Chowers et al. investigate Altered High-Density Lipoprotein Expression Pattern in the Aqueous Humor From Eyes With Age-Related Macular Degeneration, iovs.arvojournals.org/article.aspx....

Kriegova et al. share their work on Transcriptomic Profiling of Orbital Fat Tissue and Ocular Surface Wash in Active Thyroid Eye Disease Requiring Urgent Orbital Decompression, iovs.arvojournals.org/article.aspx....

Welzel et al. report on The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies, iovs.arvojournals.org/article.aspx....

Chengyue Zhang, Li Li et al. from Beijing Children's Hospital identify pathogenic variants associated with congenital bony nasolacrimal duct obstruction (bony CNLDO) and clarify genotype-phenotype correlations. doi.org/10.1167/iovs.66.15.69

Yutao Liu et al. from the Medical College of Georgia, Augusta use proteomic analysis to provide insights into PPIP5K2 function and its impact on corneal energy metabolism. doi.org/10.1167/iovs.66.15.67

Margaret A. MacNeil, Widnie Mentor & Alexander Birk from York College of the City University of New York find that mitochondrial-targeted HDAP2 preserves retinal ganglion cells and increases pressure tolerance in DBA/2J mice. doi.org/10.1167/iovs.66.15.66

Farivar et al. investigate Letter Distortion Mapping in Amblyopia: Spatial Patterns, Stability, and Relationship to Visual Acuity, iovs.arvojournals.org/article.aspx....

Okumura et al. share their work on the Protective Effects of Estradiol on Disease Progression in a Murine Model of Fuchs Endothelial Corneal Dystrophy, iovs.arvojournals.org/article.aspx....

Guangming Jin et al. report that Degradation of Elastic Fiber Triggers Lacrimal Gland Dysfunction in Marfan Syndrome Mice, iovs.arvojournals.org/article.aspx....

Jianhua Wang et al. from Bascom Palmer Eye Institute evaluate changes in retinal neurovascular and mitochondrial function after a 24-week yoga intervention in healthy older adults. doi.org/10.1167/iovs.66.15.62

Matthew Campbell et al. from Trinity College Dublin investigate dynamic inner blood retina barrier disruption in retinitis pigmentosa. doi.org/10.1167/iovs.66.15.61

Jeffrey Goldberg, Michael Kapiloff et al. from Stanford University School of Medicine find that HDAC4 promotes neuroprotection of retinal ganglion cells after optic nerve injury. doi.org/10.1167/iovs.66.15.60

Qiang Li, Dongyue Liu & Min Zhang from Jinan University find that obstructive sleep apnea accelerates progression of intermediate age-related macular degeneration. doi.org/10.1167/iovs.66.15.59

Hong Yan et al. from The Second Affiliated Hospital of Xi'an Jiaotong University investigate the role of glutaredoxin 2 (Grx2) in regulating ferroptosis under oxidative stress conditions induced by high glucose in lens epithelial cells (LECs). doi.org/10.1167/iovs.66.15.58

Jinsong Zhao et al. from The Second Hospital of Jilin University find that extracellular matrix stiffness regulates cancer stemness in uveal melanoma via the PIEZO1–DOT1L axis. doi.org/10.1167/iovs.66.15.57

Nobuhiro Kato et al. from Kurume University School of Medicine investigate the association of molar dose and early retinochoroidal blood flow changes after intravitreal anti-vascular endothelial growth factor therapy. doi.org/10.1167/iovs.66.15.56

Takashi Ueta et al. from the University of Tokyo Hospital find that iPLA2β protects retinal pigment epithelium from ferroptosis in a sodium iodate–induced model of dry AMD. doi.org/10.1167/iovs.66.15.55

Ursula Schmidt-Erfurth et al. from Medical University of Vienna evaluate the association between structural optical coherence tomography biomarkers and functional outcomes in intermediate age-related macular degeneration. doi.org/10.1167/iovs.66.15.54

Zhijie Li et al. from the People's Hospital of Zhengzhou University investigate how sustained stress alters circadian regulation in the lacrimal gland (LG) and the role of neuroendocrine signaling in stress-induced dry eye disease. doi.org/10.1167/iovs.66.15.53

Xingtao Zhou, Jing Zhao et al. from Fudan University investigate the characteristics of retinal oxygen kinetics and blood flow across varying degrees of myopia and to explore associated factors. doi.org/10.1167/iovs.66.15.52

Zijing Huang et al. from the Chinese University of Hong Kong investigated the involvement of autophagy in the early stages of optic nerve injury and explored potential therapeutic strategies. doi.org/10.1167/iovs.66.15.51

Zhijie Li et al. from the People's Hospital of Henan University find that chronic restraint stress misaligns corneal clock via β-adrenergic and glucocorticoid signaling. doi.org/10.1167/iovs.66.15.50

Harumasa Yokota et al. from Asahikawa Medical University present evidence supporting autotaxin as a potential new drug treatment target in patients with advanced diabetic retinopathy. doi.org/10.1167/iovs.66.15.49

Yuanbin Li, Pengfei Jiang et al. The Affiliated Yantai Yuhuangding Hospital of Qingdao University find that cyclosporine A ameliorates inflammatory responses in dry eye by inactivating cGAS–STING signaling via the initiation of autophagy. doi.org/10.1167/iovs.66.15.48

Xianqun Fan et al. from Shanghai Jiao Tong University School of Medicine find that erianin abrogates cancerous vasculogenic mimicry through targeting m5C methylase NSUN2 in uveal melanoma. doi.org/10.1167/iovs.66.15.47

Campbell et al. present their work on the Automated Assessment of Retinal Vascular Integrity Across Species, iovs.arvojournals.org/article.aspx....

