Albert Heck
@hecklab.bsky.social
📤 629
📥 251
📝 66
Professor in Biomolecular Mass Spectrometry and Proteomics, Utrecht University, the Netherlands
The next episode in our quest at
@utrechtuniversity.bsky.social
to answer "what do we know about your antibodies?" Structural promiscuity in the human circulatory IgA1 clonal repertoire | PNAS
www.pnas.org/doi/10.1073/...
. Funded by
@erc.europa.eu
. Congrats to Amber Rolland
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Structural promiscuity in the human circulatory IgA1 clonal repertoire | PNAS
Immunoglobulin A (IgA) is the most abundant antibody in humans, with high concentrations in both mucosae/secretions and circulation. While mucosal ...
https://www.pnas.org/doi/10.1073/pnas.2533440123
25 days ago
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Albert Heck
ASMS
27 days ago
Congratulations to Albert J.R. Heck, recipient of the 2026
#ASMS
John B. Fenn Award for Distinguished Contribution! A leader in the field, his work continues to shape the future of
#massspectrometry
. We’re excited to celebrate his achievements at
#ASMS2026
in San Diego.
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A nice Polish - Dutch collaboration with the
@iimcb.bsky.social
. Congratulations to Mayra Borrero, Vanessa Linke and
@tkadava.bsky.social
. A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity | Science Advances
www.science.org/doi/10.1126/...
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A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity
Human TOM complex was revealed as a dynamic hub, with FKBP8 as a human-specific interactor shaping biogenesis.
https://www.science.org/doi/10.1126/sciadv.aeb2995
about 1 month ago
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Albert Heck
Joost Snijder
2 months ago
We did a plasma proteomics study on dengue disease severity in children with Tineke Cantaert and identified early markers of endothelial and inflammatory activation. Great work by
@tshamorkina.bsky.social
and Sofia! Thanks to all co-authors
@hecklab.bsky.social
.
www.medrxiv.org/content/10.6...
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Albert Heck
Joost Snijder
2 months ago
Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription.
www.biorxiv.org/content/10.6...
Check out our latest preprint. Great work by
@tshamorkina.bsky.social
. Thanks to co-authors Danni Snikkers and
@hecklab.bsky.social
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A nature-inspired ion trap for parallel manipulation of ions on a massive scale | Science Advances
www.science.org/doi/10.1126/...
. Very nice work by Brian Chait and Andrew Krutchinsky from
@rockefeller.edu
inspired by parallel sequencing in genomics and other technologies. Congratulations
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A nature-inspired ion trap for parallel manipulation of ions on a massive scale
A nature-inspired ion trap enabling massively parallel mass spectrometry.
https://www.science.org/doi/10.1126/sciadv.aec7048
2 months ago
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Beautiful ride home today
2 months ago
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Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry: Cell Systems
www.cell.com/cell-systems...
. How great would it be to sequence proteins without a gene-template! We might be approaching this soon.
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Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry
Highly efficient hyperthermal acidic proteases combined with hybrid-fragmentation schemes provide five times more unique peptide reads than trypsin or chymotrypsin, greatly boosting confidence in de n...
https://www.cell.com/cell-systems/fulltext/S2405-4712%2826%2900018-9
3 months ago
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Albert Heck
Joost Snijder
3 months ago
These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to
@tshamorkina.bsky.social
@tkadava.bsky.social
@lperezpaneda.bsky.social
and
@hecklab.bsky.social
www.sciencedirect.com/science/arti...
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Albert Heck
Elisa Fadda
3 months ago
I wonder... 🤔🤔🧪
#chemsky
a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT b) how such high school science level of disgrace pass peer review in
@nature.com
? Note this was Fig.4.a NOT in SI
www.nature.com/articles/s41...
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Albert Heck
Chris Ashwood
5 months ago
Got an Orbitrap-based mass spec that couldn’t do STORI/direct mass technology before (any aside from the UHMR and Tribrid Ascend)? This is a cool open-source implementation that even works on an Orbitrap Elite!
#teammassspec
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A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics | Analytical Chemistry
pubs.acs.org/doi/10.1021/...
