Hello numerous people who joined and followed! I want to hear your neuroscience takes, but not the same old debates. There's so much we can discuss that's truly new. Here I'll start: -The brain: too big, or not big enough -Most overrated region of cortex -manifolds: isn't just one fold sufficient

Remarkably, Yuefeng Huang, a post doc in Rita Goldstein’s lab at Sinai, started by sharing that SUD is understudied in women compared to men, though it’s well known that risks and tolerance are v different. They’ve designed a cue-reactivity task to capture the sex differences more effectively.

Moving to humans, Anna Konova of Rutgers implicates neurocognitive mechanisms underlying opioid use risk increase in females through estradiol fluctuation, which scales with striatal reward error signals

Outstanding #acnp2026 day 2 start with @nicolagrissom.bsky.social reminding us of the principle that sex differences in neural mechanisms may drive behavior similarity. Leaning into the ambiguity of hidden markov models and showing that females exploit more; males explore more in a set shift task

Next fantastic talk by Erin Calipari showing incredible novel function of estradiol to potentiate dopamine release by direct action on nicotinic receptor, leading to observable functional differences between male and females, and females at different life stage #perimenopause #acnp2026

If you want to figure out what this poster says (or discover the secret of life) come and hang out at the dopamine dinner. Tomorrow Sunday 8pm-End. Waterfront bar & grill. Share with friends, even serotonin people will feel welcome.

I fell ill and so can't be there as planned but #SfN25 this morning has awesome posters from lab members @nicglewwe.bsky.social and @micaelaporod.bsky.social

This morning #SfN25 check out @micaelaporod.bsky.social’s poster KK17, part of dream team collab with @nicolagrissom.bsky.social

This is one of the most profoundly beautiful pieces I have read in a long time

✨smart 🐁 experiments… read 🧵👇

Free NIH cognition and neuroscience workshop Apr 23, 11–5 ET, online. Register now. Reasoning algorithms across species, models, diagnoses & development. 🧪🧠 events.teams.microsoft.com/event/46b514...

Touchscreen response precision is sensitive to the explore/exploit tradeoff https://www.biorxiv.org/content/10.1101/2024.10.23.619903v1

Sex-biased computations underlying differential set shift performance in mice https://www.biorxiv.org/content/10.1101/2025.04.01.646712v1

Hi everyone, the lab has been enabling my professional interest in doing weird shit with touchscreens (as opposed to my personal interest) Blessed are the mice, for they cannot doomscroll but here's some recent work you may enjoy if you want to see what mice do with their touchscreens instead

I had a fabulous visit to the Medical Discovery Team on Addiction at UMN. Was so lovely to meet with everyone. Thanks to my wonderful hosts Nicola Grissom and Jocelyn Richard!! @nicolagrissom.bsky.social @jocelynrichard.bsky.social

I feel like given today's caloritic availability the brain is too small for our available diets. Our brains could use more folds I feel like they could be something more inkin to a mandal bulb in complexity and design. Also I am not qualified to be giving hot takes on Neuroscience.

I wrote about what Laura Helmuth accomplished at Scientific American, and what her resignation means for science journalism, and for me personally defector.com/do-not-accep...

-Neuron subtypes: can we just ignore them? -Did evolution make brains recurrent to annoy us? -Neuropixels should be the name of an imaging tool

Due to widespread confusion about its status, the hippocampus can be the most overrated cortical region AND the most overrated subcortical region.

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics

All that energy spent on memory when some of us just want to forget. So overrated.

Very smooth brained of you 😌 "Being sure" is the hobgoblin of a brain bedevilled by wrinkles

A real pleasure to talk with The Transmitter about our recent perspective on being less binary when thinking about sex mechanisms in cognition!! Read if you like hearing me rant (I know you do) or want to get your mind blown (natural consequence of my rants) www.thetransmitter.org/sex-differen...

Prefrontal: SO OVERRATED.

Hello numerous people who joined and followed! I want to hear your neuroscience takes, but not the same old debates. There's so much we can discuss that's truly new. Here I'll start: -The brain: too big, or not big enough -Most overrated region of cortex -manifolds: isn't just one fold sufficient

I really love these results from the perspective of individual differences in decision making in animals. As a field we assume that animals should be "optimal" in tasks, without questioning what the implications would be evolutionarily if this were actually true (bad, bad implications, see below)

Related: welcome back to Bluesky fellow nerds

Related: welcome back to Bluesky fellow nerds

One key skill in science and in life is knowing when to leave. I switched labs in my second year of grad school, then switched jobs in my second year on the tenure track. Better to admit that you walked through the wrong door than spend your life in the wrong room.

Cool new way to tell extortionate Biorender to go kick rocks!

Just something that made me laugh pretty hard figured the timeline could use it

You gotta love a squirrel just running around the zoo. The Bonus Animal

That’s me ❤️

The first preprint of my postdoc with @dudman.bsky.social is now online! Here we wanted to understand the algorithms mice use when learning to forage in large environments with many potential resources. www.biorxiv.org/content/10.1...

For anyone trying to follow a conference on Bluesky, using deck.blue is invaluable. Thanks to @gildaswise.com @deck.blue.

Radick: “The more you learn about genetics the less confident you can be of reading phenotype off from genotype” ASHG24

Radick: What if Weldon had lived long enough to publish his book? Would the simplicity of Mendelism be so central to (teaching) genetics? And would students have less race-centric views of human genetics? #ASHG24

I've got whole blood bulk RNA-seq data on 4000+ individuals, almost entirely women (its for autoimmune stuff). After a possible mix up with some samples, I tried using a set of sex-specific transcripts to double check and let me tell you - that does not work. There's just too much chimerism.

For folks who were asking about numbers for non-XX/XY karyotypes: “Current estimates for alternative sex karyotypes are at least 1 out of 440 people.”

Friendly neighborhood geneticist here again! As someone who’s run literally THOUSANDS of human genetic samples, let me tell you one more time - there’s far more variability around XX or XY than most people will ever know. For most people, it never matters. Sex != gender, and karyotype != phenotype.

We tried to figure this out for a recent review. Best guess: bsky.app/profile/nico... "Current estimates for alternative sex karyotypes are at least 1:440 people, but some chromosomal combinations...such as Kleinfelter's syndrome (XXY), [are] thought to be unidentified in up to 65% of carriers"

👋😉

Very happy to announce our paper! "Sex mechanisms as nonbinary influences on cognitive diversity" A pleasure to contribute to this special issue of Hormones and Behavior about how to be less binary and more inclusive in behavioral and cognitive neuroscience www.sciencedirect.com/science/arti...

Next week! I will be talking about how geneticists have long recognised a multiplicity of sexes but how eugenics muted the queer potentialities of sexological genomics through the 20th century. 🏳️‍🌈🧬🏳️‍⚧️ #histsci #histbio #hpbio #philsci 🗃️ Info and registration: www.genome.gov/event-calend...

lol lmao I briefly looked at the interactions with this piece on the other site and there are some angry little men. Anyway let's talk about nonbinary sex mechanisms here instead

Fierce mosaic art by Saiman Chow for today's story @oliviagieger.bsky.social : Breaking the binary view of sex traits can enable researchers to represent the broader complexity of behavior and cognition. @thetransmitter.bsky.social : www.thetransmitter.org/sex-differen...

Breaking the binary view of sex traits can enable researchers to represent the broader complexity of behavior and cognition. By @oliviagieger.bsky.social www.thetransmitter.org/sex-differen...