Great talk from @sj-marzi.bsky.social for the UAB Biochemistry and Molecular Genetics seminar series - lots of cool results on chromatin modifications linking human gene variation to neurodegenerative disease risk. Supports what seems to be an emerging consensus of a major role for microglia.

Happy to share the newest study from our lab, led by superstar postdoc Dr. Rodrigo Campos Cardoso, where we resolve the infralimbic cortex GABAergic circuits of fear extinction: tinyurl.com/38vvr2my

Very happy to share a new paper in @npp-journal.bsky.social I thought I knew what would predict escalation of cocaine use. Well, I was wrong. After tracking behavior daily for weeks, the answer turned out to be the opposite of my prediction, and it changed how I see addiction.

Stunning art installation at BHM (the airport). Can’t tell if it’s permanent or up for BHM (the month) but it really is quite striking.

These are the curves for new and competitive renewal grants. The number of new awards is increasing slightly, but only slightly. 17 out of 25 institutes and centers with funding authority have now made awards. 3/4

PSA for all #microglia lovers: certain Iba1 antibodies (see our new paper below for details) label not only microglia, but also vasopressin neurons, at least in mice. Brain region and species matter. A friendly reminder to always validate your antibodies! 🔬 www.eneuro.org/content/13/2...

Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6... 1/3

🧵Good news out of #NIH today. (1) NIH is extending #ESI and #K99/R00 eligibility to accommodate researchers whose eligibility would have ended during the previous shutdown. Take a look at NOT-OD-26-020. If your ESI status would have ended in 2025, you get an automatic extension through 2026/03/31.

We could all use some extra stress #resilience rn. But how does it work in the brain? On the surface, resilience looks like ignoring stress. Does the brain fail to respond? Or are active adaptations required? Or are resilience and susceptibility divergent paths? doi.org/10.1016/j.celrep.2025.116867

Now out in @nature.com: Biological insights into schizophrenia from ancestrally diverse populations. @sinaibrain.bsky.social @sinaigenetics.bsky.social cs.bsky.social @timbigdeli.bsky.social #CDNeurogenomics #MountSinaiPsych #MillionVeteranProgram and many collaborators Read: rdcu.be/eZ7he

The core herpes simplex-1 fusion complex drives cell-to-cell spreading of pathological Tau https://www.biorxiv.org/content/10.64898/2026.01.21.700770v1

Drug discovery for nervous system disorders is really challenging. We think early/rapid in vivo testing with zebrafish will accelerate the drug development cycle for conserved targets. Check out our proof-of-principle pilot study and virtual drug discovery pipeline (tinyurl.com/3whr23hs). #Skytorial

I edited a special issue of Addiction Neuroscience on dopamine circuitry & heterogeneity in addiction - now complete!🧠🧪 Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...

Honored to have made the frontal cortex (cingulate?) of @npp-journal.bsky.social reviewers this year!

TF-MINDI is out! A new method to learn cis-regulatory codes through rich embeddings of TF binding sites. TF-MINDI decomposes motif neighbourhoods, and works downstream of any sequence-to-function deep learning model. We deeply study the enhancer code in human neural development, check out the thread

Check out the preprint: doi.org/10.64898/202... and the TF-MINDI package: github.com/aertslab/TF-MINDI. With @lukasmahieu.bsky.social ’s help this has become an amazing and user-friendly package, please give it a try and provide feedback.

Don’t know what was more thrilling, the Atlantis water slides #ACNP2026 or the high-speed Bahamian roundabouts on the way to and from the airport. Great meeting with great people and I’m already excited for next year.

Congrats to the new @acnporg.bsky.social Fellows! #ACNP2026

Banned from travel to #ACNP2026 at the last minute, the NIH Institute Directors will join the meeting via remote. Koob, Volkow and Acting Director Beckel-Mitchener for NIAAA, NIDA and NIMH.

If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch. IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE. Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.

🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗​​https://unc.peopleadmin.com/postings/308455 #Neuroscience #TeachingJobs #AcademicJobs #HigherEd

The first one is not a test of replicability. It is a test of generalization. It is important to stop conflating these.

Department of Psychological & Brain Sciences at Johns Hopkins is inviting applications for 3 open-rank tenured/tenure-track positions in (1) Behavioral Neuroscience, (2) Cognitive Neuroscience, and (3) Cognitive Psychology. pbs.jhu.edu/about/jobs/

New computational paper from the lab! Thanks to the reviewers for helping us improve this paper from the preprint version and Nucleic Acids Research for a smooth publication process.

