🌐 Join @keystoneSymposia.bsky.social meeting #Neuroinflammation in Health & Disease, this June in Whistler 🚠 JEM's @lucie-jexpmed.bsky.social is attending! Scholarship, abstract & discount reg deadlines are approaching 👉 www.keystonesymposia.org/conferences/... #KSNeuroInflam26

🌐 Deadlines are approaching for @keystoneSymposia.bsky.social #Neurodegeneration: Neurocentric to Systems Perspectives, this June in Whistler 🚠 JEM's @lucie-jexpmed.bsky.social is attending! See scholarship, abstract & discount reg dates 👉 www.keystonesymposia.org/conferences/... #KSNeurodegen26

Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy #gdTcells @jem.org

🌐 Join @keystoneSymposia.bsky.social #TumorMicroenvironment: Drivers of Progression & #Resistance, this May in Whistler 🚠 JEM's @zhijuanjexpmed.bsky.social is attending! Don't miss deadlines for abstract, scholarship, early reg 👉 www.keystonesymposia.org/conferences/... #KSTumorMicro26

🌐 Join @keystoneSymposia.bsky.social meeting, #Inflammation Resolution: Concepts, Mechanisms & Disease, this May in Whistler! 🚠 JEM's @zhijuanjexpmed.bsky.social is attending! Don't miss deadlines for abstract, scholarship, early reg 👉 www.keystonesymposia.org/conferences/... #KSInflammation26

In a new opinion article, Silva-Santos, @rafaelblancodom.bsky.social et al. @gimminstitute.bsky.social discuss the potential of Vδ1⁺ γδ T cells for #cancer #immunotherapy, focusing on delta one T (DOT) cells. rupress.org/jem/article/... #FoundInTranslation #TumorImmunology

Very much looking forward to attending the GRC Lymphatics meeting in a few weeks! Get in touch if you would like to chat, I'll be there all week!

Delighted to share our new paper on LXR agonism pre-conditioning T cells to more readily adopt effector states, out in @jem.org today. This was a long project started in @sohailtavazoie.bsky.social's lab and completed across the atlantic here in Berlin at Charité.

Nasal #vaccination aims to generate protection from pathogens. Liu, Stoler-Barak, and @zivshulman.bsky.social demonstrate that B cells in the nasal lymph nodes depend on BCR affinity and CCR6 for positioning in the NALT subepithelial dome and class switching to IgA. rupress.org/jem/article/...

@ostendorflab.org, @immushuang.bsky.social, @sohailtavazoie.bsky.social et al. show that activation of LXRs elicits a T cell "pre-effector" state that enhances priming and promotes anti-tumor immunity. rupress.org/jem/article/... #TumorImmunology

A recent JEM study from Aroca-Crevillén, @drusqui.bsky.social et al. (rupress.org/jem/article/... ) may provide a novel clue into the connection between neutrophils and the severity of daytime heart attacks. More in @jama.com: jamanetwork.com/journals/jama/fullarticle/2844961

Birui Pan, Chen Dong et al. identify Zbtb32 as a key promoter of terminally exhausted CD8⁺ T cell differentiation, enhancing cell cytotoxicity and anti-tumor function. This study valuable insights for cancer #immunotherapy. rupress.org/jem/article/...

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. New study from Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth @yaleschoolofmed.bsky.social, Uthaman Gowthaman @umasschan.bsky.social and colleagues: rupress.org/jem/article/... #LymphocyteBiology

Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers, say Yuliang Wang, Xinyi Yang, Yunli Wang, Xiaoming Wang, Jingjing Chen (Nanjing Medical University) and colleagues: rupress.org/jem/article/... #LymphocyteBiology #Epigenetics #Metabolism

In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. New study from Lesly Calderón @lesly-calderon.bsky.social, Meinrad Busslinger and colleagues @impvienna.bsky.social: rupress.org/jem/article/... #Hematopoiesis

JEM’s February issue is here! rupress.org/jem/issue/22... 🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)

Our manuscript "In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation" was just published in the @jem.org, @rupress.org!!!

Siniscalco, Fisher, Lu, Eisenbarth, Gowthaman et al. reveal that DOCK8 and STAT3 cooperate in CD4⁺ T cells to restrain Tfh13 differentiation and prevent food-specific IgE. rupress.org/jem/article/... #LymphocyteBiology #MucosalImmunology #HumanDiseaseGenetics

Yuliang Wang, Xinyi Yang, Jingjing Chen et al. demonstrate CD205 is upregulated in pre-plasma cells. The H3K27 demethylase Kdm6b, not Kdm6a, allows prePCs to become bona fide PCs by removing H3K27me3 marks at the Irf4 locus. rupress.org/jem/article/... #LymphocyteBiology #Epigenetics #Metabolism

@lesly-calderon.bsky.social, Busslinger et al. @impvienna.bsky.social describe an in vivo #CRISPR/Cas9 screening system for identifying novel regulators of B cell activation and plasma cell development in the context of the splenic microenvironment of immunized mice. rupress.org/jem/article/...

Explore new #Immunology papers incl. antitumor T cell responses, intestinal #MucosalImmunology, metabolic adaptation in Th2 responses, #myeloid cells ontogeny & the impacts of #circadian checkpoints on their function, and local B cell alterations in #neuroinflammation. 👉 rupress.org/jem/collecti...

