Publishing in JGP enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more: 👉 rupress.org/pages/nih-hh...

Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels. A new review by Magnus Behringer, Gerhard Thiel and colleagues @tuda.bsky.social rupress.org/jgp/article/... #IonChannels

Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles. New study from Manuel F. Muñoz, Fernando Santana @lfsantana68.bsky.social and colleagues @ucd-physiology.bsky.social rupress.org/jgp/article/... #IonChannels #CardiacMuscle

Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell sub-populations. New study from Claire H. Levitt, Richard K.P. Benninger et al. @cuanschutz.bsky.social: rupress.org/jgp/article/... #Pathophysiology #SystemsPhysiology #Diabetes #GabJunctions

Behringer et al. from @tuda.bsky.social show how coarse-grained computational methods uncover long-range mechanical connectivities in HCN #IonChannels. Together with high-res #cryoEM structures, these methods provide insights into their allosteric regulation. rupress.org/jgp/article/...

📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers

Levitt, Benninger et al. @cuanschutz.bsky.social investigate how loss of #GapJunctions under diabetogenic environments and their protection influence subpopulations of #insulin-producing β-cells rupress.org/jgp/article/... #Diabetes

Thank you for the thorough, constructive review process!

Muñoz, @lfsantana68.bsky.social et al. show that beat-locked cytosolic and mitochondrial ATP transients in sinoatrial node myocytes sort into high-gain, low-gain, or consumption-dominant modes aligned with superior–inferior vascular–mitochondrial gradients. rupress.org/jgp/article/... #CardiacMuscle

At JGP, your research is evaluated fairly, edited thoughtfully, and shared with a like-minded community of physiologists. Learn how scientists set the course and publish your next paper 👉 hubs.la/Q0445GC_0

Publishing in JGP enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more: rupress.org/pages/nih-hh...

Deep learning as a generator of sodium channel state hypotheses. Lisa Schmidt and Wojciech Kopec @mpi-nat.bsky.social discuss recent work by Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social (rupress.org/jgp/article/...) in Commentary: rupress.org/jgp/article/... #IonChannels

Titin's P-zone domains A164-167 are essential for thick filament structural arrangement. New study from Catherine Hoover Browne, Henk Granzier and colleagues @uarizona.bsky.social: rupress.org/jgp/article/... #SkeletalMuscle #CardiacMuscle #MolecularPhysiology #CellularPhysiology #Titin

Sequential membrane remodeling by #cholesterol distinctly modulates HCN channels in naïve & neuropathic DRG neurons. New study by Lucas J. Handlin, Gucan Dai (@gucandai.bsky.social) et al (Saint Louis University School of Medicine): rupress.org/jgp/article/... #lipids #Biophysics #Pain #IonChannels

“This rigorous process ultimately improves the quality of our manuscripts, thereby helps to advance our field of study.” — Dr. Daniel Fitzsimons Learn how scientists set the course at Journal of General Physiology 👉 hubs.la/Q0445GC_0

#Cholesterol in cell membranes plays a key role in controlling how #pain-sensing #neurons respond. Handlin et al. show that distinct cholesterol pools—OMD-associated & freely accessible cholesterol—differently influence HCN #IonChannels, which regulate nerve excitability. rupress.org/jgp/article/...

Hoover Browne, Granzier et al. @uarizona.bsky.social report that deleting the P-zone domains A164–167 from #titin in a novel mouse model reveals their critical role in #muscle function and thick filament structure, including maintaining titin’s α and β conformations. rupress.org/jgp/article/...

Opening of rod #photoreceptor CNG channels by photodynamically generated singlet oxygen. New study from Gaogao He, Lei Zhou and colleagues (Shenzhen Bay Laboratory): rupress.org/jgp/article/... #Biophysics #MolecularPhysiology #IonChannels

“The editors and reviewers ensure that feedback on our work is insightful, intuitive, and informative.”— Dr. Daniel Fitzsimons. Learn how scientists set the course at JGP 👉 hubs.la/Q0445GC_0

#CallForPapers ⏰️ Don't miss the March 15th deadline! Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery 👉 rupress.org/JGP/pages/ca...

