iGluSnFR4 is now available @natmethods.nature.com www.nature.com/articles/s41... Glutamate indicators with increased sensitivity and tailored deactivation rates 🧪

Apropos of nothing I was reminded of this quote today by Bernard Shaw: “Do not wrestle a pig. You get dirty, and besides, the pig likes it.”

A study in Nature finds that five groups of disorders share most of their genetic risk in a screen of 14 psychiatric conditions, including depression, anxiety, and schizophrenia. The findings could help to improve diagnoses and lead to new treatments that work across several conditions. 🧬 🧪

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

Love it when random but intriguing results in the lab have me tracking down pre-internet periodicals at the library.

We invite applications for postdoctoral researchers with strong expertise in in vivo electrophysiology and circuit neuroscience to join our team at the Paris Brain Institute (ICM).

I might actually submit to eLife if this were the case.

🥳Excited to share our latest human multipatch paper, now out in @natneuro.nature.com 🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals. www.nature.com/articles/s41... Join us: penglab.de

“Biological fidelity is a computational necessity!!!” Going to put that on a t-shirt

Delighted to share our latest article on brain mechanisms of pain, appetitive & aversive learning, led by @yilizhao.bsky.social & In-seon Lee, out now in @sfnjournals.bsky.social! We show that brain mechanisms of expectancy are domain general, not unique to pain! www.jneurosci.org/content/earl...

This new ERC study uses an overlapping set of human 🧠 donors as our just dropped locus coeruleus preprint. Availability of data from both regions in the same donor facilitates our current efforts to analyze molecular signaling across the circuit, which is highly vulnerable in Alzheimer's disease.

Great news! We are looking for an NHP neuroscientist as the assistant professor level. We have no preconceived ideas -- looking for the most exciting research going. If you have any questions, please reach out. universityaffairs.ca/search-jobs/...

$600 million dollar bet by Astera Foundation to solve consciousness via reading and writing of neural activity led by Doris Tsao. astera.org/neuroscienti...

Code red.... Does anyone know a not-by-hand hack to grade 493 scantrons without a scantron machine? ⚰️

🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗​​https://unc.peopleadmin.com/postings/308455 #Neuroscience #TeachingJobs #AcademicJobs #HigherEd

NHP neuroscience faculty position ALERT!!!

We tend to think of neurons as either excitatory or inhibitory, but some neurons chemically inhibit their downstream targets while electrically exciting their neighbors. What is gained by having an inhibitory neuron excite its neighbor? www.biorxiv.org/content/10.6...

Buying your lab a Nespresso machine with an American Express Platinum VWR Black card?…Priceless. bsky.app/profile/gers...

scientist men on bluesky i promise you can exist on this platform without everything you post trying to argue about how the brain works (consciousness, waves, whatever the fuck). it will be okay

Dear journals, collaborators, potential trainees, & colleagues: Please be patient with your nih friends. Those of us who are still around are doing everything in our power to focus on science & keep the long view in mind. But life is very much one day at a time, & catch up from shutdown is a beast 🫠

There is no “Moonlight Graham” in the stats driven era of baseball. Why would a ghost crossover if he couldn’t wink at the pitcher and stretch a double into a triple. Baseball is greatest when there is unexpected uncertainty (i.e. Roy Hobbs). Expected uncertainty ruins the magic of the game.

Join us for Fall 2026. In our group, you can run studies from human behavior and neuroimaging, to large-scale NHP ephys, and join them up with a robust computational foundation. Bonus: you can help build the reading list.

Department of Psychological & Brain Sciences at Johns Hopkins is inviting applications for 3 open-rank tenured/tenure-track positions in (1) Behavioral Neuroscience, (2) Cognitive Neuroscience, and (3) Cognitive Psychology. pbs.jhu.edu/about/jobs/

when someone tells me not to use em dashes because AI uses em dashes

GIF THREAD ALERT – With pleasure, we present our @SfNJournals #JNeurosci article www.jneurosci.org/content/45/4... by my grad student Jackson Schumacher and former post doc Mieke Van Holstein

For the oculomotor nerds out there… we’re excited to share our paired papers on precerebellar circuitry! These two studies look at how internuclear pathways talk to the cerebellum and what that means for eye movement control. 👀🧠 #neuroskyence #science

Glad to see the knowledge gained through lesion studies in nonhuman primates being utilized as a foundation for this work www.nature.com/articles/s41...

