Researchers at Karolinska Institutet have identified small molecules capable of influencing a hard-to-target receptor family linked to #cancer development. The findings have been published in @natcomms.nature.com and the Journal of Biological Chemistry 🧪 #pharmacology news.ki.se/cracking-the...

Researchers at KI and @kthuniversity.bsky.social have developed a computational method that reveals how cells change and specialise. It can provide important knowledge about why this process sometimes goes wrong and leads to disease. Published in @pnas.org 🧪 #CellBiology news.ki.se/new-algorith...

KI researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase in action, revealing how this essential mitochondrial enzyme degrades RNA through an elegant base-flipping mechanism. Published in @narjournal.bsky.social 🧪 #mitochondria doi.org/10.1093/nar/...

KI researchers report that human oligodendrocyte progenitor cells help eliminate synapses, highlighting a key mechanism in early #BrainDevelopment. The study was done on advanced human brain organoids, and was published today in @natcomms.nature.com 🧪 #Neuroscience news.ki.se/new-clues-to...

A study in @pnas.org reveals that conscious awareness is tightly linked to our sense of bodily self. Using bodily illusions and computational models, researchers show body ownership relies on conscious processing – reshaping theories of #Consciousness and self-perception 🧪 news.ki.se/new-study-re...

A new study published in Neurology shows impaired kidney function raises most #Alzheimers blood biomarkers, including p-tau217, but doesn’t increase dementia risk – though it may speed symptom onset. #Nephrology 🧪 news.ki.se/kidney-healt...

A KI study in @alzdemjournals.bsky.social shows that common conditions like kidney disease, diabetes or vascular problems can affect #Alzheimers blood biomarkers. Adjusting for these improves test precision, with p-tau217 as the most reliable marker for brain changes 🧪 news.ki.se/study-finds-...

A large international study published in @thelancetoncol.bsky.social shows AI can detect #PancreaticCancer on routine CT scans with higher accuracy than radiologists (AUROC 0.92 vs 0.88). This suggests AI could enable earlier diagnosis and better outcomes. #AIinMedicine 🧪 doi.org/10.1016/S147...

Researchers have performed a large-scale genetic screen to uncover the hidden roles of #microproteins. One of the discovered microproteins, named PIPPI, was found to protect cells from stress in the endoplasmic reticulum. Published in @narjournal.bsky.social 🧪 #proteomics news.ki.se/new-micropro...

A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...

Maternal #diabetes may predispose sons, but not daughters, to early #cardiovascular dysfunction, even without metabolic disease. Study in @cp-cellrepmed.bsky.social by @qiaolindeng.bsky.social and @zhaoallan.bsky.social highlights oxidative stress as a key driver🧪 news.ki.se/sons-of-moth...

A new study by @tetsuichi.bsky.social et al published in @natgenet.nature.com shows that human blood #stemcells have stable, intrinsic lineage biases. Some replenish all blood cell types, others only a subset. These patterns persist over decades and after transplantation 🧪 #bloodcancer rdcu.be/ePlJW

A study by @borgkvistlab.bsky.social published in Science Advances shows that dopamine modulates basal ganglia output not via DA receptors, but through serotonin and 5-HT1B activation. Findings in mice suggest a new mechanism relevant to #Parkinsons therapy. #Neuroscience 🧪 doi.org/10.1126/scia...

Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...

New cryo-EM structures of HSV-1 origin-binding protein reveal how herpesvirus initiates DNA replication, offering new antiviral targets beyond DNA polymerase. Study published in @narjournal.bsky.social 🧪 academic.oup.com/nar/article/...

Adrenal glia-support cells act as hidden #stemcells that regenerate tissue, but can also initiate adrenal #cancer. A new study in npj Precision Oncology by @schlisio-lab.bsky.social reveals a DLK1-NOTCH switch, deciding whether the cells build healthy tissue or fuel disease 🧪 doi.org/10.1038/s416...

The specific weight loss properties of GLP-1R agonists are key to improving neurological recovery after #stroke in diabetic mice, according to a new study from Karolinska Institutet and Södersjukhuset published in @diabetologiajnl.bsky.social 🧪 #diabetes doi.org/10.1007/s001...

