New study from Werner, Mogensen et al. @au.dk this study identifies genetically heterozygous but transcriptionally homozygous IRF7 deficiency as #InbornErrorsOfImmunity underlying #herpesvirus central nervous system infection. rupress.org/jem/article/... #HumanDiseaseGenetics #Immunodeficiency

Very happy to share the final #People&Ideas of 2025 from Esther Obeng! I met Esther earlier this year and I was really struck by her passion for her work and her patients. Read more here 👉 rupress.org/jem/article/...

Kun Yang, Nan Yan and colleagues show that the STING pathway drives non-inflammatory #neurodegeneration in NGLY1 deficiency. rupress.org/jem/article/... 📘 In our #Neuroscience collection: rupress.org/jem/collecti... #SfN25

Esther Obeng: It's exciting to tackle questions that don't yet have answers. @lucie-jexpmed.bsky.social recently spoke to Esther about her move from St. Jude to Emory, how her patients inform her research, as well as the joys and struggles of running as a hobby. rupress.org/jem/article/...

Andrea Cooper discusses two recent JEM studies (@wjbranchett.bsky.social et al. rupress.org/jem/article/... and @bengern.bsky.social et al. rupress.org/jem/article/...) providing detailed insight into the early events in #TB. rupress.org/jem/article/... #Tuberculosis

Skoda and Silvennoinen highlight new work from Zhou et al. (rupress.org/jem/article/...) describing the different effects of heterozygous and homozygous JAK2V617F mutations on hematopoietic progenitors rupress.org/jem/article/... #Hematopoiesis

Ping et al show that ILC2s can enter the brain from the blood circulation early after ischemic #stroke in a CXCR1-dependent manner & improve long-term recovery of sensory-motor functions by promoting angiogenic sprouting rupress.org/jem/article/... 📘 Neuroscience 2025: rupress.org/jem/collecti...

🧠 Read our new #Neuroscience collection of research articles and reviews to accompany #SfN25 @sfn.org! Explore the latest discoveries in #neuroscience, including meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...

Transcriptomics- and 3D imaging-based characterization of the lymphatic vasculature in human skin. New study from Aline Bauer, Cornelia Halin and colleagues @ethz.ch: rupress.org/jem/article/... #CardiovascularBiology #InnateImmunity #inflammation #Lymphatics

Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/... #InnateImmunity #inflammation @hhmi.org

Explore the latest discoveries in #cancer #immunology and #immunotherapy published in JEM. This collection covers a broad range of topics, including T cell biology, immune checkpoint inhibitor therapies, and signaling pathways involved in antitumor immunity. 👉 rupress.org/jem/collecti... #SITC25

It’s exciting to finally talk about the new gig!

Xiaofei Yu and colleagues uncover MCRS1 as a new activator of major histocompatibility complex (MHC) class I, which elicits anti-tumor immunity and enhances anti-PD-1 therapy. rupress.org/jem/article/... 📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

Wen et al. review how YTHDF proteins regulate tumor responses to #radiotherapy by modulating DNA repair & the immune microenvironment, and discuss their potential as therapeutic targets. rupress.org/jem/article/... 📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

Attending #SITC25 @sitcancer.bsky.social this week? Meet our Senior Scientific Editor, Lucie Van Emmenis @lucie-jexpmed.bsky.social! Connect with Lucie to learn about the journal and how to publish your research 🔍 📄 See our latest #Cancer #Immunotherapy collection 👉 rupress.org/jem/collecti...

Arja Ray, @maxkrummel.bsky.social et al. show that targeting CD206⁺ #macrophages disrupts the establishment of a key antitumor immune axis. rupress.org/jem/article/... 📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

📕New in Journal of Experimental Medicine: Chen et al., show that radiotherapy may promote metastasis by upregulating YTHDF2 in dendritic cells, impairing MHC-1 cross presentation and CD8+ T cell activation. Ludwig Cancer Research https://ow.ly/BAeq50Xown3

Beautiful talk from Sohail Tavazoie at #SITC25! The intersection between neuroscience and cancer is fascinating, and particularly enjoyed the reminder that nerves in cancer were identified in @jem.org in 1897! 🧐 #JEMlegacy rupress.org/jem/article-...

Cinque et al. @leuccilrcb.bsky.social showed that the #lncRNA LISRR contributes to the emergence of #melanoma clones resistant to the immune attack by assembling #specializedribosomes at the ER. rupress.org/jem/article/... 🎥 See a short video summary: youtu.be/AKSuTne83jQ #Ribosomes

Explore recent studies on antiviral defense programs in human placenta, responses elicited after microbial sensing, noninflammatory #neurodegeneration, tumor-derived signals controlling #cancer progression, links between #arthritis and #obesity, and more 👉 rupress.org/jem/collecti... #Cytokines

Annuntio vobis gaudium magnum: Habemus papam! Our paper on the role of LISSR in the generation of #DTPC is out today in @jem.org rupress.org/jem/article/...

@kepauken.bsky.social, Sharpe et al. show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/... 📘 #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

Villavicencio Gonzalez and Zoghbi review emerging insights into how proteins with an expanded #polyglutamine tract disrupt distinct cellular functions, and examine a multitude of discoveries that are inspiring and reshaping novel therapeutic strategies. rupress.org/jem/article/... #Neuroscience

Xbp1 controls the reparative function of intestinal ILC2s during #colitis, say Yanyan Cui, Zixiao Zhao, Jing Shen, Yatai Chen, Qiuheng Tian, Shiyang Li and colleagues (Shandong University): rupress.org/jem/article/... #MucosalImmunology

Ferry, Goldrath et al. show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. rupress.org/jem/article/... 📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy. The SPI1–YTHDF2–Notch signaling–MHC-I axis orchestrates the antigen cross-presentation function of dendritic cells. rupress.org/jem/article/...

