For #PeerReviewWeek's AI focus, we want to take a moment to thank the people behind the peer review process. Our position is that rigorous peer review demands direct accountability that only human reviewers can provide. Thank you for all that you do!

#CallForPapers 📣 We're accepting submissions on the topic of @sgpweb.bsky.social's 2025 Meeting "Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) – with Guest Editors Anne Carlson and Zhaozhu Qiu! 👉 rupress.org/JGP/pages/ca...

NALCN/Cch1 channelosome subunits originated in early eukaryotes. New study from Adriano Senatore @utoronto.ca and colleagues: rupress.org/jgp/article/... #Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels

Investigating the Role of the I–II Linker in Nav1.5 Channel Function. New study from Emily Wagner, Jonathan Silva and colleagues @washuengineers.bsky.social: rupress.org/jgp/article/... #Biophysics #Pathophysiology #IonChannels

ICYMI: JGP 2025 Highlights Collection provides new insights into the mechanism of fast inactivation of voltage-gated sodium channels, the stoichiometry of pannexin channels, the modulation of ion channel properties by glycosylation and toxins, and more 👉 rupress.org/jgp/collecti... #SGP2025

What happened to the pursuit of truth? Eve Marder discusses a recent Viewpoint (rupress.org/jgp/article/... ) on the advent of #AI #LLM and their indiscriminate use to speed up the production of papers. rupress.org/jgp/article/... 📙 In JGP Highlights collection 2025: rupress.org/jgp/collecti...

Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers. From Smriti Gupta, Douglas Bayliss and colleagues: rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Adriano Senatore @utoronto.ca and colleagues explore the evolutionary origins of the sodium leak channel NALCN and its ancillary subunits FAM155/Mid1, UNC79, and UNC80. rupress.org/jgp/article/... #Evolution #IonChannels

PANX1 hexamers work but cells prefer heptamers. Andrew Harris provides commentary on work from Gupta et al. (rupress.org/jgp/article/...): rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Yichen Liu and Francisco Bezanilla show that a sodium channel mutant removes fast inactivation with the inactivation particle bound rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Hi1a reduces ischemic cell death by inhibiting ASIC1a channels. Berger & MacLean show each domain of Hi1a binds to the same site on ASIC1a subunits, accounting for this peptide’s unusual functional effects rupress.org/jgp/article/... 📙 JGP Highlights Collection 2025: rupress.org/jgp/collecti...

Wagner, Silva et al. @washuengineers.bsky.social show that deleting large sections of the Nav1.5 I–II linker does not affect voltage-dependent gating. But changes to the protein sequence does affect gating, showing how certain variants can alter channel function. rupress.org/jgp/article/...

Beaudoin, Jackson et al. investigate the structural effects of N-linked glycosylation on Naᵥ channels using molecular modeling and dynamics simulations. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Resolving zone-specific regulation of cardiac #myosin. Shane Nelson @uvmvermont.bsky.social provides commentary on work from Pilagov et al. (rupress.org/jgp/article/...) that explores role of MyBP-C in regulation of the myosin SRX state in cardiac muscle. rupress.org/jgp/article/... #Myofilaments

In this Viewpoint, Hull and @lampertlab.bsky.social explore the role of metaphors in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Mercado-Perez, Beyder et al. show that some Piezo2 clusters in these cells interact with E-cadherin and #actin #cytoskeleton at the lateral wall. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

França & Monserrat discuss how large language models are likely to amplify the worst incentives of academia, greatly increasing the volume of scientific literature while diluting its quality. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Skeletal muscle gets some help down the stretch. Woods et al. (rupress.org/jgp/article/...) suggest that stretch activation is important in fatigued skeletal muscle when stretch-activated tension persists even as Ca2+-activated force production declines. In Research News: rupress.org/jgp/article/...

We’re pleased to present a special collection highlighting some of the most read and discussed papers published over the past 12 months. Gain new insights to accompany the 2025 Meeting of the Society for General Physiologists (@sgpweb.bsky.social) #SGP2025 👉 rupress.org/jgp/collecti...

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle, say Bin Sun, Alec Loftus, Peter Kekenes-Huskey and colleagues @loyolachicago.bsky.social: rupress.org/jgp/article/... #Myofilaments #Biophysics #ComputationalBiology #MolecularPhysiology

🧑‍🔬🎙️ Did you know that JGP supports video summaries of your research? When you publish with JGP, you can reach more of your community by submitting a short video! 🎦 See our guidelines: rupress.org/jgp/pages/vi... ▶️ Watch video summaries from our authors: www.youtube.com/@JGenPhysiol

Our September issue is here! rupress.org/jgp/issue/15... The cover shows a molecular model illustrating how the binding between ABLIM1 and titin is dynamically regulated to tune contraction (Sun and Loftus et al. doi.org/10.1085/jgp....). Image courtesy of Audrey Deyawe Kongmeneck.

Exploring a peripheral PIP2 binding site and its role in the alternative regulation of the TRP Channel Superfamily. New study from Gonzalo Espinoza-Arcos, Mariela González-Avendaño, Ariela Vergara-Jaque, Horacio Poblete and colleagues (University of Talca, Chile): rupress.org/jgp/article/...

#CallForPapers 📣 We're accepting submissions on the topic of @sgpweb.bsky.social's 2025 Meeting "Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) – with Guest Editors Anne Carlson and Zhaozhu Qiu! 👉 rupress.org/JGP/pages/ca...

Commentary from Shane Nelson @uvmlarnermed.bsky.social: new study from Pilagov and colleagues (rupress.org/jgp/article/...) explores role of MyBP-C in regulation of the #myosin SRX state in cardiac muscle. rupress.org/jgp/article/...