. Making your data better viuable, no matter whether it is "boring" proteomics, or more exciting glycoproteomics, cross-linking mass spectrometry etc.
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A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics
Accurate and comprehensive peptide spectrum annotation is a crucial step to interpreting mass spectrometry-based proteomics data. While peak assignment in peptide fragmentation spectra is central to a...
https://pubs.acs.org/doi/10.1021/acs.analchem.5c02832
5 months ago
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Albert Heck
Silvia Surinova
6 months ago
Interested in ultra low input phosphoproteomics? Here we summarised the current considerations and opportunities when working with rare populations of cells. Congrats to
@emgaiz.bsky.social
!
#TeamMassSpec
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Albert Heck
Ying Ge
7 months ago
#HUPO2025
interested in
#topdownproteomics
please come to join us in the Friends of HUPO reception 18:45-19:45 pm Westin Frontenac Ballroom Foyer 😀❄️
@nlkproteomics.bsky.social
@proteoforms.bsky.social
@jyates.bsky.social
@hecklab.bsky.social
#teammassspec
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Every day’s commute on bike. Not every day is the same
7 months ago
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Since early 2024 we have been working with
@brukercorporation.bsky.social
on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See
www.biorxiv.org/content/10.1...
7 months ago
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Albert Heck
American Society for Biochemistry and Molecular Biology
7 months ago
🔬 For more, delve into this paper published in Molecular & Cellular Proteomics (
@asbmbjournals.bsky.social
):
www.mcponline.org/article/S153...
. Congratulations to
@tkadava.bsky.social
,
@hecklab.bsky.social
and colleagues on this fascinating work!
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Albert Heck
Carolyn Bertozzi
7 months ago
For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc
@jfhevler.bsky.social
🙏
arxiv.org/abs/2508.096...
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Thermal Tracks: A Gaussian process-based framework for universal melting curve analysis enabling unconstrained hit identification in thermal proteome profiling experiments
Thermal Tracks is a Python-based statistical framework for analyzing protein thermal stability data that overcomes key limitations of existing thermal proteome profiling (TPP) work-flows. Unlike stand...
https://arxiv.org/abs/2508.09659v1
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Albert Heck
Bavarian Center for Biomolecular Mass Spectrometry
8 months ago
🧵(4/7) 🔬 We have put together a fascinating
#Keynote
#Speakers
team: • Prof. Albert Heck -
@hecklab.bsky.social
• Dr. Hamish Stewart -
@hamishs.bsky.social
• Prof. Olga Vitek -
@olgavitek.bsky.social
l • Prof. Ron M.A. Heeren
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Albert Heck
Ruth Huttenhain
8 months ago
My lab
@stanfordmedicine.bsky.social
is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec
#Proteomics
#GPCR
#Postdoc
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Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs
https://postdocs.stanford.edu/prospective/opportunities/open-postdoctoral-position-faculty-mentor-ruth-huttenhain
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Having a great time at
msandm2025.org
with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs
@joostsnijder.bsky.social
@vixklen.bsky.social
& Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.
8 months ago
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Albert Heck
Joost Snijder
8 months ago
We’re hosting the MS+M conference in Utrecht today, lots of great talks ahead at the intersection of mass spec and microscopy. Here’s
@hecklab.bsky.social
kicking things off.
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Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry: Molecular Therapy Nucleic Acids
www.cell.com/molecular-th...
. Even visualizing > 10 million Da plasmids by the incredible Eduard Ebberink
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Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry
Heck and colleagues developed a mass photometry-based method for accurate and fast mass determination of plasmid DNA. Conventional mass photometry methods are not applicable for large DNA particles; h...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531%2825%2900186-6
9 months ago
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Preparations in full swing. Exciting program, looking forward to
msandm2025.org
and welcome our guests in Utrecht to discuss mass spectrometry, atomic force & electron microscopy and single molecule techniques
9 months ago
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Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP - Molecular & Cellular Proteomics
www.mcponline.org/article/S153...
