Takahiko Hayashi et al. from Nihon University School of Medicine characterize dome-shaped protrusions of Descemet's membrane in bullous keratopathy, and to determine how DSPs differ from classic guttae in Fuchs endothelial corneal dystrophy. doi.org/10.1167/iovs.67.5.63

Xiao-Jian Han et al. from The First Affiliated Hospital of Nanchang Medical College find that blue light induces retinal ganglion cell damage by stimulating Drp1-dependent mitochondrial fission and activating the NF-κB/NOX4 axis. doi.org/10.1167/iovs.67.5.62

Huijing Ye ety al. from Zhongshan Ophthalmic Center develop GSH-responsive PBAE polymers for IL-12 mRNA delivery in melanoma immunotherapy. doi.org/10.1167/iovs.67.5.57

Anfisa Ayalon et al. from the University of Pittsburgh provide a comparative analysis of intravitreal diffusion patterns across ex vivo human and in vivo/ex vivo animal models. doi.org/10.1167/iovs.67.5.56

Hitomi Saito et al. from the University of Tokyo Graduate School of Medicine investigate intrapapillary damage and its functional association in normal tension glaucomatous eyes with and without peripapillary intrachoroidal cavitation. doi.org/10.1167/iovs.67.5.55

Mary A. Carr, Eva M. Bengtén & Mary E. Marquart from the University of Mississippi Medical Center find that loss of streptococcus pneumoniae iga causes more severe keratitis in mice. doi.org/10.1167/iovs.67.5.54

Xialin Liu et al. from Zhongshan Ophthalmic Center characterize sex-specific and offspring number–associated patterns of ocular aging in Macaca fascicularis. doi.org/10.1167/iovs.67.5.53

Baihua Chen et al. from The Second Xiangya Hospital of Central South 15 University find that activation of PPARγ attenuates age-related lacrimal gland dysfunction by alleviating endoplasmic reticulum stress-mediated ferroptosis. doi.org/10.1167/iovs.67.5.52

Xuan Li et all from Tianjin Eye Institute find that YTHDF1-mediated m6A modification of NREP promotes corneal fibrosis via TGF-β–smad signaling. doi.org/10.1167/iovs.67.5.51

Akiko Maeda et al. from Kobe City Eye Hospital find that RPE abnormality is a potential primary cause for retinal degeneration in mucopolysaccharidosis type VI patients and in a rat model. doi.org/10.1167/iovs.67.5.41

Yuanjie Qian, Yue Song & Jin Ma from Zhongshan Ophthalmic Center find that Integrin β3 promotes retinal neovascularization via endoplasmic reticulum stress-mediated endothelial cell senescence. doi.org/10.1167/iovs.67.5.40

Frederic Michon et al from the University of Montpellier find that sexual dimorphism is associated with corneal nerve and epithelial alterations and tear-film defects in Pax6 haploinsufficiency mouse model. doi.org/10.1167/iovs.67.5.39

Lena Gunhaga et al. from Umeå University describe the opposing roles of OPN3 and OPN5 affecting the intrinsic pupillary light reflex of the mammalian iris. doi.org/10.1167/iovs.67.5.38

Kai Hu et al. from Nanjing University find that inhibition of SGK1 alleviates apoptosis and oxidative stress in dry eye disease by activating FoxO3a-mediated autophagy. doi.org/10.1167/iovs.67.5.37

Xuri Li et al. from Zhongshan Ophthalmic Center find that an inhibitory aptamer against PDGF-C overcomes anti-VEGF refractoriness and reduces choroidal neovascularization and fibrosis. doi.org/10.1167/iovs.67.5.36

Yun-e Zhao et al. from Wenzhou Medical University use single-cell sequencing analysis to reveal dysregulated energy metabolism and altered synaptic connectivity in the mouse retina following dark rearing. doi.org/10.1167/iovs.67.5.35

Yan-Jie Li et al. from Shanxi Medical University evaluate retinal and optic-disc changes in papillary thyroid carcinoma (PTC) following post-surgical radioactive iodine (¹³¹I) therapy and identify the factors influencing these changes. doi.org/10.1167/iovs.67.5.34

Shintaro Nakao et al from Juntendo University investigate the molecular mechanisms underlying subretinal fibrosis in nAMD focusing on RPE and Rho-associated coiled-coil-containing protein kinase (ROCK)–mediated epithelial-mesenchymal transition. doi.org/10.1167/iovs.67.5.33

Hiroshi Horiguchi et al. from Jikei University determine whether the spatial topography of retinal sensitivity predicts photophobia severity specifically in glaucoma. doi.org/10.1167/iovs.67.5.32

Stela Vujosevic et al. from IRCCS MultiMedica investigate spectrally resolved fundus autofluorescence as a biomarker of retinal metabolic Integrity in intermediate and atrophic AMD. doi.org/10.1167/iovs.67.5.31

Julien Guégan, Noé Hirschauer, Qi Xu & Astrid Lassalle from EssilorLuxottica R&D explore the objective markers of visual fatigue using conventional eye-tracking and an innovative spectacle frame equipped with photodiodes and infrared emitters. doi.org/10.1167/iovs.67.5.30

Enrico Borrelli et al. from the University of Turin characterize etiologies and clinical–imaging features of peripapillary choroidal neovascularization (CNV) and identify predictors of underlying disease and visual outcomes. doi.org/10.1167/iovs.67.5.29

Weirong Chen, Hui Chen et al. from Zhongshan Ophthalmic Center characterize the aqueous humor cytokine profiles across clinical subtypes of congenital cataracts with posterior polar abnormality & assess their associations with postoperative complications. doi.org/10.1167/iovs.67.5.28