Latest in Research News: study from Woods, Swank, and Miller (rupress.org/jgp/article/...) suggests that stretch activation of fast-contracting skeletal muscle fibers might increase muscle endurance by boosting force production during fatigue. rupress.org/jgp/article/... #Myofilaments

Sun, Loftus, Kekenes-Huskey et al. @loyolachicago.bsky.social provide a new lens to understand dynamic control and dysfunction in #cardiomyocyte contraction via an understanding of ABLIM1 and the complexities of its phosphorylation and interactions in the #sarcomere. rupress.org/jgp/article/...

Espinoza-Arcos and González-Avendaño et al. identify a peripheral PIP2-binding site conserved across TRP channels using coarse-grained #MolecularDynamics simulations. rupress.org/jgp/article/... #Lipids #ComputationalBiology #IonChannels

🧑‍🔬🎙️ Did you know that JGP supports video summaries of your research? When you publish with JGP, you can reach more of your community by submitting a short video! 🎦 See our guidelines: rupress.org/jgp/pages/vi... ▶️ Watch video summaries from our authors: www.youtube.com/@JGenPhysiol

Kinetics of aldosterone-dependent ENaC trafficking in the kidney. New study from Gustavo Frindt, Lawrence Palmer (Weill Cornell Medicine) and colleagues: rupress.org/jgp/article/... #CellularPhysiology #MolecularPhysiology #MembraneTransport

Stretch activation combats force loss from fatigue in fast-contracting mouse skeletal muscle fibers, say Philip Woods, Douglas Swank, and Mark Miller @umassamherst.bsky.social: rupress.org/jgp/article/... #SkeletalMuscle #Myofilaments

📣 #CallForPapers 📣 Topics of interest include, but are not limited to, #ionchannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca... @sgpweb.bsky.social

Charybdotoxin binding to Shaker K⁺ channels is temperature sensitive in high external K⁺ but not in high external Na⁺, say Nieves Navarro-Quezada, Francisca Salas-Sepulveda, Horacio Poblete, & David Naranjo (Universidad de Valparaíso, Chile): rupress.org/jgp/article/... #IonChannels

Frindt, Palmer et al. study the kinetics of processing of the epithelial Na channel (ENaC) in rat kidney. Alterations in levels of aldosterone produced rapid changes in cleaved γENaC and αENaC, with slower changes in full-length forms of the subunits. rupress.org/jgp/article/...

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains, say Rebeca Martínez-Lázaro, David Bartolomé-Martín, Teresa Giraldez et al. @ull.es rupress.org/jgp/article/... #Biophysics #CellularPhysiology #IonChannels

Woods, Swank, and Miller @umassamherst.bsky.social demonstrate that stretch-activated force production is maintained under fatiguing conditions, while calcium-activated force declines in fast-contracting #SkeletalMuscle fibers. rupress.org/jgp/article/...

Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation, say Martin Heiss, Bernhard Flucher et al. @i-med.ac.at rupress.org/jgp/article/... #IonChannels

📣 #CallForPapers 📣 Submit your research on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on #IonChannels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...

#CallForPapers 📣 We're accepting submissions on the topic of @sgpweb.bsky.social's 2025 Meeting "Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) – with Guest Editors Anne Carlson and Zhaozhu Qiu! 👉 rupress.org/JGP/pages/ca...

Navarro-Quezada, Naranjo et al. show that charybdotoxin binding to Shaker K⁺ channels is temperature-sensitive in high external K⁺ but not in high external Na⁺. Binding of CTX to Shaker appears to be diffusion limited and, counterintuitively, is temperature dependent. rupress.org/jgp/article/...

Martínez-Lázaro, Bartolomé-Martín, Giraldez et al. @ull.es show that two GRIN2B variants disrupt nanoscale coupling btwn NMDA receptors & BK channels, revealing nanodomain dysfunction as a potential mechanism contributing to GRIN2B-associated pathophysiology rupress.org/jgp/article/...

Martin Heiss, Bernhard Flucher et al. @i-med.ac.at unravel molecular mechanisms in a voltage-sensing domain that governs the kinetics and voltage dependence of calcium channel activation. rupress.org/jgp/article/... #IonChannels

🧑‍🔬🎙️ Did you know that JGP supports video summaries of your research? When you publish with JGP, you can reach more of your community by submitting a short video! 🎦 See our guidelines: rupress.org/jgp/pages/vi... ▶️ Watch video summaries from our authors: www.youtube.com/@JGenPhysiol

📣 #CallForPapers 📣 We're now accepting submissions on the topic of the Electrophysiology & #IonChannel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...

Consider this call for papers! We cannot wait to receive your ⭐️EpIC⭐️ submissions! Please spread the word. P.S. this cool EpIC logo was designed with help of my son!

Mind the midpoints: Rethinking variability in cardiac INa. Commentary from @clancyatheart.bsky.social @ucd-physiology.bsky.social highlighting the new study from @michaelclerx.com and colleagues (rupress.org/jgp/article/...): rupress.org/jgp/article/...

Variability in reported midpoints of (in)activation of cardiac Ina. New study from Michael Clerx @michaelclerx.com, Paul Volders, and Gary Mirams @mirams.bsky.social @uniofnottingham.bsky.social: rupress.org/jgp/article/... #ComputationalBiology #CardiacMuscle #CellularPhysiology #IonChannels

Exciting news! The EPIC/SGP Symposium at UC Davis will be accompanied by a special issue in the Journal of General Physiology. Stay tuned for more details about this incredible event celebrating cutting-edge research on ion channels!

📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...

🧑‍🔬🎙️ Did you know that JGP supports video summaries of your research? When you publish with JGP, you can reach more of your community by submitting a short video! 🎦 See our guidelines: rupress.org/jgp/pages/vi... ▶️ Watch video summaries from our authors: www.youtube.com/@JGenPhysiol