🧪 We are kicking off this week’s MAGIC meeting! First up is @guillaumeandrieu.bsky.social from @inem-necker.bsky.social (Normal & Pathological Lymphoid Differentiation Lab). He is presenting "Leukemia on ChIP: application," diving into new methodologies for understanding leukemia. 🔬 🧵👇

🧪 We are kicking off this week’s MAGIC meeting! First up is @guillaumeandrieu.bsky.social from @inem-necker.bsky.social (Normal & Pathological Lymphoid Differentiation Lab). He is presenting "Leukemia on ChIP: application," diving into new methodologies for understanding leukemia. 🔬 🧵👇

It was great to visit the @institutimagine.bsky.social yesterday for a seminar on our work on cell-autonomous immunity in the #CNS 🧠🦠🧬 and interesting exchanges with many PIs & friends 😊 Today I got to visit & talk @institutpasteur.bsky.social (too busy for a pic!) 🥰 Fantastic 2 days! Thank you 🙏🏻

🚨Happy to share that our research on splice modulation therapy for X-linked Alport syndrome using organoid models has just been published! I am grateful to all co-authors! @institutimagine.bsky.social @insight.jci.org @gdorval.bsky.social @hkd-l.bsky.social insight.jci.org/articles/vie...

Happening now at Institut Imagine! 🏛️✨ Prof. Anna Kajaste-Rudnitski (Univ. of Pavia) is on stage dissecting the "double-edged sword" of innate immunity. ⚔️🧬 She is explaining how the same mechanisms that protect us from viruses can block gene therapies and drive CNS inflammation.

Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease. New study by Qinhua Zhou (Fudan University), Jacinta Bustamante @institutimagine.bsky.social, Jonathan Bohlen @jonathanbohlen.bsky.social @lmumuenchen.bsky.social & colleagues rupress.org/jhi/article/...

A study from @casanovalab.bsky.social shows that autoantibodies in a small subset of the population can allow weakened vaccine viruses to escape control, explaining some adverse events tied to one kind of Chikungunya vaccine, which is no longer available in the U.S.

Jensen, @casanovalab.bsky.social, Mogensen @au.dk and colleagues study type I interferon neutralizing autoAbs in people with #HIV, and find that the prevalence does not significantly differ from that in the general population. rupress.org/jhi/article/... @esidsociety.bsky.social

📢 Kicking off today’s MAGIC meeting: Jean-François Gautier (Lariboisière) is discussing the shift in how we view Type 2 Diabetes, not just as a metabolic disorder, but as a chronic inflammatory disease. 🧬

🧬 Advancing Research in Paris with the Region's First AVITI24™ (Element Biosciences) ! We are thrilled to announce that Institut Imagine has officially acquired the first AVITI24 system in Paris.

Live at our weekly seminar: Prof. Chantal Pichon (Univ. Orléans) on the design of imidazolium lipid-based LNPs for mRNA delivery. 🧬 These LNPs use pH-responsive headgroups to improve cytosolic release for cancer vaccines & immune cell engineering. The future of nanomedicine! 🧪🎯 #mRNA #LNP

X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. In @jhumimmunity.org, Zhou et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...

X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Zhou, Bustamante, Bohlen et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...

1/ We are excited to share our new report in PNAS: all three cases of encephalitis triggered by the live-attenuated chikungunya (CHIKV) vaccine (IXCHIQ®) are due to pre-existing autoantibodies neutralizing type I IFN (AAN-I-IFN) (doi.org/10.1073/pnas...).

🔬 Que se passe-t-il vraiment derrière une découverte scientifique ? Le vendredi 6 mars 2026, l’Institut Imagine vous invite à participer à une rencontre d'une demi-journée sur le thème : « Qu’est-ce que la Recherche à l’Institut Imagine ? » 📌 Inscriptions : yji1wvqwixz.typeform.com/to/spGbo2dC

Yet another reason to screen people over 65 years of age for type I IFN autoantibodies: Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis | PNAS www.pnas.org/doi/10.1073/...

