Hong Qi et al. from Peking University investigate Epstein-Barr virus-induced upregulation of GPR183 as a potential upstream mechanism in IgG4-related ophthalmic disease. doi.org/10.1167/iovs.67.8.30

Yongxiang Jiang et al. from the Eye, Ear, Nose and Throat Hospital of Fudan University characterize aqueous humor (AH) proteomic alterations in ADAMTSL4-associated congenital ectopia lentis (CEL) and identify disease-related molecular features. doi.org/10.1167/iovs.67.8.29

Srinivas R. Sadda et al. from Doheny Eye Institute determine the prevalence and imaging characteristics of thin and thick idiopathic epiretinal membranes (ERMs) using high-resolution OCT. doi.org/10.1167/iovs.67.8.28

Jiang Bian et al. from Shandong Key Laboratory of Eye Diseases find that ocular IL-1α/IFN-γ delay the corneal wound healing in rheumatoid arthritis through mitochondrial dysfunction and NLRP3 inflammasome activation. doi.org/10.1167/iovs.67.8.27

Nicolas A. Yannuzzi et al. from the Bascom Palmer Eye Institute compare the antimicrobial efficacy and ocular surface toxicity of povidone-iodine (PI) and chlorhexidine gluconate (CHX) against clinical endophthalmitis isolates. doi.org/10.1167/iovs.67.8.26

Deqiang Zheng et al. from Capital Medical University use whole-exome analysis to identifies candidate genes associated with diabetic retinopathy. doi.org/10.1167/iovs.67.8.25

Eyvind Rødahl et al. from the University of Bergen identify and characterize a novel gene variant associated with late-onset, non-syndromic retinitis pigmentosa. doi.org/10.1167/iovs.67.8.24

Xiaodong Sun, Bo Yu et al. from Shanghai General Hospital find that enhanced endocytosis and mitochondrial stress underlie severe retinitis pigmentosa with RHO P347L mutant. doi.org/10.1167/iovs.67.8.23

Christine A. Curcio et al. determine cross-sectional associations among intake of xanthophyll carotenoids lutein and zeaxanthin (L&Z), plasma L&Z, and two wavelength autofluorescence (2WAF) retinal imaging in aging and AMD. doi.org/10.1167/iovs.67.8.22

New Editorial by IOVS editors Subhabrata Chakrabarti, Anthony Khawaja, Jeremy A. Guggenheim & Janey L. Wiggs updates the journal's guidelines bit.ly/4wpr4eE for ophthalmic genetic studies. doi.org/10.1167/iovs.67.8.20

Kyoung A. Viola Lee & Mary C. Whitman from Boston Children's Hospital identify rare and common copy number variants (CNVs) associated with strabismus and amblyopia. doi.org/10.1167/iovs.67.8.21

Yi Y. Zuo et al. from the University of Hawaii at Manoa use a controlled-area droplet evaporimeter to reveal surface pressure-dependent evaporation resistance of the tear film lipid layer. doi.org/10.1167/iovs.67.8.19

Alessio Antropoli et al. from IRCCS San Raffaele Scientific Institute investigate the longitudinal behavior of the hyper-reflective ganglion cell layer band and its association with ellipsoid zone constriction over time in molecularly characterized RP. doi.org/10.1167/iovs.67.8.18

@arvoinfo.bsky.social's TVST journal is calling for papers for a special issue on Digital Twins and Personalized Medicine in Eye Care. Original research using experimental data, real-world and clinical trial cohorts, simulations and advanced modeling welcome. Learn more: https://bit.ly/4wlcqoM

Shuai Shi et al. from Wenzhou Medical University find that AAV8-mediated retinal PD-L1 gene transfer attenuates experimental autoimmune uveitis by restoring local immune tolerance. doi.org/10.1167/iovs.67.8.17

Xiaorong Wu et al. from Jiangxi Medical College investigate the associations between the estimated glucose disposal rate (eGDR), a composite indicator of insulin sensitivity, and the risks of incident age-related cataract (ARC) and AMD. doi.org/10.1167/iovs.67.8.16

