This beautiful video showing a 3D reconstruction of a “hungry” microglia was generated by Celeste Laporte, a brilliant PhD student in the lab and a co-author on the paper: www.cell.com/neuron/abstr...

Targeting the brain's vasopressin neurons could be a novel treatment for high blood pressure 📹 Ning Gu et al @mashapk.bsky.social lab @mcgilluniversity.bsky.social in @cp-neuron.bsky.social ➡️ bpod.org.uk/archive/2025... with @rooph.bsky.social

Not pomegranates but lupus-affected kidney glomeruli – importance of PLD4 deficiency in human disease revealed & a target for treatment 📷 Qintao Wang, Honghao Zhu, Xiangwei Sun, Changming Zhang & Shuangyue Ma et al Zhejiang University China in @nature.com ➡️ bpod.org.uk/archive/2025...

Stunning results with minimal sample disruption using super resolution structured illumination microscopy (SIM) 📷 created @ the Micron imaging facility @oxfordbiochemistry.bsky.social by Leopold Czermak, Madeleine Trussell & River Wang ➡️ bpod.org.uk/archive/2025/9/18 with @antdlewis.bsky.social

The ear's organ of Corti as a model system of how developmental instructions coordinate across spatial scales so that tissues are sculpted reproducibly 📷 @prakash-patterns.bsky.social et al @tifr.res.in in @plosbiology.org ➡️ bpod.org.uk/archive/2025...

Very excited to have this back-end-of-an-embryo cell-neighbour-analysis image from our latest paper featured as today's Biomedical Image of the Day! Congrats to first author and ace image-analyst Matthew French bpod.org.uk/archive/2025...

An image analysis toolkit to streamline the study of cell fates in embryo development Image made with @leicamicrosystems.bsky.social microscopy 📷 Matthew French et al @cellysally.bsky.social lab University of Edinburgh in @plosbiology.org ➡️ bpod.org.uk/archive/2025...

New protocol for growing mouse embryo-like models (blastoids) from stem cells, aiding study of environmental factors on embryo development 📷 Victoria Jorgensen, Min Bao & Sergi Junyent et al @zernickagoetz.bsky.social lab @caltech.edu in @cp-devcell.bsky.social ➡️ bpod.org.uk/archive/2025...

Noses can become more sensitive to certain smells by new growth of neurons specific for that odour 📷 Kawsar Hossain et al @cumedicalschool.bsky.social in @elife.bsky.social ➡️ bpod.org.uk/archive/2025... with @antdlewis.bsky.social

AI-generated vascular models from patients' medical images allows analysis of blood flow & vessels to aid diagnosis, research & treatments 📷 Pan Du & Delin An et al @notredame.bsky.social in @science.org Science Advances ➡️ bpod.org.uk/archive/2025...

Clear Headed: Hi-res of individual neurons in whole brain made possible with new microscopy called ExA-SPIM 📹 @adamkglaser.bsky.social & Jayaram Chandrashekar et al @alleninstitute.org in @elife.bsky.social ➡️ bpod.org.uk/archive/2025... with John Ankers

Secretion of extracellular matrix is regulated by the Golgi apparatus – here the roles of different Golgi components revealed 📹 George Thompson et al, School of Biochemistry @bristoluni.bsky.social in @jcb.org ➡️ bpod.org.uk/archive/2025...

Salmonella bacterium analysis reveals its adaptations in locations worldwide, enabling treatment honing 📷 Cheryll M Sia et al @thedohertyinst.bsky.social in @elife.bsky.social ➡️ bpod.org.uk/archive/2025... with @antdlewis.bsky.social

MSRB3 gene variants are associated with inherited deafness – MSRB3 found necessary for maintenance & maturation of hair cells & sterocilia 📷 Gowri Nayak & Elodie M. Richard et al @cincyresearch.bsky.social @medschool.umaryland.edu in & on cover @dmmjournal.bsky.social ➡️ bpod.org.uk/archive/2025/9/9

Feeding Frenzy: Protein syntaxin-2 regulates phagocytosis (gobbling up & ingesting waste material) by macrophages 📷 Suman Samanta et al, Indian Institute of Science Education and Research Kolkata in @jcellsci.bsky.social ➡️ bpod.org.uk/archive/2025... with Lux Fatimathas

Conflict between the innate & adaptive immune system responses determines the kind of damage lungs suffer when infected with TB Image made with @leicamicrosystems.bsky.social microscopy 📷 @bengern.bsky.social et al @seattlechildrens.org in @jem.org ➡️ bpod.org.uk/archive/2025...

