Read the full paper here: www.nature.com/articles/s4...

Very happy to share a new paper in @npp-journal.bsky.social I thought I knew what would predict escalation of cocaine use. Well, I was wrong. After tracking behavior daily for weeks, the answer turned out to be the opposite of my prediction, and it changed how I see addiction.

Biological sex impacts TMS intensity because ♀️ typically have shorter scalp-to-cortex distances than ♂️ While these differences are widespread, they are absent in the motor cortex—the site usually used to determine clinical dosage

This study found that cue labeling, the simple act of using words to describe 🚬 triggers, significantly ⬇️ 🚬cravings & associated 🧠activity. This cognitive technique is a scalable, effective self-regulation strategy for smokers

This study examined how comorbid anxiety alters structural brain connectivity in major depressive disorder, with findings that challenge the dysconnection hypothesis in anxious depression & support symptom-based neuroimaging approaches 🧠

This perspective reframes psychiatric treatment as a control engineering problem grounded in dynamical systems theory, with psychopathology reflecting distortions in low-dimensional cognitive–affective manifolds 🧠

NPP and Member in the News...Check out the recent news article highlighting Edythe London, Ph.D.'s recent @npp-journal.bsky.social paper at bit.ly/4rtMtkk. The original research article can be found at rdcu.be/e2bFd

Another week has flown by, and we're back with an exciting recap of what's new #ThisWeekInNPP See below for the latest on late-life neuropsychiatric disorders, perineuronal nets, ovarian hormones and risk aversion, and more! ⬇️

#ThisWeekInNPP This 💫Research Highlight 💫 discusses recent findings showing that common genetic variation substantially contributes to individual differences in lifetime cannabis use, based on large-scale genome-wide association analyses

ENX-104 is a selective dopamine D2/D3 antagonist that partially blocks presynaptic inhibitory receptors: At low receptor occupancy, it ⬆️ NAcc DA levels & ⬆️ reward responsiveness, while higher occupancies produce antipsychotic-like effects

Our latest paper about teen #cannabis use and brain maturation. In a longitudinal cohort (MRI at 13, 15, and 17 years old) we found that cortex was thinner-than-expected during years when teens escalated their cannabis use. Join our follow-up: www.coventuremontreal.com #neuroimaging, #pediatrics

Why do some individuals with serious mental illness experience earlier age-related decline? 🧬 Our new paper in @npp-journal.bsky.social investigates the role of premature biological aging ⌛ in SMI and what it means for future treatments. Check it out here: www.nature.com/articles/s41...

Chronic corticosterone shifts behavior from flexible to inflexible by differentially regulating striatal plasticity genes: Cort ⬇️ plasticity gene expression in the dorsomedial striatum & ⬆️ plasticity programs in the dorsolateral striatum

This review explains why ketamine acts within hours when monoamine & HPA-axis theories cannot. By rapidly resetting hippocampal plasticity at molecular, synaptic, and circuit levels, ketamine reveals a new framework for truly fast-acting antidepressants

This paper discusses how inconsistent clinical associations of bipolar disorder (BP) polygenic risk score (PRS) largely reflect collider bias from case- & treatment-based sampling, which distorts correlations b/w scores & alters BP-PRS links to outcomes

We're leaning into the #NewYearNewUs trend to bring you not one, not two, not three, but FOUR pages of what's new #ThisWeekInNPP 🤩 See below for 18 (!!!) of the newest takes covering all things neuropsychopharmacology 💊 🧠 👇

This Research Highlight discusses findings showing that heavy alcohol use decreases BDNF in the ventrolateral orbitofrontal cortex (vlOFC) of mice & that increased BDNF in the vlOFC–dorsolateral striatum pathway decreases alcohol intake, seeking & relapse

This recently published longitudinal study found that ⬆️ adolescent cannabis use within individuals was linked to ⬇️ cortical thickness, especially in ♂️ & in regions with ⬆️ CB1 receptor expression

A single dose of psilocybin or a selective 5-HT2A agonist produces antidepressant-like effects lasting 3months; ephys showed functional plasticity in mPFC neurons, altered firing & excitability, without detectable structural or gene-expression changes

Recent US data shows overdose deaths involving both synthetic opioids & stimulants rose from 2018 until 2023, then declined sharply in 2024, driven by decreases in opioid-involved deaths. Despite recent declines, polydrug overdose mortality remains high

