Aroca-Crevillén, @drusqui.bsky.social et al. @isciiisalud.bsky.social show that a #circadian #neutrophil checkpoint protects tissues from exuberant #inflammation and can be activated to protect the host. rupress.org/jem/article/... #CardiovascularBiology #InnateImmunity

New findings from Urs Mörbe, William Agace et al. provide an important framework for understanding gut-associated lymphoid tissue (GALT) diversity and function. rupress.org/jem/article/... #MucosalImmunology #IBD #Crohns

Xiaoyun Li, Sofie Hedlund Møller, Ping-Chih Ho et al. show that tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor #macrophages 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti... #TumorImmunology

New study from Yongkang Yang, Gregg Semenza et al. @jhu.edu suggests that targeting ISG20, in combination with #immunotherapy, could be an effective therapeutic strategy for triple-negative #BreastCancer. rupress.org/jem/article/... #Hypoxia #Metastasis

New work by @ursmoerbe.bsky.social et al. provides an important framework for understanding gut-associated lymphoid tissues (GALT) diversity and function. rupress.org/jem/article/... 🎥 See a short video summary by Mörbe: youtu.be/iIWKSSnwFTg

Bringing Natural killer cells to the clinic: opportunities beyond #cancer. New review from Marjorie Cayatte, Valentin Picant, Marie Vétizou, and Eric Vivier @ciml.bsky.social: rupress.org/jem/article/... #Autoimmunity #NKCells #Neurodegeneration

New work by Smyth et al (rupress.org/jem/article/... ) opens a new direction for #Alzheimers research, identifying CSF clearance at arachnoid cuff exits as a potential therapeutic target for modifying disease progression. Insights from Ting Du et al. rupress.org/jem/article/...

As 2025 is drawing to a close, @jem.org would like to highlight all of the women who have contributed to the #WomenInSTEM #Viewpoint series over the last 3 years! Learn more about their scientific journeys on the path to independence here 👉 tinyurl.com/2wrxk4mk

Tanaka, Maeda, Sakaguchi et al. provide a general model of how altered TCR signaling evokes #autoimmune disease. rupress.org/jem/article/... 📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...

FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis. New study from Liling Xu, Facundo D. Batista and colleagues @ragoninstitute.bsky.social: rupress.org/jem/article/... #LymphocyteBiology #Metabolism #Autophagy #Mitophagy

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/... #InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome

The ability to specifically engage tumor-reactive T cells for therapeutic benefit is the ultimate goal of cancer #immunotherapy. New review by Mirabile-Brightman and Butterfield discusses advances in the development of personalized neoantigen therapies. rupress.org/jem/article/... #TumorImmunology

Horton, Wenzel et al. @uthealthhouston.bsky.social identify mechanometabolism as a determinant of hematopoietic fate that could inform engineering of hematopoietic stem cells for disease modeling and treatment. rupress.org/jem/article/... #Metabolism #CardiovascularBiology #Hematopoiesis

Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M #malaria #vaccine. From Jonathan McDaniel, William Voss, @profkatieewer.bsky.social and colleagues 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...

In this Viewpoint, Shimon Sakaguchi recounts the work which lead to the identification of regulatory T cells. (Part of JEM's 125th Anniversary Historical Testimonials series): rupress.org/jem/article/... 📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...

New study from the Ye Zheng lab @salkinstitute.bsky.social and colleagues uncovers an essential role of REV-ERB in the regulation of colonic RORγt⁺Foxp3⁺ Treg cell differentiation and function. rupress.org/jem/article/... #Tolerance #Autoimmunity #LymphocyteBiology

Put a perspective piece together on how fever may have driven the evolution of antiviral genes: rupress.org/jem/article/...

Natural killer (NK) cells are primarily being assessed to treat cancer, but they have substantial potential for Rx of neurodegenerative diseases, viral infections, and autoimmune conditions. A first-rate review, open-access rupress.org/jem/article/...

New video summary from Pamela Wenzel (@uthealthhouston.bsky.social) on a new study "Mechanometabolism instructs hematopoietic stem cell specification" (Horton et al. rupress.org/jem/article/...) youtu.be/T8VHOsA6o40 #Metabolism

A 2019 study from Sakaguchi and colleagues showed that the tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells rupress.org/jem/article/... 📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...

Marjon Wouters, Isabelle Meyts @isabellemeyts.bsky.social and colleagues show that dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti... #InbornErrorsOfImmunity

#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia. @RockUPress @RockefellerUniv rupress.org/jem/article/...

Today's #JEMSpotlight @jem.org highlights the work of Michael Gerner & colleagues investigating early Th2 differentiation in lymph nodes after cutaneous allergen administration with quantitative imaging 📸 rupress.org/jem/article/...

Today’s #JEMjc @jem.org highlights the work of Alan Saltiel & colleagues @nature.com reporting the role of neutrophil-derived IL-1β in preserving lipid stores during metabolic stress. www.nature.com/articles/s41...

Rhodehouse, Siliciano @jhu.edu and colleagues show that, in a nonhuman primate (NHP) model, natural control can be nearly as effective as antiretroviral therapy in controlling viral replication. rupress.org/jem/article/... #Virology #LymphocyteBiology #InfectiousDisease #HostDefense

HIF-1-mediated ISG20 expression promotes #BreastCancer stemness and immune evasion, say Yongkang Yang, Gregg Semenza and colleagues @jhu.edu: rupress.org/jem/article/... #SolidTumors #Hypoxia #Metastasis

New findings from Zhang, Honjo, Chamoto et al. @ccii-kyoto.bsky.social indicate that a subset of cancer cells expressing CTAs is sufficient to evoke overall antitumor immunity by broadening T cell responses to other neoantigens. rupress.org/jem/article/... #TumorImmunology

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action, from Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social and colleagues 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti... #Inflammasome

In 2005, Ko et al. of the Sakaguchi group reported treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3⁺ CD25⁺ CD4⁺ regulatory T cells. rupress.org/jem/article/... 📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...

