This is a powerful message from Freeman Hrabowski. 🧵 1/12

🎓 Senior Graduate Students & Early Postdocs! Explore #Postdoctoral Training at Rutgers University! Rutgers Health & Rutgers Brain Health Institute invite you to Postdoc Peek, a two-day, all-expenses-paid, on-campus visit on May 19–20! Apply now: brainhealthinstitute.rutgers.edu/2026/01/26/2...

Cooperative Effects of Cannabidiol and Cannabigerol on Autophagy in Epithelial Cells https://www.biorxiv.org/content/10.64898/2026.01.31.703011v1

Can you easily distinguish between value, valence, and salience? Probably not, but the prefrontal cortex of mice seems to achieve this by creating a sort of multidimensional orthogonal neural space, where each dimension corresponds to one of these subjective elements www.nature.com/articles/s41...

Terrific resource on @medrxivpreprint.bsky.social: a publicly available resource of cis- and trans-eQTLs and an in vivo scaffold for human gene-regulatory networks 🧪🧬 www.medrxiv.org/content/10.6...

From doing science to saving science www.thelancet.com/journals/lan...

In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...

Avoiding common errors in psychedelic drug discovery! open.substack.com/pub/zendudes...

If only we knew which aspects of the polypharmacology to keep and what to discard

Psilocybin and MDMA promote adult oligodendrocyte and myelin plasticity.

Congratulations to the University of Toronto for continuing to lead in Canada and the world. Great universities are where great students go and where great citizens come from.

TIME magazine's university rankings (time.com/7358185/top-...) and the Times Higher Education subject rankings (www.timeshighereducation.com/world-univer...), both released in the past week, continue to demonstrate that research intensity, not UN SDGs and other measures are what drive reputation.1/2

Is it an outrage if your NIH grant score goes from nearly funded to ND after you revise it? drugmonkey.wordpress.com/2026/02/06/i...

#fluorescencefriday distribution of microglia in the whole brain

Microglia mapped across the whole brain from the Western Mouse team—because in neurodegeneration, every cell counts. #Fluorescencefriday 🧠😍🔬

Manuscript handling is, to some extent, a skill. The image below shows that the paper’s AE logged into the system 6 times in 3 months to invite reviewers. What are the unknowns? - # reviewers invited - lag between declines and new invites - manuscript-reviewer match - invites in junk mail 🧵

🎉HUGE CONGRATULATIONS @paulkennyphd.bsky.social! We are delighted to announce the appointment of world-renowned neuroscientist Dr. Paul Kenny as Director of the #FriedmanBrainInstitute, one of the nation's largest neuroscience research hubs dedicated to understanding brain function. Wonderful news!👏

Traumatic brain injury has a lasting impact on hippocampal neurogenesis and Notch1 is involved in regulating this injury response https://www.biorxiv.org/content/10.64898/2026.02.03.703567v1

Nociceptive activity enhances GABAA receptor mediated facilitation of proprioceptive afferent transmission to motoneurons, and is gated by serotonin. https://www.biorxiv.org/content/10.64898/2026.02.02.703408v1

Emergence of microglia structural and functional heterogeneity between hippocampal subregions during development into early adulthood https://www.biorxiv.org/content/10.64898/2026.02.04.703826v1

Accessible and reproducible mesoscale fMRI at 5.0 T: A Pulseq-based open framework for human laminar mapping https://www.biorxiv.org/content/10.64898/2026.02.03.703466v1

A quick trip down the road to visit Binghamton University today. First thing I saw was these giant brain prints on the windows. 🧠😀

#SnapshotsinNeuroscience | Featured on the #eNeuro blog from Pofahl et al., granule cells in the dentate gyrus of a mouse, with visible extensions of their dendrites reaching out into the molecular layer. Photo Credit: Martin Pofahl https://blog.eneuro.org/2026/02/snapshots_dentate_gyrus

We are delighted to sponsor both the GRC and GRS meetings, supporting innovative science and the next generation of leaders in basal ganglia research. #CoherentCorp #GRCBasalGanglia

A tale of many twos www.science.org/doi/10.1126/... by @holdenthorp.bsky.social "...scientific community should strive to bridge gaps within itself while finding a common voice to talk about what has happened & how best to move forward." Agree! Team science needs to work together! 💪

Discover @thetransmitter.bsky.social's Mentorship Directory, connecting mentors and mentees at all stages of their careers. #neuroskyence www.thetransmitter.org/mentorship-d...

