Cool new work from Bruno Gegenhuber in Michael Greenberg's lab defines the transcriptional programs that glucocorticoid receptors use to remodel astrocytes. www.nature.com/articles/s41...

Beyond obvious fraud, there are still so many issues with antibody purchasing from commercial vendors. Almost always, the burden of proof that an antibody is not as advertised falls on individual labs.

@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro...

Even with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear. n.pr/4dwU7Fi

Interesting work from friend (and former bandmate) @fluketc.bsky.social on the impact that reward magnitude has on learning rate. Stands to reason that unexpectedly large rewards use dopamine-dependent mechanisms to support maladaptive (yet very efficient) learning in the context of gambling.

Thrilled to share my main postdoctoral work out @nature.com ! This project tackles a fundamental question: how do pregnancy and postpartum experiences promote lifelong changes to the brain? www.nature.com/articles/s41...

There are a lot of barbecue sauces out there, and people have very strong opinions on which are the best. Wirecutter did their own taste test of 18 different sauces, spanning different regional styles and flavor profiles. nyti.ms/4dy51e1

Is there a German word for when your 13 year old declares the music that took you through college and grad school “the worst music ever made”?

All the philosophy students who pursued their passion made a wise decision. Learning how to think is a always a good investment. Psychology grads are not doing too badly on the job market either.

Really important to assess what controls are on any technique before diving in and using 😬

A colleague received bad news from her NIH program officer today: my colleague’s grant got a great score, but NIH still can’t pay it, and my colleague will have to closer her lab. The call ended with the program officer (not my colleague) crying. Awful on so many levels.

Important new publication in Neuron led by CNC member Dr. Jeremy Herskowitz (@herskowitzlab.bsky.social) showing that tau protein spreads through connected neurons in people with Alzheimer’s disease. www.uab.edu/news/researc...

Congratulations to CNC faculty members @kacummings.bsky.social, Ronald Lazar, and Cynthia Owsley, each of which received a 2026 Dean's Excellence Award from the UAB Heersink School of Medicine.

Very cool preprint by former lab undergraduate Jasmin Revanna on APOE4 contributions to lysosomal and mitochondrial regulation in human-derived microglia. So much recent convergence around microglia dysfunction in neurodegeneration, this provides a potential mechanism!

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

FINALLY HR has the posting up for a postdoc opening in my lab ! Particularly interested in folks with electrophysiology, photometry, or behavioral experience. www.gwu.jobs/postings/125...

Really pleased that this work with @dudman.bsky.social is now out in Neuron: A global dopaminergic learning rate enables adaptive foraging across many options

Fun visit to University of Calgary for the Hotchkiss Brain Institute seminar series - many thanks to @cannabrain.bsky.social for the invite and trainees and faculty for great discussions! Some amazing work going on here!

Although cohesin-sensitive, long-range enhancer activation is equivalent in nature to proximal activation. Cooperativity can arise from different levels of activation inputs operating on a non-linear response function. @eliasfriman.bsky.social @uoe-igc.bsky.social www.biorxiv.org/content/10.6...

Psilocybin in the Treatment of Cocaine Use Disorder jamanetwork.com/journals/jam... Some really cool findings from Peter Hendricks of UAB Psychiatry!

Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6... 1/9

The UAB Comprehensive Neuroscience Center and Civitan International Research Center are excited to host keynote speaker Dr. Hongkui Zeng, Executive Vice President and Director at the Allen Institute for Brain Science, for our annual 2026 retreat. Save the date for August 26-27, 2026!

Happy to share with you that we have a new preprint up on @biorxivpreprint.bsky.social " Biased signaling at NTSR1 differentially regulates inhibitory synaptic transmission in the extended amygdala and suppressess motivated feeding in mice" www.biorxiv.org/content/10.6...

An experimental pancreatic cancer drug that’s been shown to double survival in patients with advanced stages of the disease is poised to revolutionize the way the cancer is treated, oncologists say.

I’m recruiting a new lab manger! Please pass on to anyone who might be interested, and have them reach out to me once they’ve applied. Photo proof of awesome lab to join research-princeton.icims.com/jobs/21793/r...

Excited to share this preprint. We mapped transcription initiation in astrocytes at single-base-pair resolution to define cell-type-specific active regulatory elements.

Scientists keen to achieve more precise control over an organism’s genetics are experimenting with a surprising approach that leaves the genome itself unharmed econ.st/4n0MVFM Illustration: Mark Pernice

🆕 review with @jpunfried.bsky.social out in Nature SMB. Direct roles of lncRNAs in transcriptional activation. What do we understand about how lncRNAs lure Pol2 and set the stage for RNA production, and what do we still miss? www.nature.com/articles/s41...

