We’ve thought a lot about how 💊 drugs act on dendrites of neurons, but what about when it is a 🧬 mutation that affects dendrites? PhD student Hao Wu studied #Scn2a deficiency in mice. Just out at @pnas.org, her research led to two major findings. www.pnas.org/doi/10.1073/... 1/6

To study how animals understand the physical world (and the rules that govern its dynamics), @jinyao-y.bsky.social trains rats to play fetch with robots 🐀🤖🎾 To learn more, come to our poster Tuesday morning! [Board W11] Rats learn and use intuitive physics knowledge to solve fetch tasks. #SfN2025

Posters are up now for another hour and a couple more tomorrow! #SfN25 #SfN2025 @sfn.org

Research on brain disorders may slow as young neuroscientists struggle to find jobs and research grants. n.pr/4pgmAna

Lab is thrilled to leave frigid NY to go to sunny San Diego for #SfN2025 😂 Mon AM posters: LBP182 - Psilocybin and layer 1 interneurons LBP183 - Psilocybin in chronic stress model LBP184 - Drugs + snRNAseq Tue PM posters: LL18 - Psilocybin and pyramidal cell types MM3 - Drugs + rabies tracing

Researchers with lived experience of mental illness/SUDs bring vital insight to our field, yet remain underrepresented and face barriers to participation & leadership This Perspective calls for removing such barriers & proposes reforms to build inclusive environments www.nature.com/articles/s44...

Beautiful “action potential” stained glass made by @laurenatlas.bsky.social Picked 🔵 because it reminds me of our #ChR2 optotagging experiments 🤓🧪

Incredibly proud of Lingxiao Shao for receiving the prestigious Peter and Patricia Gruber International Research Award this year! 🎉🎉🎉 A true trailblazer who has been driving research on #psychedelic drug action in the brain. 🧠🧪 @sfn.org #SfN2025

Many of our big insights into brain function come from trying to mimic it, writes @timothyoleary.bsky.social. This lesson should guide how we organize research programs. www.thetransmitter.org/systems-neur... #neuroskyence

When #FluorescenceFriday falls on Halloween, we break out the spooky data 👻 Here we are looking at the blood vessels of a zebrafish through its eye 🎃

My department, Cornell BME, is hiring! This tenure-track faculty position is a great opportunity to join a vibrant community that values research, teaching, and entrepreneurship. 📝 academicjobsonline.org/ajo/jobs/30816

Preparing tomorrow’s visit to @tulanebrain.bsky.social @tulaneu.bsky.social by grabbing a muphuletta 😀 #NewOrleans

For #FluorescenceFriday - projection neurons from the mouse prefrontal cortex to the locus coeruleus 🔴 with Fos labeling activated cells 🟢. Image credit to the Circuits team in the Translational Neuroscience Division @lieberinstitute.bsky.social 🧠🔬🧪

Today I found the secret chess♟️spot at Cornell, with an unbeatable lake view

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging

This one hits close to home. Jim is my office neighbor. Absolutely devastating.

www.nature.com/articles/s41... Finally out!!

This is a beautiful paper showing reliable gene editing in single targeted neurons in the brain. 🧬🧠 The results are striking. It’s been awhile since I’ve seen such an elegant study.

@deffinger.bsky.social and @melissaherman.bsky.social argue that, though many human psychedelic clinical trials are underway, preclinical studies remain our best bet to answer fundamental questions about the neurobiology of psychedelics. #neuroskyence www.thetransmitter.org/psychedelics...

Latest imaging data from our completely re-designed ExA-SPIM system. Expansion-assisted imaging (3X expansion, 0.3 NA) enables brain-wide imaging with high-contrast and <400 nm effective resolution.

Updated funding curve (with two weeks to go in the fiscal year) (Posted on jeremymberg.github.io/jeremyberg.g... )

Excited to highlight a new paper from my graduate student Sergio Bernal Garcia who, together withLuke Hammond, developed RESPAN, a new deep-learning pipeline automating the segmentation of neuronal morphology and dendritic spines from fluorescent microscopy images: www.cell.com/cell-reports...

SCN2A loss is strongly linked to neurodevelopmental delays and, at times, seizure. In an amazing collaboration with @nadavahituv.bsky.social, led by Serena Tamura, Andrew Nelson, and Perry Spratt, we leveraged CRISPR activator approaches to rescue this loss. rdcu.be/eGU0W

It was fun to host Lucas Pinto at for our department seminar last week. Lucas showed a new VR task combining evidence accumulation and delay-match-to-sample. Mice did the task using near-orthogonal coding scheme across cortical regions 👉 www.biorxiv.org/content/10.1...

