Animal studies clarify how vaccines protect, but limited human correlates complicate interpretation Kate Bridges et al. now show cross-species blood transcriptional correlates of BCG-mediated protection include innate & adaptive immune processes: doi.org/10.1172/jci....

The first article of my PhD has been published! 🤩

Celebrating 10 years of JCI Insight! The video highlights selected covers through the years — Music: Bensound; License code: LDOZSSOUYFKAOLR8; Artist: Theatre Of Delays

Count down: Our top 5 most-accessed manuscripts of 2025! #1: Human Pegivirus alters immune and transcriptomic profiles in brain and blood of Parkinson's Disease patients: insight.jci.org/articles/vie... @igorkoralnik.bsky.social @nmneurology.bsky.social

Count down: Our top 5 most-accessed manuscripts of 2025! #2: Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice: doi.org/10.1172/jci....

Count down: Our top 5 most-accessed manuscripts of 2025! #3: NAD+ prevents chronic kidney disease by activating renal tubular metabolism: doi.org/10.1172/jci....

Count down: Our top 5 most-accessed manuscripts of 2025! #4: AAV-mediated base editing restores cochlear gap-junction with a GJB2 dominant-negative mutation causing syndromic #hearing loss: doi.org/10.1172/jci....

Count down: Our top 5 most-accessed manuscripts of 2025! #5: An insider’s guide to understanding and obtaining an NIH K career development award: doi.org/10.1172/jci....

Here is a solid sub-analysis of a landmark clinical trial✨✨ Johann de Bono & team reveal circulating tumor cells with features of chromosomal instability predicts resistance to chemotherapy in patients with prostate cancer: doi.org/10.1172/jci....

In #Sjögren’s disease CD4+ T cells infiltrate the salivary glands, but little is known about their distinguishing receptors. Here, A. Darise Farris & team provide a comprehensive characterization comparing tissue and blood samples: doi.org/10.1172/jci....

When to target the most abundant protein in the heart? @droch.bsky.social & team show myosin becomes maladaptive in X-linked myotubular myopathy, consuming excessive energy, and inhibiting its ATPase activity in mice partly rescues the molecular defects: doi.org/10.1172/jci....

KID mutations in mice provide insight into the insulin/IGF1R paradox of aging Here, Andrey A. Parkhitko & team show mutation in kinase insert domain (KID) of IR or IGF1R produces features of long-lived mice while maintaining metabolic health: doi.org/10.1172/jci....

A strategy to protect pancreatic beta cells from lipotoxicity… This Issue’s Cover: Kyu-Sang Park & team show that palmitate triggers ROS-induced Ca2+ overload and mTORC1 activation at the lysosomal membrane, resulting in autophagy defects: doi.org/10.1172/jci....

The BabyGRO cohort included 80 children born at term following pregnancies with suboptimal fetal growth risk Reena Perchard & team report genes connecting poor growth in the womb to higher BP in children & teens, helping detect heart health risks earlier: doi.org/10.1172/jci....

ICYMI: After blood stem cell transplants, T cells change metabolism Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci.insight.192774

From earlier this week: A power move in the study of sepsis-associated acute kidney injury Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci.insight.177004

Should we treat blood donors with iron? Steven L. Spitalnik & team report on a double-blind randomized trial for iron-deficient blood donors, finding treatment appears to affect brain function, brain iron, and myelin levels: doi.org/10.1172/jci....

After blood stem cell transplants, T cells change metabolism Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci....

Enhancing antibiotic efficacy in sepsis Daniele G. Souza & team find BDKRB1 activation contributes to sepsis-induced hyperinflammation and impairs neutrophil migration via PI3Kγ & CXCR2—with its pharmacological inhibition improving survival in mice: doi.org/10.1172/jci....

A new therapeutic target in renal clear cell carcinoma Boa Kim & team report on a mechanism underlying kidney tumor cell growth involving the cancer-driving protein HIF2α that blocks clustering/activation of glutaminase: doi.org/10.1172/jci....

A power move in the study of sepsis-associated acute kidney injury Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci....

From earlier this week: You're only as old as your organs Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci.... The figure shows a spider plot of three patient clusters.

Previously shared: A study to take to heart This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....

Could TRPV4 blockers benefit patients with pancreatic cancer? ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....

In a new @insight.jci.org study co-led by @yaleneuro.bsky.social's Amy Arnsten, @yaleschoolofmed.bsky.social researchers uncover how the brain 🧠 uses GLO1 protein to buffer calcium buildup & protect 🛡️against neurodegenerative diseases like #Alzheimer's! More 👇 medicine.yale.edu/news-article...

You're only as old as your organs Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci.... The figure shows a spider plot of three patient clusters.

Researchers make strides toward preventing #parenteralNutrition-associated #liverDisease. G. Guthrie, D. Burrin et al #BCMDeptMedicine @insight.jci.org @bcmhouston.bsky.social blogs.bcm.edu/2025/12/09/f...

A ten-year analysis of #HIV-1 reservoir cells in two elite controllers ASCI member Xu G. Yu & team @BrighamWomens discover elite controllers possess fewer genome-intact proviruses in lymphoid tissues than in blood, and these proviruses decline over time: doi.org/10.1172/jci....

