Milan Rai, Kaiyip Choi &Henry Ho-lung Chan from The Hong Kong Polytechnic University find that acute ocular hypertension diminishes flicker-induced enhancement in retinal blood flow and full-field electroretinogram in a mouse model. doi.org/10.1167/iovs.67.2.33

Michaël J. A. Girard from the Singapore National Eye Centre use AI to identify strain-sensitive regions of the optic nerve head linked to functional loss in glaucoma. doi.org/10.1167/iovs.67.2.29

Elena Sanz et al. from the Universidad Autónoma de Madrid investigate differences in smooth pursuit and associated saccades in children with two common types of strabismus. doi.org/10.1167/iovs.67.2.28

Hanako Ohashi Ikeda et al. from Kyoto University Graduate School of Medicine find increased gut microbiota diversity in patients with retinitis pigmentosa and implications for disease phenotypes and progression. doi.org/10.1167/iovs.67.2.27

Vivien J. Coulson-Thomas et al. from the University of Houston characterize the anatomy and morphology of the ocular surface and accessory glands of the Acomys cahirinus mice. doi.org/10.1167/iovs.67.2.26

Pete A. Williams et al. from St. Erik Eye Hospital find that semaglutide protects retinal ganglion cells against rotenone-induced degeneration via improved glucose metabolism. doi.org/10.1167/iovs.67.2.25

Brad Fortune et al. from Devers Eye Institute find that microvascular volume loss exceeds nerve fiber layer but not neuroretinal rim tissue loss during progression of nonhuman primate experimental glaucoma. doi.org/10.1167/iovs.67.2.24

Patricia J. McLaughlin et al. from Penn State University find that mitigation of oxidative stress pathways in the diabetic cornea and lacrimal glands contributes to the rapid reversal of diabetic dry eye by naltrexone. doi.org/10.1167/iovs.67.2.23

Wenlong Li et al from Shandong Key Laboratory of Eye Diseases find that AIF-1 drives corneal neovascularization by promoting inflammatory macrophage activation via the MAPK and PI3K/AKT/mTOR signaling pathways. doi.org/10.1167/iovs.67.2.22

Xuehao Cui et al. from the University of Cambridge use integrative proteogenomic analysis to identify genetically supported plasma proteins, metabolites, and pathways in glaucoma. doi.org/10.1167/iovs.67.2.21

Tatyana Appelbaum, William A. Beltran et al. from the University of Pennsylvania investigate crosstalk between R-Loops, RNA/DNA modifications, and cell death dynamics in canine models of retinitis pigmentosa. doi.org/10.1167/iovs.67.2.20

Anna Esteve-Garcia et al. from Bellvitge University Hospital investigate genotype-phenotype correlations in ABCA4-associated retinopathy. doi.org/10.1167/iovs.67.2.19

Lin Xie et al. from The Third Affiliated Hospital of Chongqing Medical University investigate the molecular mechanisms and therapeutic potentials of engrailed-1 in fibrotic scar formation post glaucoma filtration surgery. doi.org/10.1167/iovs.67.2.18

Ya Xing Wang et al. from Beijing Tsinghua Changgung Hospital investigate ocular and general determinants of intraocular pressure. doi.org/10.1167/iovs.67.2.17

Qingjun Zhou, Qun Wang et al. from Shandong First Medical University find that taurochenodeoxycholic acid activates calcium signaling to protect against Fuchs’ endothelial corneal dystrophy. doi.org/10.1167/iovs.67.2.16

Zhijie Li et al. from Henan Eye Hospital investigate how chronic psychological stress alters circadian, immune, and lipid regulatory networks in meibomian glands (MGs) and to assess the efficacy of β-adrenergic blockade in mitigating these effects. doi.org/10.1167/iovs.67.2.15

Shuai Chang, Xinping Yu et al. from Zhongshan Ophthalmic Center evaluate motor skill impairments in children with intermittent exotropia (IXT), and to investigate associations between clinical visual parameters and motor deficits. doi.org/10.1167/iovs.67.2.14

