New atlas shows how adult brain cells retain traces of their development. 🧪 “For this #SingleCell #epigenomic mapping of the human brain, extensive #DNAsequencing was required,” says @gocastelobranco.bsky.social More here ↓ www.scilifelab.se/news/new-atl...

KI researchers have created a detailed map showing how genetic activity is controlled in individual cells of the adult human #brain and #spinalcord. Oligodendroglia retain an epigenetic memory of developmental programs long after these genes are no longer active 🧪 news.ki.se/new-map-reve...

Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! www.nature.com/articles/s41...

Check our latest preprint, Christoffer et al. at our lab developed KaroSpace, with which you can quickly generate a browser to explore your own or published spatial omics data! And here goes my soundtrack to spatial explorations, DJ-Kicks by Erlend Øye youtu.be/naKrdCozPUg?...

Congrats @patrikernfors.bsky.social!!! Our head of the MolNeuro unit at @ki.se, an inspiration to all of us!

Registration for Single Cell Biology 2026 is now open! #SingleCell26 Join us as we explore new single cell research insights and discoveries beyond the traditional model organisms🧬 🗓️ 10-12 June 📍 Wellcome Genome Campus, UK Bursaries available 📎 bit.ly/4pyTK21#SingleCell26#SingleCell #Spatial #Genomics

Curling kick off 2026 of our Molecular Neurobiology unit @ki.se! @hjerling-leffler.bsky.social @onurdagliyan.bsky.social @patrikernfors.bsky.social @matzag.bsky.social @gvolkmer.bsky.social ...and many others!

A super intense and fantastic sunny week in Alicante discussing single cell and spatial omics in the CNS! Thanks all the students for lots of discussions, great flash talks and lots of fun in the social activities, the local organizers, aka @silviadesantis.bsky.social and my co-chair Ana Falcão.

This week, the #FENS-Hertie #WinterSchool 2025-2026, “Single-Cell and Spatial Omics to Understand Brain Heterogeneity”, is taking place in Alicante. 🇪🇸 🧠 Monday's programme kicked off with a session led by Bosiljka Tasic, followed by Gabriel Santpere Baró, and a roundtable discussion.

Now online! Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

My 2025 soundtrack, with the music I was listening to for our papers, preprints, etc, including Sonic Surf City's Surfing Santa (by Ola Hermanson)... for Ola. open.spotify.com/playlist/5ts... Happy Xmas and 2026!

SciLifeLab PULSE postdoc program, our lab can be one of the hosts!

Physiology or Medicine Nobel Lectures 2025 at @ki.se , with the key experiments and notes leading to the Tregs discovery!

First paper from the lab is now online @natneuro.nature.com ! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1

🧬 Gonçalo Castelo-Branco | Plenary Speaker How do glial cells influence disease and brain repair? On 10 July at #FENS2026, join Prof. Gonçalo Castelo-Branco to explore the molecular mechanisms behind #oligodendrocyte lineage cells in development and #neuroinflammatory diseases.

A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...

Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com! Check it out at: www.nature.com/articles/s41... with @pkukanja.bsky.social, @deckardw.bsky.social, among others

Our latest, a tour de force from @carlstrom.bsky.social ! And here is my soundtrack for the journey, The Bike Song, by Mark Ronson and The Business Intl, dedicated to Karl's bike! youtu.be/rVELTxKRoHA?...

Join us for the inaugural annual Ernest Arenas Memorial Lecture at the Nobel Forum at @ki.se. with Prof. Roger Barker, University of Cambridge "Repairing the human brain using transplants - is it possible? The story of Parkinson's disease" Tuesday November 25th at 15:00 news.ki.se/calendar/the...

Researchers @ki.se and Yale University have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation #research supported by Knut and Alice Wallenberg Foundation #MS #neuroscience @gocastelobranco.bsky.social news.ki.se/scientists-m...

Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Fantastic Gioele!

Developing Brains on!

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...

@peruhlen.bsky.social @ki.se news.ki.se/from-a-crash...

Ana Falcão's lab latest on multi-omics profiling of the Lateral Ventricle Choroid Plexus! @icvs-uminho.bsky.social www.biorxiv.org/content/10.1...

Deadline (September 2) approaching! Join us and start your lab at @ki.se!

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

Wallenberg Scholar @gocastelobranco.bsky.social @ki.se is seeking to discover what happens in the brain during the progression of #multiplesclerosis (MS). His findings may lead to new ways of diagnosing and treating the disease earlier than is currently possible #research tinyurl.com/3kb22kkh

Join us at the FENS Single-Cell & Spatial Omics Winter School with: @sarabiz86.bsky.social @rongfan8.bsky.social @gokcegroup.bsky.social @gioelelamanno.bsky.social @sj-marzi.bsky.social @jplopez-atalaya.bsky.social Ana Falcão Florian Rosenberger Gabriel Baró Bosiljka Tasic Barbara Treutlein

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)

🚨 Don’t forget to register for #Neuroepi25! ⏳ The deadline is fast approaching - Thursday 7th August 2025. This is your last chance to join; don't miss out on a fantastic meeting! Click here to register➡️ bit.ly/4f5Zpbq #FusionNeuro #FusionAgingResearch #FusionEpigenetics

12th Dev Brains: @junyuecao.bsky.social @alainchedotal.bsky.social @cecilecharrier.bsky.social @trayon.bsky.social Isabel Espinosa-Medina Beatriz Rico Michael Ziller Dwight Bergles news.ki.se/calendar/dev... @hjerling-leffler.bsky.social @ulrikakmarklund.bsky.social @flallemend.bsky.social

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

@carlstrom.bsky.social Clemens Ries, and Ting Sun rocking at #GLIA2025! And the launch of the Carlström lab!

Great to catch up with @rongfan8.bsky.social in Marseille, where we both end up for two completely unrelated conferences!

The call just opened! ki.se/en/about-ki/... You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics ki.varbi.com/what:job/job...

Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.

Come and join us! Start your group at Karolinska Institutet @ki.se!

📢 Big news! #Neuroepi25 has just released the final programme! 👉 Check it out now on the conference website ✅ And don't forget to register - this is a conference you won’t want to miss! Click here for more information: bit.ly/3SWoIlO

Have you registered yet for #ReThinkNeuroimmunology in October? Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more

Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...

Join us for the 2025 GRC Genome Architecture www.grc.org/genome-archi... @spp2202.bsky.social @jobdekker.bsky.social @metorrespadilla.bsky.social @jopkind.bsky.social @dimplenotani.bsky.social @stanleyqilab.bsky.social @andybelmont.bsky.social @fondufemittendorf.bsky.social @boyanbonev.bsky.social

Happy to share that I will kickstart my research group at @ki.se this autumn!🎉🎉 Are you interested in glial biology, using high-end tools for gene and cell programming to study metabolic and epigenetic interactions? Stay tuned! Will be 🔭 for RA, PhD-students & postdocs! Let the journey begin! 🧬🧫🔬

Today!

Night science is improvisations, openness, import/export, puzzle switching, hypothesis liabilities, anthropomorphisms, finding questions, contradictions & awe in science; as we discussed in the legendary Karolinska Institute. 🙏 @kragesteen-lab.bsky.social Christoph Ziegenhain & Rickard Sandberg

It was amazing to do a Night Science workshop today at the Karolinska Institute in Stockholm!

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...