Electroconvulsive therapy triggers significant acute and sustained shifts in mitochondrial energy metabolism with reductions in ketone bodies seen specifically in patients whose depression improved.

Mindfulness-based cognitive therapy for recurrent depression changes how the brain shifts between neural states during rumination, with these brain changes linked to reduced rumination and fewer depressive symptoms three months later.

Two brain-based subtypes of depression show distinct electrical activity patterns that predict whether patients will respond to antidepressants versus placebo, highlighting the need for more personalized treatments.

People with bipolar disorder who have attempted suicide show reduced white matter integrity in the cingulum hippocampus, and these findings were replicated across two independent samples and linked to impulsive behavior.

Children whose brain structure more closely resembles their parent's psychosis-related brain patterns are more likely to develop psychiatric symptoms themselves, suggesting personalized, family-based brain comparisons could help predict who is most at risk for developing psychotic disorders.

Recent trauma exposure is linked to greater thickness in the primary visual cortex independent of PTSD symptoms, suggesting trauma may leave a distinct structural mark on early sensory brain regions.

Depressed older adults show smaller volumes in specific hippocampal subregions compared to healthy and recently remitted individuals, and these differences appear tied to the active depressive state rather than accelerated brain aging.

The habenula shows atypical connectivity with sensory regions in autistic individuals, and habenula circuitry develops differently among autistic adolescents, with links between habenula hyperconnectivity and social behaviors.

Children with autism and language delay show a distinct pattern of impaired brain microstructure in language regions that is linked to low iron and high lead levels.

Growing evidence suggests GLP-1 receptor agonists could be repurposed to treat stimulant and nicotine use disorders.

Continuous theta-burst stimulation (cBTS) targeting the prefrontal cortex reduced the risk of returning to heavy drinking over 12 months in people with alcohol use disorder.

Brain lesions associated with OCD map to a common network that aligns with brain imaging abnormalities and brain stimulation outcomes in patients with OCD.

Anxiety and depression appear more genetically distinct than previously thought, and much of their apparent genetic overlap may stem from including people who have both conditions in research studies.

A study of 12.6 million people across three generations found that older grandfathers on the maternal side, but not the paternal side, were linked to increased autism risk in grandchildren, suggesting genetic risk factors for autism can be passed down through the female lineage.

The heartbeat evoked potential, a brain signal reflecting heart-brain communication, has been proposed as a biomarker for various health conditions. However, a comprehensive meta-analysis finds too much methodological inconsistency across studies to draw firm conclusions about its clinical utility.

There are widespread disruption in emotion and reward circuits in individuals with bipolar disorder, with greater structural wiring abnormalities linked to longer illness duration, psychosis history, and certain medications.

Diagnostic criteria for autism and OCD are built largely around male presentations, contributing to underdiagnosis in females, gender-diverse individuals, and marginalized populations.

GLP-1 receptor agonists show promise as a new class of treatment for depression and bipolar disorder, with potential to target symptoms like anhedonia and cognitive impairment that current medications often fail to address.

A new framework reframes depression not as a disorder of negative thoughts but of cognitive flow. It proposes that depressed thinking is stuck, slow, and narrow, and treatments restoring the brain's ability to move fluidly between ideas may be key to recovery.

Losing just one night of sleep made adolescent rats seek out rewards more intensely for days afterward but blocking the brain's orexin system reversed this effect.

A specific set of neurons in the oval subnucleus of the bed nucleus of the stria terminalis drive hunger and ramp up during food restriction, offering a new target for understanding how the brain balances stress signals with the motivation to eat.

A review of 18 studies found no consistently reproducible subtypes of schizophrenia, suggesting that differences in brain structure across patients may reflect a spectrum rather than discrete biological categories.

People with PTSD exhibit poorer threat discrimination during fear learning, a deficit not seen with trauma exposure or anxiety alone, revealing a neural mechanism unique to PTSD.

Mothers with more post traumatic stress symptoms show blunted brain responses to their own baby's cries in salience and prefrontal regions. However, as their symptoms improve over the first year, these responses can recover, suggesting a treatable pathway for supporting both mom and baby.

In youth taking fluoxetine for depression and anxiety, drug levels in the brain or blood don't predict who gets better, but NAA/Cr levels do.

Excited to share a new commentary piece, now out in in @biologicalpsych.bsky.social: CNNI, discussing recent findings by Tsomokos et al. that examined how socioeconomic disadvantage relates to internalizing problems via pubertal effects on cortical thinning in adolescence!

GLP-1 receptor agonists show benefits for weight loss, heart and kidney protection, and potentially brain health and psychiatric conditions.

Among young people at high risk for psychosis, those who use both cannabis and tobacco together show worse cognitive performance than those using either alone.

We're inviting submissions for a Special Issue on Increasing the Ecological Validity of Biological Psychiatry! Learn more here: www.bpsgos.org/content/bpsg...

