Today marks the start of #PostdocAppreciationWeek, so we're kicking it off by sharing our first of three videos celebrating postdocs here at NDM 📽️🥼 Watch @whitefishlab.bsky.social and two postdocs in his research group at @ludwigcancer.bsky.social Oxford in the video below 👀👇 #NPAW2025

‼️See below terrific opportunity for a postdoc post with a leading group in Oxford, super exciting science! 🔥🔥👇

Congrats to Ludwig Institute Scientific Director Chi Van Dang, Ludwig Oxford Director Xin Lu, Ludwig Lausanne’s Mikael Pittet and Ludwig Stanford’s @michellemonje.bsky.social, whose teams have been picked as one of a dozen finalists for the prestigious @cancergrand.bsky.social award. bit.ly/4mAhFvE

A team led by Ludwig Lausanne’s @johannajoyce.bsky.social & former postdoc @alvarezprado.bsky.social reports a potential drug target whose loss in certain GBM cells triggers antiviral alarms to stall cell proliferation & makes GBM tumors in mice more amenable to anti-cancer immunity. bit.ly/4nhZ7Bj

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

Platelets are known for blood clotting, but that's not all. Researchers at @ludwigcancer.bsky.social Oxford have discovered another function - suppressing systemic inflammation. This information has the potential to improve cancer detection going forward 🩸 Find out more 👉 buff.ly/tzbL1yh

How can we reawaken the body’s own anti-viral defenses to fight brain cancer? Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏 #BrainTIME 🧠🦠🧪 🧵 www.sciencedirect.com/science/arti...

Researchers led Ludwig Princeton’s Yujiao Han and Yibin Kang have discovered how metastatic breast cancer cells employ mimicry and manipulation to thrive in the low-oxygen microenvironment of bone marrow—and how this trickery likely causes anemia in patients. bit.ly/4ncN2wM #CanSky #OncoSky

Researchers led by Ludwig @ox.ac.uk’s @bethpsaila.bsky.social & @l-cmurphy.bsky.social have discovered that platelets help suppress systemic inflammation. The way they do so can be harnessed to improve the minimally invasive detection of cancer & the sensitivity of prenatal screening. bit.ly/4mOWVk4

Congratulations to Ludwig @unil.bsky.social's George Coukos on his election to the 2025 class of Fellows of the Academy of Immuno-Oncology! #CanSky #OncoSky

Study co-led by Ludwig @weillcornell.bsky.social’s Tao Shi & Taha Merghoub with researchers in China shows how neutrophils are reprogrammed by bone metastases to suppress anti-tumor immune responses. Blocking that process restores the tumors’ sensitivity to immunotherapy. bit.ly/457Uwez #CanSky

Researchers led by Ludwig @unil.bsky.social’s Denarda Dangaj Laniti & Eleonora Ghisoni have identified four immunologic subtypes of recurrent ovarian cancers and detailed how the gene expression and immune landscape of each evolve upon relapse to drive therapeutic resistance. bit.ly/3INfir8 #CanSky

Researchers led by Ludwig Princeton’s @lydialynch.bsky.social have discovered that in obese people, who are at high risk for many cancers, a diet rich in animal fats—but not plant-derived fats—suppresses antitumor immunity and promotes cancer progression. bit.ly/4fcfWu9 #CanSky #OncoSky

A team co-led by Ludwig ‪Weill Cornell’s Tao Shi and Taha Merghoub & colleagues in China has identified precursors of neutrophils that suppress anti-tumor immunity & drive tumor growth. They also propose a strategy to alter the developmental path of the cells for therapy. bit.ly/40Zz6xx #CanSky

Researchers led by Ludwig @unil.bsky.social’s Ping-Chih Ho, Xiaoyun Li and Sofie Hedlund Møller report that cancer cells secrete fats that prompt fibroblasts to flip macrophages into a pro-cancer state. Disrupting this process impairs tumor growth in mouse models of melanoma. Details: bit.ly/3U5WYfj

Congrats to Ludwig Princeton’s Vanha Nhat Pham, who has been named the first Ludwig Cancer Research-Jane Coffin Childs Fellow @jcchildsfund.bsky.social. Pham plans to explore the roles molecular components of cell membranes known as phospholipids play in cellular physiology. bit.ly/463HJdQ #CanSky