@jengommerman.bsky.social lab reveals that dynamic changes in the brain, leptomeninges, & dural B cells are associated w/ age-dependent disease severity in an animal model of progressive #MultipleSclerosis rupress.org/jem/article/... 📘 #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

MHC one–two punch knocks out #cancer. Amir Ghorbani and Jonathan Yewdell @niaidnews.bsky.social discuss new study by Zhang, Chamoto and colleagues @ccii-kyoto.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/... #TumorImmunology #Immunotherapy

Oral antigen exposure under co-stimulation blockade induces Treg cells to establish immune #tolerance. From Masaya Arai, Ryoji Kawakami, Shimon Sakaguchi and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

SLC7A8 is essential for metabolic fitness and function of Th2 cells. From Santosh Panda, Marco Colonna and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

XPR1 regulates fetal liver #macrophage development, identity and pyrenocyte clearance, say Sebastian Stifter, Melanie Greter and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. From Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

Fibroblast diversity within human gut-associated lymphoid tissues. From Urs Mörbe (@ursmoerbe.bsky.social), William Agace and colleagues: rupress.org/jem/article/... 📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

Aroca-Crevillén, @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/... 📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood. From LeBlanc, Sobel, @mikerobe.bsky.social and colleagues: rupress.org/jem/article/... 📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

Cunzhen Li et al. find that in #Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense. rupress.org/jem/article/... 📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

#Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central #tolerance. From Jiří Březina, Dominik Filipp and colleagues @imgprague.bsky.social: rupress.org/jem/article/... 📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

Explore the latest #Immunology research, incl. antitumor T cell responses, central & peripheral #tolerance establishment and maintenance, intestinal #MucosalImmunology, metabolic adaptation in Th2 responses, and more, to accompany @midwinter-immun.bsky.social conference 👉 rupress.org/jem/collecti...

For this month #JEMjc we would like to highlight this study from Eva Harris lab linking anti-NS1 IgA antibodies in plasma from a primary ZIKV infection, to drive neutrophil activation and correlate with increased risk of subsequent severe DENV2 disease. More here: www.nature.com/articles/s41...

Ghorbani and Yewdell discuss work by Zhang et al. (rupress.org/jem/article/...), which describes complete T cell antigens, comprised of class I & class II immunogenic peptides fused in a single polypeptide that greatly increase the effectiveness of #cancer #immunotherapy rupress.org/jem/article/...

Registration for the 2026 Henry Kunkel Society Meeting is well underway! 📍 @rockefeller.edu | 🗓 April 16–18 Join us for three days focused on “Autoantibodies Against Cytokines”. 🔗 Register now: henrykunkelsociety.app.neoncrm.com/eventReg.jsp... 🤝 Meeting in partnership with @jem.org

👀 Check it out - MCB faculty member Pam Rosato (@pcrosato1.bsky.social) is a 2026 Associate Editor at Journal of Experimental Medicine! 🎉

Explore the 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 papers in basic #immunology, #immunotherapy and #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, and #inflammation 👉 rupress.org/jem/collecti... THANK YOU to our authors, reviewers, and readers for your interest and continued support for JEM!

Welcome to @jem.org!

Join the #EMBL conference "The new cardiobiology: engineering, vascular, and molecular insights," 🗓️ February 16-19. Register for virtual attendance by February 9 👉 www.embl.org/about/info/c... #EMBLCardioBiology @events.embl.org

Excited to join!

Happy to join @jem.org as an Associate Editor for 2026 and to contribute to the journal’s publishing process and community!

🌐 Early registration deadline is approaching for @keystoneSymposia.bsky.social meeting, #Aging: #Immune Function & #OrganHealth, March 22-25 in Banff 🏔️ Register here 👉 www.keystonesymposia.org/conferences/... #KSAging26

🌐 Early registration deadline is approaching for @keystoneSymposia.bsky.social meeting, #InnateImmunity: Diversity in #HostDefense & Disease, March 22-25 in Banff 🏔️ Register here 👉 www.keystonesymposia.org/conferences/... #KSInnateImmune26

Spatiotemporal dynamics of fetal liver hematopoietic niches. From Mesquita Peixoto, Soares-da-Silva, Bonnet, Zhou, Baroud, Pinto-do-Ó, Cumano, and colleagues 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...

📢 JEM is delighted to introduce the 2026 Associate Editors: Semir Beyaz, Coco Chu, Erin M. Gibson (@erinmgibson.bsky.social), Benjamin G. Hale (@benhale.bsky.social), Guideng Li, Esther Obeng, João Pereira, and Pamela Rosato. Welcome! 👉 rupress.org/jem/pages/as...

🌐 Explore emerging research w/ field leaders @keystoneSymposia.bsky.social #CancerImmunotherapy: Mechanisms, Clinical Advances & Combinations, March 15-18 in Québec 🏰 JEM's Senior Editor @montse-jexpmed.bsky.social is attending! Register 👉 www.keystonesymposia.org/conferences/... #KSCancerImmune26

Single-cell and spatial profiling highlights #TB-induced myofibroblasts as drivers of lung pathology. From Ian Mbano, Nuo Liu, Paul Elkington @unisouthampton.bsky.social, Alex Shalek @mit.edu, Alasdair Leslie (Africa Health Research Institute) et al: rupress.org/jem/article/... #Tuberculosis

🌐 Explore emerging research with field leaders @keystoneSymposia.bsky.social #MyeloidCells : Heterogeneity & Therapeutic Promise, February 23-26 in Keystone🌲 JEM's Deputy Editor Gaia Trincucci @gaiajexpmed.bsky.social is attending! Register 👉 www.keystonesymposia.org/conferences/... #KSMyeloid26

It’s #JEM_Spotlight time again: this month we would like to highlight the detailed analysis of serological antibodies elicited after R21/Matrix-M malaria vaccine. Because, you know, vaccines work. doi.org/10.1084/jem.20241908