Kira Höffler
@kirahoeffler.bsky.social
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📥 222
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PhD research fellow @ University of Bergen 🇳🇴 | epigenetics in psychiatry 🧠🧬 | she/her
new
#preprint
: our epigenetic study on psychotherapy response in OCD is available on medRxiv - includes longitudinal analyses and integration with genetic data.
www.medrxiv.org/content/10.6...
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Epigenetic Markers of Response to Psychotherapy in Obsessive-Compulsive Disorder
Background Cognitive-behavioral therapy (CBT) is a widely used treatment for mental disorders, yet the biological mechanisms underlying its effects, and the factors contributing to response, remain po...
https://www.medrxiv.org/content/10.64898/2026.03.20.26348888v1
25 days ago
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Writing your PhD thesis in a windowless office with no daylight is not for the weak.
about 1 month ago
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I had the opportunity to present my PhD research at the Norwegian Institute of Public Health in Oslo today :)
2 months ago
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reposted by
Kira Höffler
Joni Coleman
2 months ago
Out earlier this week in
@natgenet.nature.com
: GWAS of major anxiety disorders in 122,341 European-ancestry cases identifying 58 loci (
www.nature.com/articles/s41...
) Awesome work, and great news for the anx genetics community — each
@pgcgenetics.bsky.social
paper seeds 100s more papers!
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Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling - Nature Genetics
Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism...
https://www.nature.com/articles/s41588-025-02485-8
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Happy and thankful for this award!☺️
3 months ago
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reposted by
Kira Höffler
ECNP
3 months ago
The
#ECNP
Roadmap Meeting on
#PrecisionPsychiatry
wrapped up yesterday ✨ Experts across science, clinical practice, regulation, industry & patient advocacy explored how to move
#biomarkers
from research to real‑world impact 🔍 Inspiring discussions and clear next steps 🚀
www.ecnp.eu/roadmap-meeting
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reposted by
Kira Höffler
Psychiatric Genomics Consortium (PGC)
4 months ago
🥁🎇✨ ... first up is KIRA HÖFFLER
@kirahoeffler.bsky.social
from the
#UniversityofBergen
in Norway and
#McLeanHospital
in Boston ! So tell us, Kira, what do you do in
#functionalgenomics
and @pgc_fg ?🤔 Any
#funfacts
#genetics
🐝❓ 🧵3/3
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reposted by
Kira Höffler
Dan Jagger
5 months ago
The human brain goes through distinct phases in life, with turning points at ages 9, 32, 66 & 83, scientists have revealed. ~4,000 people up to the age of 90 had scans to reveal the connections between their brain cells. We "peak" in our early 30s ... 🧪🧠
#neuroskyence
www.bbc.com/news/article...
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Four pivotal ages in your brain's development revealed in new scientific study
Brain scans on thousands of people reveal the dramatic shifts the brain goes through between birth and death.
https://www.bbc.com/news/articles/cgl6klez226o
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reposted by
Kira Höffler
PGC Functional Genomics
6 months ago
✨Hello folks!✨ We're back in your feed with an amazing paper spotlight by
@kirahoeffler.bsky.social
& colleagues📰🔦 "Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches" 🔗http://bit.ly/49syndi Read our overview below! 🧵1/6
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New method for DNA methylation studies 🧬: EpiAnceR+ improves ancestry adjustment without requiring genotyping data, while removing technical and biological noise. Easy to use in existing R pipelines.
link.springer.com/article/10.1...
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Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches - Epigenetics & Chromatin
Background Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs)...
https://link.springer.com/article/10.1186/s13072-025-00627-0#Sec27
6 months ago
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Curious whether response to psychotherapy in OCD can be predicted using clinical and DNA methylation data? Come see Poster 1️⃣ at
#WCPG2025
. I’ll be presenting our first machine learning findings!
6 months ago
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Back at my favourite conference
#WCPG2025
- this time in a slightly different setting (an all-inclusive beach hotel)
#cancun
#mexico
@ispg.bsky.social
6 months ago
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reposted by
Kira Höffler
Biological Psychiatry
7 months ago
The Biological Psychiatry family of journals is now officially on Bluesky! Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.
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Inspiring AI Cures Conference at MIT with stunning views of beautiful Boston.
7 months ago
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www.nature.com/articles/s44...
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A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison - Nature Mental Health
The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesti...
https://www.nature.com/articles/s44220-025-00486-4
7 months ago
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I find it somewhat disappointing that medRxiv does not accommodate the use of the "ö" in my surname and instead only allows the internationalized spelling.
9 months ago
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reposted by
Kira Höffler
Maximilian Rieger
9 months ago
Dieses Spiel werden die Beteiligten und Fans vorm Fernseher so schnell nicht vergessen. Drei Stunden komplett aufreibender Fußball.
#FRAGER
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reposted by
Kira Höffler
Prof Andy Field
10 months ago
After more than 7 years working on it, I’ve just submitted the manuscript for Discovering Statistics using R second edition. Tonnes more work on website/package and so on, but getting to this stage is monumental psychologically. It’s the book I feared I’d never finish.
