www.nature.com/articles/s41... Finally out!!

This is a beautiful paper showing reliable gene editing in single targeted neurons in the brain. 🧬🧠 The results are striking. It’s been awhile since I’ve seen such an elegant study.

🚨 Psychedelics in pregnancy - can a single dose reach the embryo and matter? Yes. In mice they hit embryonic CSF within minutes, activate choroid plexus→CSF axis, & shift cortical development with adult behavioral signatures. @lehtinenlab.bsky.social Preprint: www.biorxiv.org/content/10.1... 1/13

@deffinger.bsky.social and @melissaherman.bsky.social argue that, though many human psychedelic clinical trials are underway, preclinical studies remain our best bet to answer fundamental questions about the neurobiology of psychedelics. #neuroskyence www.thetransmitter.org/psychedelics...

Latest imaging data from our completely re-designed ExA-SPIM system. Expansion-assisted imaging (3X expansion, 0.3 NA) enables brain-wide imaging with high-contrast and <400 nm effective resolution.

Updated funding curve (with two weeks to go in the fiscal year) (Posted on jeremymberg.github.io/jeremyberg.g... )

Excited to highlight a new paper from my graduate student Sergio Bernal Garcia who, together withLuke Hammond, developed RESPAN, a new deep-learning pipeline automating the segmentation of neuronal morphology and dendritic spines from fluorescent microscopy images: www.cell.com/cell-reports...

SCN2A loss is strongly linked to neurodevelopmental delays and, at times, seizure. In an amazing collaboration with @nadavahituv.bsky.social, led by Serena Tamura, Andrew Nelson, and Perry Spratt, we leveraged CRISPR activator approaches to rescue this loss. rdcu.be/eGU0W

It was fun to host Lucas Pinto at for our department seminar last week. Lucas showed a new VR task combining evidence accumulation and delay-match-to-sample. Mice did the task using near-orthogonal coding scheme across cortical regions 👉 www.biorxiv.org/content/10.1...

Excited to share this super comprehensive review of psychedelic research in NHPs! W/ Alex Kwan. This work was by our grad student Jamie who is passionate about psychedelics. Her in-depth knowledge is impressive as reflected here. www.nature.com/articles/s41...

Glad to have shared with high school students about opportunities at the intersection of neuroscience 🧠 and engineering 🖥️, as part of this @danafoundation.bsky.social seminar series. The talk is now available on YouTube. www.youtube.com/watch?v=HuRy...

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/

Two flagship papers from the International Brain Laboratory, now out in ‪@Nature.com‬: 🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0 🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +

At Dave Putnam's legendary drug formulation and delivery class. @cornellengineering.bsky.social A treat for me to be a student again this semester. 📚

We watched mice follow scent trails drawn on an “endless” treadmill. By manipulating trail geometry/statistics, perturbing mouse nose & brain, and modeling behavior with a Bayesian framework, we show that mice use predictive (rather than reactive) strategies.

This was a fun piece to write for @cp-trendspharma.bsky.social “The ABCs of Psychedelics: A Preclinical Roadmap for Drug Discovery” with John McCorvy and @jmantsch.bsky.social www.cell.com/trends/pharm...

Are hallucinogenic effects critical to the therapeutic benefits of psychedelics? 🆕 Primer by Dr. Albert Garcia-Romeu @jhpsychedelics.bsky.social breaks down what's known about the role of therapy & subjective effects in driving psychedelics' putative efficacy www.nature.com/articles/s44...

Time off last week with the kids scavenging at the beach #Alaska

Fun #FluorescenceFriday image from Olivia Drake in the lab of a sagittal rat brain section. Cyan = DAPI, a DNA marker Yellow = Substance P, a protein product of the Tac1 gene

New preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. www.biorxiv.org/content/10.1... 1/12

🚨Pre-print alert🚨 We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭 How is this possible? Strap in! (1/9) 👇🧵 doi.org/10.1101/2025...

5 Concatenating primate brains based solely on their size provides a 1st striking illustration of the importance of mechanical morphogenesis: despite jumping across far branches of the phylogenetic tree, the sequence is largely continuous, hinting at a common underlying organising principle.

New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬 We found that psilocybin prolongs the neurovascular response, independent of neural activity. This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️

Over the weekend, I stumbled upon a forgotten study from 1967 that was likely the first paper about psychedelics from Cornell University. 🤔 “Psilocybin: Reaction with a Fraction of Rat Brain” by Gilmour and O’Brien. www.science.org/doi/10.1126/...

