Revealing potential therapeutic targets in membranous nephropathy doi.org/10.1172/jci.... Using a multi-omic approach in a murine model of MN, Huang et al. elucidate the action of anti-THSD7A autoantibodies in the kidney in the context of autoimmunity.

Supporting the concept that GLP1 agonist drugs lower blood pressure independent of weight loss: doi.org/10.1172/jci.... @danieljdrucker.bsky.social & team @sinaihealth.bsky.social identify the vascular smooth muscle GLP-1 receptor as a key cellular target for GLP-1s to lower BP

Presenting a resource for scientists to study the cellular landscape of the eye in health & disease: doi.org/10.1172/jci.... This issue’s Cover: Colin J Chu @colinchulab.bsky.social & team @ucl.ac.uk detail a new spatial proteomic atlas of the mouse & human retina.

Building baby’s first maze: doi.org/10.1172/jci.... In this Research Article, Derek C. Sung & team use a mouse model in which Dll4 was deleted only in the placental vasculature to show an essential role for notch-chemokine signaling in assembling the placental vasculature.

Refuting the idea that coagulation contributes to persistent inflammation in treated HIV: doi.org/10.1172/jci.... ASCI member Ivona Pandrea & team report that adding FXa inhibitor to ART did not affect the pathogenesis of SIV infection or reduce hypercoagulability & inflammation

🌟Technical advance🌟 doi.org/10.1172/jci.... Martin Prlic & team @fredhutch.org demonstrate the feasibility of the FDA-approved blood lancet Tasso+ as an at home blood collection device for remote immune monitoring by high parameter flow cytometry.

ICYMI: Angiopoietin 2 promotes vascular permeability in peripheral organs, but its role in brain is unclear. doi.org/10.1172/jci.... Li et al. show ANGPT2 loss in mice leads to region-specific brain malformations and blood-brain barrier leakage.

Keeping an eye on first line treatments in glaucoma! doi.org/10.1172/jci.... Jeremy M. Sivak & team perform lipidomic analysis from aqueous humor in patients, finding Latanoprost induces production of Lipoxin A4 to inhibit pro-inflammatory cues and promote TGF-beta production.

Presenting the 1st high-resolution spatial profiling of human aortitis samples: doi.org/10.1172/jci.... Shi et al. report on TNC accumulation in lesions as contributing to persistent inflammation in giant cell aortitis and find tocilizumab alleviates the phenotype in a cell model.

The role of 9p deletion in B-ALL has been elusive since its discovery 40+ yrs ago doi.org/10.1172/jci.... Here, Isidro Sánchez-García, @jmartcan.bsky.social & team combine genomic analyses & functional models to show that the co-deletion of Pax5 & Cd72 in mice drives oncogenesis

Activated neutrophils are a hallmark of acute lung injury doi.org/10.1172/jci.... Vellingiri et al. find endothelial ERG loss shifts PMN transcriptome towards an inflammatory fate via IL8/CXCR2 & block with Reparixin reduces infiltration & improves survival in a pneumonia model.

New research from @gottschalklab.bsky.social, @satarupa2025.bsky.social and their team identifies GATA2 as an important regulator of inflammatory responses and metabolism in alveolar macrophages, providing new insights into pulmonary diseases driven by GATA2 deficiency.

Congratulations to recent PMI graduate Morgan Jackson-Strong from the @gottschalklab.bsky.social on her new paper!

From our physician-scientist development category: doi.org/10.1172/jci.... Cynthia Y. Tang & team analyzed 36,298 applicants, reporting dual-degree training shapes residency application strategies, interview rates, specialty choice, and program prestige.

Rachel A. Gottschalk @gottschalklab.bsky.social, Satarupa Ganguly @satarupa2025.bsky.social & team show lung macrophages lacking GATA2 during inflammation promote metabolic dysfunction & profibrotic gene expression in mice: doi.org/10.1172/jci....

Plasma GDF-15 concentration predicts early recurrence after atrial arrhythmia ablation doi.org/10.1172/jci.... In this Research Letter, Johanna Tennigkeit & team assess plasma samples before catheter ablation, discovering GDF-15 can predict arrhythmia recurrence within 24 hrs.

