🏅 Notre directrice générale, la Pr Bana Jabri, figure dans le palmarès 2026 du TIME France Health, parmi « Les 20 personnalités françaises qui font la santé » !

Congratulations to LS1 grantees @hecklab.bsky.social and Annarita Miccio at @institutimagine.bsky.social , for being awarded ERC POC grants! :)

We're live from the Future of Genetic Medicine Symposium today at Institut Imagine! 🧬 We are incredibly delighted to partner with @genethonfr.bsky.social & the Broad Institute's Center of Genetic Surgery for this event.

🔬 Kicking off our weekly MAGIC meeting! Our own Alice Lepelley is on stage sharing novel insights into type I IFN neuroinflammation driven by PTPN1 mutations in humans. 🧠🧬 #Neuroinflammation #Genetics #Interferon

🧬 Happening now: Prof. Yenan Bryceson (Karolinska Institutet) is presenting today's Monday Seminar at Imagine. He's discussing the "Regulation of flexibility in T cell signaling," exploring the biology of cytotoxic T cells to better understand primary immunodeficiencies & develop cancer therapies.

Studying cancer avoidance isn’t straightforward. It means finding individuals who don’t develop cancer, and analysing them at scale. That level of research needs global collaboration, and Cancer Grand Challenges makes it possible. Read about this work ➡️ www.technologynetworks.com/cancer-resea...

Live from Institut Imagine for the MAGIC seminar! 🧬 Today, we're exploring major advances in therapeutic antibodies and immunology with 4 experts. Follow this thread for key takeaways from the presentations. ⬇️

STAT2 R148 variant: A 16th-century founder mutation and clinical response to high-dose JAK inhibitor therapy. New study from Nima Parvaneh (Tehran University of Medical Sciences), Jacinta Bustamante @institutimagine.bsky.social and colleagues: rupress.org/jhi/article/... #Autoinflammation #IEIs

Wrapping up Monday with some fantastic science! 👏 Earlier today, we had the pleasure of hosting Dr. Enzo Poirier (Institut Curie) for our #MondaySeminar. Huge thanks to him for sharing his work on engineering immunotherapies by harnessing the conservation of immunity. 🧬

🧠 What makes the human brain uniquely... human? That's the question at the heart of a study just published in @nature.com by Denis Jabaudon, Esther Klingler, and their teams. 📄 Javed, Gómez et al., Nature (2026) — DOI: lnkd.in/eF_mH72U

🔴 LIVE: Our weekly MAGIC seminar is starting! First up: Kesia Dethelot Delag on bridging the gap between clinical sites. She is discussing uncertainty quantification & federated learning strategies to improve patient stratification and rare disease diagnosis while keeping data secure. 🧬📊

Why are some people immune to cancer? Learn more about team ATLAS, led by Paul Bastard, @institutimagine.bsky.social👉 www.youtube.com/watch?v=dFJA... ATLAS is funded by @cancerresearchuk.org and Torrey Coast Foundation through Cancer Grand Challenges.

Happening now at Institut Imagine! 🔬 Prof. Luis Barreiro (UChicago) is taking the stage for today's Monday Seminar to discuss why individuals and populations differ in their susceptibility to infections and immune-related diseases. 🦠🧬

Ribosomal RNA processing impairments in a B cell immunodeficient patient with WDR75 variants. New study from Nidia Moreno-Corona, Sven Kracker @institutimagine.bsky.social and colleagues: rupress.org/jhi/article/... #RareDisease #ClinicalPhenotypes #InbornErrorsOfImmunity

1/ We are thrilled to share our collaborative study of B cells producing auto-Abs neutralizing type I IFNs in @cellpress.bsky.social (www.cell.com/cell/abstrac... ).

C’est avec une profonde tristesse que l’Institut Imagine annonce le décès du Professeur Claude Griscelli, son président fondateur, pédiatre, immunologiste et pionnier de la recherche sur les maladies génétiques. www.linkedin.com/feed/update/...

Nidia Moreno-Corona, Sven Kracker et al. describe WDR75 variants in a patient with B cell immunodeficiency and #autism. Their findings suggest that altered #ribosome biogenesis may contribute to this rare presentation. rupress.org/jhi/article/... #RareDisease @institutimagine.bsky.social

🔬 What if we could spot preeclampsia before symptoms appear? Research by @manusingh.bsky.social in Genome Biology shows ancient viral remnants in our DNA act as "molecular switches" for placental development—leaving traces in maternal blood when they malfunction. 🎥 www.linkedin.com/feed/update/...