Ludwig @mit.edu’s Amy Wisdom sat down with us at the Center’s 2025 retreat to discusses her research on coaxing the immune system to target a deadly brain cancer and how collaboration has been essential to her studies. Check it out here: youtu.be/EyW9Fz4gG9c #CanSky #OncoSky

We congratulate Ludwig @ox.ac.uk’s Helen Byrne on her receipt of the Naylor Prize and Lectureship in Applied Mathematics from the London Mathematical Society for her incisive modeling of the heterogeneity, topological features and immune landscapes of tumors. bit.ly/4eysUlG #CanSky #OncoSky

At the Ludwig @mit.edu 2025 retreat, @fsrmit.bsky.social took us through his lab’s scientific focus and his journey in cancer research, including his years in the Ludwig MIT community as, initially, a trainee and now a principal investigator. youtu.be/BvMZ8ETu6sM #CanSky #OncoSky

A team led by Ludwig Lausanne’s Camilla Jandus identified a subset of CD4+ T cells that not only support the killing of cancer cells expressing a common cancer antigen but kill those cells themselves. They also harness these cells to devise a potential cancer immunotherapy. bit.ly/3TUtksY #CanSky

We hosted the first in-person meeting of the multi-institutional Ludwig immunometabolism initiative in New York for a day of exciting discussions on their recent discoveries and ongoing studies exploring the interface of diet, cancer metabolism and anti-tumor immunity. bit.ly/4nGFkMG #CanSky

Ludwig @mit.edu Co-director Tyler Jacks spoke with us at the Center’s 2025 retreat about his career and how interdisciplinary collaboration fuels cancer research at Ludwig MIT. Check it out here: youtu.be/dHJgSbvCc5Y #CanSky #OncoSky

Check out the latest issue of eLudwigNews conta.cc/3TCMjbp and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews #CanSky #OncoSky

Congratulations on 20 years @johannajoyce.bsky.social!

Mammary gland CXCR4+ macrophages support growth of both normal stem cells & cancer-initiating stem cells 📹 Eunmi Lee et al Kang lab @ludwigcancer.bsky.social @ Princeton University in @natcomms.nature.com ➡️ bpod.org.uk/archive/2025...

The Ludwig community extends a warm welcome to our newest Distinguished Scholar David MacMillan, a recipient of the 2021 Nobel Prize in Chemistry. His scientific creativity will greatly enrich the Princeton Branch’s exploration of cancer metabolism. bit.ly/4n02RYn #CanSky #OncoSky

We recently attended the Ludwig @mit.edu retreat and caught up with many of our colleagues there. Here, founding Director, Ludwig Professor and giant of cancer research Robert Weinberg reflects on his scientific fascinations and career. youtu.be/UEDP2_RA6MI #CanSky #OncoSky

In the May 2025 issue of the Ludwig Link we have a special treat for all enthusiasts of microscopic imaging: a gallery of arresting micrographs shared with us by cancer researchers from across the global Ludwig community. Check it out here: bit.ly/4jKV6D4 #CanSky #OncoSky

Check out the latest issue of eLudwigNews conta.cc/4ksC5WT and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews #CanSky #OncoSky

The May 2025 edition of the Ludwig Link is here! Catch up on the latest from Ludwig researchers, including awards, new leadership and a gallery of beautiful (and fascinating) micrographs. Check it out online here bit.ly/3Fo6LJR or download the PDF bit.ly/3Sq6Uze #CanSky #OncoSky

The newest member of the Ludwig Princeton team, @lydialynch.bsky.social, describes her research at the intersection of nutrition, immunity, and metabolism, and how she sees the field evolving. youtu.be/sWyNA7wqt_4 #CanSky #OncoSky

A team co-led by Ludwig @unil.bsky.social’s Helen Carrasco Hope & Nicola Vannini reports that age-related metabolic decline impairs CAR-T cell function. Replenishing NAD+, a key metabolic molecule, in the cells restores their efficacy in preclinical models of cancer. bit.ly/4kspK4H #CanSky #OncoSky

