Inflammation drives nearly every major disease—cancer, heart disease, and autoimmune conditions. Yet we've never been able to watch it progress in living tissue. We're funding 15 projects to build real-time molecular tools to change that. Learn more ➡️ bit.ly/4wFDJej

New in @natbiotech.nature.com from Aly Khan: a platform combining yeast display with fine-tuned protein language models to identify antigens driving autoimmune disease. In collaboration with Chris Garcia at @stanfordpress.bsky.social / @hhmi-science.bsky.social 🧵

Datasets of recognition profiles for individual TCRs vs millions of peptides offers a scalable approach to mapping TCR recognition, accelerating antigen discovery and guiding TCR engineering @stanforduniversity.bsky.social @biohub.org #Garcia @natbiotech.nature.com www.nature.com/articles/s41...

Great to see Biohub's investment in the future of AI and cell biology with its 5-year Virtual Biology Initiative programme. Beautiful alignment with the roadmap for HCA 2.0, and lots of excitement about future synergies.

By scaling high-quality foundational datasets to train virtual cell models, we can directly accelerate progress against complex diseases. We look forward to working with Biohub and other partner organizations on this effort.

Today we're launching the Open Source for Science Fund, a new multi-donor philanthropic fund by Renaissance Philanthropy, seeded by @biohub.org and @wellcometrust.bsky.social, with support from @kavlifoundation.org and @researchsoftware.bsky.social 🧵 os4science.org/news/open-so...

Today we're announcing the Virtual Biology Initiative—a major new commitment to build the data foundation biology needs to power the next generation of AI models. Next-gen imaging. Molecular engineering tools. Open data infrastructure for the entire scientific community. Read more: bit.ly/3ONTkHO

On the cover of @cp-cellbiomat.bsky.social! New study by Kangfu Chen, Danile Wang, Shana Kelly uses omics/engineering tools to better understand how tissues and cells behave in vivo, advancing both fundamental biology and better treatment options for cancer.

We're hosting the NY Symposium on Immune Cell Engineering and Reprogramming this July—bringing together researchers across immunology, synthetic biology, bioengineering, and AI to explore the next phase of programming immune systems. 📅 July 22–23. In-person + virtual registration: bit.ly/4ttMyGh

Excited to share our paper about copick, a dataset API and toolkit for collaborative annotation and analysis of #cryoET data! Whether you're picking particles or curating segmentations, copick reduces friction and brings #OME-Zarr to cryoET without breaking pipelines. 🧵👇 doi.org/10.1002/pro.70578

How can modeling and #AI help build predictive, cell-scale theoretical frameworks? CB@S – a one-day symposium on AI-driven modeling & the future of #CellBiology. 📍 Stockholm, Sweden. 📅 June 3, 2026 🤝 Co-hosted by SciLifeLab and @biohub.org Info & registration ↓ www.scilifelab.se/event/cell-b...

#UMAP in VR for #3DThursday! In this zebrafish embryogenesis dataset, RNA-seq + ATAC-seq across 94k+ cells reveal changing regulatory programs over time. 🥼 Yang-Joon Kim, Loic Royer @loicaroyer.bsky.social , Matthias Haury 📝 www.biorxiv.org/content/10.1... 🏛️ Biohub @biohub.org 🎬 #syGlass v2.6.0

The 2nd Chicago BioEngineering Conference (CBEC) is coming! We have a stellar lineup of speakers and sessions on omics, bioelectronics & AI × bio. See you in downtown Chicago Sept. 17-18! Space is limited — register early. Learn more ➡️ biohub.org/event/chicag...

*POSTDOC Positions* Multiple positions open in my group at @biohub.org & @feinberg.northwestern.edu / @nitmb.bsky.social We welcome PhDs from diverse disciplines interested in QBio & BioE job-boards.greenhouse.io/biohub/jobs/... job-boards.greenhouse.io/biohub/jobs/... www.goyallab.org/positions

We’re thrilled to welcome 11 new investigators—visionary scientists from @columbiauniversity.bsky.social, @rockefeller.edu & Yale University who will pursue ambitious, high-impact research and contribute to our Immune Cell Reprogramming work. Learn more ➡️ biohub.org/news/investi...