. See this work of
@tkadava.bsky.social
@utrechtuniversity.bsky.social
artistically interpreted
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9 months ago
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🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of
@tkadava.bsky.social
doi.org/10.1016/j.mc...
@bijvoet-centre.bsky.social
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9 months ago
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Albert Heck
Vadim Demichev
9 months ago
www.biorxiv.org/content/10.1...
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Slice-PASEF: Maximising Ion Utilisation in LC-MS Proteomics
Quantitative mass spectrometry (MS)-based proteomics has become a streamlined technology with a wide range of usage. Many emerging applications, such as single-cell proteomics, spatial proteomics of t...
https://www.biorxiv.org/content/10.1101/2022.10.31.514544v3
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Albert Heck
Ying Ge
9 months ago
Our graduate student, Holden Rogers and Marie Curie postdoc fellow, Boris Krichel, did a fantastic job presenting their research projects at
#TDP2025👍👏😀
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Albert Heck
Ying Ge
9 months ago
#TDP2025
@proteoforms.bsky.social
a great opening session with fantastic talks!
@nlkproteomics.bsky.social
@joelooucla.bsky.social
@hecklab.bsky.social
@metamorpheus.bsky.social
👍thanks Hartmut for organizing the conference! 👏
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Albert Heck
Lorne Proteins
9 months ago
🥁🥁🥁 The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞 February 8–12, 2026 Register here:
www.lorneproteins.org
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Albert Heck
IonOpticks
10 months ago
New plasma glycoproteomics method out of the
@hecklab.bsky.social
uses narrow-window DIA on Orbitrap Astral with Aurora Ultimate XT column. 50% more glycopeptide IDs vs. traditional approaches, with 181 glycoproteins detected across 7 orders of magnitude in just 10-40 minute runs.
bit.ly/45bDXhv
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Revolutionising plasma glycoproteomics with Orbitrap Astral and narrow-window DIA - IonOpticks
Jager et al.'s study into plasma glycoproteomics uses a 25 cm x 75 μm IonOpticks Aurora Ultimate 25x75 UHPLC column.
https://bit.ly/45bDXhv
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Albert Heck
Tereza Kadavá
10 months ago
🕷️ Spiders from our blood 🕷️ Check out our new paper from
@hecklab.bsky.social
describing how the spider-like immune regulator C4BP interacts with its native binding partners. 🔗
www.mcponline.org/article/S153...
#MassSpec
#StructuralBiology
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Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP
C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalent...
https://www.mcponline.org/article/S1535-9476(25)00145-8/fulltext
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Albert Heck
Tereza Kadavá
10 months ago
We show that C4BP has two distinct binding modes, either involving a single “spider leg” or the entire spider-like structure wrapping around the target. Thanks to everyone involved!
@victoryin.bsky.social
,
@hecklab.bsky.social
, Jürgen, Johannes, Maryam, and Leendert
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Albert Heck
Vanessa Linke
10 months ago
🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility
@iimcb.bsky.social
in Warsaw! Apply here
tinyurl.com/y47mzafa
or send any questions my way.
#TeamMassSpec
please share widely!
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Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa
Job offer Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa
https://tinyurl.com/y47mzafa
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Albert Heck
Ardem Patapoutian
10 months ago
confession: I often get excited by n=1 results.
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Albert Heck
10 months ago
Special thanks to our keynote speakers: Alexander Makarov, Albert Heck(
@hecklab.bsky.social
), Kelly Stecker, Noortje de Haan & Ron Heeren. And to the organising team: Corine Heuzer, Albert Heck, Pavel Sinitcyn(
@sinitcyn.bsky.social
) & the full MaxQuant team(
@coxlab.bsky.social
).