Commentary: Schmidt and Kopec @mpi-nat.bsky.social discuss how Lopez-Mateos et al. @vyy-sf.bsky.social (rupress.org/jgp/article/...) used AlphaFold 2 to generate structural ensembles of voltage-gated sodium channels across different conformations. rupress.org/jgp/article/... #IonChannels

Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere. New review from Angela C. Greenman, Willem de Lange, and J. Carter Ralphe @wiscpediatrics.bsky.social: rupress.org/jgp/article/... #CardiacMuscle #Contraction #CellMotility #Biophysics

#CallForPapers ⏰️ Don't miss the March 15th deadline! Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery 👉 rupress.org/JGP/pages/ca...

Gaogao He, Lei Zhou et al. demonstrate that #ionchannels from #photoreceptors in the retina are very sensitive to photodynamic modification mediated by singlet oxygen, ¹O2, the molecular oxygen in electronically excited states. rupress.org/jgp/article/... #Biophysics #MolecularPhysiology

“We have chosen to submit our work to the Journal of General Physiology because we are confident that the review process will be fair.”— Dr. Daniel Fitzsimons. Learn how scientists set the course 👉 hubs.la/Q0445GC_0

📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers #WSCC26

Greenman et al. review the role of cMyBP-C post-translational modifications in health & disease. During cardiovascular disease, oxidative stress may drive the inverse relationship btwn. phosphorylation & S-glutathionylation of cMyBP-C, identifying new therapeutic targets rupress.org/jgp/article/...

SGP congratulates Dr. Rosa Scala on receiving the 2026 Cranefield Postdoctoral Fellow Award for her outstanding JGP paper, “Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice” doi.org/10.1085/jgp.202513781 @jgp.org

SGP congratulates Sho Horie on receiving the 2026 Cranefield Student Award for his outstanding JGP paper, “A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness” doi.org/10.1085/jgp.202413749 @jgp.org

Our March issue is here! rupress.org/jgp/issue/15... Subthreshold current pulses delivered to pairs of electrically coupled MesV neurons with systematically varied inter-pulse delays reveal that electrical synapses enable coincidence detection. See Dapino and Curti rupress.org/jgp/article/...

Putative RNA editing of a nicotinic receptor increases acetylcholine sensitivity. New study from Cecilia Borghese, Ying Lu, Edward Bertaccini, and Harold Zakon @utaustin.bsky.social: rupress.org/jgp/article/... #MolecularPharmacology

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel. New study from Yuki K. Maeda, Katsumasa Irie and colleagues (Wakayama Medical University): rupress.org/jgp/article/... #Biophysics #IonChannels

Are you interested in discussing your work with a JGP Editor in-person at #BPS2026? Our Editorial team is available to chat with you! Stop by our booth #504 TUESDAY 2/24👇️ 11:00-12:00 Olaf Andersen 12:00-1:00 Teresa Giraldez 1:00-2:00 Eduardo Ríos 3:00-4:00 Joe Mindell

Our final day at #BPS2026! Come by our booth #504 and chat about the journal! 🔬 📄 💡 💬 Don't forget to pick up a copy of the 2026 JGP Research News magazine 📚️ and an exclusive zip-up pouch 🎁

📣 Call for Papers 📣 You are invited to submit papers on the topic of the @sgpweb.bsky.social 2026 meeting, “Membrane Excitability and Reproductive Biology,” to be published throughout the year and highlighted in a special issue! Learn more and submit here 👉 rupress.org/JGP/pages/ca...

JGP in 2026. In this Editorial, JGP Editor-in-Chief David Eisner reflects on the past year of excellent science and introduces the new members of the Editorial Advisory Board, who give freely of their time and expertise to critique and improve submissions. rupress.org/jgp/article/...