We’re hiring! The Suthana Lab @ Duke is looking for a Research Assistant to join our team studying human memory & real-world 🧠 dynamics using wearable tech & intracranial recordings. Apply: careers.duke.edu/job/Durham-C... You can also email [email protected] with CV/questions. Please share!

www.policyalternatives.ca/news-researc... 'As we watch in horror the assault on knowledge and science in the United States—the assault on truth—cuts at Statistics Canada send precisely the wrong message. We urge you to reverse course.' @policyalternatives.ca

Weird, given the years of sustained energy the administration has been putting into convincing people that they should be in a union. In like 5 years they turned around the least-unionizable group of professors in the country... they should get some kind of organizer-of-the-year award.

So grateful that have heard these impactful researchers offer their perspectives at #ACNP2026 . These are some of the unique voices that NIH should be supporting

🚨Faculty position just dropped. We are seeking a Psychology Clinic Director at the @unm.edu Dept of Psychology psychclinic.unm.edu, this position is focused on clinical training of PhD students in sunny, affordable, and progressive New Mexico. Come join us! unm.csod.com/ux/ats/caree...

Yes, it’s a race to the bottom between better AI detection software and better AI algorithms. Somehow, the only benefactors will be the OpenAI’s of the world.

Diversity supplements weren’t just for folks from underrepresented racial/ethnic backgrounds. Eligibility extended to first gen college students and researchers with disabilities, among others Cancelling these supplements limits opportunities for the next generation of scientists, as explained here

My pet peeve about doing CIHR reviews is that they want reviewers to write a summary. The applicants have already written TWO SUMMARIES. Why? Why do I need to write one too? It's an absolute waste of energy and time.

Nice article but the social dynamics of science mean that peer review is de facto a "throughout problem". LLM usage in PR will increase because it reduces pressures on overstretched researchers. We can't stop LLM PR without addressing those pressures. www.timeshighereducation.com/opinion/ai-n...

Telling Lies to Children: The NIH Chaos Edition drugmonkey.wordpress.com/2026/02/04/t...

Congratulations to Dr. @danipalombo.bsky.social and her research collaborators who received a Canadian Institutes of Health Research Priority Announcement Grant to explore how memory influences mental health following pregnancy loss. More: psych.ubc.ca/news/2025-fa...

Both chambers of Congress have now passed the FY26 minibus with NIH provisions. The President will sign. (1) $48.7 billion for NIH (2) Full IDC recovery (3) No more multi-year funding (4) No NIH reorganization, maintaining the current IC structure.

“Diagnostic and Scientific Manual” sounds like a much more appropriate DSM label. And emphasizing a focus on the underlying causes and spectrums of psychiatric disorders are both huge positives!

Cancer touches all of us in different ways — through family, friends and loved ones. We're marking #WorldCancerDay by sharing the people and ideas changing what it means to be diagnosed with cancer. The Catalysts explores the breakthroughs, challenges and questions shaping cancer research today.

Striking paper from researchers at Anthropic using a randomised control trial to look at the effects of AI use on skills acquisition. TL:DR ‘We found that using AI assistance led to a statistically significant decrease in mastery.’ www.anthropic.com/research/AI-...

PSA for all #microglia lovers: certain Iba1 antibodies (see our new paper below for details) label not only microglia, but also vasopressin neurons, at least in mice. Brain region and species matter. A friendly reminder to always validate your antibodies! 🔬 www.eneuro.org/content/13/2...

13% success rates at #CIHR, is a really 87% fail rate for>4000 scientists. At a time when 🇨🇦 is investing millions to recruit more scientist into a broken funding environment. 🇨🇦, U need a strong science foundation 2 attract success. #CIHR, fix your science foundation, it is eroding in real time

PSA: it is in fact possible for universities to address financial challenges by slashing (incredibly expensive and largely useless) admin positions. Memorial University just downsized VPs from 7 to 3. Yes we can! universityaffairs.ca/news/memoria...

Longitudinal whole-human-brain quantitative MRI study on autolysis, fixation, rehydration, and shrinkage effects https://www.biorxiv.org/content/10.64898/2026.01.31.702882v1

Astrocytes mediate a positive feedback loop for oxytocin https://www.biorxiv.org/content/10.64898/2026.02.02.699227v1

Cerebellar circuits anticipate dopamine rewards https://www.biorxiv.org/content/10.64898/2026.02.02.703324v1

"Under severe defunding, about 22.6 million more deaths were forecast by 2030, including 5.4 million among under-fives. Mild defunding would mean 9.4 million excess deaths, of which 2.5 million would be young children." These deaths are avoidable! www.theguardian.com/global-devel...

Why I think that, with the right kind of push, Canadian higher education might be on the verge of a wave of good innovations.

This is the most interesting paper I have read in a while. The organization of a neural system (nucleus, layer or whatever) does not matter for function as long as it contains the right cell types connected the right way. Thanks to @gquattrocolo.bsky.social for inviting me to her Journal Club