In @jem.org, Cinque et al. @leuccilrcb.bsky.social showed that the #lncRNA LISRR contributes to the emergence of #melanoma clones resistant to the immune attack by assembling #specializedribosomes at the ER. rupress.org/jem/article/... 🎥 See a short video summary: youtu.be/AKSuTne83jQ #Ribosomes

In @jcb.org, Calvo, Patel, Alonso @uva-es.bsky.social et al. describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. rupress.org/jcb/article/... #CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes

In @jcb.org, Okada, Bi et al. @upenn.edu show that Bni5 interacts with #septin filaments, septin-associated kinase, and #myosin-II to regulate septin hourglass architecture and remodeling, retrograde #actin flow, and #cytokinesis. rupress.org/jcb/article/... #CellDivision #Cytoskeleton #Genetics

In @jcb.org, Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/... #ER_literature #Migration #Organelles

In @jem.org, Chen, Weichselbaum et al. discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy. The SPI1–YTHDF2–Notch signaling–MHC-I axis orchestrates the antigen cross-presentation function of dendritic cells. rupress.org/jem/article/...

@jem.org is pleased to introduce Natalie Cain as the Executive Editor of the journal! Natalie will guide the collaborative editorial process at JEM. Follow her at 🦋 @nataliecain.bsky.social Learn more about Natalie 👉 rupress.org/jem/pages/je...

In @jgp.org, De Giorgis, Neely et al. show that the auxiliary β-subunit remodels only voltage sensor II and its allosteric contribution to CaV1.2 channel opening upon the translocation of two charges before reaching full activation. rupress.org/jgp/article/... #IonChannels

Esther Obeng is an attending physician and associate professor at Emory University, where she leads a research group focused on myelodysplastic syndromes (MDS). @jem.org spoke with Esther about her career, how her patients inform her research, and more: rupress.org/jem/article/... #WomenInSTEM

Congratulations to Cedars-Sinai Postdoc Katarzyna Chojnacka, winner of the @jem.org Early Career Travel Award to attend the #Cytokines2025 meeting in Seattle. Learn more here: rupress.org/jem/pages/ea...

In new study @jcb.org from Ryken, Bezanilla et al., analysis of PIIB-type calcium pump localization and function elucidates one of the molecular mechanisms that maintains the strength of the calcium gradient during polarized growth. rupress.org/jcb/article/... #PlantBiology #Cytoskeleton

In @jcb.org, Xu Liu, Ya Huang et al. show that the transcriptional regulator RTF1 promotes #circadian rhythm by enhancing CLOCK occupancy and H3K4me3 deposition at pacemaker gene loci. rupress.org/jcb/article/... #Chromatin #Epigenetics

Retrospective study @jhumimmunity.org from Gilbert, Ong, Farmer et al. highlights that acute use of nirmatrelvir/ritonavir significantly reduces the risk of post-acute sequelae of #SARSCoV2 infection (#longCOVID) in immunodeficient patients. rupress.org/jhi/article/... #COVID19

New @jem.org study from Bauer, Halin et al. @ethz.ch reveals how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–based textbook description. rupress.org/jem/article/... #Lymphatics

In @jcb.org, Glushkova, Böhm, & Beck develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...

@jem.org's new collection highlights the latest discoveries in #cancer #immunology and #immunotherapy, including T cell biology, immune checkpoint inhibitor therapies, and more. Explore new research in JEM to accompany this week's #SITC25 @sitcancer.bsky.social! 👉 rupress.org/jem/collecti...

Spotlight @jcb.org: Jianuo Han and Yansong Miao highlight recent findings from Magliozzi et al. (rupress.org/jcb/article/...), identifying a novel “composite” #actin nucleator for the assembly of thick actin cables. rupress.org/jcb/article/... #Biochemistry #Cytoskeleton

In @jcb.org, Li, Hua et al. demonstrate that B4GALT1 and WLS cooperate to retain the canonical #Wnt receptor LRP5/6 on the #Golgi apparatus, leading to specific inhibition of the Wnt/β-catenin signaling in such Wnt-receiving cells that have no expression of Wnt proteins. rupress.org/jcb/article/...

In @jgp.org, Vonk, Esen, Kirby et al. @amsterdamumc.bsky.social report that 3D culture environments preserve #muscle fiber health and contractility better than 2D systems, offering an improved model for drug screening and testing genetic interventions. rupress.org/jgp/article/...

Localization of the #septin #cytoskeleton is controlled by regulatory factors, membrane curvature, & charge. In @jcb.org, @gladfelterlab.bsky.social finds changes to #lipid composition that modulate lipid packing defects to impact septin assemblies in vitro & in cells. rupress.org/jcb/article/...