Teens with rising depressive symptoms show a progressive disconnection between brain regions involved in emotion regulation across adolescence, suggesting this shifting brain circuit could serve as a marker for youth depression.

Thank you to Mount Sinai Psychiatry and the Society of Biological Psychiatry for coming to NAMI-NYC for a special discussion on the intersection of neuroscience and mental health.

A combination of brain responses to alcohol cues, childhood trauma, and adolescent behavioral problems predicts alcohol use problems seven years later with up to 87% accuracy, suggesting this model could help identify at-risk youth before problems develop.

A 25-year follow-up of bipolar patients found that those who attempted suicide had a more severe illness course, with earlier onset, more depressive episodes, and less benefit from lithium, highlighting the need for closer monitoring and alternative treatments in higher-risk patients.

If you are at #SOBP2026 @sobp-org.bsky.social - Friday poster F159 - travel awardee 👏 Neil Savalia will talk about psychedelics, 5-HT2A/1A receptors, and imaging dendrites 🔬 Saturday poster S170 - travel awardee 👏 Pasha Davoudian will show work on psilocybin and GABAergic interneurons 🧠

SO PROUD of my amazing students representing team ACORN Lab @acornlab.bsky.social at #SOBP2026! I am the luckiest mentor! 🥰 Way to go Natalie, @caitiebaten.bsky.social and @heatherarobinson.bsky.social! 🎉

Amazing talk by @liisagalea.bsky.social at #SOBP2026 on how reproductive experiences shape the brain 🧠

Anxiety and anhedonia may distort the brain's model of the world in opposite ways. Anxious people overestimate how rapidly threatening environments change, while anhedonic people underestimate change, potentially fueling hypervigilance and hopelessness respectively.

Adults who experienced more childhood adversity show altered mitochondrial function, revealing a potential biological pathway through which early stress becomes biologically embedded to affect lifelong health.

Looking forward to our @biologicalpsych.bsky.social conference panel on science and social media today! Hope to see some of you there :)

You’re invited! Join us for the #SOBP2026 Business Meeting & Awards. 🗓️ Friday, May 1 | 11:00–11:30 AM 📍 Broadway Ballroom Celebrate the achievements of our peers and stay informed on the future of the Society. All are welcome!

In people at high risk for psychosis, reduced excitability of pyramidal cells predicts who will later convert to develop psychosis, suggesting this may be a root cause of schizophrenia rather than a consequence of the illness.

One join us on Saturday for the High Stakes Session! Featuring @zivacooper.bsky.social @heatherwardmd.bsky.social @siararouzer.bsky.social @rachelrabin.bsky.social #SOBP2026 If you are around on Saturday, come say hi!

Headed to #SOBP2026? Come visit our posters on stress and mental effort! F325: Investigating the Role of Serotonin in Stressor Controllability and Mental Effort Allocation (me!) S297: Learning and Generalization of Stressor Controllability for Mental Effort allocation (Tony El Nemer)

Kick off #SOBP2026 in style! After a full day of discovery, join us Thursday evening at 7:30 PM for the Welcome Reception. Let’s celebrate the start of our 2026 Annual Meeting together in the heart of New York City! Time: 7:30 PM - 9:00 PM Location: Hard rock cafe times square

Day 1 at #SOBP2026 - Symposium on TMS work in VA setting. Nicole Evangelista spoke on brain connectivity changes following TMS- predicts PTSD (but not MDD) symptom reduction. Noah Phillip speaks on design- beam F3/efield targeting and 10hz/iTBS/dTMS similarly effective but room for improvement (1/2)

Are you attending @sobp-org.bsky.social?? Come check out the Neuroscience for Primetime symposium! I'll be presenting new work on the role of ambient air pollution on neurobiological risk for PTSD. Looking forward to the discussion with fellow speakers + @nateurneuro.bsky.social!

Gearing up for #SOBP2026? Check out some of our Committee's online content and stay in the loop with all things SOBP! 🎥Women in Science Interviews by CAWL: www.youtube.com/playlist?lis... 📰Synapse Spotlight Newsletter by the Communications Committee sobp.org/synapse-spot...

Five posters from the Jones lab at SOBP! 🧠 💭 Come chat with us about biophysical mechanisms, deep learning approaches to EEG analysis, and treatment response prediction!

Really excited for this conference! We’ve all been digging deep into different ways to use EEG to better understand and treat psychiatric diseases If you’re at SOBP definitely stop by our posters if you want to chat biophysical mechanisms, biomarkers, and deep learning approaches to EEG analysis

Are you at SOBP 2026 in NYC and interested in learning about training opportunities at NIMH/NIH in the Intramural Research Program? Come visit me at the 6th floor lobby at the Marriott Marquis! #SOBP26