Brain Folds: Flexible 3D probes inspired by kirigami paper-folding for use in diverse brain-machine applications 📷 Marie Jung et al Viviana Rincón Montes lab @fz-juelich.de in Advanced Materials ➡️ bpod.org.uk/archive/2025/9/6 with @antdlewis.bsky.social

3D-printed simulated tissue engineered to have the mechanical properties of living flesh & embedded fluid-filled capsules to mimic blood 📹 (sped up 2X orig) Adarsh Somayaji et al Dept of Mechanical Engineering, University of Minnesota in @science.org Science Advances ➡️ bpod.org.uk/archive/2025...

Anti-inflammatory protein thymosin β4 identified in organoids as an Alzheimer's therapeutic target 📷 Peng-Ming Zeng et al Shanghai Tech University in @stemcellreports.bsky.social ➡️ bpod.org.uk/archive/2025/9/4 with @rooph.bsky.social

A new method called Ultrack enables cells to be tracked in 2D & 3D, over time, over different scales & packing densities 📹 ‪@jookuma.bsky.social et al ‪@loicaroyer.bsky.social lab @czbiohub.bsky.social in @natmethods.nature.com ➡️ bpod.org.uk/archive/2025...

Details of how sensory hair cells form synapses – dependence on microtubules revealed 📷 Saman Hussain et al, National Institute on Deafness and other Communication Disorders in @elife.bsky.social ➡️ bpod.org.uk/archive/2025... with John Ankers

CMG2 (alias the anthrax toxin receptor) on gut cells is vital for replenishing intestinal stem cells – insights into genetic disorder hyaline fibromatosis syndrome 📷 Lucie Bracq et al EPFL (Swiss Federal Technology Institute of Lausanne) in @embomolmed.org ➡️ bpod.org.uk/archive/2025...

Stretching fibre tension triggers muscle-building proteins to add new sarcomeres inside existing ones 📹 Clement Rodier et al @frankschnorrer.bsky.social lab IBDM Marseille ‪@univ-amu.fr in @science.org Science Advances ➡️ bpod.org.uk/archive/2025... with John Ankers

Cancer encouraged to progress by immune cells in its microenvironment via Toll-JNK-Hippo signalling cascade & Pvf1 ligand/receptor interaction 📷 Sihua Zhao & Yifan Guo et al Westlake University, Hangzhou, China in @embojournal.org ➡️ bpod.org.uk/archive/2025...

Identifying genes essential to survival of bacteria Mycoplasma pneumoniae – the relevant new treatment targets 📷 ‪Maria Lluch-Senar, research Samuel Miravet-Verde & Raul Burgos et al Serrano lab @crg.eu in @molsystbiol.org ➡️ bpod.org.uk/archive/2025... with @rooph.bsky.social

Damage to axons in white matter by early glioblastoma (GBM) cells drives progression & spread of this aggressive, incurable brain tumour #GBM 📹 Melanie Clements, Wenhao Tang, Zan Florjanic Baronik, Holly Simpson Ragdale et al @ucl.ac.uk in @nature.com ➡️ bpod.org.uk/archive/2025...

Fuse Breaker: PIEZO1 drives trophoblast fusion & placental development, early essentials in pregnancy 📷 Yang Zhang, Ke Z. Shan & Pengfei Liang et al @duke-university.bsky.social Med School in @natcomms.nature.com ➡️ bpod.org.uk/archive/2025/8/27 with John Ankers

Higher Fidelity: Encapsulating kidney cells in hydrogel – new 3D technique engendering more life-faithful kidney development than trad flat culture 📷 from 📹 Aria Zheyuan Huang et al @upenn.edu in @natcomms.nature.com ➡️ bpod.org.uk/archive/2025...

Chickening Out: 3D printed animal and plant based food 📹 Sushila Maharjan et al @harvardmed.bsky.social in @natcomms.nature.com ➡️ bpod.org.uk/archive/2025... with John Ankers

Morbid obesity disturbs body fat's normal function – TIPE2-deficient macrophages promote iron-dependent cell death in adipose stem cells 📷Yan Tao et al Shandong University, Jinan, China in @natcomms.nature.com ➡️ bpod.org.uk/archive/2025...

A cell's internal spin direction results from myosin chirality – insight into how left-right symmetry is broken in certain tissues & organs 📷 Takaki Yamamoto et al @riken-bdr.bsky.social in @elife.bsky.social ➡️ bpod.org.uk/archive/2025... with Lux Fatimathas

Looking Swell: Water & ions binding to extracellular matrix in swollen tissue exploited to enhance MRI scan detection of the injury 📷 Matthias R. Kollert et al, Charité - Universitätsmedizin Berlin in @natureportfolio.nature.com Biomedical Engineering ➡️ bpod.org.uk/archive/2025...