Altering gene syntax, defined by the relative order and orientation of neighboring genes, changed DNA supercoiling and affected both the level and variability of gene expression @science.org www.science.org/doi/10.1126/...

Excited to share an early look at psilo-seq, a web portal for exploring our lab’s single-nucleus RNA-seq data in mice following psychedelic treatment.

A multicentre trial reported in Nature shows that a gene therapy improved hearing and speech perception in 90 percent of patients with OTOF‑related congenital deafness. go.nature.com/4sWJzFd 🧬🧪

New preprint led by recent PhD graduate Dalton Fitzgerald characterizing two distinct populations of VTA dopamine neurons that differ in ion channel expression, intrinsic excitability, and response to drugs of abuse. www.biorxiv.org/content/10.6...

This work is now available online in @elife.bsky.social - thanks to the reviewers for excellent comments! Check it out if you are interested in the intersection of pain, opioids, and the ventral tegmental area! elifesciences.org/reviewed-pre...

For #FluorescenceFriday and in celebration of a paper acceptance - super excited to get this one out to the community soon 🤩, cluster of "D1 islands" in the nucleus accumbens of the human 🧠 (🟢 MBP; 🔴 DRD1; 🟡 RXFP1; 🟣 OPRM1). Image credit to @svitlanabach.bsky.social @ishbeldelrosario.bsky.social 🔬👩‍🔬

Fantastic talk from @christineliu.art as part of the UAB Neuroscience Seminar series - really intriguing to see rigorous quantification of the behavioral effects of psychedelics across several institutions, and mechanistic circuit dissections with cutting edge tools!

Really thrilled to share my lab's latest work where we characterize the role of the CeA in integrating exogenous GLP-1 signals. www.biorxiv.org/content/10.6...

Delighted to share our latest research from the 23andMe Research Team, just published in @nature.com ! We looked at data from >27,000 participants to uncover how human genetics influences weight loss efficacy and side effects of GLP-1 medications like semaglutide. A short thread 🧵👇

A short episode of social interaction reduces reinstatement of cocaine seeking after abstinence This effect depends on a competition between functionally specialized dopaminergic ensembles within the VTA www.nature.com/articles/s41...

This Saturday, meet the UAB CNC team at Hoover Library at 11AM for Brain Chats in collaboration with the @uabcappi.bsky.social! UAB CAPPI Director, Dr. Karen Cropsey will present “Trying the Tide on Overdose: Science, Solutions, and Hope”. Bring a friend and join the discussion! 🧠

Very cool to see the UAB Comprehensive Neuroscience Center leading the charge in communicating neuroscience to our local communities in a variety of formats. Last week we reached over 3,000 people as part of #BrainAwarenessWeek activities with the McWane Science Center (@mcwanescience.bsky.social).

For #FluorescenceFriday, some of my favorite sections from a new 10X Xenium run at different locations in the anterior/posterior axis of the mouse brain (credit to Olivia Drake, an MD/PhD student in the lab). Each dot marks the location of a specific type of deep layer excitatory neuron.

Our NIAAA funded Post-DoctT32 has received its NoA (non competing renewal). Are you looking for a post-doc and interested in joining our amazing center? If so, reach out! Here is a convenient form that you can use to upload CV and a cover letter! unc.az1.qualtrics.com/jfe/form/SV_...

🚨The Sweis Lab for Translational Neuroeconomics at Mount Sinai is searching for a postdoctoral research fellow! If you or someone you know is searching for a position, please share! 📄 📌Link to job flyer here: tinyurl.com/3vapfpn5 🧠 🐁 🔬🏙️🌆🧪🧬💊🧫💡🏥 @sinaibrain.bsky.social @mountsinai.bsky.social

NRSA levels for FY26. grants.nih.gov/grants/guide...

Great conversations with representatives for Senator Britt, Senator Tuberville, Rep. Palmer, and Rep. Sewell as part of @sfn.org's Hill Day activities. We discussed the need for stable and timely federal support for biomedical research and shared what this support means for Alabama. #hillday

Did not have snow flurries on my calendar for today! Springtime weather in Birmingham is always a fun surprise.

Snooping through the lab network drive for #FluorescenceFriday images and came across this stunning image from UAB master's student Caroline Fiore. 🟡 is mu opioid receptor protein in the rat brain in a coronal section that includes the nucleus accumbens and dorsal striatum.

Also see news story on these findings from @npr.org. www.npr.org/2026/03/10/n...

New work involving CNC member Dr. Peter Hendricks shows that psilocybin therapy is more likely to result in long-term smoking cessation as compared to a nicotine patch. jamanetwork.com/journals/jam...

"GRNs, which should provide mechanistic explanations, are increasingly reduced to statistical correlations — ‘hairballs’ that fail to capture molecular causation" By Maizels and @jamesbriscoe.bsky.social www.nature.com/articles/s41...