusoidal Lining Cells Mediates Two-Step Bacterial Clearance in the Human Spleen www.researchsquare.com/article/rs-7...

Preprint: a Self-Amplifying mRNA-LNP Complex for Phenylalanine Hydroxylase and Its Efficacy Evaluation in Gene Therapy for Phenylketonuria papers.ssrn.com/sol3/papers....

Forum @cp-trendspharma.bsky.social The interplay of the cGAS–STING pathway with the lysosome www.cell.com/trends/bioch...

RSK1 reprograms the ubiquitin pathway to promote immune suppression @cp-cellreports.bsky.social www.cell.com/cell-reports...

Mucus-derived glycans are inhibitory signals for Salmonella Typhimurium SPI-1-mediated invasion @cp-cellreports.bsky.social @mitdeptofbe.bsky.social www.cell.com/cell-reports...

Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains @cellcellpress.bsky.social www.cell.com/cell/fulltex...

Reference genome choice compromises population genetic analyses @cellcellpress.bsky.social www.cell.com/cell/fulltex...

An immune-competent lung-on-a-chip for modelling the human severe influenza infection response @natbiomedeng.nature.com @vanderbilt.edu www.nature.com/articles/s41...

Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke @natmetabolism.nature.com www.nature.com/articles/s42... www.nature.com/articles/s42...

CD40L and IL-4 suppress NK cell-mediated antibody-dependent cellular cytotoxicity through the HLA-E:NKG2A axis academic.oup.com/immunotherap...

Review @frontiersin.bsky.social Dysfunction of NK cells promotes immune escape and disease progression in endometriosis www.frontiersin.org/journals/imm...

A Scalable Protocol for Ex Vivo Production of CAR-Engineered Human NK Cells @fda.gov www.mdpi.com/2409-9279/8/...

@biorxivpreprint.bsky.social Bi-cistronic OR-gated CAR T-cells specific CD70 & active Integrin β2 overcome antigen heterogeneity to allow broader targeting of Acute Myeloid Leukemia blasts @apwiita.bsky.social @ucsfcancer.bsky.social www.biorxiv.org/content/10.1...

A novel lncRNA, lncMCL1, modulates neural pyroptosis associated with epilepsy via stabilizing DDX3X www.nature.com/articles/s41...

If you, like me, are the parent of a neuro-atypical child dreading this autism press conference, please remember: These are the people hurting our kids. Not us. They are the ones stigmatizing and pathologizing them. They are the ones peddling untested science. And we should be very, very angry.

My only regret is that we didn't go with the title "One buffer to rule them all, and in the darkness bind them", although "Squeaky clean staining" was a pretty good options too!

Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIV @natimmunol.nature.com www.nature.com/articles/s41...

Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis www.nature.com/articles/s41... @natcellbio.nature.com @stjuderesearch.bsky.social

Review @natrevgastrohep.nature.com @ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment www.nature.com/articles/s41...

Perspective @natrevimmunol.nature.com Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumor immunity and tumor escape www.nature.com/articles/s41...

Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant @natbiomedeng.nature.com www.nature.com/articles/s41...

GZMB+GNLY+ CD8+ T cells are the main expanded subset across different autoantibody statuses, highlighting their central role in Sjögren’s disease pathogenesis, while memory B cells enriched in anti-CENT-positive patients @natcomms.nature.com www.nature.com/articles/s41...

Perspective @cp-immunity.bsky.social A roadmap for defining “extrafollicular” B cell responses www.cell.com/immunity/ful... @stephanieeisen.bsky.social @vinuesalab.bsky.social et al

Infectious bacteria, but not the microbiota, induce a NOX-ATM-cytokine pathway that controls epithelial turnover @cp-cellreports.bsky.social @nicobuchon.bsky.social www.cell.com/cell-reports...

Taurine transport is a critical modulator of ionic fluxes during NLRP3 inflammasome activation @cp-cellreports.bsky.social www.cell.com/cell-reports... @imperialcollegeldn.bsky.social

CD7 regulates the persistence of terminally exhausted CD8+ T cells during chronic infection @cp-cellreports.bsky.social www.cell.com/cell-reports... @bcmhouston.bsky.social

Innate immune molecular landscape following controlled human influenza virus infection @cp-cellreports.bsky.social www.cell.com/cell-reports... @williamthistle.bsky.social @sindhuvangeti.bsky.social @flatironinstitute.org

Inflammatory modalities shape the IgA repertoire via stochastic processes @cellreports.bsky.social www.cell.com/cell-reports...

@biorxivpreprint.bsky.social Bispecific Targeting of CHI3L1 and PD-1/PD-L1 Axis as a Novel Therapeutic Strategy for Idiopathic Pulmonary Fibrosis www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social PD-1 is essential for the early expansion and survival of HBV-specific CD8⁺ T cells during acute infection and does not suppress their effector cytokine function www.biorxiv.org/content/10.1...

DDX3X can regulate gouty inflammation by activating the NLRP3 inflammasome and mediating macrophage pyroptosis www.sciencedirect.com/science/arti...

@biorxivpreprint.bsky.social Fetal and maternal immune cells exhibit tandem maturation across gestation and dysregulation in preterm birth www.biorxiv.org/content/10.1...

Myasthenia gravis is characterized by a tolerance checkpoint swap where pathological B cells shift from requiring T cell help and antigen-specific selection to depending on BAFF for survival @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social NK cells undergo transcriptional and functional reprogramming following Streptococcus pneumoniae infection @institutpasteur.bsky.social www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social Dysbiosis in postmenopausal osteoporosis promotes expands IL-17-producing Nkp46- ILC3 & inhibits IL-22-producing Nkp46+ ILC3, the temporal dynamics of which are linked to progressive inflammatory bone loss www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social Educated NK cells from HLA I-disparate donors to evade HLA-driven inhibition & avail activating receptors may be more effective allogeneic NK therapy for pancreatic ductal adenocarcinomas @dalhousieu.bsky.social @jeanetteeb48.bsky.social www.biorxiv.org/content/10.1...