Le secret pour vaincre le cancer se cache peut-être chez ces fumeurs, buveurs et autres resquilleurs, une vie passée à coucher avec le mal sans jamais se faire prendre.Quest-ce qui les protègent ? Projet immensément prometteur @institutimagine.bsky.social @lexpress.fr www.lexpress.fr/sciences-san...

David, Frémond @institutimagine.bsky.social et al. identify a heterozygous P2RY8 E323G substitution in a father and son with cutaneous #lupus and enhanced type I #interferon signaling supports a role for P2RY8 in lupus causation rupress.org/jhi/article/...

How do “super-avoiders” manage to stay cancer-free? Set up to investigate this is Paul Bastard and team ATLAS – one of five newly funded teams awarded $25m (£20m) through Cancer Grand Challenges. Watch the takeover episode (on YouTube): youtu.be/hAjvmBReo-8

🏆 Le Pr Polak a reçu le prix Gilberte et Jacques Tacussel, récompensant le travail clinique et de recherche à long terme mené par toute son équipe sur le diabète du très jeune enfant, menant à découvrir les propriétés neuro-protectrices de molécules insulino-sécrétrices.

Institut Imagine is proud to lead a clinical research project named “EU-IFNp”, coordinated by Professor Marie-Louise Frémond. This is a multicentric European study dedicated to children and adults with genetic type I interferonopathies (IFNp-I) : www.institutimagine.org/en/eu-ifnp-e...

🔴 Happening NOW at Institut Imagine! Dr. Mira Kassouf (WIMM, @ox.ac.uk) is presenting our Monday Seminar: "The role of facilitators in super-enhancers and gene regulation." 🧬 She is presenting her fascinating research on the intricacies of gene control! #Genetics #InstitutImagine

Le Colloque « Génétique et Société » a réuni hier à l’Institut Imagine scientifiques, médecins, philosophes et représentants de la société civile, en partenariat avec le CCNE et l’Agence de la Biomédecine.

🔴 C'est parti pour le colloque "Génétique et Société" (42e Séminaire P. Royer) ! Ouverture de cette riche journée par le Pr Bana Jabri (Inst. Imagine) et le Dr Marine Jeantet (Agence de la Biomédecine). Suivez notre live ! 🧬

👏 Congratulations to Maria Alejandra Lizarralde-Iragorri on being awarded the highly prestigious Marie Skłodowska-Curie Postdoctoral Fellowship! Maria will be carrying out her research in Hermine Laboratory, under the co-supervision of Sara El Hoss and Thiago Trovati Maciel.

The STING HAQ haplotype and clinical non-penetrance in COPA syndrome. New report from Clémence David, Marie-Louise Frémond @mlfremond.bsky.social @institutimagine.bsky.social @upcite.bsky.social and colleagues: rupress.org/jem/article/... #HumanDiseaseGenetics #InnateImmunity #inflammation

Cerebral amebiasis due to #Acanthomoeba sp. in a patient with complete gp91phox deficiency. New report from Marie Roelens, Jacinta Bustamante and colleagues @hopitalnecker.bsky.social @institutimagine.bsky.social: rupress.org/jhi/article/... @esidsociety.bsky.social

I am very happy to share that I've started my new position @upcite.bsky.social and opened my lab @institutimagine.bsky.social 🎉 In the lab we will study how differences in X-linked gene dosage between the sexes affect fetal growth and survival and contribute to sex differences later in life 👩‍🔬🧪🧬🧫

🎙️ Live from Institut Imagine's Monday Seminar! Dr. Edor Kabashi is currently presenting "From Charcot to ALS: Defining therapeutic avenues." Fascinating deep dive into the next steps for ALS treatments. 🧬✨ #InstitutImagine #ALSResearch #Charcot

1/ Which human infectious disease is best understood in 2026? West Nile virus encephalitis, with 40% of cases attributed causally and mechanistically to auto-Abs neutralizing type I IFNs. doi.org/10.70962/jhi...

STING haplotype alone does not fully account for disease expression in COPA syndrome @jem.org rupress.org/jem/article-... @institutimagine.bsky.social

What makes brain development unique across different species? We’re diving into that exact question at our weekly Monday Seminar! Prof. Denis Jabaudon (University of Geneva & Institut Imagine) is presenting his work: "Developmental gene expression driving species-specific cortical development." 🧠

👩🏻‍🔬 À l’occasion de la Journée internationale des droits des femmes, l’Institut Imagine donne la parole à celles qui font avancer la recherche. Voir la vidéo : www.youtube.com/watch?v=2v_W...