WaveOrder – a wave-optical framework using machine learning & computation to enhance & clarify biological microscopy images 📷 Talon Chandler et al @mattersoflight.bsky.social lab @biohub.org in @arxiv-soc-ph.bsky.social ➡️ bpod.org.uk/archive/2026... with @antdlewis.bsky.social

Cell Biology at Scale (CB@S) is coming to Europe for the first time! 🇸🇪 🧪 Join us & @biohub.org for a one-day symposium on multimodal data, AI-driven modeling & the future of #CellBiology. 📍 Stockholm, Sweden | June 3, 2026 Learn more ↓ www.scilifelab.se/event/cell-b...

Biohub engineers, led by Rafael Gómez-Sjöberg & Michelle Khoo, designed and built the 3D organoid bioprinter for this work, which will help improve research on how our organs form and function, and develop new treatments for disease. New in @natmater.nature.com

Cell Biology at Scale (CB@S) is coming to Europe for the first time! 🇸🇪 Join @scilifelab.se & Biohub for a one-day symposium on multimodal data, AI-driven modeling & the future of cell biology. 📍 Stockholm, Sweden | June 3, 2026 Learn more: bit.ly/4cTXIib

Studies of uterus transplant recipients reveal how immune cells shape pregnancy outcomes, an amino acid cocktail enhances nanoparticle delivery of therapeutic mRNAs in mice, and more this week in #ScienceTranslationalMedicine. https://scim.ag/3N6ee45

Coinjection of an amino acid cocktail with LNPs enhanced in vivo delivery efficacy and improved preclinical mRNA therapy outcomes www.science.org/doi/10.1126/... @biohub.org

What if the key to better mRNA therapies wasn't redesigning the delivery vehicle—but feeding the cell? A new study from Daniel Wang & @shanakelley.bsky.social describes a surprising solution to a stubborn problem. Read more ➡️ bit.ly/3MXj7MT

Immune profiling links #autoimmune #hepatitis to human #herpes virus 6 and relaxin receptor antigens. New study from Arielle Klepper, Joseph DeRisi @biohub.org, Michele May-Sien Tana and colleagues @ucsanfrancisco.bsky.social: rupress.org/jem/article/... #Autoimmunity #Fibrosis

New in Nature Immunology: @rohamparsa.bsky.social & @danmucida.bsky.social / @rockefeller.edu reveal that where a T cell gets activated shapes what it becomes, foundational to our mission of programming immunity for early disease detection. Read more ▶️ biohub.org/blog/track-t...

A new tool from Rockefeller's @danmucida.bsky.social and @czbiohub.bsky.social allows scientists to closely follow newly activated T cells as they travel and change during an infection—it may inform future therapies for infection, cancer, and autoimmunity. 🔗: https://bit.ly/3NjZEWD

🩷💚💙💜 We stand in solidarity with the rare disease community worldwide. On #RareDiseaseDay, we light up our offices to honor patients, families, clinicians, and researchers advancing understanding and care.

That's a wrap on our AI Applications in Biology Symposium. Grateful to our keynotes, Nikos Hatzakis, @martinsteinegger.bsky.social, Xinyi Zhang, and all presenters for an inspiring day of explorations at the crossroads of machine learning and biological discovery.

🧵Antibiotic resistance is a public health crisis. But viruses called phages have been solving this problem for millennia. New research in @nature.com reveals how 3 different phages attack the same weak spot—a protein called MurJt—potentially leading to a new class of antibiotics.

Our 2nd monthly issue, "Biology's New Era," is live now on www.bigthink.com. In this issue, we explore the bleeding edge of biotech, as well as the scientists, writers, and philosophers whose efforts helped get us here.

The human body is an information system — and AI is helping us decode it to cure or prevent disease. In @bigthink.com, our scientists and researchers explain how #AI is helping us simulate human cells, visualize hidden biology, and detect disease before symptoms appear. bit.ly/46fBq6f

New research led by Andrea Califano, Dr, unveils a framework to decode hundreds of thousands of previously “uninterpretable” cancer mutations— helping clinicians prioritize more effective treatments and avoid unnecessary ones. @biohub.org 🔗 www.cancer.columbia.edu/news/turning...