Advanced methods allow a deeper understanding of T cells that guide antibody responses in malaria Here, @drmichelleboyle.bsky.social & team use scRNAseq & spectral flow cytometry to identify two Tfh2 cell phenotypes that associate with Ab-mediated immunity in malaria: doi.org/10.1172/jci....

New publication in @insight.jci.org! 🎉 We uncover a key role for #Nectin-4 in #PancreaticCancer, opening the door to new therapeutic strategies. Read the full paper here: insight.jci.org/articles/vie... Stay tuned — our multicenter phase II clinical trial #NEC4NEOP is coming next year! 🔬✨

Co-first authors Emmanuel Rapp and Jiayi Pang tell us about their discovery on Carnosic acid in topical rosemary extracts and how it reduces scar formation in injured skin: doi.org/10.1172/jci....

JCI Insight - Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism insight.jci.org/articles/vie...

Turning over a new leaf in skin healing Thomas H. Leung & team show carnosic acid in topical rosemary extract reduces scar formation in injured mouse skin: doi.org/10.1172/jci....

Our latest work used Phip-Seq to explore the autoantibody repertoire in rheumatic fever ➡️ saw evidence of epitope spreading and identified a new disease associated antigen with biomarker potential 🧪 Great collaboration with MSSM and led by @rhcmcg.bsky.social and @laurencarlton.bsky.social at UoA

A study to take to heart This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....

A minimally invasive method for diagnosing inherited retinal diseases. Using a CRISPRa-based approach, Elvir Becirovic & team activated retinal disease-related genes in isolated human blood and skin cells, establishing a diagnostic strategy. insight.jci.org/articles/vie...

New paper out in JCI Insight: PhIP-Seq uncovers marked heterogeneity in Acute Rheumatic Fever Autoantibodies. ARF is a serious sequela of Strep A infection. While autoantibodies are known to drive pathogenesis, the specific human protein targets remain unclear. Link: doi.org/10.1172/jci.... 1/5

Previously shared: In cancer, persister cells are drug-tolerant and grow after treatment ends. Here, David J. Kwiatkowski & team discover mTORC1 inhibitor persistent cells rely on the mitochondria and are sensitive to copper-induced cell death: insight.jci.org/articles/vie...

From earlier this week: Averting atrial fibrillation-induced neurocognitive and vascular dysfunction… Elaine Y. Wan & team show reduction of mitochondrial ROS prevents vascular dysfunction, restores perfusion & improves cognitive flexibility in a mouse Afib model: insight.jci.org/articles/vie...

@DanKellyPennCVI.bsky.social show mice without the transcriptional corepressor RIP140 in muscles have enhanced endurance that exercise further enhances, providing a target for age-related sarcopenia and other muscle diseases. insight.jci.org/articles/vie...

In cancer, persister cells are drug-tolerant and grow after treatment ends. Here, David J. Kwiatkowski & team discover mTORC1 inhibitor persistent cells rely on the mitochondria and are sensitive to copper induced cell death: insight.jci.org/articles/vie...

New research out in @insight.jci.org finds that carnosic acid in topical rosemary extract enhances skin repair via TRPA1 activation ft. Emmanuel Rapp, Jiayi Pang, Stephen Prouty, Thomas Leung (Dermatology) & Borna Saeednia (@pennchemistry.bsky.social) insight.jci.org/articles/vie...

Effective healing of diabetic wounds involves myofibroblasts that contract to aid in wound closure. Here, Katherine Gallagher & team show fibroblasts from diabetic wounds have increased Setdb2, which represses the fibroblast-to-myofibroblast transition: insight.jci.org/articles/vie...

The HOXB13 gene is downregulated in ~30% of metastatic castration-resistant prostate cancer tumors. Here, Jindan Yu & team show HOXB13 loss promotes metastasis in prostate cancer, revealing a therapeutic vulnerability to p300/CBP inhibition: insight.jci.org/articles/vie...

Averting atrial fibrillation-induced neurocognitive and vascular dysfunction… Elaine Y. Wan & team show reduction of mitochondrial ROS prevents vascular dysfunction, restores perfusion & improves cognitive flexibility in a mouse Afib model: insight.jci.org/articles/vie...

Our top-read research article this month... Stimulation of skeletal stem cells in the growth plate promotes linear bone growth: insight.jci.org/articles/vie...

From earlier this week: This issue’s Cover: @ebrahim-lab.bsky.social @dominikrobak.bsky.social & team report on the septin cytoskeleton at apical junctions of intestinal epithelial cells, whereby it maintains barrier integrity & protects from inflammation: insight.jci.org/articles/vie...

Even mild vitamin A deficiency delays wound healing… Here, Sabine Werner & team use a multi-omics approach combined with functional studies in mouse models, identifying retinol metabolism as a key pathway in wound repair. insight.jci.org/articles/vie...

A new way to approach genotype-specific therapy ASCI member Bjorn C. Knollmann & team present a two-step high-throughput approach for drug repurposing, identifying evacetrapib as a potential treatment for the channelopathy Long QT Syndrome (#LQTS): insight.jci.org/articles/vie...

These images show before and after treatment in the same eye of a retinal cystoid edema model Here, Harald J. Junge & team introduce a cystoid edema mouse model, identify roles of C1q, and show that a FZD4/LRP5 agonist resolves cystoid edema: insight.jci.org/articles/vie...