Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...

✨Hello folks!✨ We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦 "Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches" 🔗http://bit.ly/49syndi Read our overview below! 🧵1/6

Hey bsky-ers! New preprint from the lab on #psilocybin & social behaviour in #female mice in contexts relevant to eating disorders (food restriction, exercise & combo of) by PhD student Sheida 💙🦋

Final speaker in the first session of (news.ki.se/calendar/dev...) with Michael Ziller (Muenster) talking about functional genomics of scizophrenia

Next up in our great line up at Developing Brains (news.ki.se/calendar/dev...) is Beatriz Rico (King’s College)

Kicking off the 12th edition of the Developing Brain Conference (news.ki.se/calendar/dev...) with Cecile Charrier (ENS).

A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible! www.sciencedirect.com/science/arti...

Having a great time at the HiiLIFE Science Days at @Helsinki.fi Gracious hosts, beautiful venue, fantastic science and plenty of real coffee.

Incredibly proud of @kxhuang.bsky.social for persisting with such a challenging dataset from her PhD! We found some intriguing genetic targets in a corticostriatal circuit that may be involved in the development of #anorexia nervosa 🤔 onlinelibrary.wiley.com/doi/10.1002/...

How do neutrophils contribute to mental health? Delighted to share research led by @staceykigar.bsky.social: meningeal neutrophils shape how the brain responds to stress. Out today @natcomms.nature.com. More in the thread⬇️ @psychiatry-ucam.bsky.social @medcambridge.bsky.social @camneuro.bsky.social

Understanding why antidepressants don't always work 🧠🛡️ New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression. 📖https://bit.ly/469cXyI

New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Wow Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions ki.se/en/about-ki/...

Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...

I definitely never regretted the decision to leave New York for Stockholm and Karolinska - now you can join us: big call for assistant professors across medical disciplines coming up. news.ki.se/ki-to-recrui...

#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience! Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia. Sharing appreciated, and happy #FluorescenceFriday !

Our study on the impact of altered serotonin (5-HT) signalling on the developing sensory cortex is now live at Nature Comms. We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.

While commercialization and decreasing costs has democratized access to genomics and transcriptomics techniques for many, including in the neurosciences (good thing), there's been, IMO, some issues in adoption without corresponding best case analysis practices from the genomics field (bad thing)

Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...

Happy to share that I will kickstart my research group at @ki.se this autumn!🎉🎉 Are you interested in glial biology, using high-end tools for gene and cell programming to study metabolic and epigenetic interactions? Stay tuned! Will be 🔭 for RA, PhD-students & postdocs! Let the journey begin! 🧬🧫🔬

Lastly to round up the 🧵: Science works doesn't mean every scientific study produces a fact ready for public consumption. Scientific work is incremental, iterative, nonlinear, slow, imperfect, relentless. Continuous improvement upon what was. Science works not despite but because of many failures.

At times like these it's important to remember the 3 branches of science

A recent preprint from the lab. Turns out biology trumps technical measures for benchmarking of transcriptomics.

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

Detta är ett allvarligt underbetyg för 🇸🇪. Det är många aspekter som spelar in här: den stramare migrationspolitiken, informella värderingar som gör det svårt att komma in i det svenska universitetsväsendet utifrån & en slutenhet som tex illustreras av att Etikprövning bara kan göras på svenska.+

Check out this cool work from my superstar student Elie developing a new dimensionality reduction algorithm that compares two conditions! It works on many types of data

Does your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747 This tool was born out of necessity, here is the story. 🧵 1/

We are looking for a PhD student! If you are interested in Drosophilids, systematics, bioinformatics, fiddling with museum specimens of old/weird flies, and chemosensation, then maybe this is for you! Please rebutterfly(?)! Apply below. lu.varbi.com/en/what:job/...

👇🏻Looking for a postdoc position? Want to do some truly innovative research on schizophrenia and the adolescent 🧠? How about a great boss? Jens has it all! Check it out.

Alert! Postdoc positions available - at least two. Interested in coming to Karolinska and work on adolescent development/schizophrenia? Have a background in neuroscience, functional genomics, computational analysis or spatial transcriptomics? Large data sets available for analysis. Get in touch!

Are you a researcher active outside of Europe who might consider coming to Sweden? Check out this @vetenskapsradet.bsky.social grant for recruitment of international visiting researchers! www.vr.se/english/appl...

PhD Position Available! 🧑‍🎓🧠🧬 We’re looking for a motivated PhD student to join our team and explore the fascinating world of human brain development and evolution. su.varbi.com/what:job/job...

Hot off the press! 🧬🔬 We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ: doi.org/10.1126/scie...

Are you an established (”distinguished”) researcher outside Europe? Thinking of moving here for some reason? Grant opportunity just dropped: www.vr.se/english/appl...

Watch the video📽️attached to see what each of these awesome #FemsinSTEM are up to! 🧵3/3

One of Norway's largest fuel companies just announced that they will no longer refuel US Navy vessels after Trump’s treatment of Zelenskyy. “It made us sick... We encourage all Norwegians and Europeans to follow our example.”

Vance saying Sweden is backsliding on free speech, a country that will rigorously defend freedom of speech even at the expense of its own national security, while his own administration is deleting whole datasets and freezing research around words and ideas they don’t like, is simply projection.

'Did you even say thank you?'

I want to thank all the people moving through my lab and all my collaborators for making this possible! Time do get dr*nk!

We have a new Professor in the house @ki.se ! Congrats Professor Jens Hjerling Leffler @hjerling-leffler.bsky.social!

A great line-up of speakers for the "Blueprints of life: cell fate choices and lineages" conference @ki.se organized by @anderssonlab.bsky.social To register 👇 news.ki.se/calendar/blu...

⚠️Useful!⚠️ Protocol for assessing myelination by human iPSC-derived oligodendrocytes in Shiverer mouse ex vivo brain slice cultures by Themistoklis Tsarouchas, @erinmgibson.bsky.social @lidazoupi.bsky.social @annawilliamslab.bsky.social #neurosky www.sciencedirect.com/science/arti...

Check out our latest paper, led by our good friends from @ki.se Thuy-Dung and Lu Yi, about the #genetic basis of psychotic major depressive disorder #MDD, a rare subtype of #MDD characterised by psychotic symptoms that occur exclusively during mood episodes! www.sciencedirect.com/science/arti...

Just giving this a boost for those who may not have seen it yet... we have a PI position (molecular and cellular basis of cognition) at The Hospital for Sick Children (Toronto). The position comes with an appointment at Assist/Assoc Prof level at U of T. Share widely! can-acn.org/scientist-se...

Postdoc recruitment for an ERC-funded project! Are you eager to resolve embryonic cell fates with next generation single cell linege tracing? We use in utero barcoding & omics to map development, providing a basis for high throughput perturbations.. Pls re-post! Apply: ki.varbi.com/en/what:job/...

Excited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...

Excited to share our latest paper from a collab w Patrick Sullivan and others where results from two different data-driven approaches (GWAS/human-snRNAseq and fMRI) converge on the amygdala and hippocampus as key regions for schizophrenia: nature.com/articles/s41...

first thing to share here! excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning www.biorxiv.org/content/10.1...

Nature, nurture, or "not sure" Sorry.