So, who are the the Functional Genomics Working Group? 🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠 We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪 🧵1/3

The @fg-pgc.bsky.social is all about understanding how our genetic findings🔬translate into psychiatric conditions 🧠 We have 5 project groups, and we are excited to introduce the✨Functional Validation✨group first! We asked them for a status update and a highlight of the year...

The second of our 5 project groups we are thrilled to introduce is the✨Isoforms✨group! Isoforms are different versions of RNA transcripts or proteins🧬 They are a result of splicing✂️during gene expression and are an important part of how one gene can act in different ways!

Next up is the awesome✨Methylation-wide association studies✨group! AKA the MWAS group😉 #Epigenetics are changes that happen to DNA expression🧬without actually changing the sequence! Instead, these changes happen to molecules that are attached to the DNA - how cool 🤯!

Our fourth group is the ✨Multi-level Quantitative Trait Loci✨group! 🧬AKA themQTL group🧬 🔎QTL analysis is a way to understand how genetic sequences🧬affect gene expression... 🧐Think RNA transcripts and proteins! All these methods to understand genetics🤩

Before we get started, let’s introduce our two Social Media Reps - @natashaberthold.bsky.social and @evacschulte.bsky.social! We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part! 💫Check out their profiles💫

Check out our posts on the main @pgcgenetics.bsky.social account over the next two weeks!

✨Hello folks!✨ We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦 "Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches" 🔗http://bit.ly/49syndi Read our overview below! 🧵1/6

Happy #internationalwomensday for 2025 folks! 🎉 We hope you had a great day, and thought we’d celebrate some of our awesome #FemsinSTEM with you all👩‍🔬 🧵1/3

We are super excited to do our first BlueSky #science paper highlight! Shuyang Yao and @hjerling-leffler.bsky.social et al. have performed an awesome investigation🕵️of how #genetics may functionally affect brain connectivity in psychiatric disorders🧠 Check out the summary video and find the🔗below!

The PGC Functional Genomics workgroup serves as a dynamic hub for collaborative, open discovery science and scalable method development. We aim to understand how genes, cells and molecules impact the symptoms and course of psychiatric disorders in populations globally.