ACTA2 gene mutation causes childhood-onset stroke disorder via smooth muscle cell dysfunction => blocked arteries 📷 Anita Kaw & Suravi Majumder et al McGovern Medical School, Houston, Texas in @natcomms.nature.com ➡️ bpod.org.uk/archive/2025... with @antdlewis.bsky.social

Model Jaw Drops: Jaw bone organoids created from human pluripotent stem cells provide 3D means to study jaw development & disease 📷 Souta Motoike et al, Center for iPS Cell Research and Application, Kyoto University in @natbiomedeng.nature.com ➡️ bpod.org.uk/archive/2025...

Split Decision: Insight into the apparent paradox that Wnt/β-catenin pathway can induce stem cell differentiation or pluripotency 📷 Kevin R. Yi et al Minerva Biotechnologies in @plosone.org ➡️ bpod.org.uk/archive/2025... with @antdlewis.bsky.social

Organ Synthesiser: A mouse embryo model capable of progressing to organogenesis – created using es cells coaxed to embryo founder cells 📷 Huanhuan Li, Wei Guan, Jiahui Huang et al Guangzhou International Bio Island in @cellpress.bsky.social Cell ➡️ bpod.org.uk/archive/2025...

Following the behaviour of food-additive titanium oxide at destinations in the human body 📷 John W. Wills et al @camvetschool.bsky.social in @natcomms.nature.com ➡️ bpod.org.uk/archive/2025... with @antdlewis.bsky.social

How the functional architecture of the zebrafish heart is shaped during development 📹 @tobyandrews.bsky.social et al @rashmi-priya.bsky.social lab @crick.ac.uk in @cellpress.bsky.social Developmental Cell ➡️ bpod.org.uk/archive/2025...

The brain's emotional pain pathway identified – new targets for developing pain medication 📷 Sukjae J. Kang et al @salkinstitute.bsky.social in @pnas.org ➡️ bpod.org.uk/archive/2025... with @rooph.bsky.social

Cytoskeletal microtubules bring myofibrils within muscle cells into close contact with mitochondria to provide energy for muscle building 📷 Jerome Avellaneda et al @univ-amu.fr in Developmental Cell @cellpress.bsky.social ➡️ bpod.org.uk/archive/2025...

Blood Running Cold: Cryo-scanning electron microcopy of haematology samples 📷 Irina Davidovich, Carina Levin & Yeshayahu Talmon Technion-Israel Institute of Technology in @jofmicroscopy.bsky.social ➡️ bpod.org.uk/archive/2025... with Lux Fatimathas

Provision of right number of organelles called peroxisomes needed by a cell is regulated by PKC enzyme Image made with @leicamicrosystems.bsky.social microscopy 📷 Anya Borisyuk et al Ecole Polytechnique Fédérale de Lausanne & @unisouthampton.bsky.social in @jcb.org ➡️ bpod.org.uk/archive/2025...

Peripheral Vision: Entire peripheral nervous system of a mouse fluorescently imaged for the first time 📹 Mei-Yu Shi, Yuchen Yao & Miao Wang et al, University of Science & Technology of China in Cell @cellpress.bsky.social ➡️ bpod.org.uk/archive/2025... with @rooph.bsky.social

Human foetal kidney-derived organoids grown for prolonged periods as faithful models of kidney development show Notch is developmental regulator 📷 Michael Namestnikov et al Sheba Medical Center, Tel HaShomer, Israel in @embojournal.org ➡️ bpod.org.uk/archive/2025...

Look Again: A dense labelling system for more accurate 3D alignment after repeated tissue expansion & imaging 📷 Hyunwoo Kim & Joon-Goon Kim et al Korea Advanced Institute of Science and Technology in @plosbiology.org ➡️ bpod.org.uk/archive/2025... with @antdlewis.bsky.social

Advanced machine learning + classical image analysis pipeline for gross & cellular high-throughput 3D screening of organoids 📹 Hui Ting Ong & Esra Karatas et al National University of Singapore in @natmethods.nature.com ➡️ bpod.org.uk/archive/2025...

How streptococci bacteria infect the brain to cause meningitis revealed in zebrafish 📹 Sumedha Ravishankar et al, School of Biological Sciences, UC San Diego in @plosbiology.org ➡️ bpod.org.uk/archive/2025... with @antdlewis.bsky.social

Pre-cancer cells secrete Netrin 1 that promotes sprouting & branching of nerve projections providing conditions ripe for cancer progression 📷 Hiba Haidar et al, Aix-Marseille University in @natcomms.nature.com ➡️ bpod.org.uk/archive/2025...

Insights into how TB bugs can evade vaccine-trained immunity 📷 Kimra S. James et al ‪ @utah.edu in @natureportfolio.nature.com npj Vaccines ➡️ bpod.org.uk/archive/2025... with @rooph.bsky.social

Epithelium repair is promoted by bursts of hydrogen peroxide from DUOX2 protein 📷 Maurice O’Mara, Suisheng Zhang & Ulla G. Knaus Conway Institute @ucddublin.bsky.social in @natcomms.nature.com ➡️ bpod.org.uk/archive/2025...