The Chameau gene helps flies survive starvation at lower temps, but a mere 2{degree sign}C rise makes it obsolete! This temperature-dependent role in metabolism and resilience has big implications for climate change biology. @reviewcommons.org www.life-science-alliance.org/content/9/1/...

This study presents an in vitro analysis of centriole and cilium formation during early mouse embryonic development, using 3D models to mimic implantation, tissue patterning, and axis elongation. @chribue.bsky.social @isabellavoelkl.bsky.social www.life-science-alliance.org/content/9/1/...

The study shows that NSUN1-mediated m5C RNA methylation drives TDP-43 cytoplasmic accumulation and neurotoxicity, revealing a new pathway contributing to ALS/FTD pathogenesis. #ALS #TDP-43 www.life-science-alliance.org/content/9/1/...

Using in vitro stimulation & CRISPR/Cas9-mediated gene editing, Abir et al. found that Th1 cell identity is anchored in glycolysis by fostering STAT1 O-glycosylation, STAT1 Ser727 phosphorylation & Th1 cell effector capacity. @mielenzlab.bsky.social www.life-science-alliance.org/content/9/1/...

BCL6 limits CD8 T cell responses to tumors by inhibiting Glut3 expression. Conditional deletion of Bcl6 in activated CD8 T cells or pharmacological inhibition of BCL6 in mice represses tumor growth. www.life-science-alliance.org/content/9/1/... @scripps.edu

Our November issue is here! Two articles in this issue uncover amino acid sensing mechanisms and outcomes. Also, discover which T cell subset targets pediatric neuroblastoma, the evolutionary conservation of a meiotic protein, and much more! www.life-science-alliance.org/content/8/11

Using HDX-MS, this study demonstrates that conformational flexibility in beetle luciferases governs bioluminescence color, revealing how active site dynamics and domain-specific mutations fine-tune red- and blue-shifted light emission. www.life-science-alliance.org/content/9/1/...

This exciting study by the Buecker lab @chribue.bsky.social & first author Isabella Voelkl @isabellavoelkl.bsky.social explores in vitro differentiation models for their usability in studying cilia and centriole formation in mouse embryonic development www.life-science-alliance.org/content/9/1/...

DA-Raf efficiently associates with the plasma membrane phosphatidylserine via the RBD and CRD domains and thus predominates over Raf proteins in the binding to Ras, thereby preventing the ERK pathway. www.life-science-alliance.org/content/8/12...

I've been claimed! Life Science Alliance @lsajournal.org is now on @researchgate.bsky.social 🥳 If you peruse ResearchGate, give us a follow!

Luan & colleagues show that a lack of BCL6 expression in activated CD8 T cells or pharmacological BCL6 inhibition inhibits tumors. The findings suggest ways to improve the CD8 T cell function in cancer by changing their energy utilization @scripps.edu www.life-science-alliance.org/content/9/1/...

Check out this research article: POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels www.life-science-alliance.org/content/8/12... @kuhl-lab.bsky.social

Why do some beetle luciferases glow red while others glow green? HDX-MS reveals a simple rule: motion sets the hue. Red variants stay more flexible; green ones are more rigid. Flexibility around the active site acts like a dial that shifts the spectrum. www.life-science-alliance.org/content/9/1/...

This study shows that DA-Raf localizes to the plasma membrane, binds preferentially to phosphatidylserine and active Ras via its Ras-binding and cysteine-rich domains (RBD/CRD), and thereby inhibits Raf activation and the Ras-ERK pathway. www.life-science-alliance.org/content/8/12...

Mitochondria-generated reactive oxygen species influence centrosome replication, leading to microtubule reorganization and impacting endosomal transport. #CellBiology #Research www.life-science-alliance.org/content/9/1/...

This study investigates effects of increased POLRMT levels and reports stimulation of mtDNA transcription initiation and enhanced exercise capacity without an effect on steady-state mRNA levels. www.life-science-alliance.org/content/8/12... @kuhl-lab.bsky.social

This review outlines the scientific utility and ethical imperatives of human brain slice cultures, calling for global ethical standards in ex vivo neuroscience research www.life-science-alliance.org/content/8/12...

Have you already seen this research article, recently published in LSA: PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...

Exploring the pros and cons of AHR activation during gut infections: AHR can both aid in fighting off pathogens and potentially worsen inflammation. #GutHealth #AHRImpact www.life-science-alliance.org/content/8/12...

Check out this recently published paper in LSA: A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling @reviewcommons.org www.life-science-alliance.org/content/8/12...

This study shows that reactive oxygen species produced by mitochondria alter centrosome duplication, causing microtubule rearrangements that alter endosomal trafficking. www.life-science-alliance.org/content/9/1/...

KANSL3 is an epigenetic regulator of hepatocyte metabolism and differentiation, essential for liver development and key to maintaining liver health. @mwiese.bsky.social www.life-science-alliance.org/content/8/12...

New in #neuroscience: Human brain slice cultures (HBSCs) are revolutionizing disease modeling, drug testing & neuroethics. Our latest work explores their translational promise-and the need for global ethical standards www.life-science-alliance.org/content/8/12...

This study identifies PARP10 as a key regulator of stress granule assembly by ADP-ribosylating G3BP1 and modulating eIF2α phosphorylation and translation factor recruitment @leunglab.bsky.social www.life-science-alliance.org/content/8/12...

ADAMTS10 and ADAMTS17 regulate bone growth and extracellular matrix formation by promoting secretion and deposition of fibronectin, fibrillin-1, and collagen type VI www.life-science-alliance.org/content/8/12...