DREPAMIR est lancé ! Cet essai de thérapie génique pour la #drépanocytose, la plus fréquente des maladies du sang en France, est porté en collaboration par @institutimagine.bsky.social, @ap-hp.bsky.social et @afm-telethon.bsky.social#drépanocytose, ℹ️ 7M de personnes sont atteintes dans le monde 👉 afm-telethon.fr

L'équipe internationale ATLAS, coordonnée par le Dr Paul Bastard de l'Institut Imagine, vient de décrocher un financement exceptionnel : jusqu'à 25 millions de dollars sur près de 5 ans, attribué par le prestigieux programme Cancer Grand Challenges !

We're proud to announce that infectious disease pioneer Jean-Laurent Casanova, MD, PhD, of @rockefeller.edu, @institutimagine.bsky.social, @hhmi-science.bsky.social, & @casanovalab.bsky.social, is the recipient of the 2026 Mechthild Esser #NemmersPrize in Medical Science: spr.ly/6008hCUaM

Congratulations to Jean-Laurent Casanova, MD, PhD (@casanovalab.bsky.social) of @Rockefeller.edu & Institut Imagine, recipient of the 2026 Mechthild Esser #NemmersPrize in Medical Science at Northwestern! A well-deserved recognition and an incredible honor recognizing his outstanding research. 🧬🔬

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

📰 News announcement! www.cancergrandchallenges.org/new-teams-an... We’re thrilled to welcome five world-leading scientific teams, each awarded up to £20 million, to take on some of the toughest unanswered questions in #CancerResearch. Find out more about the teams and their challenges.

L’Institut Imagine est signataire de l’Appel de Paris-Saclay, un collectif de plus de 25 acteurs d’excellence — universités, organismes de recherche et entreprises — réunis pour placer la science au cœur de la souveraineté européenne.

À l'occasion de la Journée internationale des maladies rares, l'Institut Imagine a organisé la projection du film « Qui brille au combat » de la réalisatrice Joséphine Japy — qui porte un regard sensible et puissant sur l'intimité d'une famille confrontée à la maladie.

📣 Call for young rare disease advocates! ERDERA is inviting young patients aged 12–21 to join the in‑person training in Paris on 23–25 April 2026. 🔗 Find out more and apply: https://loom.ly/yaURaLI ⏳ Application deadline: 8 March 2026 #ERDERA #RareDisease

Happening now! 🔬 Dr. Mickaël MENAGER (Institut Imagine, INSERM) is taking the stage to share insights from a decade of research. Topic: "Lessons learned from almost 10 years of single-cell RNA-seq analyses in patients with autoimmune and autoinflammatory diseases." 🧪

↪️ Retour sur la web émission #MaladiesRares de Pharmaceutiques Les intervenants ont analysé comment des pathologies touchant un très faible nombre de patients sont devenues un puissant moteur d’ #innovation pour l’ensemble du système de santé. Pour en savoir plus : respifil.fr/actus/actual...

In this organoid model, no collagen IV trimer assembly is detected in the tubular or glomerular basement membranes—ASO treatment restored the defect. @institutimagine.bsky.social @upcite.bsky.social

Alport syndrome is a frequent cause of hereditary glomerulonephritis, and some pathogenic variants affect splicing. Here, Hassan Saei @hassansaei.bsky.social & team establish a kidney organoid platform of AS & correct gene splicing using ASO therapy: doi.org/10.1172/jci....

Success! 🧪✨ BridgeBio confirms positive Ph3 results for infigratinib: the 1st oral therapy to improve growth in achondroplasia. From Laurence Legeai-Mallet’s 2016 lab work to real impact today. 🧬 For more info: www.linkedin.com/posts/instit...

