We report an unexpected and complementary pathway in which mGluR5 PAMs enhance synaptic potentiation and produce antidepressant-like effects, mirroring ketamine’s rapid effects in preclinical models (3/3) Amazing work from the incredible Clara MCarthy and ZZackMa

We investigated nanoscale organization of Ca2+ signaling in dendritic spines and identified distinct Ca2+ signaling pathways—mediated by NMDAR and mGluR5—which differentially regulate synaptic plasticity, protein synthesis, and antidepressant-like effects (2/3)

Thrilled to share our latest work showing spatially segregated Ca2+ signals of NMDAR and mGluR5 have opposing effects to maintain synapse homeostasis, with implications towards rapid antidepressant action (1/3) www.pnas.org/doi/10.1073/...

We are delighted to welcome Dr. Kate Fitzgerald @KDFitzgerald_MD, professor at @columbiapsych.bsky.social and expert in child and adolescent psychiatry, as the newest Associate Editor at NPP! "Meet the Editor" with Dr. Kate Fitzgerald youtu.be/zDnOFSm9kxg?... via @YouTube @npp-journal.bsky.social

Our latest work extends ketamine’s antidepressant action and highlights the importance of a specific form of synaptic plasticity in the effects www.science.org/doi/10.1126/...

Delighted to have a wonderful former colleague, Ryan Hibbs @UCSD visiting today! @VandyPharm @VanderbiltBrain @VUBasicSciences

“Women are asked more questions during a seminar and the questions asked of women presenters are more likely to be patronizing or hostile. These effects are not due to women presenting in different fields, different seminar series, or different topics…” www.nber.org/papers/w28494

Having a difficult day, but I'm glad to have microscopy to inspire me and hopefully inspire others as well. 💔 The brain keeps being amazing. These are neurons in the neocortex #FluorescenceFriday 🔬

Travel Award Stipends - Students, Postdocs, Junior faculty. GBB25 19-22 May, 2025, Yanuca Island, Fiji Deadline: 17th January 2025. More here: www.ibangs.org/travel-award... @twbredy.bsky.social

Congrats to all the new @acnporg.bsky.social Associate Members, Members, & Fellows. We're grateful to have you as part of ACNP 🤩 #ACNP2024

Amazing NPPR session on neuroimaging! A special thanks to Deanna Barch and @conorliston for a great 2025 NPPR issue. #acnp2024 @npp-journal.bsky.social @acnporg.bsky.social

Assistant Prof job in Behavioral Neuroscience at UC Riverside aprecruit.ucr.edu/JPF02011

Stop by and say hi as Dist Ongur and I welcome attendees at the registration desk #acnp2024 this afternoon @npp-journal.bsky.social @acnporg.bsky.social

On the ground for #ACNP2024. I’m Lisa, Director of the Vanderbilt Brain Institute, where I study synaptic plasticity mechanisms in psychiatric disorders and their treatments, including rapid antidepressant action. Co-Editor of NPP. Looking forward to the amazing science and community.

My home department at Columbia just opened a search for a tenure track position. Very supportive department with 7 junior faculty members who are all thriving. Apply! apply.interfolio.com/160181

Assistant / Associate Professor in Computational Neuroscience opening at University of Texas Dallas. jobs.utdallas.edu/postings/28027

Anyone interested in faculty positions in Canada? If so, check out the very special Canada Excellence Research Chairs program. www.cerc.gc.ca/home-accueil... The next competition is about to be announced and it requires "matchmaking", i.e. specific recruitment of an identified person! /1

Join our Biomolecular Pharmacology graduate program @ Boston University Chobanian and Avedisian School of Medicine vimeo.com/1035301649/6...

Beautiful fall morning on Vanderbilt campus

📢 New job alert: The Dept. of Psychological & Brain Sciences at UCSB is hiring a new Director for our Brain Imaging Center! Join us in sunny Santa Barbara and please help spread the word! (Full Professor position—due by Dec 2) 🧠 🌊 recruit.ap.ucsb.edu/JPF02858

Nashville winter continues

Exciting day ahead