We are live for our weekly scientific meeting! 🧪 First up, Pierre Isnard from @inem-necker.bsky.social is presenting on HNF1B. He is discussing how this factor integrates signals that drive failed repair and the progression of kidney disease. Critical insights into renal pathophysiology. 🩺

[email protected] announces Drs Stephen Ward (Cell and Gene Therapy Catapult) & Annarita Miccio @institutimagine.bsky.social as keynote speakers for #ELRIGCGT2026 📆 9–10 Mar📍 #Cambridge UK #pressrelease 🗞️ elrig.org/elrig-announ... Free registration 👉 elrig.org/portfolio/ce... #ELRIG #messengersinscience

En 2026, continuons à faire avancer une recherche qui change des vies. En ce début d’année, je vous adresse mes vœux les plus sincères. Merci à toutes celles et ceux qui nous soutiennent et nous font confiance. Voir la vidéo : youtu.be/dVpBP92F2FI

[SEMINAR] 📢 Paris Postdoc Seminar at INEM on Thursday January 22 Maria Lizarralde-Iragorri from @institutimagine.bsky.social will present the @parispostdocs.bsky.social seminar "Investigating Hematopoiesis and Erythropoiesis in Sickle Cell Disease" More info ➡️ tinyurl.com/ykjnp873

Monogenic disorders of immunity: Common variants are not so rare: Cell Genomics www.cell.com/cell-genomic...

📢 We are live for our weekly scientific meeting! First up is Fabian Zanchetta (O. Hermine Lab) tackling "Unexplained Erythrocytosis." 🩸 Using the Dr. Warehouse clinical database, they are identifying new genetic drivers for patients with high red blood cell counts. 📉🔍

📣 this is tomorrow - seminar @devstempasteur.bsky.social 🗓️ 2025 Tuesday Jan. 13th 🕣11am 📍Amphi Ullmann Agnese Loda, Ph.D. Institut Imagine, Paris, France Understanding the sex-specific regulation and function of X-linked gene dosage Invited by Romain Levayer

Pour la Pr Bana Jabri, investir dans la science est un choix essentiel pour notre santé et notre économie. 📖 Retrouvez l'entretien complet dans Le Figaro : sante.lefigaro.fr/medecine/pr-...

Can bacteria teach us about human immunity? 🦠➡️🐘 Today at Institut Imagine, Dr. Aude Bernheim from @institutpasteur.bsky.social discusses how ancient antiphage systems in bacteria can be ancestors to eukaryotic immune pathways. A fascinating look at the evolutionary conservation of defense!

🫁 New study by Hermine Lab at Institut Imagine finds Acute Chest Syndrome is driven by local lung complement activation. Analyzing "golden sputum" paves the way for new anti-complement trials in #SickleCell. 🩸 Read more: onlinelibrary.wiley.com/doi/10.1002/...

Fier de voir nos recherches en thérapie génique dans le Top 10 des percées 2026 de L'Express ! 🚀 Un immense bravo à la Pr Marina Cavazzana et nos équipes. Notre objectif : passer à la vitesse supérieure pour les familles touchées par des maladies rares. À lire ici : www.lexpress.fr/sciences-san...

🔥🎉 🧠 SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. 🧵1/8 Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome. www.biorxiv.org/content/10.1...

We are live from our weekly MAGIC meeting! 🧬 First up, Annarita Miccio sets the stage! 🩸 She is introducing the session and discussing editing approaches for hemoglobinopathies. Her team’s work on Sickle Cell Disease is paving the way for next-gen therapies for blood. #sicklecelldisease

Paris just got its first AVITI24™ 🇫🇷✨ Institut Imagine is now home to the first AVITI24 in Paris and the Île-de-France region, using it for both sequencing and cytoprofiling. Thanks to the amazing team for a great training and warm welcome! #AVITI24 #Multiomics #Cytoprofiling

Does a neuron’s "address" define its function? 🧠 Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure ≠ function! For more information: www.linkedin.com/posts/instit...

