Jason Tan
@yjtan.bsky.social
๐ค 35
๐ฅ 54
๐ 12
CS PhD student at Stanford; prev Rice CS
pinned post!
Does every enhancer work with every promoter? With
@jengreitz.bsky.social
and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour ๐งต๐
www.biorxiv.org/content/10.6...
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Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers
Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...
https://www.biorxiv.org/content/10.64898/2026.06.25.734173v1
3 days ago
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59
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reposted by
Jason Tan
Abby Thurm
3 days ago
Great experience compiling years of collective screening experience to produce what we hope is a comprehensive protocol for others to accessibly scale up experiments! And some fun new data hidden in there :)
@joshtycko.com
www.nature.com/articles/s41...
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High-throughput measurements of protein domain functions using magnetic separation - Nature Protocols
This Protocol presents a scalable magnetic separation-based method for screening large protein domain libraries in mammalian cells, providing a simple and quantitative alternative to fluorescence-acti...
https://www.nature.com/articles/s41596-026-01397-z
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Does every enhancer work with every promoter? With
@jengreitz.bsky.social
and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour ๐งต๐
www.biorxiv.org/content/10.6...
loading . . .
Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers
Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...
https://www.biorxiv.org/content/10.64898/2026.06.25.734173v1
3 days ago
2
59
36
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