Yanning Yang et al. from Wuhan University explore the exosome-related gene network in herpes stromal keratitis and identify molecular drivers, focusing on the role of secreted phosphoprotein 1 & investigating the therapeutic potential of ursolic acid. doi.org/10.1167/iovs.67.8.15

Jiawei Zhou, Yiqiu Lu et al. from Wenzhou Medical University find that sensory eye dominance remains stable across binocular combination and rivalry in normal and anisometropic amblyopic vision. doi.org/10.1167/iovs.67.8.14

Review article by Zhimin Cen et al. from Zhongshan Torch Development Zone People's Hospital discusses the molecular basis of ocular aging, including mechanisms, pathologies, and emerging therapeutics. doi.org/10.1167/iovs.67.8.13

Jan Skerswetat et al. from Northeastern University introduce a self-administered near visual acuity (VA) test using the Angular Indication Measurement paradigm (AIM-VA) and evaluate it in children with and without amblyopia. doi.org/10.1167/iovs.67.8.12

Shunmei Ji et al. from Zhongshan Hospital affiliated to Fudan University find that Opn1mw deficiency prims the retina for exaggerated response to environmental defocus. doi.org/10.1167/iovs.67.8.11

Jianping Ji et al from Zhongshan Ophthalmic Center find that the CXXC1-IGFBP6 axis maintains corneal epithelial differentiation via H3K4me3-dependent transcriptional activation. doi.org/10.1167/iovs.67.8.7

Nazlee Zebardast, Massachusetts Eye and Ear Infirmary use spatial decomposition of longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure–Function and Genetic Signatures doi.org/10.1167/iovs.67.8.6

Martin Rao et al. from Bayer AG find that aflibercept and faricimab equipotently restore endothelial barrier function. doi.org/10.1167/iovs.67.8.5

S. Priya Narayanan et al. from the University of Georgia use proteomic profiling of optic nerves from SMOX-deficient mice to identify regulators of neuroinflammation and axonal damage in optic neuritis. doi.org/10.1167/iovs.67.8.4

Yusuke Murakami et al. from Kyushu University find that Myd88 deficiency accelerates retinal degeneration and alters microglial dynamics in a mouse model of retinitis pigmentosa. doi.org/10.1167/iovs.67.8.3

Nazlee Zebardast et al. from Massachusetts Eye and Ear identify and characterize clinically meaningful phenotypic subtypes of POAG using unsupervised clustering of multimodal clinical data. doi.org/10.1167/iovs.67.8.2

Chandrakumar Balaratnasingam et al from Lions Eye Institute find that degeneration of interpericyte tunneling nanotubes can occur in the absence of pericyte loss in diabetic retina disease. doi.org/10.1167/iovs.67.8.1

Wei Liu et al. from Tianjin Medical University Eye Hospital investigate the association between serum uric acid levels and primary open-angle glaucoma, and to explore potential genetic links and causal relationships using large population-based cohorts. doi.org/10.1167/iovs.67.6.57

Timothy J. Gawne et al. from the University of Alabama at Birmingham use a tree shrew model of slowly progressing childhood myopia to evaluate how regular breaks from a myopiagenic visual environment affect the development of myopia. doi.org/10.1167/iovs.67.6.56

Review article by Haoan Yi, Xu Zha et l. from Kunming Medical University discussed human crystallin variation and its implications for cataracts. doi.org/10.1167/iovs.67.6.55

Nitza Goldenberg-Cohen et al. from the Bnai Zion Medical Center investigate the etiology of primary acquired nasolacrimal duct obstruction (PANDO) by characterizing the elemental composition of tear and blood samples from affected patients. doi.org/10.1167/iovs.67.6.54

Yui Urahashi et al. from Kumamoto University develop an intravital imaging method that comprehensively shows the mouse conventional outflow pathway at high spatiotemporal resolution and investigate the fine structures and dynamics within this pathway. doi.org/10.1167/iovs.67.6.53