A new type of #MRI technique that detects subtle changes in the brain’s microstructure can identify early signs of hereditary frontotemporal #dementia, according to an international study led by KI researchers. The study is published in Molecular Psychiatry 🧪 news.ki.se/new-brain-im...

A new KI study published in Nature Immunology shows that CD56bright #NKcells temporarily reside in our organs and then leave them via the lymphatic system. The results change our understanding of how the immune system works in human organs. #Immunology 🧪 news.ki.se/the-immune-s...

AI can increase access to #CervicalCancer screening in low-resource settings, but the technology requires investments throughout the entire healthcare chain to be effective. New study from KI, Uppsala University and @helsinki.fi published in @bmj.com today 🧪 #GlobalHealth news.ki.se/ai-can-impro...

Eating a healthy plant-based diet may lower the risk of #dementia in older people with cardiovascular diseases, type 2 diabetes, or stroke, and the quality of the plant-based diet could be crucial. This is according to a new KI study published in JACC: Advances 🧪 news.ki.se/plant-based-...

KI researchers comment on this year’s #NobelPrize in Physiology or Medicine. The prize rewards discoveries that reveal how our immune system is kept in check, paving the way for possible new therapies for cancer and autoimmune diseases like type 1 diabetes and MS 🧪 news.ki.se/nobel-prize-...

A study published in @pnas.org by Marie Wahren-Herlenius and colleagues at KI and @liu.se reveals that a gene associated with several rheumatic diseases affects how cells move, providing new insights into disease mechanisms and potential future therapies 🧪 #rheumatology news.ki.se/gene-linked-...

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...

In a new study published in @natcomms.nature.com, researchers have investigated how the physical structure of fat tissue helps ovarian cancer cells invade the body, offering potential new treatment strategies 🧪 rdcu.be/eIJna

A study in @ofidjournal.bsky.social demonstrates the feasibility of detecting Mycobacterium tuberculosis DNA in respiratory aerosols using the TB Hotspot detectOR (THOR) in primary care. This method could help identify infectious TB cases. #Tuberculosis 🧪 academic.oup.com/ofid/advance...

Tumour cells grow not only in the connective tissue-rich environment typical of #PancreaticCancer, but also in damaged parts of the pancreas. This may play a role in how tumours in the pancreas develop and respond to treatment. New study published in @natcomms.nature.com 🧪 news.ki.se/tumour-cells...

A new study published in @thelancet.bsky.social discusses the efficacy and controversies of anti-β amyloid monoclonal antibodies in treating #AlzheimersDisease. The findings highlight the potential and challenges of these treatments 🧪 www.thelancet.com/journals/lan...

A study in @jamanetworkopen.com shows that women with premenstrual disorders (PMDs), particularly PMDD, have significantly lower quality of life compared to those without PMDs. This highlights the need for better healthcare and social support for affected women. 🧪 jamanetwork.com/journals/jam...

Researchers at KI, @uu.se and Northwestern University have identified a new way to protect the kidney’s blood vessels and reduce tissue damage in chronic #kidneydisease. The findings are published in @jclinical-invest.bsky.social. #Nephrology 🧪 news.ki.se/new-antibody...

Wallenberg Scholar Rickard Sandberg @ki.se aims to deepen our understanding of how the brain’s synapses develop by mapping gene activity in neurons. To achieve this, he is developing new methods of exploring the uncharted field of splicing #research @rickardsandberg.bsky.social tinyurl.com/mtpde34z

By 2021, 15% of young women in Stockholm identified as bisexual – a group facing greater mental health and social challenges than their heterosexual and homosexual peers. New KI study published in @amjpublichealth.bsky.social. #Sexuality #LGBTQ 🧪 ajph.aphapublications.org/doi/epdf/10....