🎉 Biohub Investigator @pascalge.bsky.social has been named to the 2026 #TIME100 List of the World’s Most Influential Leaders in Health for his groundbreaking epidemiological studies showing how a shingles vaccine lowers risks of developing dementia. Check it out ➡️ bit.ly/4rN5Gh7

AI-powered biology is changing how research happens. On BioTech Nation, Dr. Shana Kelley, our President of Bioengineering & Head of Biohub Chicago, shares how #AI can accelerate discovery and open new paths for understanding biology and disease. 🎧 Listen here: bit.ly/401UIZf

Modern imaging + AI are changing how biologists study living systems. What’s driving the shift? Better imaging hardware, mature computational infrastructure, and tighter collaboration between experimentalists and AI modelers. https://bit.ly/4r778L0

In @natureportfolio.nature.com: CytoTape is a protein-based recording system that lets cells store long-term gene activity histories in situ. It enables multiplexed, single-cell measurements over days to weeks without continuous live imaging 👏 @changyanglinghu.bsky.social & @denisejcai.bsky.social

📡🧵 Excited to release an updated version of our preprint: Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis 🧪🧬🖥️🐠 doi.org/10.1101/2024... A tour-de-force by @yangjoonkim with an unexpected discovery!

The convergence of machine learning, synthetic biology, and immunology is changing what’s possible for human health. https://bit.ly/49KEfgE

We’re partnering with @tahoetherapeutics.bsky.social and @arcinstitute.org to generate the largest perturbation dataset for virtual cell models. Announced at #JPM2026, the 120M+ cell dataset will be open source to accelerate development of biological foundation models. bit.ly/4pBkZbd

We’re building tools to watch immune cells in real-time and stop inflammatory disease before it starts. https://bit.ly/45Ft2g0

Hossein Zargartalebi’s TEDx talk explores a real-time molecular #Biosensor that detects protein biomarkers inside the body. This platform could shift medicine from reactive treatment of disease to proactive diagnosis or prevention. https://bit.ly/3LjHNyc

We're honored to see familiar faces among the winners of the 2026 #SPIE Society Awards 🧵 Congratulations to all of the recipients for your achievements across light-based sciences and technologies.

How close are we to programmable human cells? A new @cellpress.bsky.social perspective from Martha Gillette and Yogesh Goyal explores how synthetic biology & AI are enabling precise control over cell behavior, opening new paths for drug development and personalized therapies. https://bit.ly/48Mx1JO

Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025

WaveOrder is a powerful new #microscopy tool from Biohub that helps researchers reconstruct messy microscope data into clean, quantitative maps. It’s grounded in physics & it’s already changing how we see biology. 📚 Preprint https://bit.ly/4jgDJLB 🔬WaveOrder: https://czi.co/4pMwGgb

🧪 That's a wrap on #CellBio2025! We had a blast in Philly connecting with the cell biology and imaging communities, and sharing our open-access tools!

Join us for the AI Applications in Biology Symposium at @biohub.org! A full day of talks on ML for structural biology, imaging, single-molecule & multimodal/omics data 🗓️ Feb. 20, 2026 (1 day before BPS) 📍San Francisco 🔗 shorturl.at/uQerL Attend in-person or virtual. Submit abstracts by Jan. 20!

I'll be at the AI Virtual Cells and Instruments: A New Era in Drug Discovery and Development. Stop by to chat about generative models and virtual cells! I'll be presenting our work @biohub.org on a scalable latent diffusion model for single-cell gene expression data.

It’s our favorite time of year - hot cocoa & #CellBio2025! Come find us at booth 301 and see some of our latest tools for capturing novel biological insights across scales.

📍#NeurIPS2025! Stop by booth #833 to explore AI-powered tools pushing biology forward: 🧬VariantFormer—predicts how genetic variants affect gene expression 💡scLDM—simulates single-cell data on demand for virtual experiments 🔬ESMC + ESM3—foundational models for protein structure, function & evolution

📣 #NeurIPS2025 Expo Talk: “Building an AI Ecosystem for Multiscale Biological Discovery” w/ Dari Kimanius + Jonathan Schwartz. Today 4–5pmPT. Learn how open cryoET pipelines, multimodal datasets & the virtual cell are helping bridge imaging + AI across biological scales. bit.ly/4py5Wj4