Pourquoi certains ne développent jamais de cancer ? Sur @rfi.fr, le Dr Bastard présente ATLAS, un projet financé à hauteur de 25 M$ par @cancergrand.bsky.social pour identifier nos anticorps protecteurs. 🎧 : www.rfi.fr/fr/vid%C3%A9...

Si vous êtes sur Paris, passez voir le stand de l’institut @institutimagine.bsky.social place de la Concorde dans le cadre de l’exposition «vivre ensemble» de la fondation GoodPlanet! J’y suis et demain après-midi pour vous expliquer nos projets au @hkd-l.bsky.social #cilia #ciliopathies

We are thrilled to host Dr. Isidro Cortés-Ciriano (@ebi.embl.org/ @sangerinstitute.bsky.social) for our weekly Monday Seminar. He's sharing important insights on multimodal cfDNA profiling and novel single-molecule sequencing approaches for minimally invasive liquid biopsies in paediatric tumours. 🧬

Happening now at @institutimagine! 🔬 Prof. Elisa Oricchio (Swiss Institute for Experimental Cancer Research) is taking the stage for our Monday Seminar. She's diving into how integrating linear & 3D genomic analyses helps us understand tumor evolution & design new therapies. 🧬 #Cancer #Genomics

🧬 We are LIVE at the weekly MAGIC seminar at Imagine! Kicking us off is @joshwaterfall.bsky.social (@institutcurie.bsky.social ) presenting "Improved Out of Distribution Embeddings with AutoEncoders." Fascinating insights into computational biology! 🧵

Familial lupus associated with a P2RY8 variant: navigating the boundary between monogenic disease and genetic susceptibility to #lupus. New report from Clémence David, Marie-Louise Frémond @institutimagine.bsky.social and colleagues: rupress.org/jhi/article/... @esidsociety.bsky.social

Le secret pour vaincre le cancer se cache peut-être chez ces fumeurs, buveurs et autres resquilleurs, une vie passée à coucher avec le mal sans jamais se faire prendre.Quest-ce qui les protègent ? Projet immensément prometteur @institutimagine.bsky.social @lexpress.fr www.lexpress.fr/sciences-san...

David, Frémond @institutimagine.bsky.social et al. identify a heterozygous P2RY8 E323G substitution in a father and son with cutaneous #lupus and enhanced type I #interferon signaling supports a role for P2RY8 in lupus causation rupress.org/jhi/article/...

How do “super-avoiders” manage to stay cancer-free? Set up to investigate this is Paul Bastard and team ATLAS – one of five newly funded teams awarded $25m (£20m) through Cancer Grand Challenges. Watch the takeover episode (on YouTube): youtu.be/hAjvmBReo-8

🏆 Le Pr Polak a reçu le prix Gilberte et Jacques Tacussel, récompensant le travail clinique et de recherche à long terme mené par toute son équipe sur le diabète du très jeune enfant, menant à découvrir les propriétés neuro-protectrices de molécules insulino-sécrétrices.

Institut Imagine is proud to lead a clinical research project named “EU-IFNp”, coordinated by Professor Marie-Louise Frémond. This is a multicentric European study dedicated to children and adults with genetic type I interferonopathies (IFNp-I) : www.institutimagine.org/en/eu-ifnp-e...

🔴 Happening NOW at Institut Imagine! Dr. Mira Kassouf (WIMM, @ox.ac.uk) is presenting our Monday Seminar: "The role of facilitators in super-enhancers and gene regulation." 🧬 She is presenting her fascinating research on the intricacies of gene control! #Genetics #InstitutImagine

Le Colloque « Génétique et Société » a réuni hier à l’Institut Imagine scientifiques, médecins, philosophes et représentants de la société civile, en partenariat avec le CCNE et l’Agence de la Biomédecine.

🔴 C'est parti pour le colloque "Génétique et Société" (42e Séminaire P. Royer) ! Ouverture de cette riche journée par le Pr Bana Jabri (Inst. Imagine) et le Dr Marine Jeantet (Agence de la Biomédecine). Suivez notre live ! 🧬

👏 Congratulations to Maria Alejandra Lizarralde-Iragorri on being awarded the highly prestigious Marie Skłodowska-Curie Postdoctoral Fellowship! Maria will be carrying out her research in Hermine Laboratory, under the co-supervision of Sara El Hoss and Thiago Trovati Maciel.

