📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...

Check out this great story from our IGC colleagues in the @hannahlong.bsky.social lab!

Last chance to become a mentor in Sci.STEP, the call is about to close!

So excited to be funded by @erc.europa.eu to work with this extraordinarily talented group of scientists on the GeneMotors project - unravelling how SMC motors work, how they are regulated and how they regulate gene expression. @ceesdekker.bsky.social @uoe-igc.bsky.social

🥁This Wednesday , in #FragileNucleosome seminar, we are excited to host @hannahlong.bsky.social and @jeffvierstra.bsky.social to tell us about amazing work they are doing! 🗓️Register here for upcoming session and the entire series: us06web.zoom.us/webinar/regi...

📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways www.biorxiv.org/content/10.1...

I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)

Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679... You'll learn a lot and it'll be fun and interesting! #DKTK @dkfz.bsky.social @lmumuenchen.bsky.social

Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression www.biorxiv.org/content/10.1...

Alternative transcripts are enriched for tissue-specific expression and in genetic variants associated with disease. Many variants are predicted to be structurally damaging. Check out 🧵 below from PhD student extraordinaire Giovanna Weykopf‬! @gweykopf.bsky.social

Congratulations to @gweykopf.bsky.social for her first first author manuscript, now on biorxiv. www.biorxiv.org/content/10.1... Many thanks to all involved - @wbickmor.bsky.social @mbadonyi.bsky.social @eliasfriman.bsky.social, Joe Marsh, Jasmine Nguyen, Mark Gorrell and others.

GWAS to mechanism: when non-coding is coding. Beautiful insightful science from @gweykopf.bsky.social @simonbiddie.bsky.social Joe Marsh and many colleagues. @uoe-igc.bsky.social @cmvm-edinburghuni.bsky.social www.biorxiv.org/content/10.1...

Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!

Excited to share our hot-off-the-press @biorxivpreprint.bsky.social that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬 www.biorxiv.org/content/10.1...

Calling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function. Deadline July 15th. www.mdc-berlin.de/career/jobs/...

Postdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro

Great to see this published @genesdev.bsky.social. Evidence that enhancers can activate a bystander gene in an adjacent TAD, and that cohesin facilitates this. @uoe-igc.bsky.social. pubmed.ncbi.nlm.nih.gov/40436628/

The Robson lab's second paper! A truly fun collaboration with an unexpected and important finding - progenitors reconfigure 3D genomes organisation to commission loci for future cell fates. A heroic amount of work from a rockstar team.

Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May: www.findaphd.com/phds/project... Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social). Please share 🙏 #epigenetics

The first paper from the Robson lab and a wonderful team effort with our international collaborators. Through a lot of detective work, we unravel an important artifact, Ab-trapping, that leads to profoundly misleading signal in both microscopy and genomics. Absolutely worth a read!

📢 Our work on the orchestration of pluripotent stem cell genome reactivation during mitotic exit is now out www.sciencedirect.com/science/arti... A short 🧵

📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪

📣 New preprint from the lab – Massive work entirely driven by super-talented @simsakong.bsky.social , jointly betw. @beatfierz.bsky.social lab and mine – combining in vitro and in vivo TF single molecule imaging www.biorxiv.org/content/10.1...

Exciting research update 🎉 How do eukaryotic TFs find target sites on the chromatinized genome? How does DNA state—naked or nucleosomal—shape their search strategy? We investigated how the charge of disordered regions flanking DBDs influences target search and pioneering activity. Check it out! 👇

New preprint of my postdoc work! We found a novel group of zinc-finger proteins that rapidly evolved in a lineage-specific manner to repress regulatory activities of transposon-derived sequences through anchoring nucleosomes. #TEsky biorxiv.org/content/10.110…

We extended the early bird and abstract submission deadline for 'Hidden Cell, Dark Genome' to Wednesday 12th March - sign up now and join us for this exciting meeting! institute-genetics-cancer.ed.ac.uk/hidden-cell-...

4/ 6.5 years in the making - Answers a longstanding ❓ of the lab: how cells adapt protein decay rate when protein synthesis rates fluctuate ➡️ essential to maintain protein homeostasis. Most cell types adapt decay rates to partially preserve their proteome - but naive ESCs do it better ! Thanks mTOR

📣 One week left for early bird registration and abstract submission for the 'Hidden Cell, Dark Genome' conference 3-4th April in Edinburgh. Regulatory functions of the dark genome, uncharted proteins & RNA complexity, cellular diversity, and atomic structures at the cellular scale 🧬! Join us #HCDG25

We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics.bsky.social DM me for inquiries pl apply/share tinyurl.com/m6jnksk5

(6/6) #Epigenetics #StemCells Check out the preprint: www.biorxiv.org/content/10.1...

Do you have a new and exciting chromatin/transcription story that you'd like to share with an enthusiastic audience? If so, you should apply to give a talk in the 2025 Fragile Nucleosome seminar series: forms.gle/fwMYPFDf4az3...! We're open to scientists at all stages of their careers!

Our new paper showing how loss of the nuclear pore protein TPR leads to activation of an inflammatory gene expression programme in senescence is now published in eLife: bit.ly/4h1VcFi @wbickmor.bsky.social @uoe-igc.bsky.social @elife.bsky.social

After a month of hard work to create a pool of over 50 fantastic mentors, we have opened the call for mentee applications! If you are an early career researcher and need help navigating the career path (be it academia or industry, or anything else), see if there is a mentor for you and apply!

Postdoc positions in epigenetics! We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️ See👇or contact me for other options. Pls RS

One enhancer can activate two endogenous genes simultaneously and across a TAD Boundary. Check out our new preprint. www.biorxiv.org/content/10.1...

JOBS! JOBS!! JOBS!!! 3 open positions in my lab (PhD & 2Postdoc). 2 in collaborative projects. if you're interested in using synthetic genomics to program gene regulation (or in #HIV latency) & could imagine a working in #Berlin. Apply/DM/email me! Find details below - spread the word please

🌟 if you're thinking about becoming a #mentor but unsure: Your unique experiences can guide and #inspire others! 💙 It might be intimidating to label oneself a "mentor", but mentoring is about sharing your journey, not having all the answers, and you can help at any stage of your #ScientificCareer

Interested in difficult to access parts of genetics, cellular & structural biology? Join us in Edinburgh 2-4th April 2025 for "Hidden Cell, Dark Genome" Regulation in the dark genome Uncharted proteins, RNA complexity Atomic structures at cellular scale Cell diversity www.ed.ac.uk/c/hidden-cel...

Now for a science question. Does anyone know of an alternative to ERT2/tamoxifen for tight control of protein activity (e.g. recombinase) in tissue culture cells? Tetracycin promoter could work for inducible transcription, but requires to express an extra protein, so less convenient.