Yara T. E. Lechanteur et al. from Radboud University Medical Center investigate disease progression in AMD patients carrying rare variants in the complement factor H or complement factor I genes. doi.org/10.1167/iovs.66.14.23

Toshihide Kurihara from Keio University School of Medicine present evidence that choroidal mast cells and their degranulation are a pivotal trigger for myopia development. doi.org/10.1167/iovs.66.14.22

oseph L. Demer & Robert A. Clark from Stain Eye Institute investigate whether human globe position in the orbit is influenced by gravitational head orientation. doi.org/10.1167/iovs.66.14.21

Philip J. Rosenfeld et al. from the University of Miami Miller School of Medicine investigate changes in choriocapillaris flow deficits before and after the onset of large choroidal hypertransmission defects in AMD. doi.org/10.1167/iovs.66.14.20

Robert M. Q. Shanks et. al from the University of Pittsburgh find that Cefiderocol and Moxifloxacin have additive and synergistic activity against Pseudomonas aeruginosa including an isolate of the 2023 keratitis outbreak. doi.org/10.1167/iovs.66.14.19

Jiaxu Hong, Xujiao Zhou et al. from Fudan University find that somatostatin ameliorates corneal nerve abnormalities and inflammation through regulation of macrophage activities in dry eye disease. doi.org/10.1167/iovs.66.14.18

Li Jia Chen et al. from The Chinese University of Hong Kong investigate the combined effects of biological age acceleration and genetic risk on age-related eye diseases and blindness, and explored shared genetic pathways and potential anti-aging targets doi.org/10.1167/iovs.66.14.14

Dongsheng Yan et al. from Wenzhou Medical University explore targeting miR-184 to enhance corneal epithelial wound healing. doi.org/10.1167/iovs.66.14.13

Arda Fidanci et al . from the University of Minnesota investigate the preferred retinal locus for reading in central vision loss. doi.org/10.1167/iovs.66.14.12

Huifang Zhou, Jing Sun et al from Shanghai Ninth People's Hospital use high-throughput tear proteomics to reveals multi-faceted signatures of thyroid eye disease. doi.org/10.1167/iovs.66.14.11

Taiji Nagaoka et al from Asahikawa Medical University find that dipeptidyl peptidase 4, a novel adipokine, impairs retinal microcirculation in patients with type 2 diabetes mellitus. doi.org/10.1167/iovs.66.14.4

Amir H. Kashani et al. from the Wilmer Eye Institute @HopkinsMedicine evaluate the relationship between retinal vascular density and retinal thickness (RT) using optical coherence tomography angiography (OCTA) in subjects with diabetic retinopathy. doi.org/10.1167/iovs.66.14.3

Brian G. Ballios et al. from the University of Toronto establish a human model of USH2A RP using retinal organoids derived from patient induced pluripotent stem cells and CRISPR-Cas9-engineered isogenic-USH2A−/− induced pluripotent stem cells. doi.org/10.1167/iovs.66.14.2

Ula V. Jurkunas et al. from Schepens Eye Research Institute find that permanent senescence via p16 leads to guttae formation in an in vitro human corneal endothelial cell model. doi.org/10.1167/iovs.66.14.1

Bingyao Tan et al. from the Singapore Eye Research Institute report high-resolution optical phenotyping of retinal structure and microvasculature after optic nerve crush (ONC) in the mouse using speckle-reduced visible light optical coherence tomography doi.org/10.1167/iovs.66.13.56

New Perspective article by Thu Nga Nguyen, Louise Terry & Jeremy Guggenheim from Cardiff University examines whether the choice of genome-wide association study summary statistics can yield invalid or misleading conclusions in Mendelian randomization studies of myopia. doi.org/10.1167/iovs.66.13.57

Anna Kosovicheva et al. from the University of Toronto investigate intact perceptual interactions of interocular temporal phase and contrast disparities in amblyopia. doi.org/10.1167/iovs.66.13.55

Carole Peyrin et al. from the University of Grenoble Alpes investigate neurobehavioral changes in macular degeneration. doi.org/10.1167/iovs.66.13.54

Raman Prasad Sah, Dawn Meyer & Pete Kollbaum from the Indiana University School of Optometry investigate the dynamic characteristics of accommodative behavior in non-myopic and myopic young adults under prolonged viewing of electronic devices. doi.org/10.1167/iovs.66.13.53

Marzena Gajecka et al. from the Polish Academy of Sciences find that inter-eye molecular discrepancies in the corneal epithelium point to TFRC in the keratoconus severity signature and mechanism of cone formation. doi.org/10.1167/iovs.66.13.52

Jonathan L. Haines from Case Western Reserve University, Iris M. Heid from the University of Regensburg et al. perform a diverse-ancestry genome-wide association study of age-related macular degeneration on 16,108 examined cases and 18,038 controls. doi.org/10.1167/iovs.66.13.51

Thomas Ach et al. from University Hospital Bonn use super-resolution near-infrared autofluorescence microscopy to depict melanin containing organelles of the retinal pigment epithelium in human donor eyes. doi.org/10.1167/iovs.66.13.50

Vincent Daien et al. find that Temporal Analysis of Tear Fluid Proteome Reveals Critical Corneal Repair Events After Photorefractive Surgery, iovs.arvojournals.org/article.aspx....

Rajiv R. Mohan et al. report that Single-Cell Transcriptomics Shows Cellular Heterogeneity, Intercellular Communication, and Extracellular Matrix Remodeling in Corneal Fibrosis In Vivo, iovs.arvojournals.org/article.aspx....

Vivek Singh et al. share their work Assessing the Independent and Combined Effects of Hyperosmolarity and Inflammatory Stress on Human Corneal Epithelial Cells, iovs.arvojournals.org/article.aspx....