Borghese, Zakon et al. show that a neuronal nicotinic acetylcholine receptor from Xenopus tropicalis frogs possesses exquisite sensitivity to acetylcholine due to a single amino acid substitution in the α4 M3 domain possibly produced by RNA editing. rupress.org/jgp/article/...

JGP's Editor-in-Chief David Eisner (right) at our booth #BPS2026! Stop by Booth 504 to chat about your work and learn about the journal!

Are you interested in discussing your work with a JGP Editor in-person at #BPS2026? Stop by our booth #504 today MONDAY 2/23👇️ 10:00-11:00 Chris Lingle 11:00-12:00 David Eisner 12:00-1:00 Eduardo Ríos 2:00-3:00 Joe Mindell 4:00-5:00 Olaf Andersen We look forward to chatting with you 🔬 📄 💡 💬

Attending #BPS2026 in San Francisco? Come by our booth #504 and chat about the journal! 🔬 📄 💡 💬 Don't forget to pick up a copy of the 2026 JGP Research News magazine 📚️ and an exclusive zip-up pouch 🎁

Are you at #BPS2026 in San Francisco? Come by our booth #504 and chat about the journal! Don't forget to pick up a copy of the 2026 Journal of General Physiology Research News 📚️ as well as an exclusive zip-up pouch 🎁 🔬 📄 💡 💬

Are you attending #BPS2026 and interested in discussing your work with a JGP Editor? Stop by our booth #504 today SUNDAY 2/22👇️ 10:00-11:00 David Eisner 11:00-12:00 Chris Lingle 2:00-3:00 Henk Granzier 4:00-5:00 Teresa Giraldez We look forward to chatting with you 🔬 📄 💡 💬

Are you attending #BPS2026 @biophysicalsoc.bsky.social and interested in discussing your work with a JGP Editor? Stop by our booth #504 during Editor Hours ⏰️ 👇️ Our Editorial team is looking forward to chatting with you 🔬 📄 💡 💬

Attending #BPS2026 @biophysicalsoc.bsky.social in San Francisco? Stop by JGP's booth #504 in the Exhibit Hall and pick up a copy of the 2026 Journal of General Physiology Research News 📚️ as well as an exclusive zip-up pouch 🎁 We look forward to chatting with you! 🔬 📄 💡 💬

Are you attending #BPS2026 and interested in discussing your work with a JGP Editor? Stop by our booth #504 during Editor Hours ⏰️ 👇️ Our Editorial team is looking forward to chatting with you 🔬 📄 💡 💬

Are you attending #BPS2026 in San Francisco? Stop by JGP's booth #504 in the Exhibit Hall and pick up a copy of the 2026 JGP Research News magazine as well as an exclusive zip-up pouch! We look forward to chatting with you 🔬 📄 💡 💬

Voltage-gated sodium channels (Navs) exhibit high Li⁺ selectivity similar to Na⁺. Maeda, Irie et al. present the first prokaryotic Nav mutant that conducts Li⁺ with approximately twice the efficiency of Na⁺. rupress.org/jgp/article/... #Biophysics #IonChannels

#MolecularDynamics analyses of CLDN15 pore size and charge selectivity. New study from Sarah McGuinness, Le Shen, Fatemeh Khalili-Araghi, Christopher R. Weber and colleagues (University of Chicago): rupress.org/jgp/article/... #MembraneTransport #Biophysics #ProteinStructure #ProteinDynamics

ID helps verify coincidence detection. A recent study from Dapino and Curti (rupress.org/jgp/article/...) reveals that the D-type K⁺ current regulates coincidence detection by shaping electrical transmission between pairs of MesV neurons. More in Research News: rupress.org/jgp/article/...

Welcome to another year at JGP ! We thank the whole JGP community for its support over the last year. This is particularly appreciated today when we are all challenged by so many difficulties. Editorial from our Editor-in-Chief David Eisner: rupress.org/jgp/article/...