Fleckenstein et al. @moraneyecenter.bsky.social share their research on the Association of Mesopic and Dark-Adapted Retinal Sensitivity With Type 1 Macular Neovascularization in Age-Related Macular Degeneration, iovs.arvojournals.org/article.aspx....

Brandstätter et al. report that A Mouse Photoreceptor Proteome Resource Identifies PALS2/MPP6 as a Novel Pan-Cone Photoreceptor Marker, iovs.arvojournals.org/article.aspx....

Vukmirovic et al. present their Evidence for the Existence of Two Opposing Pulse Waves in Retinal Vein Segments Within the Optic Disc, iovs.arvojournals.org/article.aspx....

Christina Zeitz, Isabelle Audo et al. from Sorbonne Université investigate retinal impairments in mice lacking both Nxnl1 and Nxnl2 genes. doi.org/10.1167/iovs.66.15.42

Renbing Jia et al. from Shanghai Jiao Tong University School of Medicine use structural magnetic resonance imaging (MRI) to differentiate between distensible orbital venous malformations (OVMs) and nondistensible OVMs. doi.org/10.1167/iovs.66.15.40

Ya Xing Wang et al. from Tsinghua University assess the incidence of myopic changes of the optic nerve head and macula in highly myopic eyes. doi.org/10.1167/iovs.66.15.39

oseph B. Ciolino et al. from Schepens Eye Research Institute describe a way to overcome antimicrobial resistance in bacterial keratitis with an antibiotic-eluting contact lens. doi.org/10.1167/iovs.66.15.38

Yadi Chen, Kevin F. Webb & Paul J. Donaldson from the University of Auckland investigate regional differences in calcium dynamics in the intact lens. doi.org/10.1167/iovs.66.15.37

Michael Kook et al. from the University of Ulsan investigate clustering patterns of 10-2 visual field defects in normal-tension glaucoma patients with central VF involvement and identify clusters associated with visual acuity loss across disease stages doi.org/10.1167/iovs.66.15.36

Qingjiong Zhang et al. from Zhongshan Ophthalmic Center show that a Ubap1l knockout mice model recapitulates retinal degeneration phenotype observed in Ppatients and exhibits irregular photoreceptor morphology. doi.org/10.1167/iovs.66.15.35

Zhongting Chen et al. from East China Normal University find that the long-term absence of static stereopsis cultivates adaptive planning of reaching-to-grasp. doi.org/10.1167/iovs.66.15.31

Daniel I. Flitcroft et al. from Technological University Dublin generate childhood and adolescent refractive centile curves for East Asian and Western populations to facilitate evidence-based myopia control. doi.org/10.1167/iovs.66.15.30

Lucia Ziccardi from IRCCS–Fondazione Bietti report a functional assessment of inner and outer macular layers in the idiopathic epiretinal membrane. doi.org/10.1167/iovs.66.15.29

Yuri P. Tsentalovich et al. from the International Tomography Center SB RAS, Novosibirsk investigate kynurenine-derived UV filters and other cytoprotective metabolites in the eye lenses of rodents from the squirrel family. doi.org/10.1167/iovs.66.15.28

Ruifang Sui et al. from Peking Union Medical College Hospital conduct a detailed analysis of the distinct manifestations of 2 primary phenotypes of Crumbs cell polarity complex component 1 (CRB1)-related retinal dystrophy, pan-retinopathy and maculopathy. doi.org/10.1167/iovs.66.15.27

Yingfeng Zheng, Lixia Luo et al. from Zhongshan Ophthalmic Center show that the 3D genome structure of a Blcap-linked silencer loop regulates terminal differentiation during lens fiber cell denucleation. doi.org/10.1167/iovs.66.15.26

Qiong Zhou et al. from Nanchang University find that KLF10-IN-1 attenuates RPE cell apoptosis and eperimental diabetic retinopathy via the KLF10/PERK/eIF2α/ATF4/CHOP pathway. doi.org/10.1167/iovs.66.15.25

Omer Trivizki et al. from Tel Aviv Medical Center investigate the effect of pegcetacoplan on aqueous humor proteome in geographic atrophy. doi.org/10.1167/iovs.66.15.24

Qing Chang et al. from Fudan University find that conformational dynamics of PKM2 regulate hypoxia-induced pathological retinal angiogenesis. doi.org/10.1167/iovs.66.15.23

Jiaxu Hong et al. from Fudan University investigate the pathogenetic role of sphingomyelin synthase 2 (SMS2) in dry eye disease (DED) doi.org/10.1167/iovs.66.15.22

Ichasus Llamas-Cornejo & Ignacio Serrano-Pedraza from Universidad Complutense de Madrid investigate spatiotemporal characteristics of the stereoscopic anisotropy. doi.org/10.1167/iovs.66.15.21

So-Hyang Chung et al. from The Catholic University of Korea characterize LGR5 as a definitive and functional marker for human limbal epithelial stem cells. doi.org/10.1167/iovs.66.15.20

Ajoy Vincent et al. from The Hospital for Sick Children, Toronto elucidate the common and rare genetic causes of negative electroretinograms (nERGs) and their association with systemic disease and with myopia in a predominantly pediatric cohort. doi.org/10.1167/iovs.66.15.19

New Perspective article by Mark Johnson, Darryl R. Overby, W. Daniel Stamer,& C. Ross Ethier discusses scientific concerns about recent fluid-structure interaction models of the aqueous humor outflow pathway. doi.org/10.1167/iovs.66.15.18