Excited to share this super comprehensive review of psychedelic research in NHPs! W/ Alex Kwan. This work was by our grad student Jamie who is passionate about psychedelics. Her in-depth knowledge is impressive as reflected here. www.nature.com/articles/s41...

Glad to have shared with high school students about opportunities at the intersection of neuroscience 🧠 and engineering 🖥️, as part of this @danafoundation.bsky.social seminar series. The talk is now available on YouTube. www.youtube.com/watch?v=HuRy...

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/

Two flagship papers from the International Brain Laboratory, now out in ‪@Nature.com‬: 🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0 🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +

At Dave Putnam's legendary drug formulation and delivery class. @cornellengineering.bsky.social A treat for me to be a student again this semester. 📚

We watched mice follow scent trails drawn on an “endless” treadmill. By manipulating trail geometry/statistics, perturbing mouse nose & brain, and modeling behavior with a Bayesian framework, we show that mice use predictive (rather than reactive) strategies.

This was a fun piece to write for @cp-trendspharma.bsky.social “The ABCs of Psychedelics: A Preclinical Roadmap for Drug Discovery” with John McCorvy and @jmantsch.bsky.social www.cell.com/trends/pharm...

Are hallucinogenic effects critical to the therapeutic benefits of psychedelics? 🆕 Primer by Dr. Albert Garcia-Romeu @jhpsychedelics.bsky.social breaks down what's known about the role of therapy & subjective effects in driving psychedelics' putative efficacy www.nature.com/articles/s44...

Time off last week with the kids scavenging at the beach #Alaska

Fun #FluorescenceFriday image from Olivia Drake in the lab of a sagittal rat brain section. Cyan = DAPI, a DNA marker Yellow = Substance P, a protein product of the Tac1 gene

New preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. www.biorxiv.org/content/10.1... 1/12

🚨Pre-print alert🚨 We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭 How is this possible? Strap in! (1/9) 👇🧵 doi.org/10.1101/2025...

5 Concatenating primate brains based solely on their size provides a 1st striking illustration of the importance of mechanical morphogenesis: despite jumping across far branches of the phylogenetic tree, the sequence is largely continuous, hinting at a common underlying organising principle.

New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬 We found that psilocybin prolongs the neurovascular response, independent of neural activity. This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️

Over the weekend, I stumbled upon a forgotten study from 1967 that was likely the first paper about psychedelics from Cornell University. 🤔 “Psilocybin: Reaction with a Fraction of Rat Brain” by Gilmour and O’Brien. www.science.org/doi/10.1126/...

I had a great time at the first GRC psychedelics earlier this month! It was an amazing opportunity to learn about different aspects of research with psychedelics and discuss new data with many brilliant people! Can’t wait for 2027! #GRCPsychedelics

I fully agree with this take. People get hung up on what the head-twitch response is or is not as a behavior. It’s more useful to think of head-twitch response as a drug development tool.

smFISH to validate anatomical level and localize nucleus accumbens for molecular profiling experiments in tissue sections of the human 🧠. I really love looking at the striations in the white matter of the internal capsule here - so satisfying! Image credit to Staff Scientist Svitlana Bach 👩‍🔬🧪🤩

Had a fantastic time at the Neurobiology of Psychedelics GRC. Only a week yet feels like it could have been months. New community, new lab, novel and diverse ideas and perspectives, unpublished brand new research, a lot of growth. Easily one of my favourites #GRCPsychedelics

Check out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social psychedelicalpha.com/news/dispatc...

A week ago I had the opportunity to present my poster at #GRCPsychedelics! Incredible science and inspiring connections at Bryant University 🧠 🍄 Back in Bordeaux, more motivated for new experiments. Huge thanks to everyone who made it happen — hope to see you again in 2027! 🔬🐭

Did you go to #GRCpsychedelics and not get soap? Don't worry, our themed soap will be ready in 2-3 weeks. Mouse brain toppers, rainbow swirl, dendrite+spine embed. Happy to send a free bar to ~10 people/ attendees. These are handmade by an amateur, so expect imperfections.

The soap inspired by #psychadelicsgrc is curing. Lets see where this ends up. Yes those are soap mouse brains on top. Thanks for the inspo @christineliu.art

#GRCPsychedelics - What a blast! It was great to talk science with so many incredible people in the field. Can't wait to do it all over again!

Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶 Per usual, I took no pics - but luckily Missy had it covered for me 😂