Shrikant R. Bharadwaj et al. from the Brien Holden Eye Research Centre find that reduced image quality impairs monocular blur-driven accommodation in keratoconus. doi.org/10.1167/iovs.67.6.52

C. Ross Ethier et al. from Emory Eye Center investigate segmental outflow and trabecular meshwork stiffness in an ocular hypertensive mouse model. doi.org/10.1167/iovs.67.6.51

Shuichiro Aoki et al. from the University of Tokyo Graduate School of Medicine quantitatively characterize the in vivo peripapillary sclera architecture using polarization-sensitive OCT & evaluate its association with axial length & glaucoma doi.org/10.1167/iovs.67.6.50

Xu Zhang et al. from the Affiliated Eye Hospital of Nanchang University find that SIRT4 alleviates retinal ischemia-reperfusion injury via mediating astrocytes lipid metabolism and mitochondrial function. doi.org/10.1167/iovs.67.6.49

Xiaoran Wang et al. from Zhongshan Ophthalmic Center investigated the role of RIPK3-mediated necroptosis in corneal epithelial injury and inflammation in dry eye disease. doi.org/10.1167/iovs.67.6.48

Tawna Roberts et al. from Byers Eye Institute investigate the effects of blur and disparity cues on accommodative response and microfluctuations, vergence, and pupillary responses to static targets in adolescents with persistent post-concussion symptoms. doi.org/10.1167/iovs.67.6.45

Hong Yan et al. from Shaanxi Eye Hospital find that Senp1 O-GlcNAcylation promotes mitochondrial fragmentation by regulating Fis1 SUMO1-ylation underlying diabetic cataracts. doi.org/10.1167/iovs.67.6.44

David Sánchez-Porras et al. from the University of Granada investigate the histostructural modifications that may happen in the anterior sclera and iris of patients with advanced glaucoma (AG) and non-advanced glaucoma (NAG). doi.org/10.1167/iovs.67.6.43

Harry W. Flynn, Jr. et al. from Bascom Palmer Eye Institute characterize the clinical features, treatment modalities, and visual outcomes of culture-proven exogenous Fusarium endophthalmitis managed at a tertiary referral center. doi.org/10.1167/iovs.67.6.42

Lu Ye et al. from Xi'an People's Hospital characterize the genomic features, population structure, and evolutionary mechanisms of antimicrobial resistance and virulence in ocular Pseudomonas aeruginosa isolates. doi.org/10.1167/iovs.67.6.41

Kehao Wang et al. from Beihang University systematically characterize changes in lens geometry, gradient refractive index (GRIN) profile, and refractive state in developing murine eye. doi.org/10.1167/iovs.67.6.37

Kai Hu, Jiaxuan Jiang et al. from Nanjing University find that HSV-1–driven lipid metabolic reprogramming and lipid droplet accumulation in macrophages impair antiviral immunity. doi.org/10.1167/iovs.67.6.39

Matthew R. Garis, Evelyn S. Chiu & Peter Y. Lwigale from Rice University find that nephronectin promotes migration of the periocular mesenchyme via EGFR signaling. doi.org/10.1167/iovs.67.6.40

Kai Hu, Jiaxuan Jiang et al. from Nanjing University use time-course transcriptomic analysis to reveal a PANoptosis–CCL2 axis in herpes simplex keratitis. doi.org/10.1167/iovs.67.6.38

Li Jia Chen, Jason C. Yam et al. from The Chinese University of Hong Kong investigate the associations of omics-based biological aging with diabetic retinopathy (DR) and life expectancy among individuals with DR. doi.org/10.1167/iovs.67.6.36

Salma El Emrani et al. from Leiden University Medical Center develop an early prediction model for retinopathy of prematurity using placental and neonatal risk factors. doi.org/10.1167/iovs.67.6.35

Marcin Golczak et al. from Case Western Reserve University find that pharmacologic alteration of meibum lipid composition alleviates dry eye phenotype in Awat2−/− mice. doi.org/10.1167/iovs.67.6.34