I had a great time at the first GRC psychedelics earlier this month! It was an amazing opportunity to learn about different aspects of research with psychedelics and discuss new data with many brilliant people! Can’t wait for 2027! #GRCPsychedelics

I fully agree with this take. People get hung up on what the head-twitch response is or is not as a behavior. It’s more useful to think of head-twitch response as a drug development tool.

smFISH to validate anatomical level and localize nucleus accumbens for molecular profiling experiments in tissue sections of the human 🧠. I really love looking at the striations in the white matter of the internal capsule here - so satisfying! Image credit to Staff Scientist Svitlana Bach 👩‍🔬🧪🤩

Had a fantastic time at the Neurobiology of Psychedelics GRC. Only a week yet feels like it could have been months. New community, new lab, novel and diverse ideas and perspectives, unpublished brand new research, a lot of growth. Easily one of my favourites #GRCPsychedelics

Check out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social psychedelicalpha.com/news/dispatc...

A week ago I had the opportunity to present my poster at #GRCPsychedelics! Incredible science and inspiring connections at Bryant University 🧠 🍄 Back in Bordeaux, more motivated for new experiments. Huge thanks to everyone who made it happen — hope to see you again in 2027! 🔬🐭

Did you go to #GRCpsychedelics and not get soap? Don't worry, our themed soap will be ready in 2-3 weeks. Mouse brain toppers, rainbow swirl, dendrite+spine embed. Happy to send a free bar to ~10 people/ attendees. These are handmade by an amateur, so expect imperfections.

The soap inspired by #psychadelicsgrc is curing. Lets see where this ends up. Yes those are soap mouse brains on top. Thanks for the inspo @christineliu.art

#GRCPsychedelics - What a blast! It was great to talk science with so many incredible people in the field. Can't wait to do it all over again!

Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶 Per usual, I took no pics - but luckily Missy had it covered for me 😂

So happy the first #GRCPsychedelics was such a success. It was great to see everyone and share all the amazing science and community. Thank you to all the speakers and congratulations to the travel awardees!!

Had an incredible time at #GRCPsychedelics this week. Grateful to be part of such a meaningful gathering of fascinating research, inspiring scientists, and an amazing trainee community. Big thanks to everyone who made it happen. Already excited for GRC 2027! 🧠🧪🦞

Had a lovely time at #GRCpsychedelics Only took pics of bunnies, sunsets, and @cllantz.bsky.social Already looking forward to 2027!

#GRCPsychedelics is squad goals !! I learned so much, laughed even more, and slept even less Grateful for the new connections, strengthening of old ones and for the opportunity to view my favorite topics from a different lens.

Very grateful I had the opportunity to attend the first #GRCPsychedelics and connect with others in the field!

So happy I got to attend the first #GRCPsychedelics conference. Such an amazing opportunity to connect with other researchers & learn about the newest findings in the field.

Attending the first psychedelic GRC organized by @alexkwan.bsky.social & @vyazovskiy.bsky.social was surreal. The internationally representative panels ensure we are collectively/efficiently advancing our understanding of psychedelics. Special thanks to @mayoonthebrain.bsky.social for bringing me ❤️

CPCR faculty David Yaden (@existwell.bsky.social‬) presented and participated in a panel on The Evolving Theory for Explaining Psychedelic Drug Action with Mark Geyer, Harriet de Wit, Franz Vollenweider, Bryan Roth, and Scott Thompson at #GRCPsychedelics

The inaugural #GRCPsychedelics was a success! I am honored to have been one of a few chosen to receive a travel award and be able to share the stage with the leaders in the field. 🙏 to the organizers! @alexkwan.bsky.social @vyazovskiy.bsky.social @melissaherman.bsky.social @viditavaidya.bsky.social

Bring out the dancing lobsters 🦞🕺 #GRCPsychedelics @sequencemyneuro.bsky.social @fredbarrettphd.bsky.social @tanner-anderson.bsky.social

Everyone approves of the dinner to end the #GRCPsychedelics 🦞 @deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart

Had several great discussions at my poster #GRCPsychedelics Looking forward to building future collaborations :)

My first time at a GRC had to be #GRCPsychedelics. Drop by my poster today to talk about 5-MeO, Calcium transients and Gamma bands in the anterior insular cortex 🧠🐭

Great panel this morning on the human and clinical studies of psychedelics - my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics

🌈🧠 The Trip Between Bedside and Bench 🌈🧠 Join us at #SfN2025 for a deep dive into cross-species research in psychedelic neuroscience! 🧬 Posters, 🎤 panels, 🔑 keynotes, 🍸 cocktails, and 🥟 tasty apps await. RSVP, explore speaker profiles, and help spread the word: 👉 hopkinspsychedelic.org/sfn2025

We worked so well as a team for the #GRCPsychedelics @vyazovskiy.bsky.social @viditavaidya.bsky.social @melissaherman.bsky.social and congrats to @theborislab.bsky.social and @mikaelpalner.bsky.social, who will be the future vice-chairs!