The STING HAQ haplotype and clinical non-penetrance in COPA syndrome. New report from Clémence David, Marie-Louise Frémond @mlfremond.bsky.social @institutimagine.bsky.social @upcite.bsky.social and colleagues: rupress.org/jem/article/... #HumanDiseaseGenetics #InnateImmunity #inflammation

Cerebral amebiasis due to #Acanthomoeba sp. in a patient with complete gp91phox deficiency. New report from Marie Roelens, Jacinta Bustamante and colleagues @hopitalnecker.bsky.social @institutimagine.bsky.social: rupress.org/jhi/article/... @esidsociety.bsky.social

I am very happy to share that I've started my new position @upcite.bsky.social and opened my lab @institutimagine.bsky.social 🎉 In the lab we will study how differences in X-linked gene dosage between the sexes affect fetal growth and survival and contribute to sex differences later in life 👩‍🔬🧪🧬🧫

🎙️ Live from Institut Imagine's Monday Seminar! Dr. Edor Kabashi is currently presenting "From Charcot to ALS: Defining therapeutic avenues." Fascinating deep dive into the next steps for ALS treatments. 🧬✨ #InstitutImagine #ALSResearch #Charcot

1/ Which human infectious disease is best understood in 2026? West Nile virus encephalitis, with 40% of cases attributed causally and mechanistically to auto-Abs neutralizing type I IFNs. doi.org/10.70962/jhi...

STING haplotype alone does not fully account for disease expression in COPA syndrome @jem.org rupress.org/jem/article-... @institutimagine.bsky.social

What makes brain development unique across different species? We’re diving into that exact question at our weekly Monday Seminar! Prof. Denis Jabaudon (University of Geneva & Institut Imagine) is presenting his work: "Developmental gene expression driving species-specific cortical development." 🧠

👩🏻‍🔬 À l’occasion de la Journée internationale des droits des femmes, l’Institut Imagine donne la parole à celles qui font avancer la recherche. Voir la vidéo : www.youtube.com/watch?v=2v_W...

DREPAMIR est lancé ! Cet essai de thérapie génique pour la #drépanocytose, la plus fréquente des maladies du sang en France, est porté en collaboration par @institutimagine.bsky.social, @ap-hp.bsky.social et @afm-telethon.bsky.social#drépanocytose, ℹ️ 7M de personnes sont atteintes dans le monde 👉 afm-telethon.fr

L'équipe internationale ATLAS, coordonnée par le Dr Paul Bastard de l'Institut Imagine, vient de décrocher un financement exceptionnel : jusqu'à 25 millions de dollars sur près de 5 ans, attribué par le prestigieux programme Cancer Grand Challenges !

We're proud to announce that infectious disease pioneer Jean-Laurent Casanova, MD, PhD, of @rockefeller.edu, @institutimagine.bsky.social, @hhmi-science.bsky.social, & @casanovalab.bsky.social, is the recipient of the 2026 Mechthild Esser #NemmersPrize in Medical Science: spr.ly/6008hCUaM

Congratulations to Jean-Laurent Casanova, MD, PhD (@casanovalab.bsky.social) of @Rockefeller.edu & Institut Imagine, recipient of the 2026 Mechthild Esser #NemmersPrize in Medical Science at Northwestern! A well-deserved recognition and an incredible honor recognizing his outstanding research. 🧬🔬

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

📰 News announcement! www.cancergrandchallenges.org/new-teams-an... We’re thrilled to welcome five world-leading scientific teams, each awarded up to £20 million, to take on some of the toughest unanswered questions in #CancerResearch. Find out more about the teams and their challenges.

L’Institut Imagine est signataire de l’Appel de Paris-Saclay, un collectif de plus de 25 acteurs d’excellence — universités, organismes de recherche et entreprises — réunis pour placer la science au cœur de la souveraineté européenne.

À l'occasion de la Journée internationale des maladies rares, l'Institut Imagine a organisé la projection du film « Qui brille au combat » de la réalisatrice Joséphine Japy — qui porte un regard sensible et puissant sur l'intimité d'une famille confrontée à la maladie.