Lucia Sobrin, Ayellet V. Segrè et al. from Massachusetts Eye and Ear Infirmary @MassEyeAndEar identify time-dependent glucocorticoid-induced transcriptomic changes in human trabecular meshwork and Schlemm's canal cells. doi.org/10.1167/iovs.67.2.13

Srinivas R. Sadda et al. from Doheny Eye Institute perform high-resolution OCT profiling of Bruch's membrane in extensive macular atrophy with pseudodrusen-like appearance and geographic atrophy. doi.org/10.1167/iovs.67.2.12

Benjamin K. Young et al. from Casey Eye Institute Investigate retinopathy of prematurity (ROP) notch physiology, using ultra-widefield optical coherence tomography (UWF-OCT), and a computational model. doi.org/10.1167/iovs.67.2.10

Soumya Navneet & Bärbel Rohrer from the Medical University of South Carolina find that CR2-fH, a targeted inhibitor of alternative complement pathway reduces dry AMD-like phenotype in AMD patient iPSC-derived RPE cells. doi.org/10.1167/iovs.67.2.9

Timothy S. Kern et al. from UC Irvine find that theophylline inhibits capillary degeneration in early diabetic retinopathy. doi.org/10.1167/iovs.67.2.8

Curtis R. Brandt et al. from the University of Wisconsin-Madison investigate the possibility of using free-living amoeba in treating bacterial infections. doi.org/10.1167/iovs.67.2.7

Sidney M. Gospe et al. from Duke University School of Medicine find that pharmacological depletion of retinal mononuclear phagocytes Is neuroprotective in a mouse model of mitochondrial optic neuropathy. doi.org/10.1167/iovs.67.2.6

Jia-lin Wang et al. from Beijing Friendship Hospital use computational fluid dynamics and particle image velocimetry to study ophthalmic artery morphology and hemodynamics in ocular ischemic syndrome. doi.org/10.1167/iovs.67.2.5

Li Jia Chen et al. from The Chinese University of Hong Kong identify plasma proteins associated with glaucoma and assess the translational potential of key proteins as both biomarkers and therapeutic targets. doi.org/10.1167/iovs.67.2.4

Karsten Gronert et al. from UC Berkeley find that lipoxin B4 mitigates TRPV4-activated Müller cell gliosis during ocular hypertension. doi.org/10.1167/iovs.67.2.2

New article in the Nystagmus issue bit.ly/4aabXfF by Monica Daibert-Nido et al from Toronto Western Hospital explore the effectiveness of using yoked low-value prism glasses to correct abnormal head position in pediatric nystagmus. doi.org/10.1167/iovs.67.2.3

Arlene V. Drack et al. from the University of Iowa find a profound effect of light on cysts in X-linked retinoschisis using a mouse model. doi.org/10.1167/iovs.67.2.1

Amani A. Fawzi et al. from the Feinberg School of Medicine find that baseline nonperfusion and deep capillary plexus ischemia predict two-year retinal nonperfusion progression in diabetic retinopathy. doi.org/10.1167/iovs.67.1.64

Padmanabhan P. Pattabiraman et al. from the Indiana University School of Medicine find that loss of cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork. doi.org/10.1167/iovs.67.1.63

João Pedro Marques from Hospitais da Universidade de Coimbra describe enhancing molecular diagnostic accuracy in genetic eye disorders through a personalized re-evaluation strategy. doi.org/10.1167/iovs.67.1.62

Shijie Zheng, Ke Hu et al. from The First Affiliated Hospital of Chongqing Medical University find that vitamin E alleviates oxidative damage and attenuates ferroptosis caused by prolonged contraction of the ciliary muscle by activating ACOT7. doi.org/10.1167/iovs.67.1.61

Elia J. Duh, Xialin Liu et al. from Wilmer Eye Institute & Zhongshan Ophthalmic Center investigate the association among age and thickness of the retina, RPE, and choriocapillaris in cynomolgus macaques. doi.org/10.1167/iovs.67.1.60