Angiopoietin 2 promotes vascular permeability in peripheral organs, but its role in brain is unclear. doi.org/10.1172/jci.... Li et al. show ANGPT2 loss in mice leads to region-specific brain malformations and blood-brain barrier leakage.

Reporting on a biomarker that distinguishes long COVID from controls in kids doi.org/10.1172/jci.... Izquierdo-Pujol et al. immunoprofiled long COVID in kids, finding overactive immunity & weak COVID antibodies link to long COVID and myeloid CCR6 as a biomarker with 79% accuracy.

🧒🦠 What drives #LongCOVID in children? Our new @IrsiCaixa research in JCI Insight reveals: 🔹 Immune dysregulation 🔹 Reduced neutralizing antibodies 🔹 CCR6 as a potential biomarker (79% accuracy) 👉 A key step toward better diagnosis & treatments 🔗 doi.org/10.1172/jci.... #Pediatrics #Immunology

How does the most common cause of Alternating Hemiplegia of Childhood lead to abnormal repolarization and arrhythmogenesis? doi.org/10.1172/jci.... @andrewlandstrom.bsky.social & team propose a Ca2+-mediated mechanism in ATP1A3-D801N carriers & identify NCX1 as a possible target.

Challenging the idea that psoriasis is solely a skin disease doi.org/10.1172/jci.... ASCI member James G. Krueger & team reveal a strong inflammatory signature in cutaneous adipose tissue of patients with psoriasis, amplified by obesity & partially dependent on IL-17 signaling.

We’re honored to be on the cover of @insight.jci.org this month! This work uncovers a key role for sympathetic nerve-CAF interactions in driving PDAC progression and remodeling the TME.

Here is a nice feature of JCI Insight, Burns et al. in The Scientist: www.the-scientist.com/uterine-gene...

Identifying a potential therapeutic vulnerability in pancreatic cancer: doi.org/10.1172/jci.... Featured on the Cover, @eksiece.bsky.social et al. report sympathetic nerve-fibroblast crosstalk drives nerve injury, fibroblast activation & matrix remodeling in pancreatic cancer.

Very happy this work is now out on its final format! We showed that the combination of fentanyl and alcohol leads to severe apnea that is not rescued by naloxone.

Presenting a strategy to reduce alcohol-induced neurovascular damage Saikia et al. treated alcohol-exposed mice with a peptide for enhancing Nrf2 activity, revealing its role in boosting antioxidant defenses, reducing BBB damage & leukocyte migration: doi.org/10.1172/jci....

T. Cooper, R-C Hu et al provide answers to progressive #heartProblems in #muscularDystrophy and potential reversibility. #DM1 #DMPKgene #MBNLproteins @insight.jci.org @bcmhouston.bsky.social blogs.bcm.edu/2026/04/03/f...

Fentanyl and alcohol are often a fatal combination Here, @renatamarchette.bsky.social & team show overdoses from the combination in a rat model leads to severe apnea that is not fully rescued by naloxone: doi.org/10.1172/jci....

ICYMI: Metastasis is the leading cause of breast cancer mortality. Here, William J. Muller & team find the STAT3-induced cytokine CHI3L1 recruits neutrophils that break extracellular matrix barriers and enable cancer spread, using mouse models: doi.org/10.1172/jci....

Introducing an IFN-γ–mediated strategy for enhancing immunity Sharee A. Basdeo & team report immune cells that defend against early infection can be trained to better fight tuberculosis and MRSA, especially in vulnerable individuals: doi.org/10.1172/jci....

Offering a strategy to enhance the efficacy cystic fibrosis therapies In this Research Article, Alessandra Ghigo & team report on a peptide targeting PI3Kγ that boosts airway CFTR membrane localization in cells derived from patients with cystic fibrosis: doi.org/10.1172/jci....

Research Letter: Consideration of spatial companion biomarkers for targeted therapeutics in cancer: depatuxizumab mafodotin in glioblastoma Lukas et al. use multi-protein tissue imaging to demonstrate EGFR expression heterogeneity within GFAP+ GBM: doi.org/10.1172/jci....

There are no medications for reducing rupture risk of brain arteriovenous malformations Park et al. find a role for microglia & macrophages in the destabilization of bAVMs, reporting that minocycline treatment in mice limited intracerebral hemorrhages: doi.org/10.1172/jci....