So excited to see our latest paper out today in @natcomms.nature.com! Studies led by the amazing @margestelzner.bsky.social www.nature.com/articles/s41.... VTA GABA neurons have a unique role in economic decision making - they integrate reward seeking motivation and the current cost of seeking

Congratulations to Ian Maze, Ph.D. and Erin Calipari, Ph.D. for being awarded the Daniel H. Efron Research Award. 🎉#ACNP2026

The lab is presenting at #SfN2025 Come check out the amazing science being conducted by postdoc Nina Baumgartner @nbaumgar.bsky.social and grad student Alexa Jo Tellez! I am also recruiting a postdoc so please spread the word. #neuroskyence

The Day Lab will be representing our work at the annual Society for Neuroscience conference (@sfn.org) in San Diego this week in two sessions - stop by to see updates on a lot of really cool science! #SfN2025 #Neuroscience

Hi All @sfn.org attendees #SfN2025! Please come see what's happening in the lab & support some excellent researchers (whilst getting out of the rain!). With topics ranging from #HIV, #psychedelics, #fiberphotometry, #social rewards, #risky decision making, to #opioid withdrawal cog deficits!

After 10 years, I am stepping down as chair of our department and we have an active search going on! Utah is a phenomenal place to live and work and it's been the honor of a lifetime chairing the department founded by Lou Goodman. #MedSky #Neuroskyence Repost! jobs.chronicle.com/job/37914733...

Awesome work by lead author Lauren Burgeno et al: Dopamine evoked by non-contingent cues increases over cocaine use, producing greater cue reactivity; whereas dopamine evoked by contingent cues decreases over cocaine use, producing escalation of drug consumption. www.nature.com/articles/s41...

The Gowrishankar lab will be opening its doors @neuro_MUSC on Dec 1, 2025! We will be hiring at all levels. I will also be at @SfNtweets presenting my lab's vision on Wednesday, Nov 19, 8AM-12PM at poster board GG7. If you're interested, please reach out! www.raajgowrishankarlab.org

Congratulations to the 2025 SfN award & prize recipients! Their dedication to advancing the understanding of the brain paves the way for future discoveries. SfN looks forward to celebrating their achievements at #SfN25. Learn about the recipients. 🔗 vist.ly/4cni8 #neurosky

Whoever wins the #worldseries tonight is going to make a legion of fans for life The psychology of fans &identification with teams is fascinating Like goslings, boys imprint on the team that wins when they are young. A championship leads them to identify with a team for life, especially boys 8-12

ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline. Apply here: hr.umn.edu/jobs/Find-Job Assistant Prof job code: 364920 Associate/Full Prof job code: 364921

🚨The paper from my postdoc in @graeffjohannes.bsky.social’s lab at @epfl-brainmind.bsky.social is out! We show that memories can be switched on and off by simply changing the « packaging » of DNA in neurons through epigenetic editing. www.nature.com/articles/s41...

Some amazing portrait style photos of bats here. Please reply with your favorite one. jgmartinez-fonseca.smugmug.com/Bat-Photogra...

🧠✨ Genetic Tools Atlas 3.0 is here! The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets. 🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas #neuroskyence

These images of a tissue block face are part of an ongoing effort to map the molecular neuroanatomy of human 🧠 basal ganglia & basal forebrain structures at high resolution 🔬🧪. You can totally get lost staring at these - human 🧠 organization is fascinating.

First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience Our latest in @natrevneuro.nature.com Link: rdcu.be/eMX3E @jeffcolgren.bsky.social @msarscentre.bsky.social

Talk about an in-flight meal. For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn

The Cummings Lab is hiring a postdoc to work in the areas of reward and addiction! Please see the ad below:

Congratulations to Rebekah Rashford and team, it’s finally out! We tagged early life stress-activated neurons in VTA and found that chromatin those cells was much more open, even into adulthood, and that open CREs predicted greater gene expression in response to stress later in life rdcu.be/eLa9z

I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!

www.nature.com/articles/s41... Finally out!!

Check out our new work from former undergrad Akash Shanmugam and team in Addiction Neuroscience directly comparing the rewarding and analgesic potencies of morphine and methadone. www.sciencedirect.com/science/arti...

With 2 postdocs moving on to faculty positions🥳, we're looking to hire someone new. If you're interested in norepinephrine and neural circuits, please apply! tinyurl.com/42bfe24k

Excited to share this new work from the lab, in collaboration with @jtuscher.bsky.social & Rob Sorge! Here, we used single cell transcriptional profiling to define molecular adaptations induced by chronic pain and opioid experience, which often occur in conjunction. www.biorxiv.org/content/10.1...

What a great retreat! Thanks to the entire UAB neuroscience community for contributing their science, and to @ishmailsaboor.bsky.social for an awesome keynote lecture!