#Happynewyear #happy2026 We wish you all a very happy personal and professional year 2026, full of accepted papers, funding, promotion, tenured and great scientific results.

Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)

Join @stirlingchurchman.bsky.social, @moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...

Les guerres de Lucas ou l'histoire du tournage de la trilogie de #starwars Le volume 1 était vraiment super, le volume 2 est top. Vivement le volume 3 !

High-resolution binding data of TFIID and cofactors show promoter-specific differences in vivo https://www.biorxiv.org/content/10.64898/2025.12.22.691305v1

Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)

Read our new preprint where we uncover a hierarchy in human PIC assembly and establish a quantitative framework that connects factor exchange kinetics to the regulation of Pol II activity in living human cells. doi: doi.org/10.64898/202... By A. Oravecz and our collaborators @molinalab.bsky.social

🚨 Postdoctoral Opportunity for Female Scientists🚨 The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists Interested? Get in touch via direct message careers.univie.ac.at/en/postdoc/e... #MicroSky 🧪 #PostDoc @univie.ac.at

Des étudiantes posent des questions piquantes (mais nullement insultantes) à Rodolphe Saadé sur son empire médiatique. En réaction, des responsables universitaires les fustigent. Et décident qu'à l'avenir, les questions étudiantes seront cadrées en amont... L'Université meurt de l'auto-censure.

see also this 🙃 www.gustavobatista.com/hallucination/

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

New paper: A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome Kim, Huang, Johnson, Yaron-Barir, Keven Wang, Cantley, Hu, Perrimon bioRxiv 2025.10.10.681672; doi: doi.org/10.1101/2025...

💡 New paper out in @natcellbio.nature.com 💥💥💥🚀🚀🚀 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation well beyond early development, in differentiated, non-dividing cells and in vivo post implantation embryos 👇👇👇👇

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

I try to focus on posting about art and comics and not my complaints about the state of everything but GOOD GRIEF

"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"

" if you need an LLM to provide the text for you, it may be because you are unwilling to do the thinking."

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

We all need to be far more skeptical about the "promises" of AI in academia. This hands a terrifying amount of power to AI companies. And if we’re delegating all the critical thinking to AI (generate papers, summarize papers, review grants and papers, analyse data), this is the end of academia.

🤕

Research questions generated by AI. Questionnaires filled out by AI. Paper written by AI. Paper reviewed by AI. Just make it stop.

New preprint🚨 Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design? What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be? Why to be wary🧵👇

mouarf, petit test d'Emmy, le chatbot du CNRS, pour analyser l'un de mes derniers papiers. Plutôt correct mais des réponses souvent longues et un peu ampoulées. Et puis le cirage de pompe, c'est vraiment pas la peine.....

5 months from Latent-X1 to Latent-X2. AI-generated antibodies with drug-like developability and low immunogenicity in human panels — zero-shot. Available now for selected partners.

😵‍💫

New online: Evolution of promoter-proximal pausing enabled a new layer of transcription control

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II: www.biorxiv.org/content/10.6...

Dear McDonald's & Coca-Cola, that's how you make a Christmas ad 😜 Guaranteed not AI-generated youtu.be/Na9VmMNJvsA?...

Stealworkers

ha ha 🫣 Structure of human cytoplasmic Pol II complex explains global transcription repression by Gdown1 cc @triggerloop.bsky.social www.biorxiv.org/content/10.6...

🤯

Paging @agencerecherche.bsky.social @enseignementsup-recherche.gouv.fr 😬 #ESR

Date limite pour envoyer sa candidature, 12 janvier 2026 (sncs.fr/2025/12/11/c...) #ESR #CoNRS Concours 2026 bon courage pour la dernière ligne droite à toutes celles et tous ceux qui vont postuler

wait, wait, what ???? aixiv.science

My favourite conference ! And this year it's from Tuesday to Friday! It doesn't start on Saturday like in previous years!

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

Structure of cytoplasmic RNA polymerase II www.biorxiv.org/content/10.6...

mouarf #ESR #keylab 😂

Concours CNRS 2026 #ESR CRCN l'arrêté est enfin sorti ! www.legifrance.gouv.fr/jorf/id/JORF...

Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have. mrc.tal.net/vx/mobile-0/...

L’évaluation des articles scientifiques bouleversée par l’IA

Backward translation (3' to 5' Translation of Circular RNAs?) www.biorxiv.org/content/10.6...

This preprint dates from July 2024, but I just stumbled upon it. Single-molecule tracking in living yeast to assess the physiological kinetics of over 50 representative proteins encompassing all three RNAP machineries. www.biorxiv.org/content/10.1...

Pour celles et ceux qui aiment bien les statistiques, le site de l'ERC qui répertorie tous les lauréats depuis 2007 est très bien fait. #ESR On peut trier par année, par financement, par pays dashboard.tech.ec.europa.eu/qs_digit_das...

Petit rappel : Il est temps de commander Material & Methods si vous souhaitez l'offrir à Noël ! La collection est complète en seulement 4 tomes, de quoi populariser la recherche scientifique autour de vous ! pellishop.sumupstore.com

The Thinking Game, a journey into the heart of DeepMind #alphafold youtu.be/d95J8yzvjbQ?...