Zhong-Lin Lu et al. from NYU Shanghai find that training in Gabor orientation identification optimizes the temporal window of adults with anisometropic amblyopia. doi.org/10.1167/iovs.67.5.24

Zhengxuan Jiang et al from Anhui Medical University use functional magnetic resonance imaging to investigate layer-specific deficits in the retino-geniculo-striate pathway & functional alterations in the retino-tectal pathway in adult unilateral amblyopia doi.org/10.1167/iovs.67.5.23

Michel M. Sun et al. @abbvie use a tear film imager to investigate the mechanisms of tear film thinning in healthy subjects/ doi.org/10.1167/iovs.67.5.22

Lei Shi et al. from the University of Science and Technology of China investigate corneal immune cell alterations and tau pathology in a mouse model of Alzheimer’s disease. doi.org/10.1167/iovs.67.5.20

Yueping Li et al. from Tianjin Eye Hospital investigate functional and metabolic changes in the primary visual cortex (V1) and frontal eye fields (FEFs) of patients with acute acquired comitant esotropia (AACE). doi.org/10.1167/iovs.67.5.19

Wolfram Eichler et al. from Leipzig University find that pigment epithelium-derived factor from Müller cells is involved in angiopoietin-mediated survival control of retinal neurons. doi.org/10.1167/iovs.67.5.18

New in the Nystagmus issue bit.ly/499ScFg, Jonathan Erichsen et al. share their work on “Time to See” in Infantile Nystagmus, iovs.arvojournals.org/article.aspx....

Merve Oral et al. investigate the Comparative Effects of Riboflavin-UVA and Rose Bengal–Green Light Cross-Linking on Corneal Neovascularization, iovs.arvojournals.org/article.aspx....

Alice Zhang et al. present their Pilot Study of Patient-Reported Outcomes in Stargardt Disease: Correlation With Functional and Structural Findings, iovs.arvojournals.org/article.aspx....

Lihua Li et al. study the Effects of Myopia Control Spectacle Lenses on Peripheral Refraction and Contrast: Insights From Optical Modeling, iovs.arvojournals.org/article.aspx....

Rafael Ufret-Vincenty et al. report that The Transcription Factor 12 of Basic Helix-Loop-Helix Plays an Essential Role in Retinal Health, iovs.arvojournals.org/article.aspx....

Chenhao Yang et al. investigate Risk Factors and Structural Impact of Macular Edema in Preterm Infants: An OCT-Based Cohort Study, iovs.arvojournals.org/article.aspx....

Zhijie Li et al. share their finding that High-Dose Sucralose Is Associated With Lacrimal Circadian Remodeling, Reduced Immunometabolic Signatures, and Reduced Tear Secretion, iovs.arvojournals.org/article.aspx....

Ruifang Sui et al. study Independent Degeneration of Photoreceptors and Retinal Pigment Epithelium: Multimodal Imaging Evidence From Choroideremia Carriers, iovs.arvojournals.org/article.aspx....

Ming Zhang et al. find that MYCN Amplification Drives Ferroptosis Susceptibility via Cysteine Metabolism in Retinoblastoma, iovs.arvojournals.org/article.aspx....

Sarah Waugh et al. @huddersfielduni.bsky.social report that Development of Crowding Distance in Children Is Faster and Later Than Visual Acuity and Better Predicts Reading Performance, iovs.arvojournals.org/article.aspx....

Come to ARVO Central any time before 1pm to chat with @arvoiovs.bsky.social Editor-in-Chief Joseph Carroll about your journal-related questions.

Have you ever wanted to ask the Editor-in-Chief (EIC) a question? If you're at the @arvoinfo.bsky.social Annual Meeting in Denver, you can meet with EIC Joseph Carroll today 11:30am-1:00pm in ARVO Central.

Victor Rodriguez-Lopez et al. report that A Common Prescription Lens Correction Causes Motion Illusions in the Presbyopic and General Populations, iovs.arvojournals.org/article.aspx....

New in the Nystagmus issue, bit.ly/499ScFg, Chetan Ralekar and Lukas Vogelsang et al. share their research on Longitudinal Changes in Nystagmus Following Late Treatment for Congenital Blindness, iovs.arvojournals.org/article.aspx....

Zahra-Soheila Soheili et al. share their work on Suboptimal Responses to Anti-VEGF in Retinal Neurovascular Diseases: Linking Aging and Alternative Angioinflammatory Pathways, iovs.arvojournals.org/article.aspx....

Marie Elise Wistrup Torm et al. examine Retinal Neurophysiological Parameters in Young Patients With Type 1 Diabetes, iovs.arvojournals.org/article.aspx....

Can Zhao et al. report that Pigment Epithelium-Derived Factor (PEDF) Prevents Corneal Endothelial Dysfunction of Fuchs Endothelial Corneal Dystrophy, iovs.arvojournals.org/article.aspx....

Shukti Chakravarti et al from the NYU Grossman School of Medicine find that oxidative stress in keratoconus Is evident in tear fluid and stromal cells and alleviated in cell culture by sulforaphane. doi.org/10.1167/iovs.67.5.1

Furong Huang et al. from Wenzhou Medical University develop a procedure to monitor changes in retinal extracellular dopamine concentration and characterize its spatiotemporally dependent changes during the initial stages of myopia development. doi.org/10.1167/iovs.67.4.70

Itay Chowers et al. from the Hadassah-Hebrew University Medical Center evaluate the association between high-density lipoprotein cholesterol (HDL-C) levels and incident age-related macular degeneration (AMD) in a large cohort. doi.org/10.1167/iovs.67.4.69

Gregor S. Reiter et al. from the Medical University of Vienna find that choriocapillaris flow deficits are spatially linked to retinal pigment epithelium and photoreceptor integrity in geographic atrophy. doi.org/10.1167/iovs.67.4.68