I understand nostalgia, I understand style trends, but one thing I absolutely cannot understand is the comeback of portable CD players. There has never been a more infuriating piece of technology (ok well maybe the asymmetric design of the original USB port).

How many R01s does the student have?

Our multi-omic analysis of the primate striatum reveals heterogenous MSN organization across its rostro-caudal extent, new MSN subtypes, and subtype-specific disease enrichment. www.biorxiv.org/content/10.1...

Thanksgiving / early Black Friday flash sale on action potentials at www.brainedglass.com! Also last chance to order custom brains in time for holidays. I’m very grateful to all who supported my side gig during the recent govt shutdown: Thx for helping me not lose my mind during a very hard time 💕🧠

New lab paper drop, this one has been a long time coming! Driven by Rob Aukema (now a postdoc with Kerry Ressler) this paper in Science Advances answered the lingering question of what role the amygdala plays in stress-induced neuroendocrine responses. www.science.org/doi/10.1126/...

How about this banger out of the Holmes lab?

Good collaborators don’t let you submit bad cover image art. “LOL that just looks like the acid trip of a neuroscientist.” “What if I add monkeys?”

Is there #Soupskyence? @jbarkerlab.bsky.social? bsky.app/profile/artw...

In which I fruitlessly beg NIH grant-seeking folks to focus on what is actually important. drugmonkey.wordpress.com/2025/11/21/i...

Posting for no particular reason…. From the Archive: Comparing performance of within-payline and "select pay" pickup NIH grants at NIAID drugmonkey.wordpress.com/2011/10/26/c...

Very excited to hear about this! We find Bayesian multi-level modeling at the ROI level super helpful (e.g. www.cell.com/neuron/fullt... ), will be nice to not have to artificially carve the data into parcels a priori!

Perfect way to end #sfn25. Thanks @neuroamyo.bsky.social!

We are thrilled to announce that the preliminary program for the 2026 GRC on the Frontal Cortex is now live! www.grc.org/frontal-cort... Registration is now open for both the GRC and our GRS, chaired by @albitc.bsky.social and @jorge-miranda.bsky.social!

Introducing the 𝐏𝐈-𝐚𝐭-𝐜𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐒𝐥𝐚𝐜𝐤 𝐦𝐨𝐝𝐞! 🤯 When activated, it will auto-reply to your PI's frantic ideas for new experiments, analyses, and projects with "Great suggestion! Saving this for later" (aka: let's talk when you’re back and got some sleep) #sfn2025 #sfn25

Apropos of... well... I'm reviewing applications for a variety of things right now and can tell when letters are written by AI. There aren't many of them but they do exist. They are... not good. If you're an academic trainee, choose your mentors wisely.

@urochestersmd.bsky.social graduate student Daulton Meyers isn’t a modulator. Daulton Meyers is a DRIVER. Does anyone else in this ACC minisymposium hearing Whitesnake? #sfn25 #sfn2025

Amygdala milkshake is either a great band name or an apt description of the current vibe

Happening now! #sfn25 #sfn2025

How our foray into acute neural recordings from the frontopolar cortex started. Check out Kati Rothenhoefer’s LBP028 poster this afternoon (11/16) to learn about how it’s going. #sfn25 #sfn2025

Want more neuroscience of explore-exploit? Come to LBP028 right now! bsky.app/profile/vinc...

#Amygdala and @ronypaz.bsky.social brings all the neuroscientists to yard #sfn25 #sfn2025

How our foray into acute neural recordings from the frontopolar cortex started. Check out Kati Rothenhoefer’s LBP028 poster this afternoon (11/16) to learn about how it’s going. #sfn25 #sfn2025

October and November NIH grant submission deadlines will be extended. Study sections scheduled between October 1 and November 14 have been cancelled and will be rescheduled. grants.nih.gov/grants/guide...