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Albert Heck
Lorne Proteins
10 months ago
📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊
www.lorneproteins.org
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Albert Heck
Sarafan ChEM-H
11 months ago
"You can literally lose who you are." Institute Scholar Monther Abu‑Remaileh
@abu-remaileh.bsky.social
and team are working to uncover the role of lysosomes, our cells’ recycling centers, in degenerative brain disorders in order to identify a cure:
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‘You can literally lose who you are’
Scientists in the lab of chemical engineer Monther Abu-Remaileh are uncovering the cellular functions that go awry in degenerative brain disorders and identifying therapies that could treat them.
https://news.stanford.edu/stories/2025/06/research-matters-Monther-Abu-Remaileh
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Albert Heck
KNAW - Koninklijke Nederlandse Akademie van Wetenschappen
11 months ago
Breng Nederland terug aan kop, investeer in wetenschap en innovatie. Want onze veiligheid, welvaart, gezondheid en democratische waarden zijn niet vanzelfsprekend. In aanloop naar de verkiezingen doet de KNAW die oproep aan de politieke partijen:
www.knaw.nl/nieuws/breng...
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Albert Heck
Thomas Arnesen
11 months ago
Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at
@unibergen.bsky.social
to get this published.
#acetyltransferase
www.nature.com/articles/s41...
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Albert Heck
UW–Madison School of Pharmacy
12 months ago
Why is cocaine so addictive? A new study from Professor Lingjun Li (
@liresearch.bsky.social
) reveals that it’s not just about dopamine — neuropeptides across the brain play a key role. These insights could lead to better addiction treatments. Learn how:
pharmacy.wisc.edu/2025/03/22/u...
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Unlocking Cocaine’s Grip on the Brain - School of Pharmacy
Professor Lingjun Li and lab members reveal the crucial role of neuropeptides in cocaine addiction, paving the way for novel therapies.
https://pharmacy.wisc.edu/2025/03/22/unlocking-cocaines-grip-on-the-brain/?utm_campaign=spring2025DRx&utm_source=x&utm_medium=social
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Albert Heck
peterslab (BIOCEV,CZ)
11 months ago
Free structural MS hands-on workshop @ BIOCEV (CZ) 📅 Sept 15–19, 2025 For PhDs, postdocs & undergrads (CZ/SK) HDX-MS, native MS, cross-linking, high-res MS, data processing Apply by July 31 →
bit.ly/3HNyzIg
@spidocs.bsky.social
@mbuavcr.bsky.social
@ciisbinstructcz.bsky.social
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Albert Heck
SCIEX
12 months ago
Are you looking forward to attending
#EuPA2025
in beautiful Saint-Malo? Get ready for an enriching experience in extraordinary
#proteomics
! 🗓️ Mark your calendar for the SCIEX lunch symposium, taking place on Wednesday, June 18! 🔗 Full show agenda 👉
bit.ly/3HcA6Hw
#SkepticsWelcome
#ZenoTOF8600
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Albert Heck
Carolyn Bertozzi
12 months ago
Fantastic day sharing knowledge with the brilliant researchers at NIH who valiantly work to advance the frontiers of science for the cause of improving human health. Thank you again for your service 🙏 🇺🇸
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Albert Heck
Andreas Bäumler
12 months ago
Science has more than doubled our life expectancy, revolutionized our quality of life, and powered unprecedented technological advancement. But can we afford to take scientific progress for granted? What happens when science funding is slashed, diversity is suppressed, and pseudoscience takes hold?
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Albert Heck
Zhichang Liu
12 months ago
Site-specific protein labeling: Recent progress
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Albert Heck
Tereza Kadavá
12 months ago
Spiders from our blood 🕷️ Excited to present our work with
@hecklab.bsky.social
at
#ASMS2025
WP 611.
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Check it out. Even if you are afraid of spiders, Tereza is very nice and knowledgeable
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12 months ago
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Always interested to go beyond trypsin and CID
@tshamorkina.bsky.social
,
@tkadava.bsky.social
and
@lperezpaneda.bsky.social
,
@cinderbio.bsky.social
& @sciex.bsky.social produced https://
www.biorxiv.org/content/10.1101/2025.05.26.656138v1
&
@asms.org
. A truly improved de novo sequencing approach
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Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry
The ability to sequence proteins without reliance on a genomic template defines a critical frontier in modern proteomics. This approach, known as de novo protein sequencing, is essential for applicati...
https://www.biorxiv.org/content/10.1101/2025.05.26.656138v1
12 months ago
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