The Iberian ribbed newt has the ability to heal its own heart after an injury. The secret might lie in a specific protein also found in humans. Elif Eroglu @ki.se studies salamanders to discover new ways of regenerating our heart cells after a #heartattack. #research #medicine tinyurl.com/mssmcmc2

A study from KI & @helsinki.fi published in @cp-cellrepmed.bsky.social shows that low interferon type I activity in ovarian cancer cells predicts poor response to platinum-based chemotherapy. Stimulating this pathway may improve outcomes for chemo-refractory #OvarianCancer 🧪 doi.org/10.1016/j.xc...

A study shows that cancer screening not only reduces the risk of dying from cancer – it also does not increase the risk of dying from other diseases. The results counter previous criticism of benefits and safety of screening. Published in ‪@jamainternalmed.com‬ 🧪 jamanetwork.com/journals/jam...

Frequent dried blood spot sampling in mice reveals transient proteomic changes that enable early prediction and prevention of #Type1Diabetes. The study is published in Diabetologia by researchers at KI, @kthuniversity.bsky.social and @scilifelab.se. #Proteomics #Diabetes 🧪 doi.org/10.1007/s001...

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

A new study in ‪@natbiomedeng.nature.com‬ introduces GenomePAM, a method for direct PAM characterization in mammalian cells. This technique leverages genomic repetitive sequences and does not require protein purification or synthetic oligos. #GenomeEditing #CRISPR 🧪 www.nature.com/articles/s41...

Wallenberg Scholar @gocastelobranco.bsky.social @ki.se is seeking to discover what happens in the brain during the progression of #multiplesclerosis (MS). His findings may lead to new ways of diagnosing and treating the disease earlier than is currently possible #research tinyurl.com/3kb22kkh

A new study in reveals three distinct genetic subtypes of follicular lymphoma, aiding in better diagnosis and personalized treatment. This could significantly improve patient outcomes. Published in ‪@cp-cellrepmed.bsky.social‬ 🧪 #Lymphoma #Genetics www.cell.com/cell-reports...

A new study published in Modern Pathology reveals that the growth pattern of breast cancer tumors after neoadjuvant treatment can indicate the risk of recurrence. This insight is crucial for assessing patient prognosis 🧪 #BreastCancer #Oncology www.modernpathology.org/article/S089...

Researchers have discovered a previously unknown molecule that may explain why people with type 2 diabetes often suffer from muscle weakness and muscle loss – a condition that has a major impact on quality of life. Research by @annakrook.bsky.social et al 🧪 news.ki.se/newly-discov...

A new study shows that artificial intelligence (AI) combined with portable digital microscopy improves the detection of intestinal worm infections, so-called soil-transmitted helminth (STH) in resource-limited settings. Published in Scientific Reports 🧪 news.ki.se/ai-microscop...

A new study has identified 18 potential drug targets for the treatment of multiple sclerosis, MS. The study may pave the way for new treatment strategies and drug development. Published in the journal ‪@pnas.org‬ 🧪 news.ki.se/new-potentia...

There is a perception that drugs such as ibuprofen and SSRI can trigger microscopic colitis (MC). However, a new study suggests that this is not the case – meaning that patients with MC do not need to stop taking these medications. Published in ‪@annalsofim.bsky.social‬ 🧪 news.ki.se/no-evidence-...

A study shows that both cognitive behavioral therapy (CBT) and an active online control treatment lead to significant improvements for people with stress-related disorders – but the effect varies depending on the diagnosis. Published in Psychotherapy and Psychosomatics 🧪 news.ki.se/internet-bas...

A new study in JAMA Psychiatry shows that while #ADHD medication still helps reduce the risk of self-harm, injury, traffic accidents and crime, its protective effects have diminished over time as ADHD medication use in Sweden has broadened to a wider group of patients 🧪 news.ki.se/adhd-medicat...

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/...

Long-term Western diet impairs islet blood vessel function and #insulin transport even after diet reversal and weight loss, according to a new study from researchers @ki.se #research supported by Knut and Alice Wallenberg Foundation #diabetes #medicine #obesity #metabolism tinyurl.com/yembuj9r

A KI study published in the British Journal of #Dermatology shows that patients with mycosis fungoides or Sézary syndrome face notably increased mortality, especially from #lymphoma and infections, highlighting the need for closer monitoring in severe cases 🧪 academic.oup.com/bjd/advance-...