In this Molecular Cell Voices piece, @genophoria.bsky.social comments on how he thinks about bridging bench and computational work: www.cell.com/molecular-ce...

A new paper from the Patrick Hsu and Silvana Konermann labs introduces RESPLICE, a dual CRISPR system that rewrites cellular transcripts by splicing new exons directly onto target mRNAs.

"Instead of designing experiments by hand, we're going to have AI models design the experiments for us and help us troubleshoot and decide what to do next." Patrick Hsu talks about integrating AI models and biological research with Jacob Goldstein: www.pushkin.fm/podcasts/wha...

An amazing day for science at the 2nd Annual Arc Symposium! Thank you to everyone who joined us from our labs, technology centers, partner universities, and beyond. We are so grateful that you're part of our community.

We're launching the Arc AIxBio Fellows Program to support the next generation of researchers working at the interface of AI and biology. Teams of 2-3 undergrads propose and execute their own research projects over 6-12 months with Arc mentors. arcinstitute.org/news/aixbio-...

In a new review published in @cp-neuron.bsky.social, @christophthaiss.bsky.social and team synthesize emerging research on intestinal interoception, highlighting how signals from the gut shape communication between the environment, the body, and the brain to maintain human health.

It's an exciting time to be at Arc. We recently welcomed a new CSO, announced a major partnership with Tahoe Therapeutics and Biohub, and are continuing to open source models and techniques to push forward progress on virtual cells.

A new paper from Jeffrey Wang, @genophoria.bsky.social, and team describes orphan non-coding RNAs, known as "oncRNAs," as cancer-emergent molecules with important roles in tumor identity and progression, and clinical monitoring across human cancers: www.cell.com/cell-reports...

Today I’m happy to release cyto, a tool I’ve developed at @arcinstitute.org to dramatically increase our computational throughput with 10x-flex single-cell processing by more than 16X!

Arc bioinformatics scientists @noamteyssier.bsky.social and Alex Dobin have just released cyto, an ultra-high throughput processor specifically optimized for @10xgenomics.bsky.social Flex single-cell data. We are excited to make this resource open source: www.biorxiv.org/content/10.6...

The next inflection point in virtual cell modeling will require large-scale perturbative data. To get there we are partnering with @tahoetherapeutics.bsky.social and @biohub.org to help us generate a dataset to push us forward: arcinstitute.org/news/tahoe-a...

Predicting cell state in previously unseen conditions has typically required retraining for each new biological context. Today, Arc is releasing Stack, a foundation model that learns to simulate cell state under novel conditions directly at inference time, no fine-tuning required.

Today, we welcome Megan van Overbeek as our first Chief Scientific Officer. At Arc, she'll drive the discovery of novel therapeutic strategies for complex diseases, bringing expertise that bridges fundamental research with therapeutic development.

Arc’s Science Fellows program gives a springboard to recent PhD and/or MD students to become a PI right out of grad school. Interested? Apply by Jan 12 or hear from our team and current Fellows Jingtian Zhou, Uche Medoh, and @mayaarce.bsky.social in this video: youtu.be/3Qs5cmXxsWQ

Altos Labs has taken home the Generalist Prize for the most "well-rounded" model across metrics at @arcinstitute.org's Virtual Cell Challenge! The competition highlights the challenge of defining robust benchmarks for biology. #NeurIPS2025 Read at GEN: www.genengnews.com/topics/artif...

Congratulations to the winners of the @arcinstitute.org Virtual Cell Challenge using 10x Genomics GEM-X Flex technology. Ready to build your own? http://virtualcellchallenge.org/ #VirtualCellChallenge #AI

Thank you to everyone who made the inaugural Virtual Cell Challenge a success. Over 5,000 participants from 114 countries competed to build AI models that predict cellular responses to genetic perturbations. Today we're announcing the winners and reflecting on what we learned.

A preprint out today from Arc Innovation Investigator Theo Roth, Austin Hartman, Oliver Takacsi-Nagy, and colleagues introduces CRISPR All–a unified programming language for editing human cells across all major genetic perturbation types at once.

Published today in @nature.com, @adititm.bsky.social & researchers from the @brianhie.bsky.social lab report that the large-scale genomic model, Evo, is capable of using surrounding genomic context to produce novel, functional genes, enabling an an emergent approach they've termed 'semantic design'.

Congratulations to Arc Science Fellow, @uchemedoh.bsky.social, on being named a winner of the 2025 @science.org & @scilifelab.se Prize for Young Scientists! His work solves a decades-old mystery in cell biology, revealing the enzyme responsible for BMP synthesis: www.aaas.org/news/researc...

Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.

A study out today in @natgenet.nature.com from Core Investigator Luke Gilbert, Haolong Li, & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.

Welcome to our 9th Core Investigator and first physician-scientist, John Pluvinage. His team investigates the hidden overlap between autoimmunity and neurodegeneration, developing targeted treatments for mysterious neurological cases and common dementias.

The genetic code is full of synonymous codons that, for decades, were assumed to be interchangeable. Today, with NVIDIA, co-led by @genophoria.bsky.social, we announce CodonFM, a family of open-source AI models that reveal the grammar underlying codon choice: developer.nvidia.com/blog/introdu...

Arc Core Investigator @genophoria.bsky.social will speak on a free, online panel with @tkaraletsos.bsky.social, @emmalundberg.bsky.social, and @ronalfa.bsky.social on Wed., Oct. 29, as part of GENbio's “The State of AI in Drug Discovery in 2025.” Register at: webinars.liebertpub.com/e/the-state-...

