The next episode in our quest at @utrechtuniversity.bsky.social to answer "what do we know about your antibodies?" Structural promiscuity in the human circulatory IgA1 clonal repertoire | PNAS www.pnas.org/doi/10.1073/.... Funded by @erc.europa.eu. Congrats to Amber Rolland

Congratulations to Albert J.R. Heck, recipient of the 2026 #ASMS John B. Fenn Award for Distinguished Contribution! A leader in the field, his work continues to shape the future of #massspectrometry. We’re excited to celebrate his achievements at #ASMS2026 in San Diego.

A nice Polish - Dutch collaboration with the @iimcb.bsky.social. Congratulations to Mayra Borrero, Vanessa Linke and @tkadava.bsky.social. A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity | Science Advances www.science.org/doi/10.1126/...

We did a plasma proteomics study on dengue disease severity in children with Tineke Cantaert and identified early markers of endothelial and inflammatory activation. Great work by @tshamorkina.bsky.social and Sofia! Thanks to all co-authors @hecklab.bsky.social. www.medrxiv.org/content/10.6...

Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription. www.biorxiv.org/content/10.6... Check out our latest preprint. Great work by @tshamorkina.bsky.social. Thanks to co-authors Danni Snikkers and @hecklab.bsky.social

A nature-inspired ion trap for parallel manipulation of ions on a massive scale | Science Advances www.science.org/doi/10.1126/.... Very nice work by Brian Chait and Andrew Krutchinsky from @rockefeller.edu inspired by parallel sequencing in genomics and other technologies. Congratulations

Beautiful ride home today

Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry: Cell Systems www.cell.com/cell-systems.... How great would it be to sequence proteins without a gene-template! We might be approaching this soon.

These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to @tshamorkina.bsky.social @tkadava.bsky.social @lperezpaneda.bsky.social and @hecklab.bsky.social www.sciencedirect.com/science/arti...

I wonder... 🤔🤔🧪 #chemsky a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT b) how such high school science level of disgrace pass peer review in @nature.com? Note this was Fig.4.a NOT in SI www.nature.com/articles/s41...

Got an Orbitrap-based mass spec that couldn’t do STORI/direct mass technology before (any aside from the UHMR and Tribrid Ascend)? This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics | Analytical Chemistry pubs.acs.org/doi/10.1021/.... Making your data better viuable, no matter whether it is "boring" proteomics, or more exciting glycoproteomics, cross-linking mass spectrometry etc.

Interested in ultra low input phosphoproteomics? Here we summarised the current considerations and opportunities when working with rare populations of cells. Congrats to @emgaiz.bsky.social! #TeamMassSpec

#HUPO2025 interested in #topdownproteomics please come to join us in the Friends of HUPO reception 18:45-19:45 pm Westin Frontenac Ballroom Foyer 😀❄️ @nlkproteomics.bsky.social @proteoforms.bsky.social @jyates.bsky.social @hecklab.bsky.social #teammassspec

Every day’s commute on bike. Not every day is the same

Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...

🔬 For more, delve into this paper published in Molecular & Cellular Proteomics ( @asbmbjournals.bsky.social): www.mcponline.org/article/S153.... Congratulations to @tkadava.bsky.social, @hecklab.bsky.social and colleagues on this fascinating work!

For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏 arxiv.org/abs/2508.096...

🧵(4/7) 🔬 We have put together a fascinating #Keynote #Speakers team: • Prof. Albert Heck - @hecklab.bsky.social • Dr. Hamish Stewart - @hamishs.bsky.social • Prof. Olga Vitek - @olgavitek.bsky.social l • Prof. Ron M.A. Heeren

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc

Having a great time at msandm2025.org with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs @joostsnijder.bsky.social @vixklen.bsky.social & Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.

We’re hosting the MS+M conference in Utrecht today, lots of great talks ahead at the intersection of mass spec and microscopy. Here’s @hecklab.bsky.social kicking things off.

Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry: Molecular Therapy Nucleic Acids www.cell.com/molecular-th.... Even visualizing > 10 million Da plasmids by the incredible Eduard Ebberink

Preparations in full swing. Exciting program, looking forward to msandm2025.org and welcome our guests in Utrecht to discuss mass spectrometry, atomic force & electron microscopy and single molecule techniques

Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP - Molecular & Cellular Proteomics www.mcponline.org/article/S153.... See this work of @tkadava.bsky.social @utrechtuniversity.bsky.social artistically interpreted

🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of @tkadava.bsky.social doi.org/10.1016/j.mc... @bijvoet-centre.bsky.social

Our graduate student, Holden Rogers and Marie Curie postdoc fellow, Boris Krichel, did a fantastic job presenting their research projects at #TDP2025👍👏😀

#TDP2025 @proteoforms.bsky.social a great opening session with fantastic talks! @nlkproteomics.bsky.social @joelooucla.bsky.social @hecklab.bsky.social @metamorpheus.bsky.social 👍thanks Hartmut for organizing the conference! 👏

🥁🥁🥁 The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞 February 8–12, 2026 Register here: www.lorneproteins.org

New plasma glycoproteomics method out of the @hecklab.bsky.social uses narrow-window DIA on Orbitrap Astral with Aurora Ultimate XT column. 50% more glycopeptide IDs vs. traditional approaches, with 181 glycoproteins detected across 7 orders of magnitude in just 10-40 minute runs. bit.ly/45bDXhv

🕷️ Spiders from our blood 🕷️ Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners. 🔗 www.mcponline.org/article/S153... #MassSpec #StructuralBiology

We show that C4BP has two distinct binding modes, either involving a single “spider leg” or the entire spider-like structure wrapping around the target. Thanks to everyone involved! @victoryin.bsky.social, @hecklab.bsky.social, Jürgen, Johannes, Maryam, and Leendert

🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!

confession: I often get excited by n=1 results.

Special thanks to our keynote speakers: Alexander Makarov, Albert Heck(@hecklab.bsky.social‬), Kelly Stecker, Noortje de Haan & Ron Heeren. And to the organising team: Corine Heuzer, Albert Heck, Pavel Sinitcyn(@sinitcyn.bsky.social) & the full MaxQuant team(@coxlab.bsky.social).

📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊 www.lorneproteins.org

"You can literally lose who you are." Institute Scholar Monther Abu‑Remaileh @abu-remaileh.bsky.social and team are working to uncover the role of lysosomes, our cells’ recycling centers, in degenerative brain disorders in order to identify a cure:

Breng Nederland terug aan kop, investeer in wetenschap en innovatie. Want onze veiligheid, welvaart, gezondheid en democratische waarden zijn niet vanzelfsprekend. In aanloop naar de verkiezingen doet de KNAW die oproep aan de politieke partijen: www.knaw.nl/nieuws/breng...

Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...

Why is cocaine so addictive? A new study from Professor Lingjun Li (@liresearch.bsky.social) reveals that it’s not just about dopamine — neuropeptides across the brain play a key role. These insights could lead to better addiction treatments. Learn how: pharmacy.wisc.edu/2025/03/22/u...

Free structural MS hands-on workshop @ BIOCEV (CZ) 📅 Sept 15–19, 2025 For PhDs, postdocs & undergrads (CZ/SK) HDX-MS, native MS, cross-linking, high-res MS, data processing Apply by July 31 → bit.ly/3HNyzIg @spidocs.bsky.social @mbuavcr.bsky.social @ciisbinstructcz.bsky.social

Are you looking forward to attending #EuPA2025 in beautiful Saint-Malo? Get ready for an enriching experience in extraordinary #proteomics! 🗓️ Mark your calendar for the SCIEX lunch symposium, taking place on Wednesday, June 18! 🔗 Full show agenda 👉 bit.ly/3HcA6Hw #SkepticsWelcome #ZenoTOF8600

Fantastic day sharing knowledge with the brilliant researchers at NIH who valiantly work to advance the frontiers of science for the cause of improving human health. Thank you again for your service 🙏 🇺🇸

Science has more than doubled our life expectancy, revolutionized our quality of life, and powered unprecedented technological advancement. But can we afford to take scientific progress for granted? What happens when science funding is slashed, diversity is suppressed, and pseudoscience takes hold?

Site-specific protein labeling: Recent progress

Spiders from our blood 🕷️ Excited to present our work with @hecklab.bsky.social at #ASMS2025 WP 611.

Check it out. Even if you are afraid of spiders, Tereza is very nice and knowledgeable

Always interested to go beyond trypsin and CID @tshamorkina.bsky.social, @tkadava.bsky.social and @lperezpaneda.bsky.social, @cinderbio.bsky.social & @sciex.bsky.social produced https:// www.biorxiv.org/content/10.1101/2025.05.26.656138v1 & @asms.org. A truly improved de novo sequencing approach