Aging reorganizes human large-scale brain networks, with consequences for cognition & dementia risk. We’ve now mapped brain network changes over a wide range of the mouse lifespan. The changes mirror key features of human aging, but not entirely New @pnas.org paper🧵 www.pnas.org/doi/10.1073/...

Thrilled to announce our new paper in @natneuro.nature.com! We managed the impossible: precision functional mapping during #DBS, with 11.7h fMRI/patient. Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper. nature.com/articles/s41... @ndosenbach.bsky.social

Avec @cognijunior.bsky.social, Estigma et @federationfresco.bsky.social, nous proposons un atelier interactif autour du cerveau : puzzles, vidéos et goûts mystères pour la @semaineducerveau.bsky.social 🧠 📍 18 mars – 15h 📚 Médiathèque de Bagnolet #semaineducerveau #sciencescognitives #vulgarisation

As someone who has a hard time remembering my phone number, let alone 10k digits of pi, I am in awe of these memory champions who make it look easy -- but how do they do it!? 😵‍💫 @roselynechauvin.bsky.social explains it in pictures. See how their brains are wired differently! doi.org/10.64898/202...

It's pi day 3.14 ... I don't know any of the other digits but Nelson Dellis knows 10,000 of them Read how he does it doi.org/10.64898/202... And then read how you can do it too with his upcoming book "Everyday genius: Hacks to Boost Your Memory, Focus, Problem-Solving, and Much More"

And ... There might be more similarities than people think between H.M. and the 6x US memory champion 👀

How can someone train their brain to have not just improved performance, but to have unbelievable, superhuman performance? You have to hijack a brain system used for something people do very well (remembering stories) and trick it into helping with tasks we don't do well (remembering numbers).

The 6x US memory champion – Nelson Dellis – can memorize a deck of cards in 40 seconds and knows the first 10K digits of pi. To figure out how, he let us peak inside his brain. Here is what we learned in our precision brain mapping study www.biorxiv.org/content/10.6... youtube.com/shorts/MryMq...

"You see what you look for, and you look for what you know." We are proud to release FOCUS: a 100 μm deformable human subcortical atlas precisely registered to MNI space. www.biorxiv.org/content/10.6...

🚨 New preprint: Objective Quality Assessment for Precision fMRI Precision functional mapping (PFM) enables individual-level brain network studies — but demands more, and better, data. We introduce an objective framework to determine when a dataset truly supports interpretable, replicable PFM.

Such a fascinating paper! Less than 3 years after the discovery of the new motor network (SCAN) interleaved between effector motor regions, SCAN is proving highly relevant for Parkinson’s! It offers potential to improve treatment and reduce symptoms non-invasively.

www.nature.com/articles/s41... the original research article ... no paywall

Non-invasive brain surface stimulation targeting personalized SCAN alleviated symptoms in patients with Parkinson’s disease. See the videos below.(www.nature.com/articles/s41...)

Happy to share a short but super cool video that gives a quick overview of our Nature paper on the somato-cognitive action of netwokr in Parkinson's disease www.nature.com/articles/s41...

I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment. www.nature.com/articles/s41...

Parkinson's disease affects over 10 million people worldwide. A new study led by WashU Medicine researchers is paving the way for more personalized, non-invasive treatment, tackling this neurological disorder at its root. @ndosenbach.bsky.social medicine.washu.edu/news/brain-n...

A recently discovered brain network that links cognition (thinking) and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study published in Nature: spklr.io/63320DMwOi #Neuroscience #Neuroskyence #Parkinsons 🧠 🧪

Petit passage sur @iciradiocanada.bsky.social ce weekend pour parler de notre dernière publication dans @cp-cell.bsky.social sur l'effet des 💊 stimulants sur le 🧠. #TDAH A réécouter ici.radio-canada.ca/ohdio/premie... avec @benjaminkay.bsky.social @ndosenbach.bsky.social @washumedicine.bsky.social

What if we've misunderstood how ADHD stimulants work? WashU Medicine brain imaging and child neurology teams joined forces to uncover where in the brain these drugs act — knowledge that could improve how attention disorders are treated. medicine.washu.edu/news/stimula...

Things are not obvious. And I have so many new questions now.

Envie de créer un kit d'enseignement des neurosciences pour mieux apprendre à destination des lycéens ?

Un énorme projet (1 an sur le nouveau design et 3-4 ans sur les vidéos tuto !) 😱 Rendez vous lundi soir ! @cogniclasse-afsc.bsky.social @federationfresco.bsky.social

Important consideration to better model neuroimaging data

That's going to be very useful !!

Want to know the behind the scenes of the "Disuse-driven plasticity in the human thalamus and putamen" paper? discover @ndosenbach.bsky.social and I interview by @cp-cellreports.bsky.social www.cell.com/cell-reports...