@jhumimmunity.org's November issue is here! rupress.org/jhi/issue/1/4 Cover shows how genetic and immunologic modifiers shape the penetrance of TNFRSF13B variants, redefining their contribution to antibody deficiency. From Abolhassani et al. See doi.org/10.70962/jhi...

@jgp.org's November issue is here! rupress.org/jgp/issue/15... In the retina of a Trpm1-knockout mouse, rod bipolar cell axon terminals (PKCα, green) are smaller and show an altered distribution relative to starburst amacrine cells (ChAT, magenta). From Horie et al. doi.org/10.1085/jgp....

In @jem.org's Nov issue: rupress.org/jem/issue/22... Xu et al. describe the biological function of Ankrd55 in mice, working as a functional modulator of T cell metabolism impacting Th17 responses. Cover shows a colon section of a mouse that received Ankrd55−/− T cells doi.org/10.1084/jem....

@jcb.org's November issue is here! rupress.org/jcb/issue/22... Cover shows a scanning electron #microscopy image of a human osteoclast derived from blood monocytes on bone slices. Image © Dufrançais and Poincloux. See doi.org/10.1083/jcb.... @chrisverollet.bsky.social

Attending #CharlestonConference @chashub.bsky.social? Visit Rockefeller University Press in Booth 16 to chat with Miguel Peralta! 💬 Learn about our journals and our Read & Publish Agreements that support #OpenAccess research. 👉 More on RUP journals rupress.org/journals

In @jcb.org, Deng, Mitchison et al. @harvardmed.bsky.social employ two human cell models to elucidate how #tubulin binding, membrane association, and protein stability converge in the biology of STMN2, a protein implicated in amyotrophic lateral sclerosis. rupress.org/jcb/article/... #Neuroscience

What do ER exit sites really look like? Using large-scale volume FIB-SEM and a custom 3D-Unet pipeline (ASEM), Nahir et al @kirchhausenlab.bsky.social reveal that ERES are vesicular, abundant & diverse, resolving long-standing morphological discrepancies. In @jcb.org: rupress.org/jcb/article/...

In @jcb.org, Schreiner, Mikeladze-Dvali et al. show that CDK-1 primes PCMD-1 for PLK-1 phosphorylation. Mutations in PLK-1 docking sites impair SPD-5 binding, destabilize the PCM, and delay #centriole separation. rupress.org/jcb/article/... #Centrosome #PCMstability #Celegans

New in @jcb.org: Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/... #Cytokinesis

In @jem.org, Cameron Bissett, Teresa Lambe et al. @ovg.ox.ac.uk demonstrate that mucosal delivery of heterologous omicron #vaccine is able to overcome deleterious prime-derived immunological imprinting via multiple mechanisms. rupress.org/jem/article/... #InfectiousDisease #SARSCoV2 #COVID19

New review @jhumimmunity.org: Nicolai van Oers and Kathleen Sullivan summarize 22q11.2 deletion syndrome, which has complex clinical presentations, with congenital malformations of the thymus leading to many immune system changes. rupress.org/jhi/article/... #InbornErrorsOfImmunity

In @jem.org, Cui et al. reveal that the impaired IRE1α-Xbp1 pathway in gut ILC2s, caused by loss of IL-25 and rise of IFN-γ, disrupts folate-dependent one-carbon #metabolism during #colitis. Supplementation with one-carbon metabolism-derived AMP alleviates #inflammation rupress.org/jem/article/...

In @jhumimmunity.org, Noyer et al. show that a novel mutation in ORAI1 results in constitutive CRAC channel activation while abolishing stimulation-induced channel opening. The mutation is associated with severe immune dysregulation, incl. altered T & NK cell function rupress.org/jhi/article/...

In @jhumimmunity.org, Ober, Lenoir, @jrosain.bsky.social et al. report the same ultra-rare pathogenic noncoding single-nucleotide variant in the promoter of WAS in four male patients from two unrelated kindreds w/ features of Wiskott-Aldrich Syndrome. rupress.org/jhi/article/...

In @jem.org, Werner, Mogensen et al. @au.dk identify genetically heterozygous and transcriptionally homozygous deficiency of IRF7 as an inborn error of interferon immunity underlying #herpesvirus CNS infection. rupress.org/jem/article/... #HumanDiseaseGenetics #Immunodeficiency #InfectiousDisease

📣 Call for Papers from @jgp.org! 📣 You are invited to submit your research on Voltage-Gated Sodium Channels. Submit your paper by September 30, 2026, to be highlighted in a special issue. Learn more 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers #WSCC26

We’re thrilled to welcome the Journal of General Physiology @jgp.org @rupress.org to our Affiliate Program! 🎉 Authors can now seamlessly transfer their #peerreviewedpreprint @reviewcommons.org @embo.org to JGP via our transfer portal. Excited to start this new chapter with JGP @rupress.org!