Can we resolve liver fibrosis using cell-based therapies? Vijay H. Shah & team injected bone marrow-derived macrophages expressing macrophage receptor with a collagenous structure (MARCO) to reduce scarring in a mouse model of chronic liver fibrosis: doi.org/10.1172/jci....

Studying 2 distinct human cohorts with recent exposure to TB, Paul Ogongo & team find different individual Mycobacterium tuberculosis antigens induce distinct T cell responses, with important implications for TB vaccine development: doi.org/10.1172/jci....

Metastasis is the leading cause of breast cancer mortality. Here, William J. Muller & team find the STAT3-induced cytokine CHI3L1 recruits neutrophils that break extracellular matrix barriers and enable cancer spread, using mouse models: doi.org/10.1172/jci....

A promising immunotherapeutic strategy for curing persistent HIV-1 infection Mann et al. show allogeneic Vδ2 T cells expanded from people without HIV are highly cytotoxic effectors that retain characteristics necessary for effective reservoir clearance: doi.org/10.1172/jci....

El trabajo publicado en la revista JCI Insight insight.jci.org/articles/vie... aporta nuevas claves para entender por qué algunos casos de esta enfermedad son más agresivos y abre nuevas vías para mejorar su diagnóstico y tratamiento en el futuro.

Getting at the nucleus of muscle wasting in cancer Xu et al. use single nucleus & bulk RNA seq in a mouse model of pancreatic cancer, highlighting a protective role for mTORC1 & revealing signaling networks within the skeletal muscle microenvironment: doi.org/10.1172/jci....

Identifying a therapeutic target in obesity-associated metabolic disease David A. Hill (YPSA winner) & team show CD9 regulates adipose tissue macrophage adhesion and pro-fibrotic activation in mouse models: doi.org/10.1172/jci....

That's me!!

Some MYRF variants result in isolated ocular disease while others produce syndromic phenotypes Lev Prasov & team find dominant variants that partially alter gene function or dosage may lead to ocular disease, while total LOF may lead to syndromic disease: doi.org/10.1172/jci....

I am so excited to share this work from my PhD which has now been published in @insight.jci.org ✨ In this study, we used IFN-γ to induce trained immunity in human macrophages and enhanced their ability to kill M. tuberculosis and MRSA. Read more here: insight.jci.org/articles/vie...

Lysosomal dysfunction is associated with multiple inflammatory diseases Barbara J. Vilen & team now show reduced late endosomes and lysosomes function promotes systemic lupus erythematosus through chronic PI3k activity and SHP-1/SHIP-1 defects: doi.org/10.1172/jci....

Despite decades of research on heatstroke, its pathogenesis remains largely unclear Zhang et al. report peripheral immune signatures of patients with heat stroke, identifying the NLRP3 inflammasome pathway as a potential target for treatment: doi.org/10.1172/jci....

In metastatic renal cell carcinoma, pancreatic spread is associated with improved survival Here, James Brugarolas & team report on the determinants of pancreatic tropism in mRCC, revealing that pancreatic metastases arise predominantly from indolent clones: doi.org/10.1172/jci....

Technical Advance 🙌 Vihma et al. establish a multimodal dual-reporter mouse that accelerates Angelman syndrome therapeutic development via scalable cell-based screening, whole-brain mapping, live imaging, & sorting neurons with unsilenced paternal Ube3a: doi.org/10.1172/jci....

Important for the prevention and management of mineral/bone disorders from chronic electrolyte imbalance👇 Murali et al. show that a diet low in potassium causes bone loss in mice, effects that are attributable to altered calcium absorption by the kidney: doi.org/10.1172/jci....

Revealing lysine-specific histone demethylase 1a as a new target for kidney diseases Tobias B. Huber & team show LSD1 regulates kidney development, and its dysfunction disrupts key kidney cells, leading to cyst formation in mouse and organoid models: doi.org/10.1172/jci....

Incredibly proud that my dissertation work is now published! We learned some pretty cool things about how itaconate functions differently in human macrophage populations. Thank you @michaelglickman.bsky.social for being such a wonderful mentor throughout my studies!