🔔 J-30 avant le #CogniForum25 ! Du 6 au 16/10-25, rejoignez une cté unique autour des sciences cognitives de l’apprentissage Avec un parrain exceptionnel : Steve Masson de @uqam.ca 📜& inscriptions⬇️ view.genially.com/6890d92d9e9d... 🙏 Merci aux chercheur·ses et intervenant·es pour leur engagement..

I still get chills Meet Mike *30+ years severe depression *first hospitalized @ 13y *20 meds *3 rounds of ECT *2 near-fatal suicide attempts Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE see videos, read paper, follow thread doi.org/10.31234/osf...

This new Yeo Lab tool should immediately and permanently replace sample-size-only power calculations for functional MRI. www.nature.com/articles/s41...

If you missed it, the replay is available

We have argued that the brain’s Action Mode Network controls functions required for goal-directed behavior. www.nature.com/articles/s41... Now, in new work, we show that AMN contains distinct subnetworks for making decisions, implementing actions, and processing feedback. doi.org/10.1073/pnas...

Looking forward to talk about my latest research findings at the LOOPS webinar

Alert!!!! “An Action Networks Model for Pain” We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it. 👉 thread below 🧵 osf.io/preprints/ps...

🧠🔄 #NeuroThursday @roselynechauvin.bsky.social & team use daily fMRI to show that 2 weeks of arm disuse triggers spontaneous “disuse pulses” and boosts connectivity in motor cortex, thalamus and putamen. Arm in a cast? Your thalamus rewires 🩼🧠 Check out below ⬇️ 🔗 www.cell.com/cell-reports...

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

Had a great time speaking with Sydney about our most recent paper out now in @natcomms.nature.com @macwoodburn.bsky.social . Paper link here: rdcu.be/ehbOy

Happy to read @sydneywyatt.bsky.social’s piece on the recent study by @samkrimmelneuro.bsky.social @ndosenbach.bsky.social @gordonneuro.bsky.social re: the human red nucleus I was glad to discuss this great work with Sydney @thetransmitter.bsky.social www.thetransmitter.org/brain-imagin...

New research from @roselynechauvin.bsky.social & colleagues studied motor plasticity in the human subcortex during 2 weeks of upper-extremity immobilization with daily resting-state & motor task fMRI; Limb disuse increases functional connectivity www.cell.com/cell-reports...

I'm so grateful that @roselynechauvin.bsky.social analyzed subcortical effects of limb-casting on resting-state brain activity! These effects mirror those seen in Parkinson's disease, perhaps because both conditions involve disuse and plasticity that suppresses future limb movements

It turns out the brain🧠is silently🤫working when your arm is in a cast. 🩼 🚧 Plastic changes occur, and revert again when the cast is removed … not just in cortex.

Small 🧠 nucleus + PFM (dense sampling of individual) + big data = push of the knowledge boundary ! Super interested work by @samkrimmelneuro.bsky.social

Toujours un plaisir de donner cette formation et cette année, les portes sont ouvertes au public ! Ce sera Camille Roullet, la vice présidente de l'asso que l'on retrouvera ce mercredi en visio.

🚨 It’s go time! 🚨 #STATMadness is here, and WashU Medicine has TWO game-changing research projects in the running. We’re talking psilocybin’s mind-altering power to treat mental illness and a vaccine against aggressive breast cancer. Show up and vote: ➡️ www.statnews.com/feature/stat...

The brain’s action-mode network — a Perspective by Nico U. F. Dosenbach, Marcus E. Raichle & Evan M. Gordon @ndosenbach.bsky.social @gordonneuro.bsky.social www.nature.com/articles/s41...

It's out! Our work on multi-dimensional control adaptation landed on @naturehumbehav.bsky.social Free access to the full text here: rdcu.be/d5pt1 Big shout-out to @wouterkool.bsky.social for sharing the venture and for setting the bar that high in mentorship! For a quick recap, linked thread

The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️

Is it critical to stimulate @ndosenbach.bsky.social's SCAN and CON networks for clinical improvements of Tourette's patients that undergo DBS? Carlos Baldermann says yes in a cool new paper out in @natureportfolio.bsky.social comms today! www.nature.com/articles/s41...

My favorite recent read has been this @natureportfolio.bsky.social N&V by Roselyne Chauvin and @ndosenbach.bsky.social summarizing and contextualizing @kaidikang.bsky.social et als' study describing the features that contribute to reproducible BWAS studies 🧪 www.nature.com/articles/d41...

New paper out today in PNAS 🎉 demonstrating: 1) an association between social disadvantage & child brain function can be observed as early as birth 2) these alterations are brain-wide, but most pronounced in functional networks & subcortex later linked to childhood adversity doi.org/10.1073/pnas...