🧪 We are kicking off this week’s MAGIC meeting! First up is @guillaumeandrieu.bsky.social from @inem-necker.bsky.social (Normal & Pathological Lymphoid Differentiation Lab). He is presenting "Leukemia on ChIP: application," diving into new methodologies for understanding leukemia. 🔬 🧵👇

It was great to visit the @institutimagine.bsky.social yesterday for a seminar on our work on cell-autonomous immunity in the #CNS 🧠🦠🧬 and interesting exchanges with many PIs & friends 😊 Today I got to visit & talk @institutpasteur.bsky.social (too busy for a pic!) 🥰 Fantastic 2 days! Thank you 🙏🏻

🚨Happy to share that our research on splice modulation therapy for X-linked Alport syndrome using organoid models has just been published! I am grateful to all co-authors! @institutimagine.bsky.social @insight.jci.org @gdorval.bsky.social @hkd-l.bsky.social insight.jci.org/articles/vie...

Happening now at Institut Imagine! 🏛️✨ Prof. Anna Kajaste-Rudnitski (Univ. of Pavia) is on stage dissecting the "double-edged sword" of innate immunity. ⚔️🧬 She is explaining how the same mechanisms that protect us from viruses can block gene therapies and drive CNS inflammation.

Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease. New study by Qinhua Zhou (Fudan University), Jacinta Bustamante @institutimagine.bsky.social, Jonathan Bohlen @jonathanbohlen.bsky.social @lmumuenchen.bsky.social & colleagues rupress.org/jhi/article/...

A study from @casanovalab.bsky.social shows that autoantibodies in a small subset of the population can allow weakened vaccine viruses to escape control, explaining some adverse events tied to one kind of Chikungunya vaccine, which is no longer available in the U.S.

Jensen, @casanovalab.bsky.social, Mogensen @au.dk and colleagues study type I interferon neutralizing autoAbs in people with #HIV, and find that the prevalence does not significantly differ from that in the general population. rupress.org/jhi/article/... @esidsociety.bsky.social

📢 Kicking off today’s MAGIC meeting: Jean-François Gautier (Lariboisière) is discussing the shift in how we view Type 2 Diabetes, not just as a metabolic disorder, but as a chronic inflammatory disease. 🧬

🧬 Advancing Research in Paris with the Region's First AVITI24™ (Element Biosciences) ! We are thrilled to announce that Institut Imagine has officially acquired the first AVITI24 system in Paris.

Live at our weekly seminar: Prof. Chantal Pichon (Univ. Orléans) on the design of imidazolium lipid-based LNPs for mRNA delivery. 🧬 These LNPs use pH-responsive headgroups to improve cytosolic release for cancer vaccines & immune cell engineering. The future of nanomedicine! 🧪🎯 #mRNA #LNP

X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. In @jhumimmunity.org, Zhou et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...

X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Zhou, Bustamante, Bohlen et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...

1/ We are excited to share our new report in PNAS: all three cases of encephalitis triggered by the live-attenuated chikungunya (CHIKV) vaccine (IXCHIQ®) are due to pre-existing autoantibodies neutralizing type I IFN (AAN-I-IFN) (doi.org/10.1073/pnas...).

🔬 Que se passe-t-il vraiment derrière une découverte scientifique ? Le vendredi 6 mars 2026, l’Institut Imagine vous invite à participer à une rencontre d'une demi-journée sur le thème : « Qu’est-ce que la Recherche à l’Institut Imagine ? » 📌 Inscriptions : yji1wvqwixz.typeform.com/to/spGbo2dC

Yet another reason to screen people over 65 years of age for type I IFN autoantibodies: Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis | PNAS www.pnas.org/doi/10.1073/...

We are live for our weekly scientific meeting! 🧪 First up, Pierre Isnard from @inem-necker.bsky.social is presenting on HNF1B. He is discussing how this factor integrates signals that drive failed repair and the progression of kidney disease. Critical insights into renal pathophysiology. 🩺

[email protected] announces Drs Stephen Ward (Cell and Gene Therapy Catapult) & Annarita Miccio @institutimagine.bsky.social as keynote speakers for #ELRIGCGT2026 📆 9–10 Mar📍 #Cambridge UK #pressrelease 🗞️ elrig.org/elrig-announ... Free registration 👉 elrig.org/portfolio/ce... #ELRIG #messengersinscience

En 2026, continuons à faire avancer une recherche qui change des vies. En ce début d’année, je vous adresse mes vœux les plus sincères. Merci à toutes celles et ceux qui nous soutiennent et nous font confiance. Voir la vidéo : youtu.be/dVpBP92F2FI