A preclinical study led by Ludwig Princeton’s @asaelroichman.bsky.social and Joshua Rabinowitz shows how diet can, through the mediation of gut microbes, diminish the efficacy of cancer drugs known as PI3K inhibitors by activating the liver to clear them from the body. bit.ly/3FpFbM3 #CanSky

Researchers led by Ludwig Chicago's Ralph Weichselbaum report in Nature that radiotherapy can fuel the growth of untreated metastatic tumors, describe the mechanisms by which this occurs & preclinically evaluate a strategy to suppress the effect for therapy. bit.ly/4dlHkVR

Researchers led by Ludwig Princeton’s @lydialynch.bsky.social report that certain fats in ascites fluid—which accumulates as ovarian cancer spreads from the ovaries into the abdomen—sabotage anti-tumor immune responses and show how this effect might be blocked for immunotherapy. bit.ly/4jGuUtU

We caught up with some Ludwig researchers at the #AACR25 Annual Meeting and asked them about their work. Ludwig @harvard.edu's Zuen Ren describes his research here: youtu.be/3ZVGaIb4bSQ

We caught up with some Ludwig researchers at the #AACR25 Annual Meeting and asked them about their work. Ludwig @harvard.edu's Adrienne Parsons describes her research here: youtu.be/LBU_NAKIA7M

Ludwig @unil.bsky.social’s Yi-Ru Yu @ #AACR25 with his poster describing how he, Ping-Chih Ho & team identified a mode of fat uptake by immune cells in tumors that serves as a metabolic checkpoint against anti-cancer immune responses & developed a candidate immunotherapy. bit.ly/3Gr0ygr

Ludwig @jhu.edu’s Nickolas Papadopoulos, Co-editor in Chief of Cancer Prevention Research, hosted a friendly and lively discussion at an editors’ meet-and-greet at #AACR25.

Ludwig @stanford.edu’s Crystal Mackall, recipient of the AACR-Cancer Research Institute Lloyd J. Old Award in Cancer Immunology, spoke at #AACR25 about her lab’s groundbreaking work on CAR-T cell therapy, its clinical application to solid tumors and the next generation of CARTs.

Ludwig Scientific Advisor Victor Velculescu presented his lab’s work @ #AACR25 on the analysis of fragmentation patterns of DNA shed into the blood to detect cancer, including a commercialized lung cancer test spun out of his lab and ongoing work on liver cancer detection.

In a session @ #AACR25 dedicated to reality checks on AI in cancer research, Ludwig @harvard.edu’s Chris Sander spoke about the judicious use of machine learning to predict cancer risk and solve other biological problems.

Ludwig Chicago’s Chuan He presented his work @ #AACR25 on the regulation of gene expression in leukemia by epigenetic modifications made to RNAs.

Scholar-in-training (SITA) award winner Mauricio Flores of Roswell Park Comprehensive Cancer Center, who received Ludwig Institute support to attend #AACR25, discussed his research on cellular plasticity in prostate cancer.

Scholar-in-training (SITA) award winner Swetha Nakshatri of the University of Chicago received Ludwig Institute support to attend #AACR25 and share her work on disparities in neurotoxicities in cisplatin-treated cancer patients.

Ludwig @harvard.edu’s Zuen Ren shared work @ #AACR25 showing that SIRT5, a master regulator mitochondrial metabolism, is highly overexpressed and plays a key role in driving resistance to chemotherapy in triple-negative breast cancer.

Ludwig @mit.edu’s Diya Ramesh shared @ #AACR25 research showing that cancer cells exhibit novel metabolic vulnerabilities in low-lipid tissue environments.

Ludwig @harvard.edu’s Leonie Stockschlader & Chris Sander presented @ #AACR25 their largescale analysis of mutational patterns in healthy tissues & its integration with data on precancerous/cancerous tissues for insights into genetic changes that drive the evolution of tumors.

Ludwig @weillcornell.bsky.social's Sadna Budhu described her exciting preclinical studies @ #AACR25 on how metabolic drugs may improve the efficacy of immunotherapy for melanoma and breast cancer by boosting T cell activation in oxygen starved tumor microenvironments.

Ludwig @stanford.edu’s Naiara Martinez-Velez shared @ #AACR25 her work developing organoid models for pediatric cancers that capture the complex immune landscapes of tumors and can serve as platforms for the preclinical examination of immunotherapies.