In a new Perspective, Artur Cideciyan et al. discuss Location and Identity of Photoreceptors Contributing to the Full-Field Stimulus Test (FST), iovs.arvojournals.org/article.aspx....

New in the Ocular Oncology Issue bit.ly/3VWoxXG, Piotr Donizy et al. study the Dualistic Role of MITF in Uveal Melanoma: Defining Two Distinct Cellular Subpopulations With Prognostic and Therapeutic Implications, iovs.arvojournals.org/article.aspx....

Mahesh R. Joshi et al. from the University of Plymouth investigate deficits in motion and form perception in infantile nystagmus syndrome. doi.org/10.1167/iovs.66.13.44

Tsz Wing Leung et al. from The Hong Kong Polytechnic University investigate whether localized retinal exposure to astigmatic blur is sufficient to drive compensatory changes in refractive and corneal astigmatism in developing chick eyes. doi.org/10.1167/iovs.66.13.43

SriniVas R. Sadda et al. from Doheny Eye Institute compare total RPE thickness and normalized reflectivity intensity on optical coherence tomography among healthy aged and early AMD (eAMD) and intermediate AMD eyes, and to visual function. doi.org/10.1167/iovs.66.13.42

Xiaobo Xia et al. from Central South University investigate the impact of Helicobacter pylori (H. pylori) infection on ocular surface homeostasis, including dry eye symptoms, ocular microbiota alterations, and related immune responses. doi.org/10.1167/iovs.66.13.41

Cynthia A. Toth et al. from Duke Eye Center compare retinal and choroidal OCT measures and features at term equivalent age in preterm and term infants. doi.org/10.1167/iovs.66.13.40

Nan Jiang et al. report that CD40–CD154 Interactions Induced Progressive Neurodegeneration in Acute Ocular Hypertension Mice, iovs.arvojournals.org/article.aspx....

Amani Fawzi et al. present their work on Understanding How Low Luminance Visual Deficit Progresses With Advancing Diabetic Macular Ischemia and Diabetic Retinopathy, iovs.arvojournals.org/article.aspx....

Renbing Jia et al. show that Spatial Proteomic Analysis Highlights Molecular Reprogramming in Optic Nerve Invasive Retinoblastoma, iovs.arvojournals.org/article.aspx....

Niina Sandholm et al. report that Exome and Genome Sequencing Reveals Novel Variants for Severe Diabetic Retinopathy in Type 1 Diabetes, iovs.arvojournals.org/article.aspx.... @helsinki.fi

Fang Hou et al. investigate Binocular Contrast Sensitivity Function in Children With Anisometropic Amblyopia, iovs.arvojournals.org/article.aspx....

Yong Zhang et al. share their work on the Development of Two In Vitro ND1-LHON Models for Evaluating Gene Therapy Efficacy, iovs.arvojournals.org/article.aspx....

Xiaohu Ding from Zhongshan Ophthalmic Center find that acceleration of myopic shifts in refraction and axial elongation begins in the premyopia stage. doi.org/10.1167/iovs.66.13.33

Yuan Zong, Fengiuan Gao et al. from Fudan University unravel the distribution patterns of axial length (AL) in patients with inherited retinal diseases (IRDs) and identify genetic factors as the underlying cause. doi.org/10.1167/iovs.66.13.32

Artur V. Cideciyan from the Perelman School of Medicine develop a protocol that can provide photoreceptor-specific sensitivities in inherited retinal diseases using a commercial perimeter. doi.org/10.1167/iovs.66.13.31

Chun Zhang et al. from Tsinghua University investigate the biomechanical effects of high myopia (HM)-related optic nerve head (ONH) structural changes on glaucoma progression and identify key predictive parameters. doi.org/10.1167/iovs.66.13.30

Ming-Chang Zhang, Hua-Tao Xie et al. from Tongji Medical College investigate the protective effects of maresin 1 (MaR1) in meibomian gland dysfunction (MGD) induced by blue light overexposure in both in vivo and in vitro experiments. doi.org/10.1167/iovs.66.13.29

Lian Liu, Jingxiang Zhong et al. from Jinan University investigate how Fusarium solani triggers PANoptosis in fungal keratitis and to examine the toxic impacts and underlying mechanisms of deoxynivalenol (DON) on human corneal epithelial (HCE-T) cells. doi.org/10.1167/iovs.66.13.27

Peng Li, Chixin Du et al. from Zhejiang University investigate the effect of physiological aging and flickering light stimulation (FLS) parameters on retinal functional hyperemia response using functional optical coherence tomography angiography (fOCTA). doi.org/10.1167/iovs.66.13.26

Hideto Deguchi et al. from Kyoto Prefectural University of Medicine nvestigate the relationship between primary cilia and mitochondrial function in cultured human corneal endothelial cells (HCECs). doi.org/10.1167/iovs.66.13.25

Arkasubhra Ghosh, Swaminathan Sethu et al. from the Narayana Netralaya Foundation evaluate neurodegeneration markers in patients with glaucoma and correlated them with clinical parameters. doi.org/10.1167/iovs.66.13.24

Samantha Montoya et al. show that Visual Snow Is Susceptible to the Motion Aftereffect, iovs.arvojournals.org/article.aspx....

New genetics report in the IMI Myopia issue bit.ly/42yoJla by Virginie Verhoeven et al. from Erasmus MC University Medical Center provides an updated overview of current findings on myopia genetics and identifies priorities for future research. doi.org/10.1167/iovs.66.13.22

Achim Fieß et al. from Johannes Gutenberg University investigated optic nerve head morphology in children born preterm with and without retinopathy of prematurity. doi.org/10.1167/iovs.66.13.21