AHR activation can positively or negatively affect immune responses. Here we investigate whether TCDD toxicity is due to prolonged duration of AHR activation and show that duration of stimulation is not responsible on its own. www.life-science-alliance.org/content/8/12...

This study focuses on schizophrenia-related genes in a genetically tractable system and identifies the requirement of both glial and neuronal MMPs during developmental remodeling. @reviewcommons.org www.life-science-alliance.org/content/8/12...

A variant of Lnk/SH2B3 adaptor has been reported as a risk for several autoimmune diseases, including type 1 diabetes. www.life-science-alliance.org/content/8/12...

Flavonoids, plant compounds with antioxidant properties, regulate the internal biological clock in Arabidopsis plants by modulating cellular levels of reactive oxygen species. @winkellab.bsky.social www.life-science-alliance.org/content/8/12...

KANSL3 controls hepatocyte differentiation and metabolism via histone acetylation. Loss of this epigenetic regulator leads to hyperplasia and liver fibrosis. #Epigenetics #Metabolism #Hepatology #NSLComplex @mwiese.bsky.social www.life-science-alliance.org/content/8/12...

This study examines how the combined deletion of ADAMTS10 and ADAMTS17 proteases affects bone growth and skin development, suggesting roles in ECM regulation and postnatal survival. www.life-science-alliance.org/content/8/12...

The authors found that Lnk prevents the abnormal activation of DCs by GM-CSF, followed by autocrine IL-27/IL-27R loops, and protects individuals from developing autoimmune diabetes. www.life-science-alliance.org/content/8/12...

Explore how RNA-sequencing data can reveal splicing events' role in predicting nonsense-mediated mRNA decay during sepsis. This could offer new diagnostic and therapeutic insights. www.life-science-alliance.org/content/8/12...

Take a look at this recently published paper in LSA: Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas @cincychildrenscbdi.bsky.social @cincyresearch.bsky.social www.life-science-alliance.org/content/8/12...

Here comes our October issue, including: -Manchette architecture revealed by cryo-EM -Cell-free epigenome profiling in asymptomatic COVID-19 patients -How to fine-tune RING E3 ubiquitin ligase activity -HINT1 serves as a sensor of cell density, and more! www.life-science-alliance.org/content/8/10

New research shows that flavonoids aid in timekeeping in plants by controlling oxidative stress. This adds to our understanding of the plant clock, with potential for improving agriculture. @winkellab.bsky.social www.life-science-alliance.org/content/8/12...

Have you already seen this research article at LSA: Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions www.life-science-alliance.org/content/8/12...

A computational analysis of alternative splicing and nonsense-mediated decay using critically ill patients' RNA-sequencing data can elucidate sepsis transcriptomics and potentially associated protein targets. www.life-science-alliance.org/content/8/12...

SHP2 inhibition may be a general strategy to target benign tumors in which T cells and myeloid cells are pro-tumorigenic. @cincychildrenscbdi.bsky.social @cincyresearch.bsky.social www.life-science-alliance.org/content/8/12...

The authors found that insertions and deletions occur more frequently in longer internal exons and mostly encode structure-less regions, and that half of them are attributable to alterations in tandem repeats. www.life-science-alliance.org/content/8/12...

Have you already read this Research Article recently published in LSA? CTPS2 regulates CTP synthetase activity by interacting with CTPS1 @institutimagine.bsky.social www.life-science-alliance.org/content/8/11...

Artificial intelligence can unlock new gene functions, but prediction models are limited by current knowledge. Integrating mass fingerprinting with machine learning improves these predictions. www.life-science-alliance.org/content/8/11...

This study shows that overexpression of the acetyltransferases ATase1 and ATase2 in the mouse alters the quality of the secretory pathway, causing a progeria-like phenotype. @waismancenter.bsky.social www.life-science-alliance.org/content/8/12...

Human CTP synthetase 1 and 2 form complexes, co-localizing in filament-cytoophidia structures. Their interaction modifies enzymatic activity independently of cytoophidia, revealing a new regulation mechanism. @institutimagine.bsky.social www.life-science-alliance.org/content/8/11...

Human skeletal muscles play a more direct role in the pathogenesis of enterovirus D68 through productive infection, which leads to structural destruction, functional loss, and hampered regeneration. @bmlaksono.bsky.social @debbyvanriel.bsky.social www.life-science-alliance.org/content/8/11...

ES cells implement specialized survival strategies in response to different AA limitations, highlighting their ability to reprogram cellular biochemistry under nutrient stress. www.life-science-alliance.org/content/8/11...

Artificial intelligence offers a solution to unlock the potential of new gene functions. However, prediction models are limited by available knowledge. By combining mass fingerprinting with machine learning, prediction can be improved. www.life-science-alliance.org/content/8/11...

@Waismancenter.bsky.social In a new study, the Puglielli laboratory at UW-Madison shows that overexpression of the acetyltransferases ATase1 and ATase2 in the mouse alters the quality of the secretory pathway, causing a progeria-like phenotype. www.life-science-alliance.org/content/8/12...

This study reveals that TIL products expanded from pediatric neuroblastoma tumors exhibit anti-cancer capabilities, with γδ T cells as the primary active agents. #CancerResearch #Immunotherapy www.life-science-alliance.org/content/8/11...

Have you seen this recently published paper in LSA? Amino acid-dependent TSC2 dephosphorylation by lysosome-PP2A regulates mTORC1 signaling transduction www.life-science-alliance.org/content/8/11...