Published today in @natureportfolio.nature.com Biotechnology, Laine Goudy, Luke Gilbert, Alex Marson, & colleagues report an epigenetic editing platform that safely reprograms multiple genes in human T cells without many of the challenges & risks associated with traditional gene editing approaches.

Arc is looking for an outstanding early-career scientist to be our next Science Fellow. This program provides resources and freedom for those looking to transition into a principal investigator role immediately after doctoral training. Apply here: arcinstitute.org/programs/sea...

Hear how Arc, Ultima Genomics, and @10xgenomics.bsky.social are partnering to generate perturbation data at the scale needed to train virtual cell models on The Bio Report podcast with guests @genophoria.bsky.social, Gilad Almogy, and Serge Saxonov: thebioreport.podbean.com/e/transformi...

Arc's community continues to grow this fall with our 9th Core Investigator John Pluvinage and 3rd Science Fellow @mayaarce.bsky.social joining us in Palo Alto, along with 7 Innovation Investigators and 15 Ignite Awardees at our partner universities. Learn more: arcinstitute.org/news/faculty...

For decades, human genome editing has been limited to small, localized modifications. Today, in a new paper published in @science.org , researchers from Arc's Hsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.

New work from Arc's @pauldatlinger.bsky.social of our Genome Engineering Technology Center. Congrats!

Having often dealt with the frustration of binder-limited projects, we sought a more accessible source for nanobodies than yeast display or llama. Here we introduce Germinal, computationally designing antibody-like binders with such a hit rate that only tens need to be screened for each target.

In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design. Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.

Arc Innovation Investigator research highlight: Stanford Professor Zhenan Bao and colleagues have developed NeuroString, a hair-thin multichannel biosensor and stimulator with promising potential applications in drug delivery, nerve stimulation, smart fabrics, and more.

Genome foundation models, Evo 1 and Evo 2, have now generated viable bacteriophage genomes, demonstrating experimental validation of whole genomes designed by AI! @arcinstitute.org @brianhie.bsky.social @samuelhking.bsky.social Read more at GEN: www.genengnews.com/topics/artif...

In a new preprint from @brianhie.bsky.social's lab, the team reports the first generative design of viable bacteriophage genomes. Leveraging Evo 1 & Evo 2, they generated whole genome sequences, resulting in 16 viable phages with distinct genomic architectures.

🧠 Arc Workshop at the upcoming scverse conference 2025 🧠 Processing and Modeling Large-Scale Single-Cell Perturbation Data with Machine Learning 🧵 @arcinstitute.org #scverse2025 #PerturbSeq #MachineLearning #SingleCell #CRISPR #GenomicScreening #VirtualCells

Welcome to our third Science Fellow, Maya Arce (@mayaarce.bsky.social). Her team uses large-scale genomic screening and CRISPR editing to decode how genetic regulators control immune cell behavior.

In this blog post from Arc scientists, learn about some of the decisions that went into the dataset and three-metric evaluation framework developed for the first Virtual Cell Challenge. arcinstitute.org/news/behind-...

Over 2,500 people have registered for the Virtual Cell Challenge and we're nearly three months away from when final submissions are due. We created a notebook tutorial showing how to train Arc's STATE model for context generalization for anyone looking to get started: www.youtube.com/watch?v=1kKH...

Our latest Forum podcast is a roundtable on foundation models, featuring guests Marie Lopez, @instadeep.bsky.social head of genomics AI and @brianhie.bsky.social of @stanford.edu and @arcinstitute.org shows.acast.com/forum/episod...

Over 2,000 people have registered for the Virtual Cell Challenge to create an AI model that can generalize for unseen perturbations. Hundreds of competitors have been submitting results from their models and the race, as you can see from the leaderboard, is heating up:

Our 2nd Investigator Retreat wrapped up with talks from Core Investigators Christoph Thaiss and Felix Horns, our incoming Science Fellow Maya Arce, and some of our Innovation Investigators and Ignite Awardees. We look forward to seeing how the connections made this week turn into new collaborations.

The Arc Institute Investigator Retreat is off to a great start! Huge thanks to Dave Burke and @brianhie.bsky.social for for sharing their computational research, and to Isha Jain, Will Allen, Faranak Fattahi, and Alex Pollen for diving into cell biology and neuroscience.

Core Investigator @lingyinli.bsky.social's new paper in Nature Chemical Biology investigates why human STING inhibitors have shown limited efficacy, despite strong activity in mouse models.

Welcome Isha Jain, Arc's eighth Core Investigator! Jain has spent more than a decade studying how the human body senses, and responds to, external molecules—especially oxygen and vitamins.

@arcinstitute.org‬ has announced the inaugural “Virtual Cell Challenge,” sponsored by NVIDIA, @10xgenomics.bsky.social and Ultima Genomics, which will evaluate the ability of AI models to generalize to new cell contexts for therapeutic applications. 1/ www.genengnews.com/topics/artif...

Register today for the Virtual Cell Challenge and use AI to solve one of biology’s most complex problems. Announced in @cellcellpress.bsky.social, the competition is hosted by Arc Institute and sponsored by NVIDIA, @10xgenomics.bsky.social and Ultima Genomics.

Introducing Arc Institute’s first virtual cell model: STATE

“Every failure teaches us something.” Arc's Core Investigator @lingyinli.bsky.social on the path to STING activation, cGAMP, and what it means for the future of cancer treatment. news.stanford.edu/stories/2025...