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reposted by
Kira Höffler
Carolin Emcke
10 months ago
Und ich dachte bislang immer,
#CSD
und
#Regenbogenfahnen
stünden für die demokratische Tradition der Kämpfe um Anerkennung jener Rechte, die letztlich das Grundgesetz allen verspricht: Freiheit und Gleichheit und Unantastbarkeit der Würde.
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I got to meet Jacinda Ardern, my favourite politician and former Prime Minister of New Zealand, today. Just for that, moving to Boston was worth it. 😊
11 months ago
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reposted by
Kira Höffler
Magdalena Skipper
11 months ago
Women make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40%
#womeninSTEM
We want to change it, through targeted editorial policies & outreach. But change will take everyone! 🧪
www.nature.com/articles/d41...
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Gender equality in research publishing is a responsibility for everyone
A concerted effort is needed to support women in their choice of journal when submitting their manuscript.
https://www.nature.com/articles/d41586-025-01614-x
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reposted by
Kira Höffler
Jordan Smoller
11 months ago
Another breakthrough made possible by federal funding The result “is a triumph for the American peoples’ investment in biomedical research” Baby Is Healed With World’s First Personalized Gene-Editing Treatment
www.nytimes.com/2025/05/15/h...
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Baby Is Healed With World’s First Personalized Gene-Editing Treatment
https://www.nytimes.com/2025/05/15/health/gene-editing-personalized-rare-disorders.html?smid=bs-share
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reposted by
Kira Höffler
Abdel Abdellaoui
11 months ago
Check out our new OCD GWAS (53,660 cases and 2,044,417 controls) in
@natgenet.nature.com
🧬🧠 Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia. Open access:
www.nature.com/articles/s41...
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reposted by
Kira Höffler
Marietta Slomka
12 months ago
Margot Friedländer. So eine große Persönlichkeit. Bin traurig.
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reposted by
Kira Höffler
Mike Inouye
12 months ago
Big news for health data research and population diversity: The Mexico City Prospective Study data are now available securely to approved researchers worldwide.
www.ndph.ox.ac.uk/news/latin-a...
Cohort description:
www.ctsu.ox.ac.uk/research/pro...
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Latin-American genetic data available securely to approved researchers worldwide/Datos genéticos latinoamericanos disponibles para investigadores de todo el mundo
https://www.ndph.ox.ac.uk/news/latin-american-genetic-data-available-securely-to-approved-researchers-worldwide
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One sentence that stayed with me from the
#SOBP2025
fireside chat: 'Science cannot help society if it does not reflect society.'
12 months ago
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just deactivated my
#X
/Twitter account - feels great. honestly, I should’ve done it a while ago
12 months ago
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reposted by
Kira Höffler
Stephen Turner
about 1 year ago
Bioconductor 3.21 released with 72 new software packages, for a total of 2341 software packages, 432 experiment data packages, 928 annotation packages, 30 workflows and 5 books
bioconductor.org/news/bioc_3_...
🧬🖥️🧪
#Rstats
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Bioconductor - Bioconductor 3.21 Released
The Bioconductor project aims to develop and share open source software for precise and repeatable analysis of biological data. We foster an inclusive and collaborative community of developers and…
https://bioconductor.org/news/bioc_3_21_release/
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reposted by
Kira Höffler
Alicia Schowe
12 months ago
How did the COVID-19 pandemic affect epigenetic aging? Find out at poster S23!
#SOBP2025
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reposted by
Kira Höffler
Vera Karlbauer
12 months ago
Do adult blood-trained epigenetic measures generalize to child saliva? What does this mean for psychiatric epigenetics? Come find out and talk to me at poster S193 - now with new cross-tissue epigenome-wide results!
#SOBP2025
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#SOBP2025
Stop by poster 206 if you're interested in epigenetic markers for psychotherapy response - or just want to chat.
12 months ago
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One thing I did not expect to find in the US: better
#bike
infrastructure than in most European cities.
about 1 year ago
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Starting an exciting new chapter—I'll be spending all of 2025 in Boston as a visiting graduate student in the labs of Kerry Ressler and Torsten Klengel at McLean Hospital.
over 1 year ago
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work lunch with a view
#Bergen
over 1 year ago
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reposted by
Kira Höffler
Duncan Sproul
over 1 year ago
With some help from
@raduzabet.bsky.social
, I've created a starter pack of researchers working on
#Epigenetics
, Chromatin and Gene Regulation who are active on here:
go.bsky.app/TKp9YAn
I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.
add a skeleton here at some point
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Thanks to everyone who visited my poster at
#Epigenomics23
. It was a great conference, I really enjoyed it!
#epigenetics
#psychotherapy
#OCD
#DNAmethylation
over 2 years ago
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Evaluation of the new Illumina EPIC version 2:
epicom.biomedcentral.com/articles/10....
We used this array to measure DNA methylation in my PhD project.
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Comprehensive evaluation of the Infinium human MethylationEPIC v2 BeadChip - Epigenetics Communicati...
Infinium Methylation BeadChips are widely used to profile DNA cytosine modifications in large cohort studies for reasons of cost-effectiveness, accurate quantification, and user-friendly data analysis...
https://epicom.biomedcentral.com/articles/10.1186/s43682-023-00021-5
over 2 years ago
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Very grateful for their research! just got the XBB.1.5 update yesterday💉 #nobel #nobelprize
over 2 years ago
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