Alexandre Moulin et al. from Jules-Gonin Eye Hospital investigate downregulation of cyclin kinase inhibitors p16INK4a and p27 in conjunctival melanomas. doi.org/10.1167/iovs.67.1.59

Cynthia Owsley et al. from the University of Alabama at Birmingham investigate preserved contrast sensitivity in early and intermediate age-related macular degeneration and marked loss in late stage. doi.org/10.1167/iovs.67.1.58

Kun-Che Chang et al from the University of Pittsburgh School of Medicine find that enzymatic disruption of the internal limiting membrane enhances transplanted retinal ganglion cell survival. doi.org/10.1167/iovs.67.1.57

Robert M. Lavker, Han Peng, Tsutomu Kume et al. from Northwestern University find that PAX6 deficiency compromises the ability of limbal epithelial stem cells to properly differentiate into mature corneal epithelial cells. doi.org/10.1167/iovs.67.1.56

Emine Kiliç et al. from Erasmus MC evaluated the feasibility of a multi-marker circulating tumor cell capture approach in uveal melanoma patients at diagnosis, during fractionated stereotactic radiotherapy (fSRT), and at metastatic progression. doi.org/10.1167/iovs.67.1.55

Teresio Avitabile from Azienda Ospedaliero Universitaria Policlinico “G. Rodolico - San Marco” present a longitudinal in vitro assessment of the optical transparency of preserved pre-descemet layers in the absence of corneal endothelium. doi.org/10.1167/iovs.67.1.54

Qingjun Zhou, Zongyi Li et al. from Shandong Eye Institute characterize the early transcriptomic and pathologic changes of Fuchs endothelial corneal dystrophy using the Col8a2Q455K/Q455K mutant mouse model. doi.org/10.1167/iovs.67.1.53

Meng-Tian Kang, Ningli Wang et al. from Beijing Tongren Eye Center investigate the effects of repeated red laser irradiation at a supraclinical dose on histology and apoptosis-related molecular markers in guinea pig ocular tissues. doi.org/10.1167/iovs.67.1.52

Antoine P. Brézin et al. from Hôpital Cochin, Université Paris Cité investigate how ERAP1 and ERAP2 genotype combinations influence susceptibility and severity in birdshot chorioretinitis (BSCR), an HLA-A29–associated disease with variable visual outcomes doi.org/10.1167/iovs.67.1.51

Justyn W. Regini et al. from Cardiff University study the structural arrangement of crystallin proteins in the human lens during development. doi.org/10.1167/iovs.67.1.50

Valeria Marigo et al. from the University of Modena and Reggio Emilia investigate the modulation of aerobic glycolysis genes during the progression of retinitis pigmentosa. doi.org/10.1167/iovs.67.1.49

Yue Wan et al. from Beijing Tongren Eye Center investigate AAV-DJ–mediated MYOC silencing as a gene therapy approach for myocilin-associated glaucoma. doi.org/10.1167/iovs.67.1.48

Kun Liu et al. from Shanghai General Hospital use olink proteomic profiling of vitreous humor and plasma from proliferative diabetic retinopathy patients to identify a novel inflammatory molecular endotype. doi.org/10.1167/iovs.67.1.47

Xuanchu Duan et al. from Changsha Aier Eye Hospital find that digoxin attenuates ocular hypertension and protects trabecular meshwork cells via ferroptosis inhibition. doi.org/10.1167/iovs.67.1.46

Qingjun Zhou, Qun Wang et al. from Shandong First Medical University investigate the role of sensory neuropeptide calcitonin gene-related peptide (CGRP) in postrefractive surgery dry eye caused by corneal nerve severing in mice. doi.org/10.1167/iovs.67.1.45

Hauke M. Schadwinkel et al. from the University Medical Center Hamburg-Eppendorf use layer-specific proteomic profiling of the human cornea to reveal insights into structure and biological function. doi.org/10.1167/iovs.67.1.44