Kicking off 2026 with our first Monday Seminar! 🧬 How do we find proteins "missing" in human tissue? 🔍 Dr. Leon Peshkin (Harvard Medical School) is live, discussing a how to build a "periodic table" of cell types using Xenopus to map elusive proteins across development & their clinical potential. 🐸🏥

Happy new year and 3 more days to apply for Computational biology post doc position in my lab #Paris #transpoosns @inem-necker.bsky.social @institutimagine.bsky.social

🗓️ Jusqu’au 31 décembre, vous avez le pouvoir changer des vies. En France, 64 enfants par jour naissent avec une maladie génétique rare. Faites un don pour soutenir la recherche sur les maladies génétiques 👉 vaincre-les-maladies-genetiques.institutimagine.org

"L’Europe brillait quand elle osait penser autrement" : l'appel au courage de Bana Jabri ➡️ https://l.lexpress.fr/9YJ

Annual Antibody Club Workshop | 📍 Institut Imagine, Paris 🇫🇷 🗓 Feb 17, 2026 One-day meeting on advances in antibody research (functions, screening technologies, AI). Revival of the Antibody Club! Abstract submission link coming soon. Deadlines: abstracts Jan 20, registration Jan 30. Save the date!

#hiring #postdoc #bioinformatics We’re opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur. The big theme: 👉 How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? 👇⬇️🧵

🎁 [La 7e Journée #Recherche & #Innovation se dévoile] 🔬 📍@adameykolab.bsky.social du @ki.se et de @univie.ac.at nous fera l'honneur de présenter ses travaux autour de la crête neurale et de ses dérivés. 📆 17 mars 📌 @institutimagine.bsky.social ℹ️ bit.ly/48152nM #maladiesrares

📢 We are live for this week’s MAGIC scientific meeting! Today we are addressing Sex and Gender Bias in biomedical research. 🧬 First up is Pauline Chaste from Institut Imagine regarding ASD. "Leveraging Clinical Narratives together with Genomics to overcome gender bias in ASD risk prediction."

Autoantibodies neutralizing type I IFNs in a fatal case of #H5N1 avian #influenza. New study from Qian Zhang, Jean-Laurent Casanova @casanovalab.bsky.social @rockefeller.edu and colleagues: rupress.org/jem/article/... #InfectiousDisease #HostDefense #SARSCoV2

Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis. New study from Adrian Gervais, Aurélie Cobat, Jean-Laurent Casanova (@casanovalab.bsky.social), Emmanuelle Jouanguy @hopitalnecker.bsky.social and colleagues: rupress.org/jem/article/... #Autoimmunity

Drépanocytose : à la découverte d’une maladie génétique pas si rare, mais encore négligée

« Le droit à la science n'est jamais acquis : il doit être défendu. » Yasmine Belkaid (Institut Pasteur), Alain Puisieux (@institutcurie.bsky.social) et Bana Jabri (@institutimagine.bsky.social) appellent à une conférence internationale sur le droit à la science. Lire la tribune ➡️

1/ We are excited to share our new report in @jem.org showing that almost 40% cases of herpesvirus (HSV)-triggered fulminant viral hepatitis (FVH) are due to pre-existing autoantibodies neutralizing type I IFN (autoAbs-IFN) (doi.org/10.1084/jem....).

1/ A year ago, a 71-year-old Louisiana man died from H5N1, marking the first avian flu death in the US. Now we report in @jem.org that the cause of his death is rogue autoantibodies neutralizing type I IFN (AutoAb-IFN). doi.org/10.1084/jem....

If you are interested in aging and stem cells, check out our newly published work in Cell Stem Cell, in collaboration with Mickaël Ménager and his team at Institut Imagine (Paris, France), on a lysosome-based strategy that reverses aging in blood-forming stem cells.

🚀 Starting now! We're kicking off our weekly MAGIC scientific meeting with a packed agenda on stress and consequences. First up, Julien Fouchet from @inem-necker.bsky.social takes the stage to discuss the regulation of Unfolded Protein Response (UPR). #Science #ScienceSky #InstitutImagine

Human inborn errors of the alternative NF-κB pathway. New review from Tom Le Voyer, Jean-Laurent Casanova @casanovalab.bsky.social, and Anne Puel @anne-puel.bsky.social: rupress.org/jhi/article/... #InbornErrorsOfImmunity

🚀 L'événement Future4care x Institut Imagine x AFM-Téléthon : un franc succès ! Cette matinée a permis de mettre en lumière : - la dynamique croissante autour de l’IA dans le champ des maladies rares, - les collaborations structurantes - l’importance des données

👁️ Le CNRS, Variant, l’Institut Imagine et Retina France déposent conjointement un brevet pour un traitement de maladies rétiniennes génétiques 🤝 Plus de détails sur cette collaboration ▶ variant.paris/2025/12/01/v...