This recent study used a 🐀 model of cannabis vapor admin, finding that ⬆️ baseline corticosterone, ⬇️ morning anandamide, ⬇️ set-shifting, ⬆️ visual discrimination, & ⬆️ adolescent social grooming predicted ⬆️ responding for cannabis vapor

Still recovering from all the excitement of #ACNP2026? 🤩 SAME! 🥺 But don't worry - stellar science never stops here at NPP 🧠 So check out what's new #ThisWeekInNPP 👇

How does the 🧠 signal unexpected reward timing? Is this perturbed in post-trauma psychopathology? This study found that model-free & model-based fMRI evidence of abnormal amygdala & striatal signaling of temporal reward prediction errors

This recent study identified an “opioid non-responder” phenotype in opioid-naïve individuals using cumulative parenteral hydromorphone dosing: ~1/3 participants showed markedly ⬇️ subjective drug effects despite normal physiological responses

Thank you @ericjnestler.bsky.social and Marcelo Wood for the nomination 🤩

Congrats Liz! #ACNP2026

#ACNP2026 was a huge success! Great location, with even better science.

Had such an awesome #ACNP2026. Amazing science and wonderful reunions. Especially grateful for the badass women who presented at the empowerment lunch and the family friendly culture with free childcare for associate members. Kudos!

Hi 👋. We agree and that’s one reason why we exist 😁

Happy to share that I was promoted from #ACNP Member to Fellow - Thank you to Council and the Membership Committee for their support #ACNP2026 🙌🏽

Back home from acnp. Great meeting, learned so many new things to try to advance our work and happy to connect with friends old and new.

Wrapping up 👋🏽 another amazing experience #ACNP2026 🇧🇸🤩🙁@acnporg.bsky.social #Goodscience #meetings #networking. Great to catch up with #friends #colleagues #newconnections to discuss/share good science 💊🧬🧠. Wonderful family environment 😍👏🏽👍 Congrats to all the awardees 🤗 see you in SD #ACNP2027 😉

Honored to have made the frontal cortex (cingulate?) of @npp-journal.bsky.social reviewers this year!

🙏 for contributing to the amazing #ACNP2026! What'd you love? how was the Program? what'd you love for next @acnporg.bsky.social? @sbilbo.bsky.social @thebalelab.bsky.social @ahmarilab.bsky.social @madrelabutd.bsky.social @mayoonthebrain.bsky.social @cannabrain.bsky.social @jaredwyoung.bsky.social

Thank you all for an unforgettable #ACNP2026 full of cutting-edge science, insightful discussions, and positive energy! See you next year in San Diego for #ACNP2027!

I couldn't pick just one, but I had such a great time at #ACNP2026! Thank you so much for the past travel award support!! Always amazing to see the reviewers for @npp-journal.bsky.social and @dpn-journal.bsky.social each year (and to be a top reviewer again this year).

We're not ready for it to end 😭 😭 So share your favorite photos of #ACNP2026 below so we can pretend it isn't over yet 👇

📸 One last favor: Share your favorite photo from the meeting and tag us! We’d love to see #ACNP2026 through your eyes. Until next year... stay inspired!

The energy at #ACNP2026 was truly incredible. From the early morning Networking Breakfasts to the late-night Poster Sessions, your passion for discovery was on full display.

I am thrilled to join the ACNP community! Feels like home!

I should have taken a selfie after #SachinSays poured a drink all over me last night in classic fashion. But, alas, I did not, so here is a #ACNP2026 Atlantis hippocampus. Thanks to everyone for a great meeting - so many friends to catch up with, exciting science convos & a little too much fun 😴

Thrilled to be accepted to @acnporg.bsky.social @npp-journal.bsky.social and look forward to future meetings! Congrats to all new members! Also, an annual reminder to keep applying if you didn't make the cut at #ACNP2026.

Last day of #ACNP2026! Head over to Poseidon III-IV this morning from 9-11 to hear about how cross-species functional brain biomarkers are being used to improve translation and facilitate drug development in psychiatry 🧠

Yay!!! 🎉 Congratulations to our new Associate members of @acnporg.bsky.social #ACNP2026!!!!!

Congrats to all of the new @acnporg.bsky.social Members!!! #ACNP2026

And a huge congrats to our @acnporg.bsky.social Members #ACNP2026!!! 🎉

And our @acnporg.bsky.social Fellows!! 🤩 a huge congrats!! #ACNP2026

Congrats to the new @acnporg.bsky.social Fellows! #ACNP2026