We are pleased to introduce Natalie Cain as the Executive Editor of the journal! Natalie will guide the collaborative editorial process at JEM. Follow her at 🦋 @nataliecain.bsky.social Learn more about Natalie 👉 rupress.org/jem/pages/je...

Deng Pan lab report that an in vivo #CRISPR-Cas9 screen reveals that inactivation of Calreticulin (CALR) potentiates CD8⁺ T cell-mediated anti-tumor immunity and overcomes tumor immune evasion. rupress.org/jem/article/... 📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms, say Cameron Bissett, Teresa Lambe and colleagues @ovg.ox.ac.uk: rupress.org/jem/article/... #InfectiousDisease #HostDefense #MucosalImmunology #SARSCoV2 #COVID19

Vobořil, Hogquist @cfi-umn.bsky.social and colleagues reveal the #thymus as a niche for diverse, developmentally distinct #myeloid cells and elucidate their specific requirements for development and maturation. rupress.org/jem/article/... #Hematopoiesis #Tolerance #LymphocyteBiology

Huge congratulations to Katarzyna Chojnacka! 🎉 Beautiful work presented at #Cytokines2025

Chehyun Nam et al. uncover MLL3 mutations as early events driving UASCC development, highlighting their role in tumor evolution and immune modulation. rupress.org/jem/article/... 📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

Esther Obeng is an attending physician and associate professor at Emory University, where she leads a research group focused on myelodysplastic syndromes (MDS). We spoke with Esther about her career, how her patients inform her research, and more: rupress.org/jem/article/... #WomenInSTEM

✍️💻 Participate in a complimentary Journal-Based #CME activity that consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME Activity is now available 👉 mskcc.cloud-cme.com/course/cours...

Xing et al. develop an approach which potently enhanced the proliferation, metabolic fitness & immunological activities of CAR-T cells, & subsequently enhanced the OV/CAR-T synergetic cytotoxicity. rupress.org/jem/article/... 📘 #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

Herpesvirus CNS infections in genetically heterozygous - transcriptionally homozygous IRF7 deficiency. New study from Marvin Werner, Trine Mogensen and colleagues @au.dk: rupress.org/jem/article/... #HumanDiseaseGenetics #Immunodeficiency #InfectiousDisease #HostDefense #InbornErrorsOfImmunity

Congratulations to Cedars-Sinai Postdoc Katarzyna Chojnacka, winner of the JEM Early Career Travel Award to attend the #Cytokines2025 meeting in Seattle. Learn more here: rupress.org/jem/pages/ea...

Delighted to be attending #SITC25 @sitcancer.bsky.social! Please let me know if you'd like to chat about your work! 🔬

Yingying Qu et al. show that MYO1F in #neutrophils is required for the response to immune checkpoint blockade therapy. rupress.org/jem/article/... 📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

Congrats to Jinjin Xu & co-authors – an image from their recent @jem.org article that describes Ankrd55 as a modulator of T cell metabolism impacting Th17 responses was selected for the cover! Read the study here: rupress.org/jem/article-... @broadinstitute.org @mgbresearch.bsky.social

A nice discussion here of our work on the early immune response in M. tuberculosis infection and the great recent paper from @bengern.bsky.social et al

New study from Bauer, Halin et al. @ethz.ch reveals how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–based textbook description. rupress.org/jem/article/... #Lymphatics

Yan Xu et al. show that tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity: rupress.org/jem/article/... 📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti... #SITC25

Kun Yang, Nan Yan and colleagues show that the STING pathway drives non-inflammatory #neurodegeneration in NGLY1 deficiency. rupress.org/jem/article/... 📘 In #Cytokines collection rupress.org/jem/collecti... #Cytokines2025

Attending #SITC25 @sitcancer.bsky.social this week? Meet our Senior Scientific Editor, Lucie Van Emmenis @lucie-jexpmed.bsky.social! Connect with Lucie to learn about the journal and how to publish your research 🔍 📄 See our latest #Cancer #Immunotherapy collection 👉 rupress.org/jem/collecti...

Our new collection highlights the latest discoveries in #cancer #immunology and #immunotherapy, including T cell biology, immune checkpoint inhibitor therapies, and more. Explore new research in JEM to accompany this week's #SITC25 @sitcancer.bsky.social! 👉 rupress.org/jem/collecti...

First impressions count in #TB. Andrea Cooper @uniofleicester.bsky.social discusses studies by @wjbranchett.bsky.social et al. (rupress.org/jem/article/...) and @bengern.bsky.social et al. (rupress.org/jem/article/...), in Insights: rupress.org/jem/article/...

New study from recent #Nobel laureate Sakaguchi et al. shows that continuous oral antigen exposure combined with CD28 blockade generates functionally stable CD101⁺ pTreg cells, thereby establishing systemic antigen-specific #tolerance even in antigen-presensitized hosts. rupress.org/jem/article/...

Li, Møller, Ho et al. show that tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor #macrophages. rupress.org/jem/article/... 📘 In #Cytokines collection rupress.org/jem/collecti... #Cytokines2025

In Nov issue: rupress.org/jem/issue/22... @thexavierlab.bsky.social describe the biological function of Ankrd55 in mice, working as a functional modulator of T cell metabolism impacting Th17 responses. Cover shows a colon section of a mouse that received Ankrd55−/− T cells doi.org/10.1084/jem....