Insights @jem.org from Andrea Cooper: Mtb drives expression of type I IFN–mediated #neutrophil accumulation, which limits interaction btwn CD4 T cells & macrophages. Failure to limit type I IFN very early in the process allows rapid progression of disease rupress.org/jem/article/... #Tuberculosis

In @jcb.org, Xin Wang et al. identify Irg1l as a regulator of #zebrafish neuromast size. They demonstrate that the Irg1l/itaconate axis promotes supporting cell proliferation by inducing metabolic reprogramming that activates Yap signaling rupress.org/jcb/article/... #CellMetabolism #Development

Spotlight @jcb.org: Zeyad & Abu-Amer @washumedicine.bsky.social highlight work by Dufrancais @chrisverollet.bsky.social et al. (rupress.org/jcb/article/...) revealing a role of tunneling nanotubes in moesin-mediated #osteoclast fusion & regulation of #osteoclastogenesis. rupress.org/jcb/article/...

In @jcb.org, Dufrançais, Raynaud-Messina, @chrisverollet.bsky.social et al. show that moesin, a member of the ERM proteins, plays a negative regulatory role in #osteoclastogenesis. rupress.org/jcb/article/... #Physiology #Cytoskeleton #Actin

Heading to #CharlestonConference? Visit Rockefeller University Press in Booth 16 to meet Miguel Peralta. Learn about our journals and our Read & Publish Agreements that support #OpenAccess research. 👉 More on #CHSConf2025: www.charleston-hub.com/the-charlest... 👉 More on RUP rupress.org/journals

Noninfectious manifestations of CVID have not been formally summarized. In @jhumimmunity.org systematic literature review, Ducasa, March et al. provide a comprehensive summary as a reference point for the field, revealing pervasive detrimental noninfectious manifestations rupress.org/jhi/article/...

In new review @jhumimmunity.org, Andreakos et al. report the progress of the COVID Human Genetic Effort since its launch 5 years ago, with the aim to understand clinical variability, from resistance to severe outcomes, among individuals exposed to #SARSCoV2. rupress.org/jhi/article/...

@jgp.org: In two individuals w/ small fiber neuropathy carrying the p.(Tyr66Ser) variant in SCN11A, van den Braak, Dohrn et al. observed on/off-like axon hyperexcitability upon sine-wave stimulation, correlating w/ patch-clamp results of the Naᵥ1.9 channel variant rupress.org/jgp/article/...

A recent model suggests the #Parkinsons risk factor protein TMEM175 is primarily a proton-conducting channel. In @jcb.org, Riederer et al. demonstrate that TMEM175 does not mediate a lysosomal proton leak and is not responsible for preventing lysosomal over-acidification. rupress.org/jcb/article/...

In @jhumimmunity.org, Gervais, Borghesi, Casanova, and Zhang review how #autoantibodies neutralizing antiviral type I IFNs underlie a small but growing number of severe #arboviral diseases. Genetic defects of type I IFN immunity may underlie other unexplained cases. rupress.org/jhi/article/...

In @jem.org, Villavicencio Gonzalez & Zoghbi integrate established & emerging insights into the pathogenic mechanisms of polyglutamine disorders, emphasizing recent discoveries on transcriptional dysregulation, somatic expansion, protein accumulation, & cellular toxicity rupress.org/jem/article/...

Spotlight @jcb.org: Benamozig and Shoshani @weizmanninstitute.bsky.social highlight work from the Gorbsky Lab @gorbskylab.bsky.social (rupress.org/jcb/article/...), which shows how chromosomal instability can rapidly cause #aneuploidy. rupress.org/jcb/article/...

In @jcb.org, Dias Maia Henriques, Dumont, Maton et al. @ijmonod.bsky.social uncover an #anaphase A pathway, driven by the #kinesin-13 KLP-7 and opposed by the kinesin-12 KLP-18, that contributes to chromosome segregation in early #Celegans embryos. rupress.org/jcb/article/... #Mitosis #Spindle

In @jcb.org, Avilov, @plenart.bsky.social et al. @maxplanck.de used quantitative phosphoproteomics in #starfish #oocytes to identify downstream targets of the conserved Mos–MAPK pathway. rupress.org/jcb/article/... #Cytoskeleton #CellCycle #CellDivision #Physiology