Qian Zhang et al. @casanovalab.bsky.social report a fatal case of avian influenza #H5N1 infection and describe that the presence of AAN-I-IFN may facilitate infection, replication, and adaptation of zoonotic IAVs to humans and, therefore, human-to-human transmission. rupress.org/jem/article/...

A #circadian checkpoint relocates #neutrophils to minimize injury, say Alejandra Aroca-Crevillén, Andrés Hidalgo @drusqui.bsky.social and colleagues @isciiisalud.bsky.social: rupress.org/jem/article/... #CardiovascularBiology #InnateImmunity #inflammation

New study from Gervais, Cobat, @casanovalab.bsky.social, Jouanguy @hopitalnecker.bsky.social and colleagues highlights auto-Abs against type I IFNs as a major determinant of HSV-FVH and paves the way for targeted preventive or therapeutic interventions. rupress.org/jem/article/... #Autoimmunity

Kama, Tanaka, Hosokawa et al. highlight the crucial role of #Notch-mediated functional conversion of Runt-related transcription (RUNX) factors, including protein complex reorganization and genomic redeployment in initiating T-lineage program. rupress.org/jem/article/... #Immunology

Delighted out study was to be included on this list @jem.org have a scroll through and check it out (sex differences in class-switched memory B cells) - hubs.la/Q03YbLjR0

New findings from Sebastian Stifter, Melanie Greter et al. (University of Zurich) reveal that XPR1 is required for the development, identity, and function of #macrophages involved in #erythropoiesis. rupress.org/jem/article/... #InnateImmunity #inflammation

🎥 New video summary of a study "Fibroblast diversity within human gut-associated lymphoid tissues" (rupress.org/jem/article/...) by Urs Mörbe (@ursmoerbe.bsky.social), William Agace and colleagues: youtu.be/iIWKSSnwFTg #MucosalImmunology #Crohns #IBD

Does fever drive the #evolution of antiviral genes? A new Perspective by Ryan Langlois @langloislab.bsky.social: rupress.org/jem/article/... #InfectiousDisease #HostDefense #Virology

The Sakaguchi lab's 2005 report supported IL-2's critically requirement for the peripheral maintenance of natural CD25⁺ CD4⁺ T reg cells and consequently the immunologic self-tolerance sustained by them rupress.org/jem/article/... 📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...

Identification of lymphatic vessels in skull periosteum but not bone marrow reveals skull channel heterogeneity, from Qing Chang, Jian-Fu Chen and colleagues 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine: rupress.org/jem/collecti... #Lymphatics

Nice to see our study led by Kevin Groen included in the 2025 ‘Best of JEM’. We dissected the mechanisms by which pathogenic autoantibodies block IFN-I function and used the information to design decoy molecules that might form the basis for future therapies. rupress.org/jem/article/...

🎉🥂 our @jem.org paper “Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection” is in the 2025 Best of JEM collection This work was led by @benjbroom.bsky.social @wehi-research.bsky.social check out the original thread.. bsky.app/profile/groo...

Fibroblast diversity within human gut-associated lymphoid tissues. A new study by Urs Mörbe, William Agace et al. rupress.org/jem/article/... #MucosalImmunology #Crohns #IBD

New review by Cayatte, Picant, Vétizou, & @ericvivier.bsky.social @ciml.bsky.social explores the expanding roles of #NKcells beyond #cancer, highlighting their pivotal functions in viral #infections, #neurodegeneration, #autoimmune diseases, and #transplantation medicine rupress.org/jem/article/...

Liling Xu et al. of the Batista lab @ragoninstitute.bsky.social show that FIP200, a sensor involved in #autophagy regulation, governs the differentiation of plasma B cells. B cells without FIP200 are dysfunctional in #mitophagy & #metabolism. rupress.org/jem/article/...

Volodymyr Stetsenko, Daniel Gail, Stephen Carpenter et al. show that Human CD4⁺ T cells recognize Mycobacterium #tuberculosis–infected #macrophages amid broader responses 👉 rupress.org/jem/article/... 📘 Part of 2025: The Year in Experimental Medicine: rupress.org/jem/collecti...

In 2000, the Sakaguchi lab demonstrated that CTLA-4 is a key costimulatory molecule for activating CD25+CD4+ regulatory T cells to exert suppression and thereby to control self-reactive T cells. rupress.org/jem/article/... 📘 In our 2025 #NobelPrize Collection 👉 rupress.org/jem/collecti...

The 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 highlights research in basic #immunology, #immunotherapy & #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, & #inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward 👉 rupress.org/jem/collecti...

Pauline Bronnec, @cinflammasome.bsky.social et al. developed SpeckSeq, which classifies MEFV variants of uncertain significance to refine molecular diagnostics and improve our knowledge on the pyrin #inflammasome rupress.org/jem/article/... #HumanDiseaseGenetics #Autoimmunity #Autoinflammation

Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.

Bridging veins in #Alzheimers disease: Decoding waste clearance failure. Ting Du, Guojun Liu, and Maiken Nedergaard provide Insights on new study by Smyth et al. (rupress.org/jem/article/...): rupress.org/jem/article/...